Cited by 914Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 643 of the 656 references it cites were found in a registry or an index.

Neuroendocrine pharmacology of stress

Carrasco, Gonzalo A, Van de Kar, Louis D·2003·European Journal of Pharmacology

Open this paper in CoChat — free account

Abstract

Exposure to hostile conditions initiates responses organized to enhance the probability of survival. These coordinated responses, known as stress responses, are composed of alterations in behavior, autonomic function and the secretion of multiple hormones. The activation of the renin-angiotensin system and the hypothalamic-pituitary-adrenocortical axis plays a pivotal role in the stress response. Neuroendocrine components activated by stressors include the increased secretion of epinephrine and norepinephrine from the sympathetic nervous system and adrenal medulla, the release of corticotropin-releasing factor (CRF) and vasopressin from parvicellular neurons into the portal circulation, and seconds later, the secretion of pituitary adrenocorticotropin (ACTH), leading to secretion of glucocorticoids by the adrenal gland. Corticotropin-releasing factor coordinates the endocrine, autonomic, behavioral and immune responses to stress and also acts as a neurotransmitter or neuromodulator in the amygdala, dorsal raphe nucleus, hippocampus and locus coeruleus, to integrate brain multi-system responses to stress. This review discussed the role of classical mediators of the stress response, such as corticotropin-releasing factor, vasopressin, serotonin (5-hydroxytryptamine or 5-HT) and catecholamines. Also discussed are the roles of other neuropeptides/neuromodulators involved in the stress response that have previously received little attention, such as substance P, vasoactive intestinal polypeptide, neuropeptide Y and cholecystokinin. Anxiolytic drugs of the benzodiazepine class and other drugs that affect catecholamine, GABA(A), histamine and serotonin receptors have been used to attenuate the neuroendocrine response to stressors. The neuroendocrine information for these drugs is still incomplete; however, they are a new class of potential antidepressant and anxiolytic drugs that offer new therapeutic approaches to treating anxiety disorders. The studies described in this review suggest that multiple brain mechanisms are responsible for the regulation of each hormone and that not all hormones are regulated by the same neural circuits. In particular, the renin-angiotensin system seems to be regulated by different brain mechanisms than the hypothalamic-pituitary-adrenal system. This could be an important survival mechanism to ensure that dysfunction of one neurotransmitter system will not endanger the appropriate secretion of hormones during exposure to adverse conditions. The measurement of several hormones to examine the mechanisms underlying the stress response and the effects of drugs and lesions on these responses can provide insight into the nature and location of brain circuits and neurotransmitter receptors involved in anxiety and stress.

Integrity signals

Registry

Crossref · 10.1016/s0014-2999(03)01285-8

Cites

643 of 643 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533
Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965
Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 3,025
Gender differences in depression: Critical review
Piccinelli, M., & Wilkinson, G. (2000) · British Journal of Psychiatry · doi:10.1192/bjp.177.6.486 · Cited by 2,376
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270
Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
Swanson, L. W., & Sawchenko, P. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001413 · Cited by 1,991
Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study
Swanson, L. W., Sawchenko, P. E., Rivier, J., & Vale, W. W. (2008) · Neuroendocrinology · doi:10.1159/000123454 · Cited by 1,953

