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Regulation of Tiam1–Rac signalling
Abstract
The GTPases of the Rho family are molecular switches that play an important role in a wide range of cellular processes and are increasingly implicated in tumourigenesis. Unlike what was found for the Ras oncogenes in tumours, hardly any activating mutations have been found in the genes encoding Rho proteins. In the past, we have identified Tiam1 (T‐lymphoma invasion and metastasis) as a specific activator for the Rho‐like GTPase Rac. In vivo, Tiam1 deficiency protects against Ras‐induced skin carcinogenesis, underscoring the consequences of deregulated signalling for the onset and progression of tumours. Thus, an important level of regulation of signalling via the Rho‐like GTPases comes from the specific control of their activators. In this paper, we review what is known on the specific regulation of Tiam1 signalling towards Rac.
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Cites
A role for Rho in Ras transformation
Qiu, R. G., Chen, J., McCormick, F., & Symons, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11781 · Cited by 533
Cited by
Burridge, K., & Wennerberg, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00003-0 · Cited by 1,578
Crosstalk between small GTPases and polarity proteins in cell polarization
Iden, S., & Collard, J. G. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2521 · Cited by 451
Self-citationTherapeutic Strategies for Targeting Ras Proteins
Gysin, S., Salt, M., Young, A., & McCormick, F. (2011) · Genes & Cancer · doi:10.1177/1947601911412376 · Cited by 323
Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome
Belichenko, P. V., Masliah, E., Kleschevnikov, A. M., Villar, A. J., Epstein, C. J., Salehi, A., & Mobley, W. C. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20337 · Cited by 297
Control of synapse development and plasticity by Rho GTPase regulatory proteins
Tolias, K. F., Duman, J. G., & Um, K. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.04.011 · Cited by 261
Metadata
- Authors
- Mertens, A. E., Roovers, R. C., & Collard, J. G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-04-30
- Volume
- 546
- Issue
- 1
- Pages
- 11-16
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1998195598
- Cited by
- 196
- References
- 1
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mertens, A. E., Roovers, R. C., & Collard, J. G. (2003). Regulation of Tiam1–Rac signalling. FEBS Letters. https://doi.org/10.1016/s0014-5793(03)00435-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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