Cited by 59Prenatal Substance Exposure EffectsNeurotransmitter Receptor Influence on BehaviorSmoking Behavior and Cessation

Nicotine exposure during pregnancy is a factor which influences serotonin transporter density in the rat brain

Muneoka, Katsumasa, Ogawa, Tetsuo, Kamei, Kenji, Mimura, Yuichi, Kato, Hitomi, Takigawa, Morikuni·2001·European Journal of Pharmacology

Abstract

We examined the effects of nicotine exposure during pregnancy on serotonin transporter (SERT) expression in the brain. Nicotine (6 mg/kg/day) was administered to pregnant rats via subcutaneous injections or infusion pumps. Irrespective of the route of administration, nicotine increased SERT density in the forebrain on postnatal day 22, but not in the other brain regions. Our results suggest that nicotine use by pregnant women might be an environmental factor influencing SERT expression in their children.

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Crossref · 10.1016/s0014-2999(00)00925-0

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24 of 24 references verified0 citation errors · 0 not checkable

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  • Smoking exposes a developing fetus to many risks including thousands of potentially harmful chemicals and oxygen deprivation, causing changes in neurotransmitter activity in the developing brain.

    “Smoking exposes a developing fetus to many risks including thousands of potentially harmful chemicals and oxygen deprivation, collectively causing changes in neurotransmitter activity within the developing brain [138, 139].”

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Authors
Muneoka, K., Ogawa, T., Kamei, K., Mimura, Y., Kato, H., & Takigawa, M.
Affiliations
Kagoshima University (JP)
Corresponding author
Muneoka, Katsumasa
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2001-01
Volume
411
Issue
3
Pages
279-282
ISSN
0014-2999 (ISSN-L)
OpenAlex
W1966750374
Cited by
59
References
27
Citations by year
2025: 2 · 2023: 1 · 2022: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 3
FWCI
3.00
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords
nicotine, pregnancy, serotonin transporter, prenatal nicotine exposure, forebrain, maternal smoking, developmental neurotoxicity, rat brain
MeSH terms
Animals, Brain Chemistry, Carrier Proteins, Female, Infusion Pumps, Injections, Subcutaneous, Male, Membrane Glycoproteins, Nerve Tissue Proteins, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Sprague-Dawley, Selective Serotonin Reuptake Inhibitors, Paroxetine, Nicotinic Agonists, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins, Rats

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