Show all 656 references

Research works printed but not linked: 8

Dahlstrom, 1965, Evidence for the existence of monoamine-containing neurons in the central nervous system IV, Acta Physiol. Scand., 64, 1
Deak, 1999, The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress, Endocrinology, 140, 79, 10.1210/en.140.1.79 · DOI · Paper page
Lorens, 1986, The serotonin antagonist LY53857, the 5-HT agonist 8-OH-DPAT, and intra-midbrain raphe, 5,7-dihidroxytryptamine lesions do not affect condiytioned fear induced increased in rennin secretion, Soc. Neurosci. Abstr., 12, 213
Parsons, 1996, Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration, Behav. Brain Res., 73, 225, 10.1016/0166-4328(96)00101-5 · DOI
Santarelli, 2001, Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function, Proc. Natl. Acad. Sc. U. S. A., 98, 1912, 10.1073/pnas.041596398 · DOI
Van Megen, 1997, Effect of the selective serotonin reuptake inhibitor fluvoxamine on CCK-4 induced panic attacks, Psychopharmacology (Berl.), 129, 357, 10.1007/s002130050201 · DOI
Wank, 1995, Chosystokinin receptors, Am. J. Physiol., 269, G628
Zhang, 2001, Co-localization of 5-HT1A and 5-HT2A serotonin receptors on oxytocin cells in the hypothalamic paraventricular nucleus, Neurosci. Abstr., 17, 136

