The p38 MAP kinase signaling pathway in Alzheimer's disease
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Neuroinflammation is increasingly linked to the pathogenesis of Alzheimer disease.
“neuroinflammation is increasingly linked to pathogenesis of Alzheimer disease (29, 30)”
From An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease (2013) · cites this paper as [29]
Cites
Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,369 · see citing works
The p38 signal transduction pathway Activation and function
Ono, K., & Han, J. (2000) · Cellular Signalling · doi:10.1016/s0898-6568(99)00071-6 · Cited by 1,571 · see citing works
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
Grimes, C. A., & Jope, R. S. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00011-9 · Cited by 1,429 · see citing works
Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,071 · see citing works
Deák, M., Clifton, A. D., Lucocq, J. M., & Alessi, D. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4426 · Cited by 992 · see citing works
Wang, X., & Ron, D. (1996) · Science · doi:10.1126/science.272.5266.1347 · Cited by 885 · see citing works
Du, Y., Ma, Z., Lin, S., Dodel, R. C., Gao, F., Bales, K. R., Triarhou, L. C., Chernet, E., Perry, K. W., Nelson, D. L. G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251341998 · Cited by 789 · see citing works
Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)
Jiang, Y., Chen, C., Li, Z., Guo, W., Gegner, J. A., Lin, S., & Han, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17920 · Cited by 746 · see citing works
FGF and stress regulate CREB and ATF‐1 via a pathway involving p38 MAP kinase and MAPKAP kinase‐2.
Tan, Y., Rouse, J. W., Zhang, A., Cariati, S., Cohen, P., & Comb, M. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00840.x · Cited by 634 · see citing works
Kumar, S., McDonnell, P., Gum, R. J., Hand, A. T., Lee, J. C., & Young, P. R. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6849 · Cited by 507 · see citing works
Stadelmann, C., Deckwerth, T., Srinivasan, A., Bancher, C., Brück, W., Jellinger, K. A., & Lassmann, H. (1999) · American Journal of Pathology · doi:10.1016/s0002-9440(10)65460-0 · Cited by 449 · see citing works
Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P., & Arthur, J. S. C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2871-2881.2002 · Cited by 445 · see citing works
Motoneuron Death Triggered by a Specific Pathway Downstream of Fas
Raoul, C., Estévez, Á. G., Nishimune, H., Cleveland, D. W., deLapeyrière, O., Henderson, C. E., Haase, G., & Pettmann, B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00905-4 · Cited by 432 · see citing works
Zhu, X., Rottkamp, C. A., Boux, H., Takeda, A., Perry, G., & Smith, M. A. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.10.880 · Cited by 378 · see citing works
p38 Kinase Is Activated in the Alzheimer's Disease Brain
Hensley, K., Floyd, R. A., Zheng, N., Nael, R., Robinson, K. A., Nguyen, X., Pye, Q. N., Stewart, C. A., Geddes, J., Markesbery, W. R., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722053.x · Cited by 373 · see citing works
Self-citationMcLaughlin, M. M., Kumar, S., McDonnell, P., Horn, S. V., Lee, J. C., Livi, G. P., & Young, P. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8488 · Cited by 342 · see citing works
Wilms, H., Rosenstiel, P. C., Sievers, J., Deuschl, G., Zecca, L., & Lucius, R. (2003) · The FASEB Journal · doi:10.1096/fj.02-0314fje · Cited by 337 · see citing works
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.
