Can herbs provide a new generation of drugs for treating Alzheimer’s disease?

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works

Flavonoids: a review of probable mechanisms of action and potential applications

Nijveldt, R. J., van Nood, E., van Hoorn, D. E. C., Boelens, P. G., van Norren, K., & van Leeuwen, P. A. M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.418 · Cited by 3,074 · see citing works

Pathways towards and Away from Alzheimer’s Disease

Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works

Oxidative stress hypothesis in Alzheimer’s disease

Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., Chen, P. P., Kayed, R., Glabe, C. G., Frautschy, S. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404751200 · Cited by 2,336 · see citing works

Flavonoids: antioxidants or signalling molecules?

Williams, R. J., Spencer, J. P. E., & Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.001 · Cited by 2,016 · see citing works

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530 · see citing works

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,488 · see citing works

Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies

Williamson, G., & Manach, C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.243s · Cited by 1,340 · see citing works

Activation of microglial cells by β-amyloid protein and interferon-γ

Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314 · see citing works

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303 · see citing works

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J.-C., Paul, S. M., & Holtzman, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151261398 · Cited by 1,298 · see citing works

Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro

Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20025 · Cited by 1,254 · see citing works

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide

Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02173-6 · Cited by 1,114 · see citing works

Synergy and other interactions in phytomedicines

WILLIAMSON, E. (2001) · Phytomedicine · doi:10.1078/0944-7113-00060 · Cited by 1,027 · see citing works

Herbal Medicines and Perioperative Care

Ang-Lee, M. K. (2001) · JAMA · doi:10.1001/jama.286.2.208 · Cited by 981 · see citing works

Plants and human health in the twenty-first century

Raskin, I., Ribnicky, D., Komarnytsky, S., Ilić, N., Poulev, A., Borisjuk, N. V., Brinker, A., Moreno, D. A., Ripoll, C., Yakoby, N., et al. (2002) · Trends in biotechnology · doi:10.1016/s0167-7799(02)02080-2 · Cited by 915 · see citing works

The Pharmacology of Chinese Herbs

Huang, K. (1998) · Routledge eBooks · doi:10.4324/9780367801892 · Cited by 877 · see citing works

Oxidative Alterations in Alzheimer's Disease

Markesbery, W. R., & Carney, J. M. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00215.x · Cited by 789 · see citing works

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., & LaFerla, F. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.003 · Cited by 780 · see citing works

Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

Leclerc, S., Garnier, M., Hoessel, R., Marko, D., Bibb, J. A., Snyder, G. L., Greengard, P., Biernat, J., Wu, Y., Mandelkow, E., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m002466200 · Cited by 730 · see citing works

Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study

Morris, M. C. (2002) · JAMA · doi:10.1001/jama.287.24.3230 · Cited by 678 · see citing works

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

Lovell, M. A., Ehmann, W. D., Butler, S. M., & Markesbery, W. R. (1995) · Neurology · doi:10.1212/wnl.45.8.1594 · Cited by 644 · see citing works

ApoE genotype accounts for the vast majority of AD risk and AD pathology

Raber, J., Huang, Y., & Ashford, J. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.023 · Cited by 599 · see citing works

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

Anandatheerthavarada, H. K., Biswas, G., Robin, M.-A., & Avadhani, N. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207030 · Cited by 571 · see citing works

Brain to Plasma Amyloid-β Efflux: a Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease

DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M., & Holtzman, D. M. (2002) · Science · doi:10.1126/science.1067568 · Cited by 563 · see citing works

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

Coskun, P. E., Beal, M. F., & Wallace, D. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403649101 · Cited by 556 · see citing works

Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer's disease

de la Monte, S. M., & Wands, J. R. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7106 · Cited by 552 · see citing works

Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

Qiu, W. Q., & Folstein, M. F. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.004 · Cited by 538 · see citing works

Self-Assembly of Aβ ₁ _- ₄₂ into Globular Neurotoxins

Chromy, B. A., Nowak, R. J., Lambert, M. P., Viola, K. L., Chang, L., Velasco, P. T., Jones, B. W., Fernandez, S. J., Lacor, P. N., Horowitz, P., et al. (2003) · Biochemistry · doi:10.1021/bi030029q · Cited by 522 · see citing works

New Frontiers in Alzheimer's Disease Genetics

Tanzi, R. E., & Bertram, L. (2001) · Neuron · doi:10.1016/s0896-6273(01)00476-7 · Cited by 464 · see citing works

Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function

Howes, M. R., & Houghton, P. J. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00128-x · Cited by 443 · see citing works

Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning

Schenk, D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn938 · Cited by 436 · see citing works

A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects

Youdim, K. A., & Joseph, J. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00510-4 · Cited by 434 · see citing works

Differential Expression of Oxidative Phosphorylation Genes in Patients With Alzheimer's Disease: Implications for Early Mitochondrial Dysfunction and Oxidative Damage

Mańczak, M., Park, B. S., Jung, Y., & Reddy, P. H. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:2:147 · Cited by 432 · see citing works

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Howes, M. R., Perry, N. S. L., & Houghton, P. J. (2003) · Phytotherapy Research · doi:10.1002/ptr.1280 · Cited by 418 · see citing works

Inhibition of amyloid-β aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761

Luo, Y., Smith, J. V., Paramasivam, V., Burdick, A. J., Curry, K. J., Buford, J. P., Khan, I. A., Netzer, W. J., Xu, H., & Butko, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182425199 · Cited by 399 · see citing works

Aromatherapy as a Safe and Effective Treatment for the Management of Agitation in Severe Dementia: The Results of a Double-Blind, Placebo-Controlled Trial

Ballard, C. G., O'Brien, J. T., Reichelt, K., & Perry, E. K. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0703 · Cited by 396 · see citing works

Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death

Jang, J.-H. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00062-5 · Cited by 391 · see citing works

Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial

Perry, N. S. L., Bollen, C. S. C., Perry, E. K., & Ballard, C. G. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00108-4 · Cited by 384 · see citing works

The ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β‐amyloid

Bastianetto, S., Ramassamy, C., Doré, S., Christen, Y., Poirier, J., & Quirion, R. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00069.x · Cited by 378 · see citing works

Flavonoids and the brain: interactions at the blood–brain barrier and their physiological effects on the central nervous system

Youdim, K. A., Shukitt‐Hale, B., & Joseph, J. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.002 · Cited by 373 · see citing works

Differential loss of synaptic proteins in Alzheimer's disease: Implications for synaptic dysfunction

Reddy, P. H., Mani, G., Park, B. S., Jacques, J., MURDOCH, G. H., Whetsell, W. O., Kaye, J. A., & Mańczak, M. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7203 · Cited by 372 · see citing works

Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts

López, S., Bastida, J., Viladomat, F., & Codina, C. J. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02034-9 · Cited by 359 · see citing works

Plants and the central nervous system

Carlini, E. A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00112-6 · Cited by 357 · see citing works

Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial

Akhondzadeh, S., Noroozıan, M., Mohammadi, M., Ohadinia, S., Jamshidi, A. H., & Khani, M. (2003) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2003.00463.x · Cited by 345 · see citing works

Studies on molecular mechanisms of Ginkgo biloba extract

Luo, Y., & Smith, J. V. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1527-9 · Cited by 344 · see citing works

The green tea polyphenol (−)-epigallocatechin gallate attenuates β-amyloid-induced neurotoxicity in cultured hippocampal neurons

Choi, Y.-T., Jung, C., Lee, S., Bae, J., Baek, W., Suh, M., Park, J., Park, C., & Suh, S. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01438-2 · Cited by 342 · see citing works

Vitamin E and Vitamin C Supplement Use and Risk of Incident Alzheimer Disease

Morris, M. C., Beckett, L. A., Scherr, P. A., Hebert, L. E., Bennett, D. A., Field, T. S., & Evans, D. A. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199809000-00001 · Cited by 332 · see citing works

Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease

Reddy, P. H., McWeeney, S. K., Park, B. S., Mańczak, M., Gutala, R. V., Partovi, D., Jung, Y., Yau, V., Searles, R. P., Mori, M., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh140 · Cited by 327 · see citing works

Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats

Sharma, M., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02083-0 · Cited by 326 · see citing works

The CNS effects of Ginkgo biloba extracts and ginkgolide B

Maclennan, K. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00015-1 · Cited by 300 · see citing works

Microglia enhance β‐amyloid peptide‐induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species

Qin, L., Liu, Y., Cooper, C. L., Liu, B., Wilson, B. C., & Hong, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01210.x · Cited by 290 · see citing works

Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial

Akhondzadeh, S. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.7.863 · Cited by 290 · see citing works

Are mitochondria critical in the pathogenesis of Alzheimer's disease?