Sorted by citations

Items 201–300 of 910

Interleukin-1 (IL-1) in stress-induced activation of limbic-hypothalamic-pituitary adrenal axis
Gądek-Michalska, A., & Bugajski, J. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70359-5 · Cited by 56
Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5‐HT2A) receptor activity via ERK1/2 signaling
Franklin, J. M., & Carrasco, G. A. (2012) · Synapse · doi:10.1002/syn.21626 · Cited by 56
Self-citation
The stimuli-specific role of vasopressin in the hypothalamus–pituitary–adrenal axis response to stress
Zelena, D., Domokos, Á., Jain, S. K., Jankord, R., & Filaretova, L. P. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0096 · Cited by 56
Vasopressin & Oxytocin in Control of the Cardiovascular System: An Updated Review
Japundzic-Zigon, N., Lozic, M., Šarenac, O., & Murphy, D. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190717150501 · Cited by 43
Estrogen and progesterone dose-dependently reduce disruptive effects of restraint on lordosis behavior
White, S., & Uphouse, L. L. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2003.10.001 · Cited by 55
The role of the vagus nerve in fibromyalgia syndrome
Martins, D. F., Viseux, F., Salm, D. C., Ribeiro, A. C. A., da Silva, H. K. L., Seim, L. A., Bittencourt, E. B., Bianco, G., Moré, A. O. O., Reed, W. R., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.021 · Cited by 58
Estrogen Signaling in the Hypothalamus
Kelly, M. J., Qiu, J., & Rønnekleiv, O. K. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71005-0 · Cited by 54
5-HT1A, 5-HT2A, and 5-HT2C receptor mRNA modulation by antidepressant treatment in the chronic mild stress model of depression: sex differences exposed
Pitychoutis, P. M., Dalla, C., Sideris, A. C., Tsonis, P. A., & Papadopoulou‐Daifoti, Z. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.003 · Cited by 53
A Review of the Effects of Stress on Dairy Cattle Behaviour
Jurkovich, V., Hejel, P., & Kovács, L. (2024) · Animals · doi:10.3390/ani14142038 · Cited by 53
Baicalin regulates depression behavior in mice exposed to chronic mild stress via the Rac/LIMK/cofilin pathway
Lu, Y. F., Sun, G., Yang, F., Guan, Z.-W., Zhang, Z., Zhao, J., Liu, Y., Chu, L., & Pei, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109054 · Cited by 56
Brain angiotensin and anxiety-related behavior: The transgenic rat TGR(ASrAOGEN)680
Voigt, J., Hörtnagl, H., Rex, A., van Hove, L., Bäder, M., & Fink, H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.048 · Cited by 53
Role of neuronal nitric oxide synthase in the regulation of the neuroendocrine stress response in rodents: insights from mutant mice
Orlando, G. F., Wolf, G. L., & Engelmann, M. (2008) · Amino Acids · doi:10.1007/s00726-007-0630-0 · Cited by 55
Effects of repeated restraint stress on hypothalamo-pituitary-adrenocortical function in vasopressin deficient Brattleboro rats
Zelena, D., Földes, A., Mergl, Z., Barna, I., Kovács, K., & Makara, G. B. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.04.007 · Cited by 53
A current status of adaptogens: Natural remedy to stress
Pawar, V. S., & Shivakumar, H. (2012) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(12)60207-2 · Cited by 52
Pharmacotherapeutic management of insomnia and effects on sleep processes, neural plasticity, and brain systems modulating stress: A narrative review
Palagini, L., & Bianchini, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.893015 · Cited by 52
Efficacy of Vestipitant, A Neurokinin-1 Receptor Antagonist, in Primary Insomnia
Ratti, E., Carpenter, D. J., Zamuner, S., Fernandes, S., Squassante, L., Danker‐Hopfe, H., Archer, G. E., Robertson, J., Alexander, R., Trist, D. G., et al. (2013) · SLEEP · doi:10.5665/sleep.3208 · Cited by 51
Fluoxetine treatment affects nitrogen waste excretion and osmoregulation in a marine teleost fish
Morando, M. B., Medeiros, L. R., & McDonald, M. D. (2009) · Aquatic Toxicology · doi:10.1016/j.aquatox.2009.03.011 · Cited by 51
Nerve Growth Factor, Stress and Diseases
Ceci, F. M., Ferraguti, G., Petrella, C., Greco, A., Tirassa, P., Iannitelli, A., Ralli, M., Vitali, M., Ceccanti, M., Chaldakov, G. N., et al. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327999200818111654 · Cited by 53
The Role of Vasopressin in Hypothalamo‐Pituitary‐Adrenal Axis Activation during Stress: An Assessment of the Evidence
Makara, G. B., Mergl, Z., & Zelena, D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.018 · Cited by 52
The importance of housing conditions on behavioral sensitization and tolerance to ethanol
de Araujo, N. P., Camarini, R., Formigoni, M. L. O. D. S., Carvalho, R. C., Abílio, V. C., Silva, R. H., Ricardo, V. P., Ribeiro, R. D. A., & Frussa‐Filho, R. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.07.009 · Cited by 51