Lechner, C., Zahalka, M. A., Giot, J.-F., Møller, N. P. H., & Ullrich, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4355 · Cited by 327 · see citing works
Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases
Goedert, M., Hasegawa, M., Jakes, R., Lawler, S., Cuenda, A., & Cohen, P. R. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00483-3 · Cited by 308 · see citing works
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38
Harper, S. J., & LoGrasso, P. V. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00148-6 · Cited by 304 · see citing works
Savage, M. J., Lin, Y.-G., Ciallella, J. R., Flood, D. G., & Scott, R. W. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03376.2002 · Cited by 291 · see citing works
Song, L., Sarno, P. D., & Jope, R. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206047200 · Cited by 256 · see citing works
Edlund, S., Bu, S., Schuster, N., Aspenström, P., Heuchel, R. L., Heldin, N., ten Dijke, P., Heldin, C., & Landström, M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.02-03-0037 · Cited by 227 · see citing works
P38 MAP kinase is activated at early stages in Alzheimer's disease brain
Sun, A. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00180-8 · Cited by 219 · see citing works
Junn, E., & Mouradian, M. M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00425.x · Cited by 214 · see citing works
Barone, F. C., Irving, E. A., Ray, A. M., Lee, J., Kassis, S., Kumar, S., Badger, A. M., White, R. F., McVey, M. J., Legos, J. J., et al. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38747-6 · Cited by 214 · see citing works
Giovannini, M. G., Scali, C., Prosperi, C., Bellucci, A., Vannucchi, M. G., Rosi, S., Pepeu, G., & Casamenti, F. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0538 · Cited by 214 · see citing works
Ferrer, I., Blanco, R. E., Carmona, M., & Puig, B. (2001) · Journal of Neural Transmission · doi:10.1007/s007020100016 · Cited by 207 · see citing works
Kikuchi, M., Tenneti, L., & Lipton, S. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-13-05037.2000 · Cited by 197 · see citing works
Boutajangout, A., Leroy, K., Authelet, M., Anderton, B. H., Brion, J., & Woodgett, J. R. (2002) · Acta Neuropathologica · doi:10.1007/s004010100435 · Cited by 186 · see citing works
Namgung, U., & Xia, Z. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06442.2000 · Cited by 184 · see citing works
Dorion, S., Lambert, H., & Landry, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203642200 · Cited by 178 · see citing works
p38-2, a Novel Mitogen-activated Protein Kinase with Distinct Properties
Stein, B., Yang, M. X., Young, D. B., Janknecht, R., Hunter, T. R., Murray, B. W., & Barbosa, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19509 · Cited by 177 · see citing works
Atzori, C., Ghetti, B. F., Piva, R., Srinivasan, A., Zolo, P., Delisle, M. B., Mirra, S. S., & Migheli, A. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.12.1190 · Cited by 175 · see citing works
McLaughlin, B., Pal, S. K., Tran, M. P., Parsons, A. A., Barone, F. C., Erhardt, J. A., & Aizenman, E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03303.2001 · Cited by 171 · see citing works
MAPKAP Kinase 2 Phosphorylates Serum Response Factor in Vitro and in Vivo
Heidenreich, O. T., Neininger, A., Schratt, G. M., Zinck, R., Cahill, M. A., Engel, K., Kotlyarov, A., Kraft, R., Kostka, S., Gaestel, M., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14434 · Cited by 170 · see citing works
