Cited by 42Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and TreatmentsStress Responses and Cortisol

Relevance of chronic stress and the two faces of microglia in Parkinson's disease

Open access
Herrera, Antonio J., Espinosa-Oliva, Ana M., Carrillo-Jiménez, Alejandro, Oliva-Martín, María J., García-Revilla, Juan, García-Quintanilla, Alberto, de Pablos, Rocío M., Venero, José L.·2015·Frontiers in Cellular Neuroscience

Abstract

This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the inflammatory response of brain microglia and hence its potential involvement in Parkinson's disease (PD). The role of inflammation in PD has been reviewed extensively in the literature and it is supposed to play a key role in the course of the disease. Historically, GCs have been strongly associated as anti-inflammatory hormones. However, accumulating evidence from the peripheral and central nervous system have clearly revealed that, under specific conditions, GCs may promote brain inflammation including pro-inflammatory activation of microglia. We have summarized relevant data linking PD, neuroinflamamation and chronic stress. The timing and duration of stress response may be critical for delineating an immune response in the brain thus probably explain the dual role of GCs and/or chronic stress in different animal models of PD.

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Crossref · 10.3389/fncel.2015.00312

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  • Neuromelanin can activate microglial cells, inducing neuroinflammation and neurodegeneration of dopaminergic neurons in PD.

    “In addition, the neuromelanin (dark, complex endogenous polymer derived from DA) can activate microglial cells, inducing neuroinflammation and neurodegeneration of dopaminergic neurons in PD (Zecca et al., 2008; Herrera et al., 2015).”

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Authors
Herrera, A. J., Espinosa-Oliva, A. M., Carrillo-Jiménez, A., Oliva-Martín, M. J., García-Revilla, J., García-Quintanilla, A., de Pablos, R. M., & Venero, J. L.
Affiliations
Consejo Superior de Investigaciones Científicas (ES)
Venue
Frontiers in Cellular Neuroscience
Published
2015-08-14
Volume
9
Pages
312-312
ISSN
1662-5102 (ISSN-L)
OpenAlex
W1876851010
Cited by
42
References
187
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 3
FWCI
0.69
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by-nc-nd)
Funders
  • Ministerio de Economía y Competitividad (SAF2012-39029, SAF2012)
  • Junta de Andalucía (P10-CTS-6494)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
Parkinson's disease, chronic stress, glucocorticoids, microglia, neuroinflammation, Parkinson's disease model

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