Effects of benzodiazepines receptor agonists on the hypothalamic–pituitary–adrenocortical axis
Mikkelsen, J. D., Søderman, A., Kiss, A., & Mirza, N. R. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.06.049 · Cited by 50
Hormonal Aspects of Ménière’s Disease on the Basis of Clinical and Experimental Studies
Takeda, T., Takeda, S., Kakigi, A., Okada, T., Nishioka, R., Taguchi, D., Nishimura, M., & Nakatani, H. (2009) · ORL · doi:10.1159/000265113 · Cited by 49
Influence of environmental enrichment on hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine by osmotic mini-pumps, and nicotine withdrawal by mecamylamine in male and female rats
Skwara, A. J., Karwoski, T. E., Czambel, R. K., Rubín, R. T., & Rhodes, M. E. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.06.003 · Cited by 48
Direct targeting of peptidergic amygdalar neurons by noradrenergic afferents: linking stress-integrative circuitry
Kravets, J. L., Reyes, B. A. S., Unterwald, E. M., & Bockstaele, E. J. V. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0674-8 · Cited by 49
Can hospitalization be hazardous to your health? A nosocomial based stress model for hospitalization
Chang, B. (2019) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2019.07.014 · Cited by 49
Gestational Hypoxia Induces Sex-Differential Methylation of Crhr1 Linked to Anxiety-like Behavior
Wang, X., Meng, F.-S., Liu, Z.-Y., Fan, J.-M., Hao, K., Chen, X.-Q., & Du, J.-Z. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8444-4 · Cited by 52
Corticosterone administration up‐regulated expression of norepinephrine transporter and dopamine β‐hydroxylase in rat locus coeruleus and its terminal regions
Fan, Y., Chen, P., Li, Y., Cui, K., Noel, D. M., Cummins, E. D., Peterson, D. J., Brown, R. W., & Zhu, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12459 · Cited by 49
Prevalence of metabolic syndrome in pre- and post-menopausal women: A prospective study from apex institute of North India
Joshi, B., Sharma, S., Aggarwal, N., Suri, V., & Badada, S. K. (2016) · Journal of Mid-life Health · doi:10.4103/0976-7800.195695 · Cited by 48
Fluoxetine treatment affects nitrogen waste excretion and osmoregulation in a marine teleost fish
Morando, M. B., Medeiros, L. R., & McDonald, M. D. (2009) · Aquatic Toxicology · doi:10.1016/j.aquatox.2009.10.015 · Cited by 48
Sick and grumpy: Changes in social behaviour after a controlled immune stimulation in group-housed gilts
Munsterhjelm, C., Nordgreen, J., Aae, F., Heinonen, M., Valros, A., & Janczak, A. M. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.09.018 · Cited by 48
Evidence for a link between tail biting and central monoamine metabolism in pigs (Sus scrofa domestica)
Valros, A., Palander, P., Heinonen, M., Munsterhjelm, C., Brunberg, E., Keeling, L. J., & Piepponen, P. T. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.049 · Cited by 47
Increases of CRF in the amygdala are responsible for reinstatement of methamphetamine-seeking behavior induced by footshock
Nawata, Y., Kitaichi, K., & Yamamoto, T. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.01.003 · Cited by 47
The impact of perceived stress on skin ageing
Lee, C. M., Watson, R. E. B., & Kleyn, C. E. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15865 · Cited by 52
Prenatal stress in the rat results in increased blood pressure responsiveness to stress and enhanced arterial reactivity to neuropeptide Y in adulthood
Igosheva, N., Taylor, P. D., Poston, L., & Glover, V. A. S. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.130252 · Cited by 49
Role Played by Brainstem Neurons in Regulating Testosterone Secretion via a Direct Neural Pathway between the Hypothalamus and the Testes
Selvage, D. J., Parsons, L. H., & RIVIER, C. L. (2006) · Endocrinology · doi:10.1210/en.2005-1358 · Cited by 47
Changes in neuroactive steroid content during social isolation stress modulate GABAA receptor plasticity and function
Serra, M., Pisu, M. G., Mostallino, M. C., Sanna, E., & Biggio, G. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.029 · Cited by 47
The Role of the Amygdala in Anxiety Disorders
Gina, L., Andrew, M., Jamie, L. A., & Michael, J. (2012) · InTech eBooks · doi:10.5772/50323 · Cited by 48
Widespread hypothalamic–pituitary–adrenocortical axis‐relevant and mood‐relevant effects of chronic fluoxetine treatment on glucocorticoid receptor gene expression in mice
Heydendael, W., & Jacobson, L. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07131.x · Cited by 45
Estresse térmico durante o pré-abate em frangos de corte
Brossi, C., Contreras-Castillo, C. J., Amazonas, E. D. A., & Menten, J. F. M. (2009) · Ciência Rural · doi:10.1590/s0103-84782009005000039 · Cited by 45
Stress modulation of reconsolidation
Akirav, I., & Maroun, M. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2887-6 · Cited by 46