Pei, J.-J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., & Cowburn, R. F. (2001) · Journal of Alzheimer's Disease · doi:10.3233/jad-2001-3107 · Cited by 165 · see citing works
Reactivating Kinase/p38 Phosphorylates τ Protein In Vitro
Reynolds, C. H., Nebreda, A. R., Gibb, G. M., Utton, M. A., & Anderton, B. H. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010191.x · Cited by 161 · see citing works
Regulation of MTK1/MEKK4 Kinase Activity by Its N-Terminal Autoinhibitory Domain and GADD45 Binding
Mita, H., Tsutsui, J., Takekawa, M., Witten, E. A., & Saito, H. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4544-4555.2002 · Cited by 154 · see citing works
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease
Zhu, X.-W., Rottkamp, C., Hartzler, A., Sun, Z., Takeda, A., Boux, H., Shimohama, S., Perry, G., & Smith, M. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00597.x · Cited by 151 · see citing works
Lee, S. J., Drabik, K., Van Wagoner, N. J., Lee, S., Choi, C., Dong, Y., & Benveniste, E. N. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4658 · Cited by 137 · see citing works
Willaime‐Morawek, S., Vanhoutte, P., Caboche, J., Lemaigre‐Dubreuil, Y., Mariani, J., & Brugg, B. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01581.x · Cited by 127 · see citing works
Thuerauf, D. J., Arnold, N. D., Zechner, D., Hanford, D. S., DeMartin, K., McDonough, P. M., Prywes, R., & Glembotski, C. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20636 · Cited by 122 · see citing works
GRANULOVACUOLAR DEGENERATION IN THE AGEING BRAIN AND IN DEMENTIA
Ball, M. J., & LO, P. (1977) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197705000-00006 · Cited by 111 · see citing works
Galván, V., Logvinova, A. V., Sperandio, S., Ichijo, H., & Bredesen, D. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211398200 · Cited by 93 · see citing works
CD40-CD40L Interactions Induce Chemokine Expression by Human Microglia
D’Aversa, T. G., Weidenheim, K. M., & Berman, J. W. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64875-4 · Cited by 92 · see citing works
Janknecht, R., & Hunter, T. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4219 · Cited by 87 · see citing works
Mechanisms of cell death in neurodegenerative disorders
Jellinger, K. A., & Stadelmann, C. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6781-6_13 · Cited by 80 · see citing works
Dickson, D. W., Ksiȩżak-Reding, H., Davies, P., & Yen, S. H. (1987) · Acta Neuropathologica · doi:10.1007/bf00686619 · Cited by 79 · see citing works
Su, J. H., Kesslak, P. J., Head, E., & Cotman, C. W. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0548-2 · Cited by 76 · see citing works
Buée‐Scherrer, V., & Goedert, M. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02460-2 · Cited by 76 · see citing works
Hou, S., Xie, X., Baggley, A., Park, D. S., Gao, C., & Walker, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206336200 · Cited by 66 · see citing works
Sequestration of tau by granulovacuolar degeneration in Alzheimer's disease.
Bondareff, W., Wischik, C. M., Novák, M., & Roth, M. (1991) · PubMed Central · Cited by 64 · see citing works
Modulation of tau phosphorylation and intracellular localization by cellular stress
Jenkins, S. M., ZINNERMAN, M., Garner, C. C., & Johnson, G. V. W. (2000) · Biochemical Journal · doi:10.1042/bj3450263 · Cited by 63 · see citing works
Self-citationJeohn, G., Cooper, C. L., Wilson, B. C., Chang, R. C., Jang, K., Kim, H.-C., Liu, B., & Hong, J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04078.x · Cited by 60 · see citing works