Reddy, P. H., & Beal, M. F. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.03.004 · Cited by 289 · see citing works

Medicinal plants and Alzheimer’s disease: From ethnobotany to phytotherapy

Perry, E. K., Pickering, A. T., Wang, W. W., Houghton, P. J., & Perry, N. S. L. (1999) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357991772808 · Cited by 285 · see citing works

Certain Inhibitors of Synthetic Amyloid β-Peptide (Aβ) Fibrillogenesis Block Oligomerization of Natural Aβ and Thereby Rescue Long-Term Potentiation

Walsh, D. M., Townsend, M., Podlisny, M. B., Shankar, G. M., Fadeeva, J. V., El‐Agnaf, O. M. A., Hartley, D. M., & Selkoe, D. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4391-04.2005 · Cited by 284 · see citing works

The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease

Koldamova, R. P., Lefterov, I. M., Staufenbiel, M., Wolfe, D., Huang, S., Glorioso, J. C., Walter, M., Roth, M. G., & Lazo, J. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411420200 · Cited by 279 · see citing works

Discovery of Natural Products from Curcuma longa that Protect Cells from Beta-Amyloid Insult: A Drug Discovery Effort against Alzheimer's Disease

Park, S., & Kim, D. S. H. L. (2002) · Journal of Natural Products · doi:10.1021/np010039x · Cited by 278 · see citing works

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice

Li, F., Calingasan, N. Y., Yu, F., Mauck, W. M., Toidze, M., Almeida, C. G., Takahashi, R. H., Carlson, G. A., Beal, M. F., Lin, M. T. S., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02455.x · Cited by 276 · see citing works

Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation

Abe, K., & Saito, H. (2000) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(200005)14:3 · Cited by 271 · see citing works

Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis

Kong, A. T., Yu, R., Chen, C., Mandlekar, S., & Primiano, T. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02976458 · Cited by 270 · see citing works

Ginkgo for Memory Enhancement

Solomon, P. R., Adams, F., Silver, A., Zimmer, J., & DeVeaux, R. D. (2002) · JAMA · doi:10.1001/jama.288.7.835 · Cited by 269 · see citing works

Effect of <i>Centella asiatica</i> on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats

Veerendra Kumar, M., & Gupta, Y. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03842.x · Cited by 249 · see citing works

Does Donepezil Treatment Slow the Progression of Hippocampal Atrophy in Patients With Alzheimer’s Disease?

Hashimoto, M., Kazui, H., Matsumoto, K., Nakano, Y., Yasuda, M., & Mori, E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.676 · Cited by 243 · see citing works

Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites

Spencer, J. P. E., Kuhnle, G., WILLIAMS, R. J., & Rice-Evans, C. A. (2003) · Biochemical Journal · doi:10.1042/bj20021972 · Cited by 241 · see citing works

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype

Ramassamy, C., Averill‐Bates, D. A., Beffert, U., Bastianetto, S., Théroux, L., Lussier‐Cacan, S., Cohn, J. S., Christen, Y., Davignon, J., Quirion, R., et al. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00102-1 · Cited by 240 · see citing works

The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba

Watanabe, C. M. H., Wolffram, S., Ader, P., Rimbach, G. H., Packer, L., Maguire, J. J., Schultz, P. G., & Gohil, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111126298 · Cited by 234 · see citing works

Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment

Stackman, R. W., Eckenstein, F., Frei, B., Kulhanek, D., Nowlin, J., & Quinn, J. F. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00399-6 · Cited by 230 · see citing works

Non‐steroidal anti‐inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action

Gasparini, L., Ongini, E., & Wenk, G. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02743.x · Cited by 226 · see citing works

The Ginkgo biloba Extract (EGb 761) Protects and Rescues Hippocampal Cells Against Nitric Oxide‐Induced Toxicity

Bastianetto, S., Zheng, W., & Quirion, R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742268.x · Cited by 222 · see citing works

Immunotherapeutic Approaches to Alzheimer's Disease

Monsonego, A., & Weiner, H. L. (2003) · Science · doi:10.1126/science.1088469 · Cited by 217 · see citing works

The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease

Zangara, A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00111-4 · Cited by 208 · see citing works

Chronic nicotine treatment reduces β‐amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw)

Nordberg, A. K., Hellström‐Lindahl, E., Lee, M., Johnson, M. A., Mousavi, M. T., Hall, R., Perry, E. K., Bednar, I., & COURT, J. A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00874.x · Cited by 204 · see citing works

Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study

Holmes, C., Hopkins, V., Hensford, C., MacLaughlin, V., Wilkinson, D., & Rosenvinge, H. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.593 · Cited by 202 · see citing works

Deer Browsing and Population Viability of a Forest Understory Plant

McGraw, J. B., & Furedi, M. A. (2005) · Science · doi:10.1126/science.1107036 · Cited by 200 · see citing works

Butyryl‐ and acetyl‐cholinesterase inhibitory activities in essential oils of Salvia species and their constituents

Savelev, S. U., Okello, E. J., & Perry, E. K. (2004) · Phytotherapy Research · doi:10.1002/ptr.1451 · Cited by 193 · see citing works

Antioxidant strategies for Alzheimer's disease

Grundman, M., & Delaney, P. (2002) · Proceedings of The Nutrition Society · doi:10.1079/pns2002146 · Cited by 193 · see citing works

Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers

Tildesley, N. T. J., Kennedy, D. O., Perry, E. K., Ballard, C. G., Savelev, S. U., Wesnes, K. A., & Scholey, A. B. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00122-9 · Cited by 184 · see citing works

Reduction of cortical TrkA but not p75NTR protein in early‐stage Alzheimer's disease

Counts, S., Nadeem, M., Wuu, J., Ginsberg, S. D., Saragovi, H. U., & Mufson, E. J. (2004) · Annals of Neurology · doi:10.1002/ana.20233 · Cited by 183 · see citing works

The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands

Yao, Z., Drieu, K., & Papadopoulos, V. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03131-0 · Cited by 181 · see citing works

The extracts from Nelumbo Nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cells

Liu, C.-P., Tsai, W., Lin, Y.-L., Liao, J.-F., Chen, C., & Kuo, Y. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.01.019 · Cited by 179 · see citing works

Microglia as a Potential Bridge between the Amyloid β‐Peptide and Tau

Kitazawa, M., Yamasaki, T. R., & LaFerla, F. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.006 · Cited by 177 · see citing works

Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease

Zheng, F., Chang, Y. S., Cheng, Y., Zhang, B. W., Qu, Z., Qin, C., & Zhang, J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00144.x · Cited by 169 · see citing works

Ginkgo extract or cholinesterase inhibitors in patients with dementia: What clinical trials and guidelines fail to consider

Schulz, V. (2003) · Phytomedicine · doi:10.1078/1433-187x-00302 · Cited by 164 · see citing works

Up-regulation of the inflammatory cytokines IFN-γ and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APPSWE transgenic mice

Abbas, N., Bednar, I., Mix, E., Svedberg, M., Paterson, D., Ljungberg, A., Morris, C. M., Winblad, B. G., Nordberg, A. K., & Zhu, J. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00050-4 · Cited by 161 · see citing works

In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's disease

Perry, N. S. L., Houghton, P. J., Sampson, J., Theobald, A. E., Hart, S., Lis‐Balchin, M., Hoult, J. R. S., Evans, P., Jenner, P. G., Milligan, S. R., et al. (2001) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357011777846 · Cited by 159 · see citing works

Novel Diterpenoid Acetylcholinesterase Inhibitors fromSalvia miltiorhiza

Ren, Y., Houghton, P. J., Hider, R. C., & Howes, M. R. (2004) · Planta Medica · doi:10.1055/s-2004-815535 · Cited by 157 · see citing works

Immunotherapy for Alzheimer's disease

Gélinas, D. S., Silva, K. D., Fenili, D., George‐Hyslop, P. S., & McLaurin, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404866101 · Cited by 156 · see citing works

Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial

van Dongen, M. C. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00003-9 · Cited by 155 · see citing works

Pharmacological Studies Supporting the Therapeutic Use of Ginkgo biloba Extract for Alzheimer’s Disease

Ahlemeyer, B., & Krieglstein, J. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-40454 · Cited by 147 · see citing works

Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans.

Wu, Z., Smith, J. V., Paramasivam, V., Butko, P., Khan, I. A., Cypser, J. R., & Luo, Y. (2002) · PubMed · Cited by 143 · see citing works

Curcumin, the active constituent of turmeric, inhibits amyloid peptide‐induced cytochemokine gene expression and CCR5‐mediated chemotaxis of THP‐1 monocytes by modulating early growth response‐1 transcription factor

Giri, R. K., Rajagopal, V., & Kalra, V. K. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02800.x · Cited by 143 · see citing works

Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative

Sumanont, Y., Murakami, Y., Tohda, M., Vajragupta, O., Matsumoto, K., & Watanabe, H. (2004) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.27.170 · Cited by 141 · see citing works

Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins

Tohda, C., Matsumoto, N., Zou, K., Meselhy, M. R., & Komatsu, K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300388 · Cited by 139 · see citing works

Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer’s disease

Ognibene, E., Middei, S., Daniele, S., Adriani, W., Ghirardi, O., Caprioli, A., & Laviola, G. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.028 · Cited by 135 · see citing works

Effects of EGb 761® Ginkgo biloba Extract on Mitochondrial Function and Oxidative Stress

Eckert, A., Keil, U., Kressmann, S., Schindowski, K., Leutner, S., Leutz, S., & Müller, W. E. G. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-40449 · Cited by 132 · see citing works

Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway

Achike, F. I., & Kwan, C. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03885.x · Cited by 130 · see citing works

Reactive Oxygen Species-Induced Apoptosis in PC12 Cells and Protective Effect of Bilobalide

Zhou, L., & Zhu, X. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39323-1 · Cited by 129 · see citing works

Ginkgo biloba Extract EGb 761® in Dementia: Intent-to-treat Analyses of a 24-week, Multi-center, Double-blind, Placebo-controlled, Randomized Trial

Kanowski, S., & Hoerr, R. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-45117 · Cited by 127 · see citing works

Nicotine reduces Aβ in the brain and cerebral vessels of APPsw mice

Hellström‐Lindahl, E., COURT, J. A., Keverne, J., Svedberg, M. M., Lee, M., Marutle, A., Thomas, A. J., Perry, E. K., Bednar, I., & Nordberg, A. K. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03377.x · Cited by 127 · see citing works

Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera.

Russo, A., Borrelli, F., Campisi, A., Acquaviva, R., Raciti, G., & Vanella, A. (2003) · Life Science · doi:10.1016/s0024-3205(03)00476-4 · Cited by 125 · see citing works

Oxidative Damage to Proteins, Lipids, and DNA in Cortical Brain Regions from Patients with Dementia with Lewy Bodies

Lyras, L., Perry, R. H., Perry, E. K., Ince, P. G., Jenner, A. M., Jenner, P. G., & Halliwell, B. B. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71010302.x · Cited by 121 · see citing works

Herbs commonly used by women: An evidence-based review

Tesch, B. J. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.402 · Cited by 119 · see citing works

Phyto-oestrogens

Duncan, A. M., Phipps, W. R., & Kurzer, M. S. (2003) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/s1521-690x(02)00103-3 · Cited by 118 · see citing works

A Controlled Trial of Aromatherapy for Agitation in Nursing Home Patients with Dementia

Snow, L. A., Hovanec, L., & Brandt, J. (2004) · The Journal of Alternative and Complementary Medicine · doi:10.1089/1075553041323696 · Cited by 117 · see citing works

Aromatherapy and behaviour disturbances in dementia: a randomized controlled trial

Smallwood, J., Brown, R., Coulter, F., Irvine, E., & Copland, C. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.473 · Cited by 115 · see citing works

Medicinal Plants and Alzheimer's Disease: Integrating Ethnobotanical and Contemporary Scientific Evidence

Perry, E. K., Pickering, A. T., Wang, W. W., Houghton, P., & Perry, N. S. L. (1998) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.1998.4.419 · Cited by 113 · see citing works

Apolipoprotein E, transthyretin and actin in the CSF of Alzheimer's patients: relation with the senile plaques and cytoskeleton biochemistry

Merched, A. J., Sérot, J., Visvikis‐Siest, S., Aguillon, D., Faure, G. C., & Siest, G. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00234-8 · Cited by 111 · see citing works

Genotype and phenotype in Alzheimer's disease

Holmes, C. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.180.2.131 · Cited by 103 · see citing works

Aroma therapy for dementia

Holt, F., Birks, T. P., Thorgrimsen, L., Spector, A. E., Wiles, A., & Orrell, M. W. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003150 · Cited by 102 · see citing works

Amyloid precursor protein metabolism is regulated toward alpha-secretase pathway by Ginkgo biloba extracts

Colciaghi, F., Borroni, B., Zimmermann, M., Bellone, C., Longhi, A., Padovani, A., Cattabeni, F., Christen, Y., & Luca, M. D. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.03.011 · Cited by 102 · see citing works

The NMDA receptor ion channel: a site for binding of huperzine A

Gordon, R. K., Nigam, S. V., Weitz, J. A., Dave, J. R., Doctor, B. P., & Ved, H. S. (2001) · Journal of Applied Toxicology · doi:10.1002/jat.805 · Cited by 100 · see citing works

Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo

Perry, N. S. L., Houghton, P. J., Jenner, P. G., Keith, A. B., & Perry, E. K. (2002) · Phytomedicine · doi:10.1078/0944-7113-00082 · Cited by 98 · see citing works

Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats

Liang, Y. Q., & Tang, X. C. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.071 · Cited by 96 · see citing works

Neuroprotective effect of garlic compounds in amyloid-beta peptide-induced apoptosis in vitro.

Peng, Q., Buz'Zard, A. R., & Lau, B. H. S. (2002) · PubMed · Cited by 90 · see citing works

Tenuigenin treatment decreases secretion of the Alzheimer’s disease amyloid β-protein in cultured cells

Jia, H., Jiang, Y., Ruan, Y., Zhang, Y., Ma, X., Zhang, J., Beyreuther, K. T., Tu, P., & Zhang, D. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.093 · Cited by 88 · see citing works

Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein−Ligand Complementarity

Wong, D. M., Greenblatt, H. M., Dvir, H., Carlier, P. R., Han, Y., Pang, Y., Silman, I., & Sussman, J. L. (2002) · Journal of the American Chemical Society · doi:10.1021/ja021111w · Cited by 88 · see citing works

Effects of Green Tea Polyphenol on Cognitive and Acetylcholinesterase Activities

Kim, H. K., Kim, M., Kim, S., Kim, M., & Chung, J. H. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.1977 · Cited by 87 · see citing works

Anti-apoptotic properties of Ginkgo biloba extract EGb 761 in differentiated PC12 cells.

Smith, J. V., Burdick, A. J., Golik, P., Khan, I. A., Wallace, D. C., & Luo, Y. (2002) · PubMed · Cited by 84 · see citing works

Ginkgolide B inhibits the neurotoxicity of prions or amyloid-beta1-42.

Bate, C. A. W., Salmona, M., & Williams, A. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-4 · Cited by 83 · see citing works

Association of Alzheimer's Disease Onset With Ginkgo Biloba and Other Symptomatic Cognitive Treatments in a Population of Women Aged 75 Years and Older From the EPIDOS Study

Andrieu, S., Guyonnet, S., Amouyal-Barkate, K., Nourhashémi, F., Reynish, E. L., Ousset, P., Albarède, J. L., Vellas, B. J., & Grandjean, H. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.4.m372 · Cited by 83 · see citing works

Rhizoma acori graminei and its active principles protect PC-12 cells from the toxic effect of amyloid-β peptide

Irie, Y., & Keung, W. M. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04050-7 · Cited by 80 · see citing works

Lack of Pharmacokinetic or Pharmacodynamic Interaction Between Memantine and Donepezil

Periclou, A. P., Ventura, D., Sherman, T., Rao, N. S., & Abramowitz, W. (2004) · Annals of Pharmacotherapy · doi:10.1345/aph.1d638 · Cited by 80 · see citing works

Aromatherapy in dementia

Holmes, C., & Ballard, C. G. (2004) · Advances in Psychiatric Treatment · doi:10.1192/apt.10.4.296 · Cited by 71 · see citing works

Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-α in intracerebroventricular β-amyloid-(1–40) infused rats and human embryonic kidney 293 Swedish mutant cells

Zhang, H., Yan, H., & Tang, X. C. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.055 · Cited by 70 · see citing works

Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease

Gasparini, L., Ongini, E., Wilcock, D. M., & Morgan, D. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.029 · Cited by 68 · see citing works

Cholinesterase inhibitors influence APP metabolism in Alzheimer disease patients

Zimmermann, M., Borroni, B., Cattabeni, F., Padovani, A., & Luca, M. D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.002 · Cited by 67 · see citing works

ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice

Kang, S. Y., Lee, K. Y., Koo, K. A., Yoon, J. S., Lim, S. W., Kim, Y. C., & Sung, S. H. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.07.029 · Cited by 64 · see citing works

Alternative therapies for traditional disease states: menopause.

Morelli, V., & Naquin, C. (2002) · PubMed · Cited by 63 · see citing works

The herbal medicine Dipsacus asper Wall extract reduces the cognitive deficits and overexpression of β-amyloid protein induced by aluminum exposure

Zhangjin, Z., Qian, Y., Hu, H., Yang, J., & Yang, G. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00649-0 · Cited by 62 · see citing works

Red wine micronutrients as protective agents in Alzheimer-like induced insult.

Russo, A., Palumbo, M., Aliano, C., Lempereur, L., Scoto, G. M., & Renis, M. (2003) · Life Science · doi:10.1016/s0024-3205(03)00123-1 · Cited by 62 · see citing works

Bioavailability of Dietary Supplements and Impact of Physiologic State: Infants, Children and Adolescents

Krebs, N. F. (2001) · Journal of Nutrition · doi:10.1093/jn/131.4.1351s · Cited by 61 · see citing works

Ptychopetalum olacoides, a traditional Amazonian “nerve tonic”, possesses anticholinesterase activity

Siqueira, I. R., Fochesatto, C., da Silva, A. L., Nunes, D. S., Battastini, A. M. O., Netto, C. A., & Elisabetsky, E. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00113-8 · Cited by 60 · see citing works

Influence of aromatherapy on medication administration to residential-care residents with dementia and behavioral challenges

Gray, S., & Clair, A. A. (2002) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750201700305 · Cited by 56 · see citing works

Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo

Jonnala, R. R., Terry, A. V., & Buccafusco, J. J. (2002) · Life Sciences · doi:10.1016/s0024-3205(01)01529-6 · Cited by 53 · see citing works

Alzheimer's disease: the pharmacological pathway

Allain, H., Bentué‐Ferrer, D., Tribut, O., Gauthier, S. G., Michel, B., & Rochelle, C. D. L. (2003) · Fundamental and Clinical Pharmacology · doi:10.1046/j.1472-8206.2003.00153.x · Cited by 52 · see citing works

Oxidative-stress associated parameters (lactoferrin, superoxide dismutases) in serum of patients with Alzheimer's disease

Thome, J., Gsell, W., Rösier, M., Kornhuber, J., Frölich, L., Hashimoto, E., Zielke, B., Wiesbeck, G. A., & Riedcrer, P. (1996) · Life Sciences · doi:10.1016/s0024-3205(96)00583-8 · Cited by 50 · see citing works

Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants

Veurink, G. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00042-x · Cited by 48 · see citing works

Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements: The Cache County Study

Zandi, P. P. (2004) · Archives of Neurology · doi:10.1001/archneur.61.1.82 · Cited by 47 · see citing works

Androgens, ApoE, and Alzheimer's Disease

Raber, J. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.11.re2 · Cited by 46 · see citing works

Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons

Zhang, J.-M., & Hu, G. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00206-8 · Cited by 45 · see citing works

Nicotine Enhances the Biosynthesis and Secretion of Transthyretin from the Choroid Plexus in Rats: Implications for β-Amyloid Formation

Li, M. D., Kane, J. K., Matta, S. G., Blaner, W. S., & Sharp, B. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01318.2000 · Cited by 44 · see citing works

Early induction of interleukin-6 mRNA in the hippocampus and cortex of APPsw transgenic mice Tg2576

Tehranian, R., Hasanvan, H., Iverfeldt, K., Post, C., & Schultzberg, M. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01592-0 · Cited by 43 · see citing works

Effect of kami-untan-to on the impairment of learning and memory induced by thiamine-deficient feeding in mice

Nakagawasai, O., Yamadera, F., Iwasaki, K., Arai, H., Taniguchi, R., Tan–No, K., Sasaki, H., & Tadano, T. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.051 · Cited by 41 · see citing works

Inhibitory effect of zeatin, isolated from Fiatoua villosa, on acetylcholinesterase activity from PC12 cells

Heo, H.-J., Hong, S.-C., Cho, H.-Y., Hong, B., Kim, H.-K., Kim, E.-K., & Shin, D.-H. (2002) · Molecules and Cells · doi:10.1016/s1016-8478(23)15011-4 · Cited by 38 · see citing works

Nonsteroidal anti-inflammatory drugs and Alzheimer disease: what's next?

Launer, L. (2003) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.289.21.2865 · Cited by 37 · see citing works

Structure-activity Studies with Ginkgo biloba Extract Constituents as Receptor-gated Chloride Channel Blockers and Modulators

Chatterjee, S. S., Kondratskaya, E., & Krishtal, O. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-40455 · Cited by 36 · see citing works

A water extract of Curcuma longa L. (Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells

Koo, B., Lee, W.-C., Chung, K.-H., Ko, J., & Kim, C. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.07.003 · Cited by 36 · see citing works

Billion-dollar market blossoms as botanicals take root

Glaser, V. P. (1999) · Nature Biotechnology · doi:10.1038/5186 · Cited by 35 · see citing works

Effects of Yukmijihwang-tang Derivatives (YMJd), a Memory Enhancing Herbal Extract, on the Gene-Expression Profile in the Rat Hippocampus

Rho, S., Kang, M., Choi, B., Sim, D., Lee, J., Lee, E., Cho, C., Oh, J.-W., Park, S., Ko, S., et al. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.87 · Cited by 35 · see citing works

EGb 761 is a neuroprotective agent against beta-amyloid toxicity.

Bastianetto, S., & Quirion, R. (2002) · PubMed · Cited by 35 · see citing works

Plants and the central nervous system

Houghton, P. J., & Seth, P. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00161-8 · Cited by 33 · see citing works

Response Patterns of EGb 761® in Alzheimer’s Disease: Influence of Neuropsychological Profiles

Bars, P. L. L. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-40456 · Cited by 26 · see citing works

Effect of combination of extracts of ginseng and ginkgo biloba on acetylcholine in amyloid beta-protein-treated rats determined by an improved HPLC.

Liu, J., Cong, W., Xu, L., & Wang, J.-N. (2004) · PubMed · Cited by 23 · see citing works

Differentiating effects of anisodamine on cognitive amelioration and peripheral muscarinic side effects induced by pilocarpine in mice

Wang, H., Yang, L., & Chen, H. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00444-0 · Cited by 23 · see citing works

Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex

Zhang, Y., Zhao, X., Chen, X.-Q., Wang, Y., Yang, H., & Hu, G. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02565-4 · Cited by 22 · see citing works

Phytoestrogens in health and illness

Rishi, R. K. (2002) · Indian Journal of Pharmacology · Cited by 20 · see citing works

Attenuating effect of a traditional korean formulation, Paeng‐Jo‐Yeon‐Nyeon‐Baek‐Ja‐In‐Hwan (PJBH), on hydrogen peroxide‐induced injury in PC12 cells

Koo, B., Kim, Y., Park, K.-S., Chung, K., & Kim, C. (2004) · Phytotherapy Research · doi:10.1002/ptr.1457 · Cited by 18 · see citing works

Involvement of CDK4, pRB, and E2F1 in ginsenoside Rg1 protecting rat cortical neurons from beta-amyloid-induced apoptosis.

Chen, X., Li-min, C., Zhu, Y., Fang, F., Yi-can, Z., & Zhao, C. (2003) · PubMed · Cited by 15 · see citing works

Effect of Ginkgo biloba (EGb 761®) on Differential Gene Expression

Rimbach, G. H., Wolffram, S., Watanabe, C. K., Packer, L., & Gohil, K. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-40457 · Cited by 13 · see citing works

PEP Talk: Treating Nonoccupational HIV Exposure

Stephenson, J. (2003) · JAMA · doi:10.1001/jama.289.3.287 · Cited by 6 · see citing works

Chronic administration of EGb 761 modulates synaptic and mitochondrial plasticity in adult vitamin E-deficient rats.

Bertoni–Freddari, C., Fattoretti, P., Caselli, U., Paoloni, R., & Solazzi, M. (2002) · PubMed · Cited by 4 · see citing works

Resveratrol—A boon for treating Alzheimer's disease?

Anekonda, T. S. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.04.004 · Cited by 341 · see citing works

Plants traditionally used in age related brain disorders—A survey of ethnobotanical literature

Adams, M. A., Gmünder, F., & Hamburger, M. O. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.07.016 · Cited by 328 · see citing works

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases

Reddy, P. H., & Reddy, T. P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745401 · Cited by 227 · see citing works

Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture

Limpeanchob, N., Jaipan, S., Rattanakaruna, S., Phrompittayarat, W., & Ingkaninan, K. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.07.039 · Cited by 206 · see citing works

Metabolic syndrome and the role of dietary lifestyles in Alzheimer’s disease

Pasinetti, G. M., & Eberstein, J. A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05454.x · Cited by 157 · see citing works

Mitochondrial Oxidative Damage in Aging and Alzheimer′s Disease: Implications for Mitochondrially Targeted Antioxidant Therapeutics

Reddy, P. H. (2006) · BioMed Research International · doi:10.1155/jbb/2006/31372 · Cited by 153 · see citing works

Neuronal protection by sirtuins in Alzheimer's disease

Anekonda, T. S., & Reddy, P. H. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03492.x · Cited by 150 · see citing works

Oxidative stress: A bridge between Down's syndrome and Alzheimer's disease

Zana, M., Janka, Z., & Kalman, J. L. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.03.008 · Cited by 137 · see citing works

Oxidative Stress Mediated Mitochondrial and Vascular Lesions as Markers in the Pathogenesis of Alzheimer Disease

Aliev, G., Priyadarshini, M., Reddy, V., Grieg, N. H., Kaminsky, Y., Cacabelos, R., Ashraf, G., Jabir, N. R., Kamal, M. A., Nikolenko, V. N., et al. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131227161303 · Cited by 138 · see citing works

Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect

Ansari, N., & Khodagholi, F. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040005 · Cited by 131 · see citing works

Network pharmacology-based study on the mechanism of action for herbal medicines in Alzheimer treatment

Fang, J., Wang, L., Wu, T., Yang, C., Gao, L., Cai, H., Liu, J., Fang, S., Chen, Y., Tan, W., et al. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.11.034 · Cited by 127 · see citing works

Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works

Traditional Chinese Medicine for Senile Dementia

Lin, Z., Gu, J., Xiu, J., Mi, T., Dong, J., & Tiwari, J. K. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/692621 · Cited by 98 · see citing works

Neuroprotective effects of Bacopa monnieri in experimental model of dementia

Saini, N., Singh, D., & Sandhir, R. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0811-4 · Cited by 95 · see citing works

Anticholinesterse and antioxidant investigations of crude extracts, subsequent fractions, saponins and flavonoids of atriplex laciniata L.: potential effectiveness in Alzheimer’s and other neurological disorders

Kamal, Z., Ullah, F., Ayaz, M., Sadiq, A., Ahmad, S., Zeb, A., Hussain, A., & Imran, M. (2015) · Biological Research · doi:10.1186/s40659-015-0011-1 · Cited by 86 · see citing works

Phytic Acid as a Potential Treatment for Alzheimer's Pathology: Evidence from Animal and in vitro Models

Anekonda, T. S., Wadsworth, T. L., Sabin, R. D., Frahler, K., Harris, C., Petriko, B., Ralle, M., Woltjer, R. L., & Quinn, J. F. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101287 · Cited by 84 · see citing works

Oren-gedoku-to and its Constituents with Therapeutic Potential in Alzheimer's Disease Inhibit Indoleamine 2, 3-Dioxygenase Activity In Vitro

Yu, C.-J., Zheng, M., Kuang, C., Huang, W., & Yang, Q. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100684 · Cited by 85 · see citing works

SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway

Ramesh, S., Govindarajulu, M., Lynd, T. O., Briggs, G. H., Adamek, D., Jones, E., Heiner, J., Majrashi, M., Moore, T., Amin, R., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190350 · Cited by 81 · see citing works

Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway

Xiong, R., Wang, X., Wu, J., Tang, Y., Qiu, W., Shen, X., Teng, J., Pan, R., Zhao, Y., Yu, L., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112548 · Cited by 80 · see citing works

Resveratrol Suppresses Rotenone‐induced Neurotoxicity Through Activation of SIRT1/Akt1 Signaling Pathway

Wang, H., Dong, X., Liu, Z., Zhu, S., Liu, H., Fan, W., Hu, Y., Hu, T., Yu, Y., Li, Y., et al. (2018) · The Anatomical Record · doi:10.1002/ar.23781 · Cited by 71 · see citing works

Neuroprotection against Aβ25–35-induced apoptosis by Salvia miltiorrhiza extract in SH-SY5Y cells

Yu, H., Yao, L., Hongzu, Z., Qu, S., Zeng, X., Zhou, D., Zhou, Y., Li, X., & Liu, Z. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.06.001 · Cited by 69 · see citing works

Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta‐amyloid and homocysteine neurotoxicity in PC12 cells

Song, J., Lin, X., Wong, R. N., Sze, S. C. W., Tong, Y., Shaw, P., & Zhang, Y. (2010) · Phytotherapy Research · doi:10.1002/ptr.3269 · Cited by 68 · see citing works

Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria

Shinomol, G. K., & ., M. (2008) · Phytomedicine · doi:10.1016/j.phymed.2008.04.010 · Cited by 69 · see citing works

Drug discovery from Chinese medicine against neurodegeneration in Alzheimer's and vascular dementia

Ho, J. Y. S., So, K., & Chang, R. C. (2011) · Chinese Medicine · doi:10.1186/1749-8546-6-15 · Cited by 65 · see citing works

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment

Kuo, Y., Lin, C.-Y., Li, J., & Lou, Y.-I. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s128396 · Cited by 64 · see citing works

Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid

Lee, J. W., Lee, Y. K., Lee, B. J., Nam, S.-Y., Lee, S. I., Kim, Y. H., Kim, K. H., Oh, K., & Hong, J. T. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.12.003 · Cited by 62 · see citing works

Amelioration of Amyloid β‐Induced Cognitive Deficits by Zataria multiflora Boiss. Essential Oil in a Rat Model of Alzheimer's Disease

Majlessi, N., Choopani, S., Kamalinejad, M., & Azizi, Z. (2011) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2011.00237.x · Cited by 61 · see citing works

Mechanisms of over-activated innate immune system regulation in autoimmune and neurodegenerative disorders

BŁACH-OLSZEWSKA, Z., & Leszek, J. (2007) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a906 · Cited by 60 · see citing works

Memory-improving activity of Melissa officinalis extract in naïve and scopolamine-treated rats.

Soodi, M., Naghdi, N., Hajimehdipoor, H., Choopani, S., & Sahraei, E. (2014) · Europe PMC (PubMed Central) · Cited by 56 · see citing works

Lychee Seed Saponins Improve Cognitive Function and Prevent Neuronal Injury via Inhibiting Neuronal Apoptosis in a Rat Model of Alzheimer’s Disease

Wang, X., Wu, J., Yu, C., Tang, Y., Liu, J., Chen, H., Jin, B., Mei, Q., Cao, S., & Qin, D. (2017) · Nutrients · doi:10.3390/nu9020105 · Cited by 56 · see citing works

An aporphine alkaloid fromNelumbo nuciferaas an acetylcholinesterase inhibitor and the primary investigation for structure–activity correlations

Yang, Z., Zhang, X., Du, J., Ma, Z.-J., Guo, F., Li, S., & Yao, X. (2011) · Natural Product Research · doi:10.1080/14786419.2010.487188 · Cited by 55 · see citing works

In-vitro Screening for acetylcholinesterase enzyme inhibition potential and antioxidant activity of extracts of Ipomoea aquatica Forsk:therapeutic lead for Alzheimer's disease

Sivaraman, D., Panneerselvam, P., & Palayan, M. (2015) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2015.50203 · Cited by 55 · see citing works

Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea

Nwidu, L. L., Elmorsy, E. M., Thornton, J., Wijamunige, B. C., Wijesekara, A., Tarbox, R., Warren, A. Y., & Carter, W. G. (2017) · Pharmaceutical Biology · doi:10.1080/13880209.2017.1339283 · Cited by 53 · see citing works

Bacopa monnieri prevents colchicine-induced dementia by anti-inflammatory action

Saini, N., Singh, D., & Sandhir, R. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-018-0332-1 · Cited by 51 · see citing works

Production of Cytokines and Stimulation of Resistance to Viral Infection in Human Leukocytes by Scutellaria baicalensis Flavones

BŁACH-OLSZEWSKA, Z., Jatczak, B., Rak, A., Lorenc, M., Gulanowski, B., Drobna, A., & Lamer-Zarawska, E. (2008) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0125 · Cited by 51 · see citing works

Towards a bioinformatics analysis of anti-Alzheimer's herbal medicines from a target network perspective

Sun, Y., Zhu, R., Ye, H., Tang, K., Zhao, J., Chen, Y., Liu, Q., & Cao, Z. (2012) · Briefings in Bioinformatics · doi:10.1093/bib/bbs025 · Cited by 49 · see citing works

Flavonoid-Based Nanomedicines in Alzheimer’s Disease Therapeutics: Promises Made, a Long Way To Go

Prasanna, P., & Upadhyay, A. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00224 · Cited by 46 · see citing works

Critical Evaluation of Ayurvedic Plants for Stimulating Intrinsic Antioxidant Response

Shukla, S. D., Bhatnagar, M., & Khurana, S. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00112 · Cited by 45 · see citing works

Vitis vinifera acts as anti-Alzheimer's agent by modulating biochemical parameters implicated in cognition and memory

Rapaka, D., Bitra, V., Vishala, T. C., & Akula, A. (2018) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2017.06.013 · Cited by 34 · see citing works

Nootropic medicinal plants: Therapeutic alternatives for Alzheimer’s disease

Vyas, S., Kothari, S. L., & Kachhwaha, S. (2019) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2019.100291 · Cited by 44 · see citing works

Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment

Tang, Y., Yu, C., Wu, J., Chen, H., Zeng, Y., Wang, X., Yang, L., Mei, Q., Cao, S., & Qin, D. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3245 · Cited by 43 · see citing works

Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease

Aliev, G. M., Palacios, H. H., Gasimov, E. K., Obrenovich, M. E., Morales, L., Leszek, J., Bragin, V., Herrera, A. S., & Gokhman, D. (2010) · Pharmaceuticals · doi:10.3390/ph3010158 · Cited by 43 · see citing works

A combined molecular docking and charge density analysis is a new approach for medicinal research to understand drug–receptor interaction: Curcumin–AChE model

Parameswari, A. R., Rajalakshmi, G., & Kumaradhas, P. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.09.011 · Cited by 38 · see citing works

Gene expression patterns of hippocampus and cerebral cortex of senescence-accelerated mouse treated with Huang-Lian-Jie-Du decoction

Zheng, Y., Cheng, X., Zhou, W., & Zhang, Y. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.04.009 · Cited by 36 · see citing works

The Neuroprotective Effects of Ginsenosides on Calcineurin Activity and Tau Phosphorylation in SY5Y Cells

Tu, L.-H., Ma, J., Liu, H., Wang, R.-R., & Luo, J. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9421-3 · Cited by 36 · see citing works

Preclinical evaluation of Trichilia catigua extracts on the central nervous system of mice

Chassot, J. M., Longhini, R., Gazarini, L., de Mello, J. C. P., & de Oliveira, R. M. W. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.07.032 · Cited by 34 · see citing works

From Traditional European Medicine to Discovery of New Drug Candidates for the Treatment of Dementia and Alzheimer's Disease: Acetylcholinesterase Inhibitors

Russo, P., Frustaci, A., Bufalo, A. D., Fini, M., & Cesario, A. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320080002 · Cited by 33 · see citing works

Understanding the conformational flexibility and electrostatic properties of curcumin in the active site of rhAChE via molecular docking, molecular dynamics, and charge density analysis

Kandasamy, S., Kalaiarasi, C., & Kumaradhas, P. (2016) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2016.1264891 · Cited by 33 · see citing works

Flavonoids and Polyphenolic Compounds as Potential Talented Agents for the Treatment of Alzheimer’s Disease and their Antioxidant Activities

Akter, R., Chowdhury, M. A. R., & Rahman, M. H. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201102102810 · Cited by 33 · see citing works

Brain Enhancing Ingredients from Āyurvedic Medicine: Quintessential Example of Bacopa monniera, a Narrative Review

Singh, H. K. (2013) · Nutrients · doi:10.3390/nu5020478 · Cited by 32 · see citing works

Gossypium herbaceam Extracts Inhibited NF-κB Activation to Attenuate Spatial Memory Impairment and Hippocampal Neurodegeneration Induced by Amyloid-β in Rats

Ji, C., Aisa, H. A., Yang, N., Li, Q., Wang, T., Zhang, L., Qu, K., Zhu, H., & Zuo, P. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14302 · Cited by 30 · see citing works

Small Molecule Natural Products and Alzheimer’s Disease

Wu, X., Cai, H., Pan, L., Cui, G., Qin, F., Li, Y., & Cai, Z. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190201153257 · Cited by 29 · see citing works

Simultaneous determination of asperosaponin VI and its active metabolite hederagenin in rat plasma by liquid chromatography–tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study

Zhu, H., Ding, L., Shakya, S., Qi, X., Hu, L., Yang, X., & Yang, Z. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.09.014 · Cited by 30 · see citing works

Advances in the pharmacological effects and mechanisms of Nelumbo nucifera gaertn. Extract nuciferine

Ren, X., Chen, H., Wang, H., Wang, Y., Huang, C., & Pan, H. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118262 · Cited by 28 · see citing works

Ginger, a Possible Candidate for the Treatment of Dementias?

Schepici, G., Contestabile, V., Valeri, A., & Mazzon, E. (2021) · Molecules · doi:10.3390/molecules26185700 · Cited by 29 · see citing works

Comparison of Neuroprotective Effects of Melissa officinalis Total Extract and Its Acidic and Non-Acidic Fractions against A β-Induced Toxicity.

Sepand, M. R., Soodi, M., Hajimehdipoor, H., Soleimani, M., & Sahraei, E. (2013) · Europe PMC (PubMed Central) · Cited by 27 · see citing works

Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer’s disease

Kumar, A., Sharma, V., Singh, V. P., Kaundal, M., Gupta, M., Bariwal, J. B., & Deshmukh, R. R. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.05.009 · Cited by 27 · see citing works

Phytochemical composition and the cholinesterase and xanthine oxidase inhibitory properties of seed extracts from the Washingtonia filifera palm fruit

Floris, S., Fais, A., Rosa, A., Piras, A., Marzouki, H., Medda, R., Paramás, A. M. G., Kumar, A., Santos‐Buelga, C., & Era, B. (2019) · RSC Advances · doi:10.1039/c9ra02928a · Cited by 25 · see citing works

☆Protective effects of ginseng on memory and learning and prevention of hippocampal oxidative damage in streptozotocin-induced Alzheimer's in a rat model

Fereidooni, F., Komeili, G., Fanaei, H., Safari, T., Khorrami, S., & Feizabad, A. K. (2020) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2020.08.001 · Cited by 25 · see citing works

Novel polyacetylene derivatives and their inhibitory activities on acetylcholinesterase obtained from Panax ginseng roots

Murata, K., Iida, D., Ueno, Y., Samukawa, K., Ishizaka, T., Kotake, T., & Matsuda, H. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-1036-7 · Cited by 24 · see citing works

In vitro biological activities of black pepper essential oil and its major components relevant to the prevention of Alzheimer’s disease

Lomarat, P., Sripha, K., Phanthong, P., Kitphati, W., Thirapanmethee, K., & Bunyapraphatsara, N. (2015) · The Thai Journal of Pharmaceutical Sciences · doi:10.56808/3027-7922.1951 · Cited by 24 · see citing works

Neuroprotective effects of carvacrol against Alzheimer's disease and other neurodegenerative diseases: A review.

Azizi, Z., Majlessi, N., Choopani, S., & Naghdi, N. (2022) · PubMed Central · doi:10.22038/ajp.2022.19491 · Cited by 23 · see citing works

A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Aβ1–42 level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease

Seo, J., Jung, E.-Y., Kim, J., Lyu, Y.-S., Han, P., & Kang, H.-W. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.05.055 · Cited by 23 · see citing works

Lingguizhugan decoction protects PC12 cells against Aβ25-35-induced oxidative stress and neuroinflammation by modulating NF-κB/MAPK signaling pathways

Han, J., Zhang, H., Zhang, Y., Zhang, Z., Yu, M., Wang, S., & Han, F. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115194 · Cited by 22 · see citing works

Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama)

Figueiró, M., Ilha, J., Pochmann, D., Porciúncula, L. O., Xavier, L. L., Achaval, M., Nunes, D. S., & Elisabetsky, E. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.03.009 · Cited by 22 · see citing works

Neuroprotective effects of Bergenia ciliata on NMDA induced injury in SH-SY5Y cells and attenuation of cognitive deficits in scopolamine induced amnesia in rats

Barai, P., Raval, N., Acharya, S., & Acharya, N. (2018) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2018.09.011 · Cited by 21 · see citing works

Anti-aggregation effects of thymoquinone against Alzheimers -amyloid in vitro

Ismail, N., Ismail, M., Shahid, I., & Latiff, L. A. (2013) · Journal of Medicinal Plants Research · doi:10.5897/jmpr10.852 · Cited by 21 · see citing works

Herbal approaches to system dysfunctions

(2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06992-5.00009-8 · Cited by 20 · see citing works

Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease

Zhang, C., Zhao, X., Lin, S., Liu, F., Ma, J., Han, Z., Jia, F., Xie, W., Zhang, Q., & Li, X. (2019) · Molecules · doi:10.3390/molecules25010142 · Cited by 20 · see citing works

Inhibition of enzymes important for Alzheimer's disease by antioxidant extracts prepared from 15 New Zealand medicinal trees and bushes

Majid, H., & Silva, F. (2020) · Journal of the Royal Society of New Zealand · doi:10.1080/03036758.2020.1741403 · Cited by 20 · see citing works

Neuroprotective effect of red quinoa seeds extract on scopolamine-induced declarative memory deficits in mice: The role of acetylcholinesterase and oxidative stress

de Souza, S. P., Roos, A. A., Gindri, A. L., Domingues, V. O., Ascari, J., & Guerra, G. P. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103958 · Cited by 20 · see citing works

Determination of asperosaponin VI and its active metabolite hederagenin in rat tissues by LC–MS/MS: Application to a tissue distribution study

Zhang, R., Zhu, H., Ding, L., & Yang, Z. (2014) · Journal of Chromatography B · doi:10.1016/j.jchromb.2014.03.030 · Cited by 18 · see citing works

Antioxidant and Astroprotective Effects of a Pulicaria incisa Infusion

Elmann, A., Telerman, A., Mordechay, S., Erlank, H., & Ofir, R. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/157598 · Cited by 18 · see citing works

Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus

Ji, C., Li, Q., Aisa, H., Yang, N., Dong, Y., Liu, Y., Wang, T., Hao, Q., Zhu, H., & Zuo, P. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0979 · Cited by 17 · see citing works

Melissa officinalis Acidic Fraction Protects Cultured Cerebellar Granule Neurons Against Beta Amyloid-Induced Apoptosis and Oxidative Stress.

Soodi, M., Dashti, A., Hajimehdipoor, H., Akbari, S., & Ataei, N. (2017) · PubMed Central · doi:10.22074/cellj.2016.4722 · Cited by 16 · see citing works

Therapeutic effect of Melissa officinalis in an amyloid-β rat model of Alzheimer’s disease

Beheshti, S., & Shahmoradi, B. (2018) · Journal of Herbmed Pharmacology · doi:10.15171/jhp.2018.31 · Cited by 16 · see citing works

Moxibustion for cognitive impairment: A systematic review and meta-analysis of animal studies

Aum, S., Choe, S., Cai, M., Jerng, U. M., & Lee, J. (2020) · Integrative Medicine Research · doi:10.1016/j.imr.2020.100680 · Cited by 15 · see citing works

Targeting Gonadotropins: An Alternative Option for Alzheimer Disease Treatment

Casadesús, G., Puig, E. R., Webber, K. M., Atwood, C., Escuer, M. C., Bowen, R. L., Perry, G. L., & Smith, M. A. (2006) · BioMed Research International · doi:10.1155/jbb/2006/39508 · Cited by 15 · see citing works

Botanical Phenolics and Neurodegeneration

Sun, A. Y., Wang, Q., Simonyi, Á., & Sun, G. Y. (2011) · Oxidative stress and disease · doi:10.1201/b10787-16 · Cited by 15 · see citing works

Plant-derived natural products as leads for drug discovery

Pan, L., de Blanco, E. J. C., & Kinghorn, A. D. (2009) · Springer eBooks · doi:10.1007/978-0-387-85498-4_24 · Cited by 14 · see citing works

Neuroprotective response of the hippocampus region of the brain to Withania somnifera and Asparagus racemosus root extract: An in vitro study

Maheep, B., Prahlad, M., Satyendra, B., & Chetan, J. (2013) · Journal of Medicinal Plants Research · doi:10.5897/jmpr12.497 · Cited by 14 · see citing works

Therapeutic effects of Cyperus rotundus rhizome extract on memory impairment, neurogenesis and mitochondria in beta-amyloid rat model of Alzheimer’s disease

Shakerin, Z., Esfandiari, E., Ghanadian, M., Razavi, S., Alaei, H., & Dashti, G. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00493-2 · Cited by 14 · see citing works

ApoE Mimic Peptide COG1410 Reduces Aβ Deposition and Improves Cognitive Function by Inducing the Transformation of A1/A2 Reactive Astrocytes and Increasing the BDNF Concentration in Brain of APP/PS1 Double Transgenic Mice

Qiao, Y., Liu, H., He, C., & Ma, Y. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.11.023 · Cited by 13 · see citing works

Binding studies of known molecules with acetylcholinesterase and bovine serum albumin: A comparative view

Kandasamy, S., Karthikeyan, S., Sugarthi, S., & Stephen, A. D. (2021) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2021.119856 · Cited by 12 · see citing works

Camptothecin and its Analogs Reduce Amyloid-β Production and Amyloid-β42-Induced IL-1β Production

Wang, J., Shi, Z., Zhang, M., Xin, G.-Z., Pang, T., Zhou, P. H., Chen, J., Qi, L., Yang, H. Q., Xu, X., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140078 · Cited by 12 · see citing works

Medicinal plants and their derivatives with amyloid beta inhibitory activity as potential targets for drug discovery

Adewusi, E. A., & Steenkamp, V. (2015) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(15)60810-6 · Cited by 12 · see citing works

Dietary supplementation with Allium hirtifolium and/or Astragalus hamosus improved memory and reduced neuro-inflammation in the rat model of Alzheimer’s disease

Bahaeddin, Z., Yans, A., Khodagholi, F., & Sahranavard, S. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0585 · Cited by 12 · see citing works

Discovery of new potential triplet acting inhibitor for Alzheimer’s disease via X-ray crystallography, molecular docking and molecular dynamics

Sivakumar, M., Kandasamy, S., Saravanan, V., Sugarthi, S., kumar, S. M., Isa, M. A., Rajakumar, P., & Aravindhan, S. (2019) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2019.1620128 · Cited by 12 · see citing works

Panaxadiol carbamate derivatives: Synthesis and biological evaluation as potential multifunctional anti-Alzheimer agents

Quan, Y., Li, X., Pang, L., Deng, H., Chen, F., Lee, J. J., Quan, Z., Liu, P., Guo, H., & Shen, Q. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106977 · Cited by 11 · see citing works

In vitro Acetyl Cholinesterase Inhibitory assay of Acacia catechu Willd Ethanolic Seed Extract

Thangavelu, L. P., & Ramasamy, R. (2015) · Pharmacognosy Journal · doi:10.5530/pj.2015.5.5 · Cited by 11 · see citing works

Exploring the different environments effect of piperine via combined crystallographic, QM/MM and molecular dynamics simulation study

Kandasamy, S., Sivanandam, M., Hunday, G., Pavan, M. S., & Kumaradhas, P. (2019) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2019.07.019 · Cited by 11 · see citing works

The Confrontation between Ethnopharmacology and Pharmacological Tests of Medicinal Plants Associated with Mental and Neurological Disorders

Costa, G. F. C. E., Nishijo, H., Caixeta, L. F., & Aversi‐Ferreira, T. A. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/7686913 · Cited by 10 · see citing works

Combination of Carthamus tinctorius L. seed and Taraxacum coreanum exerts synergistic effects on learning and memory function by regulating metabolism of amyloid beta in mice

He, M. T., Kim, J.-H., Kim, J. H., Park, C. H., & Cho, E. J. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104048 · Cited by 10 · see citing works

Neuroprotective and anti-neuroinflammatory effects of ethanolic extract from leaves and stems of Aster glehni

Lim, M. K., Lee, S., Kim, J. Y., Jeong, J., Han, E. H., Lee, S. H., Ryu, J. H., & Lee, J. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104400 · Cited by 10 · see citing works

Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells

Elmann, A., Beit‐Yannai, E., Telerman, A., Ofir, R., Mordechay, S., Erlank, H., & Borochov‐Neori, H. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.05.012 · Cited by 10 · see citing works

Boosting the autophagy‐lysosomal pathway by phytochemicals: A potential therapeutic strategy against Alzheimer's disease

Nourbakhsh, F., Read, M. I., Barreto, G. E., & Sahebkar, A. (2020) · IUBMB Life · doi:10.1002/iub.2369 · Cited by 10 · see citing works

Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

Mahita, M. (2014) · European Journal of Medicinal Plants · doi:10.9734/ejmp/2014/9397 · Cited by 9 · see citing works

Primary Investigation for the Mechanism of Biatractylolide from Atractylodis Macrocephalae Rhizoma as an Acetylcholinesterase Inhibitor

Xie, Y.-C., Ning, N., Zhu, L., Li, D., Feng, X., & Yang, X. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/7481323 · Cited by 9 · see citing works

Determination of asperosaponin VI in dog plasma by high‐performance liquid chromatography–tandem mass spectrometry and its application to a pilot pharmacokinetic study

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Liu, Y., Aisa, H. A., Ji, C., Yang, N., Zhu, H., & Zuo, P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-112153 · Cited by 8 · see citing works

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