Gender-specific effects of fluoxetine on hippocampal glucocorticoid receptor phosphorylation and behavior in chronically stressed rats
Mitić, M., Simic, I., Djordjevic, J., Radojcic, M. B., & Adžić, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.12.012 · Cited by 46
Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor function
Choudhury, B. K., Shi, X.-Z. P., & Sarna, S. K. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90712.2008 · Cited by 46
Neuroprotective effects of sildenafil against oxidative stress and memory dysfunction in mice exposed to noise stress
Sikandaner, H., Park, S. Y., Kim, M. J., Park, S. N., & Yang, D. W. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.046 · Cited by 43
Consumption of a palatable diet by chronically stressed rats prevents effects on anxiety-like behavior but increases oxidative stress in a sex-specific manner
Krolow, R., Noschang, C. G., Arcego, D. M., Andreazza, A. C., Peres, W., Gonçalves, C. A., & Dalmaz, C. (2010) · Appetite · doi:10.1016/j.appet.2010.03.013 · Cited by 44
New approved and emerging pharmacological approaches to alcohol use disorder: a review of clinical studies
Morley, K. C., Perry, C. J., Watt, J., Hurzeler, T. P., Leggio, L., Lawrence, A. J., & Haber, P. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1892641 · Cited by 44
The study of aqueous extract of Pterocarpus marsupium Roxb. on cytokine TNF-α in type 2 diabetic rats
Srinivasan, B., Halagappa, K., & Girish, H. (2010) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.71922 · Cited by 44
Anxiogenic and antinociceptive effects induced by corticotropin-releasing factor (CRF) injections into the periaqueductal gray are modulated by CRF1 receptor in mice
Miguel, T. T., & Nunes‐de‐Souza, R. L. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.06.004 · Cited by 43
Social Opportunity Rapidly Regulates Expression of CRF and CRF Receptors in the Brain during Social Ascent of a Teleost Fish, Astatotilapia burtoni
Carpenter, R. E., Maruska, K. P., Becker, L., & Fernald, R. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096632 · Cited by 43
Antidepressant-Like Effects of the Corticotropin-Releasing Factor 1 Receptor Antagonist, SSR125543, and the Vasopressin 1b Receptor Antagonist, SSR149415, in a DRL-72 s Schedule in the Rat
Louis, C., Cohen, C., Depoortère, R., & Griebel, G. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301036 · Cited by 44
Intravenous catecholamine administration affects mouse intestinal lymphocyte number and apoptosis
Marra, S., Burnett, M., & Hoffman‐Goetz, L. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.08.008 · Cited by 43
Drug disease interactions: role of inflammatory mediators in depression and variability in antidepressant drug response.
Kulmatycki, K. M., & Jamali, F. (2006) · PubMed · Cited by 44
Endocannabinoids mediate the glucocorticoid‐induced inhibition of excitatory synaptic transmission to dorsal raphe serotonin neurons
Wang, J., Shen, R., & Haj‐Dahmane, S. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.238659 · Cited by 43
Physiological and Behavioural Responses of Farm Animals to Stress: Implications to Animal Productivity
Etim, N. N., Williams, M. E., Evans, E. I., & Offiong, E. E. A. (2013) · Cited by 43
Individual differences in amphetamine sensitization, behavior and central monoamines
Scholl, J. L., Feng, N., Watt, M. J., Renner, K. J., & Forster, G. L. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.12.001 · Cited by 43
Chronic stress and insulin resistance-related indices of cardiovascular disease risk, part I: neurophysiological responses and pathological sequelae.
Innes, K. E., Vincent, H. K., & Taylor, A. G. (2007) · PubMed · Cited by 43
Relevance of chronic stress and the two faces of microglia in Parkinson's disease
Herrera, A. J., Espinosa-Oliva, A. M., Carrillo-Jiménez, A., Oliva-Martín, M. J., García-Revilla, J., García-Quintanilla, A., de Pablos, R. M., & Venero, J. L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00312 · Cited by 42
The Orexin/Hypocretin System, the Peptidergic Regulator of Vigilance, Orchestrates Adaptation to Stress
Jászberényi, M., Thurzó, B., Bagosi, Z., Vécsei, L., & Tanaka, M. (2024) · Biomedicines · doi:10.3390/biomedicines12020448 · Cited by 42
Evidence for serotonin synthesis-dependent regulation of in vitro neuronal firing rates in the midbrain raphe complex
Evans, A. K., Reinders, N. R., Ashford, K. A., Christie, I. N., Wakerley, J. B., & Lowry, C. A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.014 · Cited by 45
Diagnostic Value of Salivary Markers in Neuropsychiatric Disorders
Kułak-Bejda, A., Waszkiewicz, N., Bejda, G., Zalewska, A., & Maciejczyk, M. (2019) · Disease Markers · doi:10.1155/2019/4360612 · Cited by 41
Cannabinoid-induced enhanced interaction and protein levels of serotonin 5-HT2A and dopamine D2 receptors in rat prefrontal cortex