Sequestration of Tubulin in Neurons in Alzheimer's disease
Price, D. L., Altschuler, R. J., Struble, R. G., Casanova, M. F., Cork, L. C., & Murphy, D. B. (1986) · Brain Research · doi:10.1016/0006-8993(86)91077-2 · Cited by 55 · see citing works
HARTZLER, A., ZHU, X., SIEDLAK, S., CASTELLANI, R., AVILA, J., PERRY, G., & SMITH, M. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00029-5 · Cited by 43 · see citing works
p38 Mitogen Activated Protein Kinase as a Therapeutic Target for Alzheimer's Disease
Dalrymple, S. A. (2002) · Journal of Molecular Neuroscience · doi:10.1385/jmn:19:3:295 · Cited by 30 · see citing works
Granulovacuolar degeneration in pyramidal cells of the hippocampus
Mann, D. M. A. (1978) · Acta Neuropathologica · doi:10.1007/bf00690983 · Cited by 23 · see citing works
Sánchez (2002) · doi:10.1379/1466-1268(2002)007
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Activation and signaling of the p38 MAP kinase pathway
Zarubin, T., & Han, J. (2005) · Cell Research · doi:10.1038/sj.cr.7290257 · Cited by 1,711 · see citing works
Rajmohan, R., & Reddy, P. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160612 · Cited by 695 · see citing works
p38MAPK: stress responses from molecular mechanisms to therapeutics
Coulthard, L. R., White, D. E., Jones, D. L., McDermott, M. F., & Burchill, S. A. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.005 · Cited by 691 · see citing works
Post-translational modifications of tau protein: Implications for Alzheimer's disease
Martin, L., Latypova, X., & Terro, F. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2010.12.023 · Cited by 645 · see citing works
Bellina, F., & Rossi, R. (2006) · Tetrahedron · doi:10.1016/j.tet.2006.05.024 · Cited by 607 · see citing works
Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
Munoz, L., & Ammit, A. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.11.010 · Cited by 370 · see citing works
Amyloid Beta in Aging and Alzheimer’s Disease
Sehar, U., Rawat, P., Reddy, A. P., Kopel, J. J., & Reddy, P. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112924 · Cited by 385 · see citing works
Finder, V. H., & Glockshuber, R. (2007) · Neurodegenerative Diseases · doi:10.1159/000100355 · Cited by 350 · see citing works
Fang, F., Lue, L.-F., Yan, S., Xu, H., Luddy, J. S., Chen, D., Walker, D. G., Stern, D. M., Yan, S., Schmidt, A. M., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-139634 · Cited by 335 · see citing works
Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
Babu, J. R., Geetha, T., & Wooten, M. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03181.x · Cited by 315 · see citing works
p38 MAP Kinase's Emerging Role as a Tumor Suppressor
Bulavin, D. V., & Fornace, A. J. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)92005-2 · Cited by 290 · see citing works
Recent advances in our understanding of neurodegeneration
Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274 · see citing works
Hua, X., Svensson, C. I., Matsui, T., Fitzsimmons, B., Yaksh, T. L., & Webb, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04451.x · Cited by 248 · see citing works
Munoz, L., Ranaivo, H. R., Roy, S. M., Hu, W., Craft, J. M., McNamara, L. K., Chico, L. W., Van Eldik, L. J., & Watterson, D. M. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-21 · Cited by 224 · see citing works
AlzPathway: a comprehensive map of signaling pathways of Alzheimer’s disease
Mizuno, S., Iijima, R., Ogishima, S., Kikuchi, M., Matsuoka, Y., Ghosh, S., Miyamoto, T., Miyashita, A., Kuwano, R., & Tanaka, H. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-52 · Cited by 151 · see citing works
