The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators

Wolfger, Hubert; Mahé, Yannick; Parle-McDermott, Anne; Delahodde, Agnés; Kuchler, Karl

doi:10.1016/s0014-5793(97)01382-3

Cited by 97Fungal and yeast genetics researchDrug Transport and Resistance MechanismsBacterial Genetics and Biotechnology

The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators

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Wolfger, Hubert, Mahé, Yannick, Parle-McDermott, Anne, Delahodde, Agnés, Kuchler, Karl·1997·FEBS Letters

DOI 10.1016/s0014-5793(97)01382-3

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Abstract

The yeast transcription factors Pdr1 and Pdr3 control pleiotropic drug resistance (PDR) development, since they regulate expression of ATP‐binding cassette (ABC) drug efflux pumps through binding to cis‐acting sites known as PDREs ( R esponsive lements). In this report, we show by Northern blotting, gel shift mobility assays and DNase I footprinting that transcription of the ABC genes PDR10 and PDR15 is also controlled by Pdr1 and Pdr3. In addition, in vitro band shift assays demonstrate that a GST‐Pdr1 fusion protein can bind to the PDREs of PDR10 and PDR15. DNase I footprinting allowed the identification of the precise PDRE binding motifs, indicating the presence of a novel slightly degenerate PDRE motif in the PDR15 promoter. Finally, PDR10 and PDR15 mRNA levels vary dramatically in abundance in isogenic yeast strains carrying either Δ pdr1, Δ pdr3 and Δ pdr1 Δ pdr3 deletions or pdr1‐3 and pdr3‐2 gain‐of‐function mutations, demonstrating that both PDR10 and PDR15 are new members of the yeast PDR network.

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Hyperactivation of Pdr1 or Pdr3 can be caused by gain-of-function (GOF) mutations in PDR1 or PDR3.
“Such hyperactivation can be caused by gain-of-function (GOF) mutations in PDR1 or PDR314,15 or mitochondrial dysfunction (e.g. loss of the mitochondrial genome), the latter of which only stimulates Pdr3-dependent gene expression16.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [15]
Hyperactivation of Pdr1 or Pdr3 is the main cause of overexpression of PDR5 leading to drug resistance.
“Hyperactivation of Pdr1 or Pdr3 is the main cause of overexpression of PDR5 leading to drug resistance.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [15]

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Authors: Wolfger, H., Mahé, Y., Parle-McDermott, A., Delahodde, A., & Kuchler, K.
Affiliations: University of Vienna (AT)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Kuchler, Karl
ORCID: Delahodde, Agnés
Kuchler, Karl
Venue: FEBS Letters
Publisher: Wiley
Published: 1997-12
Volume: 418
Issue: 3
Pages: 269-274
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(97)01382-3
OpenAlex: W2005528479
Cited by: 97
References: 30
Citations by year: 2025: 5 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 4 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 1
FWCI: 1.30
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 11 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: PDR1, PDR3, pleiotropic drug resistance, ABC transporters, drug efflux pumps, transcriptional regulation, promoter elements, transcription factor binding sites, Saccharomyces cerevisiae
MeSH terms: Bacterial Proteins, DNA-Binding Proteins, Mutation, Saccharomyces cerevisiae, Transcription Factors, Transcription, Genetic, Trans-Activators, Gene Expression Regulation, Fungal, ATP-Binding Cassette Transporters, Saccharomyces cerevisiae Proteins

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The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators

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