Franklin, J. M., & Carrasco, G. A. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112450786 · Cited by 42
Self-citation
Chronic Maternal Fluoxetine Infusion in Pregnant Sheep: Effects on the Maternal and Fetal Hypothalamic-Pituitary-Adrenal Axes
Morrison, J. L., Riggs, K. W., Chien, C., Gruber, N., McMillen, I. C., & Rurak, D. W. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000128981.38670.28 · Cited by 41
Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo
Sullivan, N. R., Crane, J. W., Damjanoska, K. J., Carrasco, G. A., D’Souza, D. N., García, F., & de Kar, L. D. V. (2005) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-004-1005-7 · Cited by 41
Self-citation
Corticosteroids for severe influenza pneumonia: A critical appraisal
Nedel, W. L. (2016) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v5.i1.89 · Cited by 42
Changes of testicular phosphorylated proteins in response to restraint stress in male rats
Arun, S., Burawat, J., Sukhorum, W., Sampannang, A., Uabundit, N., & Iamsaard, S. (2016) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1500174 · Cited by 41
The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer's disease
Torres‐Berrío, A., & Nava-Mesa, M. O. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.011 · Cited by 41
Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience
Torres‐Berrío, A., Cuesta, S., López-Guzmán, S., & Nava-Mesa, M. O. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02639 · Cited by 48
Dogmas and controversies in the handling of nitrogenous wastes:5-HT2-like receptors are involved in triggering pulsatile urea excretion in the gulf toadfish,Opsanus beta
McDonald, M. D., & Walsh, P. J. (2004) · Journal of Experimental Biology · doi:10.1242/jeb.00957 · Cited by 41
Decreased Neurokinin-1 (Substance P) Receptor Binding in Patients with Panic Disorder: Positron Emission Tomographic Study with [18F]SPA-RQ
Fujimura, Y., Yasuno, F., Farris, A. G., Liow, J., Geraci, M. F., Drevets, W. C., Pine, D. S., Ghose, S., Lerner, A., Hargreaves, R. J., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.027 · Cited by 41
Allopregnanolone modulation of HPA axis function in the adult rat
Biggio, G., Pisu, M. G., Biggio, F., & Serra, M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3521-6 · Cited by 40
Molecular mechanisms linking stress and insulin resistance
Yaribeygi, H., Maleki, M., Butler, A. E., Jamialahmadi, T., & Sahebkar, A. (2021) · EXCLI journal · doi:10.17179/excli2021-4382 · Cited by 59
Enhanced involvement of brain vasopressin V1 receptors in cardiovascular responses to stress in rats with myocardial infarction
Dobruch, J. T., Cudnoch‐Jędrzejewska, A., & Szczepanska‐Sadowska, E. K. (2005) · Stress · doi:10.1080/10253890500456287 · Cited by 40
Comparative study of perturbations of peripheral markers in different stressors in rats
Rai, D., Bhatia, G., Sen, T., & Palit, G. (2003) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y03-117 · Cited by 40
Ameliorative potential of sodium cromoglycate and diethyldithiocarbamic acid in restraint stress-induced behavioral alterations in rats
Manchanda, R. K., Jaggi, A. S., & Singh, N. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70398-x · Cited by 41
Withdrawal from extended‐access cocaine self‐administration results in dysregulated functional activity and altered locomotor activity in rats
Calipari, E. S., Beveridge, T. J. R., Jones, S. R., & Porrino, L. J. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12381 · Cited by 39
Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background
Farkas, J. I., Kovács, L. Á., Gáspár, L., Nafz, A. E., Gaszner, T., Ujvari, B., Kormos, V., CSERNUS, V. J., Hashimoto, H., Reglődi, D., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.019 · Cited by 42
Heat Stress Biomarker Amino Acids and Neuropeptide Afford Thermotolerance in Chicks
Chowdhury, V. S. (2018) · The Journal of Poultry Science · doi:10.2141/jpsa.0180024 · Cited by 39
Stress‐dependent hypertension and the role of T lymphocytes
Marvar, P. J., & Harrison, D. G. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.061507 · Cited by 38
Chronic social defeat up-regulates expression of norepinephrine transporter in rat brains
Chen, P., Fan, Y., Li, Y., Sun, Z., Bissette, G., & Zhu, M. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.11.003 · Cited by 43
Repeated episodic exposure to ethanol affects neurotrophin content in the forebrain of the mature rat
Miller, M. W. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.026 · Cited by 39
Role of the medial amygdala in mediating responses to aversive stimuli leading to hypertension
Davern, P. J., & Head, G. A. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05413.x · Cited by 39