Phospholipase A2 and arachidonic acid in Alzheimer's disease
Sanchez-Mejia, R. O., & Mucke, L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.013 · Cited by 144 · see citing works
Eldik, L. J. V., Thompson, W. L., Ranaivo, H. R., Behanna, H. A., & Watterson, D. M. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82015-0 · Cited by 141 · see citing works
Effects of p38 MAPK Inhibition on Early Stages of Diabetic Retinopathy and Sensory Nerve Function
Du, Y., Tang, J., Li, G., Berti-Mattera, L., Lee, C. A., Bartkowski, D., Gale, D., Monahan, J., Niesman, M. R., Alton, G., et al. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.09-3674 · Cited by 136 · see citing works
Boergeling, Y., Schmolke, M., Viemann, D., Nordhoff, C., Roth, J., & Ludwig, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.469239 · Cited by 134 · see citing works
Cavallini, A., Brewerton, S., Bell, A., Sargent, S., Glover, S., Hardy, C., Moore, R., Calley, J., Ramachandran, D., Poidinger, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.463984 · Cited by 133 · see citing works
“Moreover, neuroinflammation is increasingly linked to pathogenesis of Alzheimer disease (29, 30); thus; inhibition of the p38 pathway may slow AD progression through anti-inflammatory mechanisms.”
BackgroundManna, P. R., & Stocco, D. M. (2011) · Journal of Signal Transduction · doi:10.1155/2011/821615 · Cited by 126 · see citing works
Maezawa, I., Nivison, M. P., Montine, K. S., Maeda, N., & Montine, T. J. (2006) · The FASEB Journal · doi:10.1096/fj.05-5423fje · Cited by 113 · see citing works
A Review on Solvent-free Methods in Organic Synthesis
Zangade, S., & Patil, P. (2020) · Current Organic Chemistry · doi:10.2174/1385272823666191016165532 · Cited by 107 · see citing works
Fang, F., Yu, Q., Arancio, O., Chen, D., Gore, S. S., Yan, S. S., & Yan, S. F. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy017 · Cited by 103 · see citing works
Chalcones as Versatile Synthons for the Synthesis of 5- and 6-membered Nitrogen Heterocycles
Albuquerque, H. M. T., Santos, C. M. M., Cavaleiro, J. A. S., & Silva, A. M. S. (2014) · Current Organic Chemistry · doi:10.2174/1385272819666141013224253 · Cited by 100 · see citing works
RAGE is a key cellular target for A -induced perturbation in Alzheimer s disease
Yan, S. S. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s265 · Cited by 97 · see citing works
ERK1/2 is an endogenous negative regulator of the γsecretase activity
Kim, S., Park, H., Hong, H. S., Baik, E. J., Jung, M. W., & Mook‐Jung, I. (2006) · The FASEB Journal · doi:10.1096/fj.05-4055fje · Cited by 92 · see citing works
Aberrant phosphorylation in the pathogenesis of Alzheimer's disease
Chung, S. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.8.467 · Cited by 89 · see citing works
Fang, S., Sun, S. Y., Cai, H., Zou, X., Wang, S., Hao, X., Wan, X. H., Tian, J., Li, Z., He, Z., et al. (2021) · Theranostics · doi:10.7150/thno.62797 · Cited by 83 · see citing works
COLOGNATO, R., LAURENZA, I., FONTANA, I., COPPEDE, F., SICILIANO, G., COECKE, S., ARUOMA, O., BENZI, L., & MIGLIORE, L. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2005.10.005 · Cited by 81 · see citing works
Wang, J.-W., Imai, Y., & Lu, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5094-06.2007 · Cited by 80 · see citing works
“Significantly, recent findings have provided strong evidence that the p38 MAPK signaling cascade is overactivated in AD (Zhu et al., 2001; Johnson and Bailey, 2003; Sun et al., 2003).”
BackgroundZhang, X., Cui, Y., Cui, Y., Chen, Y., Na, X.-D., Chen, F., Wei, X., Li, Y.-Y., Liu, X., & Xin, W. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.017 · Cited by 80 · see citing works
Medders, K. E., Sejbuk, N. E., Maung, R., Desai, M. K., & Kaul, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902535 · Cited by 80 · see citing works
Gadd45 Proteins as Critical Signal Transducers Linking NF-κB to MAPK Cascades
Yang, Z., Song, L., & Huang, C. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909790192383 · Cited by 76 · see citing works
RAGE is a key cellular target for A -induced perturbation in Alzheimer s disease
Yan, S. S. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/265 · Cited by 108 · see citing works
Lo, J. Y., Kamarudin, M. N. A., Hamdi, O. A. A., Awang, K., & Kadir, H. A. (2015) · Food & Function · doi:10.1039/c5fo00607d · Cited by 70 · see citing works
Ahad, A., Ahsan, H., Mujeeb, M., & Siddiqui, W. A. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.08.026 · Cited by 69 · see citing works
Aruoma, O. I., Colognato, R., Fontana, I., Gartlon, J., Migliore, L., Koike, K., Coecke, S., Lamy, E., Mersch‐Sundermann, V., Laurenza, I., et al. (2006) · BioFactors · doi:10.1002/biof.5520260205 · Cited by 69 · see citing works
N-cadherin Regulates p38 MAPK Signaling via Association with JNK-associated Leucine Zipper Protein
Ando, K., Uemura, K., Kuzuya, A., Maesako, M., Asada-Utsugi, M., Kubota, M., Aoyagi, N., Yoshioka, K., Okawa, K., Inoue, H., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158477 · Cited by 66 · see citing works
Kim, Y., Lim, J., & Oh, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117277 · Cited by 65 · see citing works
Phytosterols in Seaweeds: An Overview on Biosynthesis to Biomedical Applications
Sohn, S.-I., Rathinapriya, P., Balaji, S., Balan, D. J., Swetha, T. K., Durgadevi, R., Alagulakshmi, S., Singaraj, P., & Pandian, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312691 · Cited by 64 · see citing works
Haddad, J. J. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.002 · Cited by 61 · see citing works
Role of interleukin-4, the chemokine CCL3 and its receptor CCR5 in neuropathic pain
Sun, S., Chen, D., Lin, F., Chen, M., Yu, H., Hou, L., & Li, C. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.08.006 · Cited by 58 · see citing works
DeVaughn, S., Müller‐Oehring, E. M., Markey, B. M., Bronte-Stewart, H. M., & Schulte, T. (2015) · Neuropsychology Review · doi:10.1007/s11065-015-9305-x · Cited by 56 · see citing works
Nanomedicine in Alzheimer's disease: Amyloid beta targeting strategy
Tosi, G., Pederzoli, F., Belletti, D., Vandelli, M. A., Forni, F., Duskey, J. T., & Ruozi, B. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.001 · Cited by 53 · see citing works
Sui, Z., Fan, S., Sniderhan, L. F., Reisinger, E., Stout, A., Schifitto, G., Gelbard, H. A., Dewhurst, S., & Maggirwar, S. B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.702 · Cited by 52 · see citing works
Roles of p38 MAPK signalling in intervertebral disc degeneration
Shi, Z., Zhu, L., Song, Z., Liu, T.-J., & Hao, D. (2023) · Cell Proliferation · doi:10.1111/cpr.13438 · Cited by 50 · see citing works
The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation
Oeztuerk-Winder, F., & Ventura, J. (2012) · Biochemical Journal · doi:10.1042/bj20120401 · Cited by 48 · see citing works
siRNA Therapeutics: Future Promise for Neurodegenerative Diseases
Amiri, A., Barreto, G. E., Sathyapalan, T., & Sahebkar, A. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210402104054 · Cited by 45 · see citing works
Age-induced augmentation of p38 MAPK phosphorylation in mouse lung
Li, Z., Li, J., Bu, X., Liu, X., Tankersley, C. G., Wang, C., & Huang, K. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.04.005 · Cited by 45 · see citing works
Bhowmick, S., D’Mello, V., & Muneer, P. M. A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1132-7 · Cited by 43 · see citing works
Li, Z., Jansen, M., Ogburn, K. D., Salvatierra, L., Hunter, L., Mathew, S., & Figueiredo‐Pereira, M. E. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20346 · Cited by 39 · see citing works
Zachariou, M., Minadakis, G., Oulas, A., Afxenti, S., & Spyrou, G. M. (2018) · Journal of Proteomics · doi:10.1016/j.jprot.2018.03.009 · Cited by 38 · see citing works
Edward, A. M. I. (2005) · Frontiers in bioscience · doi:10.2741/1516 · Cited by 38 · see citing works
Age-related decrease in constructive activation of Akt/PKB in SAMP10 hippocampus
Nie, K., Yu, J., Fu, Y., Cheng, H., Chen, F.-Y., You, Q., & Han, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.010 · Cited by 36 · see citing works
Mini review–vanadium-induced neurotoxicity and possible targets
Jaiswal, M. R., & Kale, P. P. (2019) · Neurological Sciences · doi:10.1007/s10072-019-04188-5 · Cited by 35 · see citing works
d-ribose and pathogenesis of Alzheimer’s disease
Javed, M., Ahmad, M. I., Javed, H., & Naseem, S. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05243-7 · Cited by 28 · see citing works
Ivanenko, K. A., Prassolov, V., & Khabusheva, E. (2022) · Molecular Biology · doi:10.1134/s0026893322050089 · Cited by 27 · see citing works
Prevention of Trabecular Bone Loss Induced by Estrogen Deficiency by a Selective p38α Inhibitor
Caverzasio, J., Higgins, L., & Ammann, P. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080410 · Cited by 29 · see citing works
Pinsetta, F. R., Taft, C. A., & da Silva, C. H. T. D. P. (2013) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2013.803441 · Cited by 25 · see citing works
Diabetes and Alzheimer's Disease - Is There a Connection?
