Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

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Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

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A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

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Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders

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Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

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Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

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Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

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A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

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A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

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Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

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NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

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Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating <i>BACE1</i> gene expression

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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

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Self-Assembly of Aβ ₁ _- ₄₂ into Globular Neurotoxins

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Alterations of the microRNA network cause neurodegenerative disease

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Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation

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Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy

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Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer’s disease: Neuropathologic evidence for a mechanism of increased β-amyloidogenesis

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Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice

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Matrix Metalloproteinase-9 Degrades Amyloid-β Fibrils in Vitro and Compact Plaques in Situ

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Sites of Tau Important for Aggregation Populate β-Structure and Bind to Microtubules and Polyanions

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Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice

McConlogue, L., Buttini, M., Anderson, J. P., Brigham, E. F., Chen, K. S., Freedman, S. B., Games, D., Johnson-Wood, K., Lee, M., Zeller, M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611687200 · Cited by 300 · see citing works

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in <i>BACE1</i> -null mice

Savonenko, A. V., Melnikova, T., Laird, F. M., Stewart, K.-A., Price, D. L., & Wong, P. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710373105 · Cited by 290 · see citing works

Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain

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SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

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Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

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Isolation, Chemical Characterization, and Quantitation of Aβ 3-Pyroglutamyl Peptide from Neuritic Plaques and Vascular Amyloid Deposits

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Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

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Mutations in APP have independent effects on Aβ and CTFγ generation

Hecimovic, S., Wang, J., Dolios, G., Martinez, M., Wang, R., & Goate, A. M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.04.018 · Cited by 70 · see citing works

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

Benilova, I., Karran, E., & De Strooper, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3028 · Cited by 1,962 · see citing works

The Cellular Phase of Alzheimer’s Disease

De Strooper, B., & Karran, E. (2016) · Cell · doi:10.1016/j.cell.2015.12.056 · Cited by 1,990 · see citing works

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

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Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

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NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

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Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

Raja, W. K., Mungenast, A. E., Lin, Y.-T., Ko, T., Abdurrob, F., Seo, J., & Tsai, L.-H. (2016) · PLOS ONE · doi:10.1371/journal.pone.0161969 · Cited by 569 · see citing works

Neurotoxicity of Alzheimer’s disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

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The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

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The role of G protein-coupled receptors in the pathology of Alzheimer's disease

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Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

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Amyloid β-protein oligomers and Alzheimer’s disease

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Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

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Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

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Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

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BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

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APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons.

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Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer’s Disease

Harris, S. S., Wolf, F., De Strooper, B., & Busche, M. A. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.005 · Cited by 161 · see citing works

Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis–mass spectrometry

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APP Function and Lipids: A Bidirectional Link

Grimm, M. O. W., Mett, J., Grimm, H. S., & Hartmann, T. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00063 · Cited by 104 · see citing works

RAGE mediates Aβ accumulation in a mouse model of Alzheimer’s disease via modulation of β- and γ-secretase activity

Fang, F., Yu, Q., Arancio, O., Chen, D., Gore, S. S., Yan, S. S., & Yan, S. F. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy017 · Cited by 103 · see citing works

miR‐186 is decreased in aged brain and suppresses <scp>BACE</scp>1 expression

Kim, J., Yoon, H., Chung, D., Brown, J. L., Belmonte, K. C., & Kim, J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13507 · Cited by 102 · see citing works

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.

Tramutola, A., Lanzillotta, C., & Di Domenico, F. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1244482 · Cited by 69 · see citing works

BACE1 Protein Endocytosis and Trafficking Are Differentially Regulated by Ubiquitination at Lysine 501 and the Di-leucine Motif in the Carboxyl Terminus

Kang, E. L., Biscaro, B., Piazza, F., & Tesco, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407072 · Cited by 55 · see citing works

Nitric oxide‐mediated regulation of ‐amyloid clearance via alterations of <scp>MMP</scp>‐9/<scp>TIMP</scp>‐1

Ridnour, L. A., Dhanapal, S., Hoos, M., Wilson, J., Lee, J., Cheng, R. Y. S., Brueggemann, E. E., Hines, H. B., Wilcock, D. M., Vitek, M. P., et al. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12028 · Cited by 54 · see citing works

Identification of Substrate-specific Allosteric Fingerprints in Matrix Metalloprotease-1 on Amyloid-beta Peptide Aggregates and Drug Screening With Single Molecule Insights

Kamboj, S., Harms, C., Wright, D., Nash, A., Klein-Seetharaman, J., & Sarkar, S. K. (2022) · doi:10.21203/rs.3.rs-1258797/v1 · Cited by 1 · see citing works