Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment
Abstract
Alzheimer's disease (AD) is characterized by cognitive decline and deposition of beta-amyloid (Abeta) plaques in cortex and hippocampus. A transgenic mouse AD model (Tg2576) that overexpresses a mutant form of human Abeta precursor protein exhibits age-related cognitive deficits, Abeta plaque deposition, and oxidative damage in the brain. We tested the ability of Ginkgo biloba, a flavonoid-rich antioxidant, to antagonize the age-related behavioral impairment and neuropathology exhibited by Tg2576 mice. At 8 months of age, 16 female Tg2576 and 15 female wild-type (wt) littermate mice were given ad lib access to tap water or Ginkgo biloba (70 mg/kg/day in water). After 6 months of treatment, all mice received Morris water maze training (4 trials/day for 10 days) to assess hippocampal dependent spatial learning. All mice received a 60-s probe test of spatial memory retention 24 h after the 40th trial. Untreated Tg2576 mice exhibited a spatial learning impairment, relative to wt mice, while Ginkgo biloba-treated Tg2576 mice exhibited spatial memory retention comparable to wt during the probe test. Spatial learning was not different between Ginkgo biloba-treated and untreated wt mice. There were no group differences in learning to swim to a visible platform. Soluble Abeta and hippocampal Abeta plaque burden did not differ between the Tg2576 groups. Brain levels of protein carbonyls were paradoxically elevated in Ginkgo biloba-treated mice. These data indicate that chronic Ginkgo b…
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Several antioxidants are reported to lessen pathologies found in transgenic mouse models of AD.
“Several antioxidants are reported to lessen pathologies found in transgenic mouse models of AD”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Stackman et al., 2003
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Self-citation
- Authors
- Stackman, R. W., Eckenstein, F., Frei, B., Kulhanek, D., Nowlin, J., & Quinn, J. F.
- Affiliations
- Oregon Health & Science University (US)
- Oregon State University (US)
- Corresponding author
- Stackman, Robert W
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 184
- Issue
- 1
- Pages
- 510-520
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2000078561
- Cited by
- 230
- References
- 4
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 12 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 8 · 2012: 14
- FWCI
- 38.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (NIA AG08017, AG07424)
- National Center for Complementary and Integrative Health (NIH-AT00066)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, Ginkgo biloba, Tg2576 mice, transgenic mouse model, spatial memory, spatial learning, amyloid plaques, oxidative stress, protein carbonyls, flavonoids, antioxidant treatment, age-related cognitive decline, hippocampus
- MeSH terms
- Aging, Alzheimer Disease, Amyloidosis, Animals, Brain Chemistry, Female, Phytotherapy, Memory Disorders, Mice, Transgenic, Nerve Tissue Proteins, Oxidation-Reduction, Pregnancy, Space Perception, Amyloid beta-Peptides, Maze Learning, Ginkgo biloba, Mice, Plaque, Amyloid
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