The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
New biomarker evidence of oxidative DNA damage in patients with non‐insulin‐dependent diabetes mellitus
Open accessAbstract
Urinary 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) has been reported to serve as a sensitive biomarker of oxidative DNA damage and also of oxidative stress. We have investigated oxidative DNA damage in patients with non‐insulin‐dependent diabetes mellitus (NIDDM) by urinary 8‐OHdG assessments. We determined the total urinary excretion of 8‐OHdG from 24 h urine samples of 81 NIDDM patients 9 years after the initial diagnosis and of 100 non‐diabetic control subjects matched for age and gender. The total 24 h urinary excretion of 8‐OHdG was markedly higher in NIDDM patients than in control subjects (68.2±39.4 μ g vs. 49.6±37.7 μ g, P=0.001). High glycosylated hemoglobin was associated with a high level of urinary 8‐OHdG. The increased excretion of urinary 8‐OHdG is seen as indicating an increased systemic level of oxidative DNA damage in NIDDM patients.
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Citations
Cites
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Diabetes mellitus and free radicals
Wolff, S. P. (1993) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072637 · Cited by 660
Cited by
Antioxidant enzymes and human diseases
MatÉs, J. M., Pérez-Gómez, C., & De Castro, I. N. (1999) · Clinical Biochemistry · doi:10.1016/s0009-9120(99)00075-2 · Cited by 2,099
Oxidative DNA damage and disease: induction, repair and significance
Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372
Radicals and oxidative stress in diabetes
West, I. C. (2000) · Diabetic Medicine · doi:10.1046/j.1464-5491.2000.00259.x · Cited by 913
Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection
Robertson, R. P., Harmon, J., Tran, P. O., Tanaka, Y., & Takahashi, H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.581 · Cited by 897
Schmeichel, A. M., Schmelzer, J. D., & Low, P. A. (2003) · Diabetes · doi:10.2337/diabetes.52.1.165 · Cited by 367
Metadata
- Authors
- Leinonen, J., Lehtimäki, T., Toyokuni, S., Okada, K., Tanaka, T., Hiai, H., Ochi, H., Laippala, P., Rantalaiho, V., Wirta, O., Pasternack, A., & Alho, H.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-11-03
- Volume
- 417
- Issue
- 1
- Pages
- 150-152
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2086501877
- Cited by
- 262
- References
- 2
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Leinonen, J., Lehtimäki, T., Toyokuni, S., Okada, K., Tanaka, T., Hiai, H., Ochi, H., Laippala, P., Rantalaiho, V., Wirta, O., Pasternack, A., & Alho, H. (1997). New biomarker evidence of oxidative DNA damage in patients with non‐insulin‐dependent diabetes mellitus. FEBS Letters. https://doi.org/10.1016/s0014-5793(97)01273-8
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