Studies on Effect of Stress Preconditioning in Restrain Stress-induced Behavioral Alterations
Kaur, R., Jaggi, A. S., & Singh, N. (2010) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.130.215 · Cited by 37
Effects of chronic stress: A comparison between tethered and loose sows
van der Staay, F. J., Schuurman, T., Hulst, M., Smits, M. A., Prickaerts, J., Kenis, G., & Korte, S. M. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.02.020 · Cited by 38
Acupuncture at ST 36 prevents chronic stress-induced increases in neuropeptide Y in rat
Eshkevari, L., Egan, R. J., Phillips, D., Tilan, J. U., Carney, E., Azzam, N. A., Amri, H., & Mulroney, S. E. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011224 · Cited by 38
Neuropeptide FF Modulates Neuroendocrine and Energy Homeostasis through Hypothalamic Signaling
Lin, Y., & Chen, J. (2019) · The Chinese Journal of Physiology · doi:10.4103/cjp.cjp_23_19 · Cited by 39
Effect of chronic psychological stress on insulin release from rat isolated pancreatic islets
Zardooz, H., Zahediasl, S., & Naseri, M. G. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.12.032 · Cited by 38
Fibromyalgia Syndrome: A Central Role for the Hippocampus—A Theoretical Construct
Wood, P. B. (2004) · Journal of Musculoskeletal Pain · doi:10.1300/j094v12n01_04 · Cited by 38
Tonic modulation of anxiety-like behavior by corticotropin-releasing factor (CRF) type 1 receptor (CRF1) within the medial prefrontal cortex (mPFC) in male mice: Role of protein kinase A (PKA)
Miguel, T. T., Gomes, K. S., & Nunes‐de‐Souza, R. L. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.05.003 · Cited by 37
Response of liver antioxidant defense system to acute and chronic physical and psychological stresses in male rats
Jafari, M., Salehi, M., Zardooz, H., & Rostamkhani, F. (2014) · Europe PMC (PubMed Central) · doi:10.17877/de290r-1067 · Cited by 37
Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation
Malta, M. B., Martins, J., Novaes, L. S., dos Santos, N. B., Sita, L. V., Camarini, R., Scavone, C., Bittencourt, J. C., & Munhoz, C. D. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02470-2 · Cited by 37
Effects of swim stress and α-MSH acute pre-treatment on brain 5-HT transporter and corticosterone receptor
Racca, S., Spaccamiglio, A., Esculapio, P., Abbadessa, G., Cangemi, L., DiCarlo, F., & Portaleone, P. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.06.014 · Cited by 37
Urotensin II, a novel peptide in central and peripheral cardiovascular control
Watson, A. M. D., & May, C. N. (2004) · Peptides · doi:10.1016/j.peptides.2004.04.016 · Cited by 37
Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats
Franklin, J. M., Mathew, M., & Carrasco, G. A. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.05.039 · Cited by 36
Self-citation
Characterization of neurotransmitters and related metabolites in Daphnia magna juveniles deficient in serotonin and exposed to neuroactive chemicals that affect its behavior: A targeted LC-MS/MS method
Fuertes, I., & Barata, C. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.127814 · Cited by 36
Effects of chronic social defeat on expression of dopamine β‐hydroxylase in rat brains
Fan, Y., Chen, P., Li, Y., & Zhu, M. (2013) · Synapse · doi:10.1002/syn.21641 · Cited by 36
Prozac affects stickleback nest quality without altering androgen, spiggin or aggression levels during a 21-day breeding test
Sebire, M., Davis, J. E., Hatfield, R., Winberg, S., & Katsiadaki, I. G. (2015) · Aquatic Toxicology · doi:10.1016/j.aquatox.2015.09.009 · Cited by 36
Influence of Sex and Corticotropin-Releasing Factor Pathways as Determinants in Serotonin Sensitivity
McEuen, J. G., Semsar, K., Lim, M. A., & Bale, T. L. (2009) · Endocrinology · doi:10.1210/en.2008-1721 · Cited by 35
Hypothalamic paraventricular nucleus, but not vasopressin, participates in chronic hyperactivity of the HPA axis in diabetic rats
Zelena, D., Filaretova, L. P., Mergl, Z., Barna, I., Tóth, Z., & Makara, G. B. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00118.2005 · Cited by 36
Drug discovery strategies that focus on the endocannabinoid signaling system in psychiatric disease
Wyrofsky, R. R., McGonigle, P., & Bockstaele, E. J. V. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.966680 · Cited by 35
Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders
Kas, M. J., Krishnan, V., Gould, T. D., Collier, D. A., Olivier, B., Lesch, K., Domenici, E., Fuchs, E., Gross, C. T., & Ċastrén, E. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.12.001 · Cited by 36
Effects of cold stress andSalmonellaHeidelberg infection on bacterial load and immunity of chickens
Borsoi, A., Quinteiro-Filho, W. M., Calefi, A. S., Ferreira, A. J. P., Astolfi-Ferreira, C. S., Flório, J. C., & Palermo‐Neto, J. (2015) · Avian Pathology · doi:10.1080/03079457.2015.1086976 · Cited by 36