Sima, A. A. F., & Li, Z.-G. (2006) · The Review of Diabetic Studies · doi:10.1900/rds.2006.3.161 · Cited by 24 · see citing works
Advanced stent coating for drug delivery and in vivo biocompatibility
Liu, Y., Wang, W., Acharya, G., Shim, Y., Choe, E. S., & Lee, C. (2013) · Journal of Nanoparticle Research · doi:10.1007/s11051-013-1962-1 · Cited by 23 · see citing works
Duan, L., Zhao, Y., Jia, J., Chao, T., Wang, H., Liang, Y., Lou, Y., Zheng, Q., & Wang, H. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166698 · Cited by 20 · see citing works
Moscato, P., Berretta, R. E., Hourani, M., Mendes, A. S., & Cotta, C. (2005) · Lecture notes in computer science · doi:10.1007/978-3-540-32003-6_9 · Cited by 20 · see citing works
Li, X., Gu, Y., Ma, L., Bai, X., Jie, J., Zhang, X.-F., & Chen, D. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.238621 · Cited by 19 · see citing works
Varga, J. M., Klausz, B., Domokos, Á., Kálmán, S., Pákáski, M., Szücs, S., Garab, D., Zvara, Á., Puskás, L. G., Kalman, J. L., et al. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.10.010 · Cited by 19 · see citing works
Recent advances in experimental modeling of the assembly of tau filaments
Ko, L., Deture, M. A., Sahara, N., Chihab, R., Vega, I. E., & Yen, S.-H. C. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.004 · Cited by 19 · see citing works
Gendelman, H. E., & Gelbard, H. A. (2014) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000111 · Cited by 18 · see citing works
Deletion of Apoptosis Signal–Regulating Kinase–1 Prevents Ventilator-Induced Lung Injury in Mice
Makena, P. S., Gorantla, V. K., Ghosh, M. C., Bezavada, L., Kandasamy, K., Balázs, L., Luellen, C. L., Thompson, K. E., Parthasarathi, K., Ichijo, H., et al. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0234oc · Cited by 18 · see citing works
Role of mitogen-activated protein kinase inhibitors in Alzheimer's disease: Rouge of brain kinases
Almasoudi, S. H., Al-Kuraishy, H. M., Al-Gareeb, A. I., Eliwa, D., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111296 · Cited by 14 · see citing works
Hyperuricemia induces lipid disturbances by upregulating the CXCL-13 pathway
Meng, J., Lv, Q., Sui, A., Xu, D., Zou, T., Song, M., Gong, X., Xing, S., & Wang, X. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00285.2021 · Cited by 14 · see citing works
Fan, B., Wang, Y., Yao, T., & Zhu, Y.-C. (2005) · PubMed · Cited by 14 · see citing works
Kopel, J. J., Sehar, U., Choudhury, M., & Reddy, P. H. (2023) · Healthcare · doi:10.3390/healthcare11060868 · Cited by 13 · see citing works
Ghara, A., Matada, G. S. P., Sah, R. K., Sneha, S., Boneka, S. S., Paik, A., Majumder, S., Pramanick, P., & Metikurki, B. (2025) · Current Molecular Biology Reports · doi:10.1007/s40610-025-00167-2 · Cited by 12 · see citing works
Zhang, X. H., Chen, C., Li, H., Hsiang, J., Wu, X., Hu, W., Horne, D. A., Nam, S., Shively, J. E., & Rosen, S. T. (2021) · FEBS Letters · doi:10.1002/1873-3468.14186 · Cited by 11 · see citing works
Multi-omics analysis revealed the role of CCT2 in the induction of autophagy in Alzheimer’s disease
Ma, X., Feng, Y., Quan, X., Geng, B., Li, G., Fu, X., & Zeng, L. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.967730 · Cited by 11 · see citing works
Nonfibrillar Abeta1–42 Inhibits Glutamate Uptake and Phosphorylates p38 in Human Fibroblasts
Zoia, C., Riva, C., Isella, V., Proserpio, P., Terruzzi, A., Arban, S., Salerno, D., Cassina, V., Mantegazza, F., Tremolizzo, L., et al. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181f9860f · Cited by 11 · see citing works
Studies on the Expression of Fibroblast Growth Factor-2 from Odontoblast-like Cells
Oliveira, S. H. P., & Santos, V. A. C. (2011) · Journal of Endodontics · doi:10.1016/j.joen.2011.08.004 · Cited by 10 · see citing works
Could Direct Inhibition of Inflammation Be the “Next Big Thing” in Treating Atherosclerosis?
Natarajan, P., & Cannon, C. P. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.213793 · Cited by 10 · see citing works
Ding, X.-Y., Gu, R.-P., Tang, W.-Y., Shu, Q.-M., Xu, G.-Z., & Zhang, M. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.246064 · Cited by 10 · see citing works
Anorexigenic neuropeptides as anti-obesity and neuroprotective agents
Strnadová, V., Pačesová, A., Charvát, V., Šmotková, Z., Železná, B., Kuneš, J., & Maletı́nská, L. (2024) · Bioscience Reports · doi:10.1042/bsr20231385 · Cited by 8 · see citing works
Gu, Y., Luo, H., Zhu, J., Ma, H., Zhang, Y., Xing, J., Liu, Y., Cai, Y., Sun, W., & Luo, P. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01826-8 · Cited by 8 · see citing works
Liu, J., Liu, S., Fu, S.-C., Lai, W.-C., Fang, K., Lin, K.-A., Ke, J.-A., Kuo, C.-Y., Su, C., & Chen, Y. (2024) · Toxicology · doi:10.1016/j.tox.2024.154014 · Cited by 7 · see citing works
Du, G., Zheng, K., Sun, C., Sun, M., Pan, J., Meng, D., Guan, W., & Zhao, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1522294 · Cited by 7 · see citing works
Pathobiology of Diabetic Encephalopathy in Animal Models
Sima, A. A. F. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-850-8_17 · Cited by 6 · see citing works
Baicalin alleviates intervertebral disc degeneration by inhibiting the p38 MAPK signaling pathway
Wu, Y., Li, F., Shu, S., Feng, Z., Qiu, Y., Li, S., & Zhu, Z. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112743 · Cited by 5 · see citing works
Paul, C. C. (2005) · Frontiers in bioscience · doi:10.2741/1551 · Cited by 5 · see citing works
Gil‐Redondo, J. C., Queipo, M. J., Trueba, Y., Llorente-Sáez, C., Serrano-López, J., Ortega, F., Gómez‐Villafuertes, R., Pérez‐Sen, R., & Delicado, E. G. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09970-x · Cited by 4 · see citing works
Molecular Aspects of Memory Dysfunction in Alzheimer’s Disease
Chin, J., Roberson, E. D., & Mucke, L. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00015-2 · Cited by 4 · see citing works
Synthesis and Evaluation of Pyridinyltriazoles as Inhibitors of p38 MAP Kinase.
Moallem, S. A., Hadizadeh, F., Abadi, F. A., Shahraki, M., & Shamsara, J. (2012) · Europe PMC (PubMed Central) · Cited by 3 · see citing works
Mammone, T., Chidlow, G., Casson, R. J., & Wood, J. P. M. (2019) · Histochemistry and Cell Biology · doi:10.1007/s00418-019-01771-x · Cited by 3 · see citing works
Immediate Early Genes, Inducible Transcription Factors and Stress Kinases in Alzheimer’s Disease
Ferrer, I., Santpere, G., & Puig, B. (2006) · Springer eBooks · doi:10.1007/978-0-387-33604-6_13 · Cited by 2 · see citing works
Laprasert, C., Chansriniyom, C., & Limpanasithikul, W. (2021) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/japtr.japtr_64_20 · Cited by 2 · see citing works
Chemical degradation identified Human p38-MAPK as a host target to combat parasitic infectionsPreprint
Singhal, J., Rawat, N., Bansal, R., Srivastava, P., Ghousepeer, G. D., Pandey, R. P., Ranganathan, A., & Singh, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.19.629355 · Cited by 2 · see citing works
Guleria, M., Malhan, A., Teli, G., Bisht, N., & Jain, S. K. (2025) · Molecular Diversity · doi:10.1007/s11030-025-11278-4 · Cited by 1 · see citing works
Stephens, G. S., You, J. C., Fu, C.-H., & Chin, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21126-7 · Cited by 1 · see citing works
Quinase p38 alfa como alvo para o planejamento de fármacos em Mal de Alzheimer
Pinsetta, F. R. (2013) · doi:10.11606/t.60.2013.tde-06092013-104102 · Cited by 1 · see citing works
Augé, C. (2004) · edoc (University of Basel) · doi:10.5451/unibas-003617456
Anti‐Inflammatory/Analgesics: An In‐Depth Look at p 38 MAP Kinases
Brown, K. L. (2011) · Wiley eBooks · doi:10.1002/9780470571224.pse446
- Authors
- Johnson, G.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Johnson, G
- ORCID
- Johnson, G
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 183
- Issue
- 2
- Pages
- 263-268
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W1994973104
- Cited by
- 106
- References
- 60
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 8 · 2012: 5
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- p38 MAPK, Alzheimer's disease, CD68, scavenger receptors, atherosclerosis, macrophages, oxidized LDL, macrophage apoptosis, reactive oxygen species, MAPK signaling, necrotic core, ApoE-deficient mice, coronary artery disease
- MeSH terms
- Alzheimer Disease, Animals, Humans, Substrate Specificity, Signal Transduction, tau Proteins, Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases
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