Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke
Abstract
Serotonin (5HT) systems play important roles in brain development, and early perturbations of 5HT receptor expression produce permanent changes in 5HT synaptic function and associated behaviors. We exposed pregnant Rhesus monkeys to environmental tobacco smoke (ETS) during gestation and for up to 3 months postnatally and examined the expression of 5HT(1A) and 5HT(2) receptors, and of the presynaptic 5HT transporter in brain regions containing 5HT projections (frontal, temporal and occipital cortex) and cell bodies (midbrain). Perinatal ETS exposure elicited upregulation of 5HT(1A) receptor expression without parallel changes in the other two proteins, a pattern consistent with specific 5HT receptor dysregulation, rather than universal disruption of 5HT synaptic development. The effects seen here for ETS in a primate model are virtually identical in direction, magnitude and regional selectivity to those obtained previously for prenatal nicotine administration in rats. Specifically, early 5HT(1A) overexpression alters the program for future synaptic and behavioral 5HT responses, thus providing a mechanistic link for the shared effects of ETS and nicotine on a specific pathway responsible for behavioral anomalies associated with perinatal tobacco exposure. These results reinforce the need to reduce ETS exposure of pregnant women and young children.
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Nicotine is a key cause of the neurodevelopmental harm from tobacco smoke exposure.
“and these studies show that nicotine itself is a critical contributor to the harmful neurodevelopmental effects of tobacco smoke exposure.(307-310)”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [309]
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Structural–functional relationships in experimentally induced brain damage
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- Authors
- Slotkin, T. A., Pinkerton, K. E., Tate, C. A., & Seidler, F. J.
- Affiliations
- Duke Medical Center (US)
- University of California, Davis (US)
- Corresponding author
- Slotkin, Theodore A.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 1111
- Issue
- 1
- Pages
- 30-35
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2037224918
- Cited by
- 51
- References
- 4
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2018: 3 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 1 · 2012: 4
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (R01ES011634, ES 011634, ES05707)
- National Center for Research Resources (P51RR000169, RR-00169)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- serotonin, environmental tobacco smoke, perinatal exposure, 5-HT1A receptor, 5-HT2 receptor, serotonin transporter, synaptic proteins, brain development, rhesus monkeys, frontal cortex, temporal cortex, occipital cortex, midbrain, behavioral anomalies
- MeSH terms
- Animals, Brain, Disease Models, Animal, Environmental Exposure, Female, Macaca mulatta, Neural Pathways, Synaptic Transmission, Pregnancy, Prenatal Exposure Delayed Effects, Serotonin, Synapses, Synaptic Membranes, Time, Nicotiana, Up-Regulation, Presynaptic Terminals, Receptor, Serotonin, 5-HT1A, Receptors, Serotonin, 5-HT2, Serotonin Plasma Membrane Transport Proteins
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