Authors: Carrasco, G. A., & Van de Kar, L. D.
Affiliations: Loyola University Chicago (US)
ORCID: Carrasco, Gonzalo A
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 2003-02
Volume: 463
Issue: 1-3
Pages: 235-272
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/s0014-2999(03)01285-8
OpenAlex: W1971277989
Cited by: 914
References: 656
Citations by year: 2026: 7 · 2025: 11 · 2024: 24 · 2023: 27 · 2022: 29 · 2021: 37 · 2020: 32 · 2019: 30 · 2018: 36 · 2017: 27 · 2016: 36 · 2015: 34 · 2014: 43 · 2013: 64 · 2012: 49
FWCI: 21.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (R01DA013669, DA 13669)
National Institute of Neurological Disorders and Stroke (NS34153)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: stress response, neuroendocrine regulation, corticotropin-releasing factor, vasopressin, renin-angiotensin system, hypothalamic-pituitary-adrenal axis, catecholamines, serotonin, substance P, vasoactive intestinal peptide, neuropeptide Y, cholecystokinin, benzodiazepines, anxiolytics, antidepressants, anxiety disorders, glucocorticoids, ACTH, sympathetic nervous system, adrenal medulla
MeSH terms: Amygdala, Animals, Brain Chemistry, Endocrine System, Humans, Hypothalamus, Neurosecretory Systems, Stress, Physiological, Neurotransmitter Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroendocrine pharmacology of stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks