The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Memapsin 2 (β‐secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2
Abstract
Memapsin 2, or β‐secretase, is a membrane‐anchored aspartic protease that initiates the cleavage of β‐amyloid precursor protein (APP) leading to the production of β‐amyloid peptide in the brain and the onset of Alzheimer's disease. Memapsin 2 and APP are both endocytosed into endosomes for cleavage. Here we show that the cytosolic domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1 and GGA2. Gel‐immobilized VHS domains of GGA1 and GGA2 also bound to full‐length memapsin 2 from cell mammalian lysates. Mutagenesis studies established that Asp 496, Leu 499 and Leu 500 were essential for the binding. The spacing of these three residues in memapsin 2 is identical to those in the cytosolic domains of mannose‐6‐phosphate receptors, sortilin and low density lipoprotein receptor‐related protein 3. These observations suggest that the endocytosis and intracellular transport of memapsin 2, mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A family of GGA adaptor proteins and PLSCR1 directly interact with the BACE tail.
“A family of GGA adaptor proteins and the phospholipid scramblase 1 (PLSCR1) have been shown to directly interact with the BACE tail (42,45).”
From The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate (2005) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876
Nielsen, M. S., Madsen, P., Christensen, E. I., Nykjær, A., Gliemann, J., Kasper, D., Pohlmann, R., & Petersen, C. M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2180 · Cited by 457
Flagged first, then by citations
Research works printed but not linked: 24
- 10.1073/pnas.97.4.1456 · DOI
- 10.1006/mcne.1999.0811 · DOI · Paper page
- 10.1038/990107 · DOI · Paper page
- 10.1152/physrev.2001.81.2.741 · DOI · Paper page
- 10.1074/jbc.M005339200 · DOI
- 10.1074/jbc.M003202200 · DOI · Paper page
- 10.1074/jbc.M006947200 · DOI · Paper page
- 10.1074/jbc.M004175200 · DOI · Paper page
- 10.1146/annurev.cellbio.12.1.575 · DOI
- 10.1126/science.272.5259.227 · DOI
- 10.1006/mcne.2001.1065 · DOI
- 10.1016/S0014-5793(01)03287-2 · DOI
- 10.1126/science.1060750 · DOI · Paper page
- 10.1126/science.1060896 · DOI · Paper page
- 10.1074/jbc.C100218200 · DOI
- 10.1083/jcb.149.1.67 · DOI · Paper page
- 10.1146/annurev.bi.61.070192.001515 · DOI
- 10.1038/nsb0402-241 · DOI
- 10.1016/S0014-5793(98)01401-X · DOI
- 10.1038/415937a · DOI
- 10.1038/415933a · DOI
- 10.1021/bi025926t · DOI
- 10.1083/jcb.138.3.671 · DOI
- 10.1021/bi9816195 · DOI
Cited by
Sorted by citations
The Alzheimer's disease Beta-secretase enzyme, BACE1
Cole, S. L., & Vassar, R. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-22 · Cited by 550
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
De Strooper, B. (2010) · Physiological Reviews · doi:10.1152/physrev.00023.2009 · Cited by 455
Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity
Tesco, G., Koh, Y. H., Kang, E. L., Cameron, A. N., Das, S., Sena-Esteves, M., Hiltunen, M., Yang, S.-H., Zhong, Z., Shen, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.012 · Cited by 337
The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate
von Arnim, C. A. F., Kinoshita, A., Peltan, I. D., Tangredi, M. M., Herl, L., Lee, B. M., Spoelgen, R., Hshieh, T. T., Ranganathan, S., Battey, F. D., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414248200 · Cited by 258
Ubiquitin Regulates GGA3-mediated Degradation of BACE1
Kang, E. L., Cameron, A. N., Piazza, F., Walker, K. R., & Tesco, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092742 · Cited by 111
He, X., Cooley, K., Chung, C. H. Y., Dashti, N., & Tang, J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3993-06.2007 · Cited by 107
Self-citationProteomic identification of sorting nexin 6 as a negative regulator of BACE1‐mediated APP processing
Okada, H., Zhang, W., Peterhoff, C., Hwang, J. C., Nixon, R. A., Ryu, S. H., & Kim, T. (2010) · The FASEB Journal · doi:10.1096/fj.09-146357 · Cited by 102
GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide
Wahle, T., Thal, D. R., Sastre, M., Rentmeister, A., Bogdanovic, N., Famulok, M., Heneka, M. T., & Walter, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1982-06.2006 · Cited by 88
Tan, J.-L., Li, Q.-X., Ciccotosto, G. D., Crouch, P. J., Culvenor, J. G., White, A. R., & Evin, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061246 · Cited by 66
Tan, J. Z. A., Fourriere, L., Wang, J., Perez, F., Boncompain, G., & Gleeson, P. A. (2020) · Molecular Biology of the Cell · doi:10.1091/mbc.e19-09-0487 · Cited by 37
O’Farrell, H., Harbourne, B., Kurlawala, Z., Inoue, Y., Nagelberg, A. L., Martinez, V. D., Lu, D., Oh, M. H., Coe, B. P., Thu, K. L., et al. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.12.004 · Cited by 23
Metadata
- Authors
- He, X., Chang, W.-P., Koelsch, G., & Tang, J.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-07-12
- Volume
- 524
- Issue
- 1-3
- Pages
- 183-187
- ISSN
- 0014-5793
- 1873-3468
- Cited by
- 93
- References
- 2
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
