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Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk

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The association of the apolipoprotein E gene promoter polymorphisms and haplotypes with serum lipid and lipoprotein concentrations

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Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals

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Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis

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Both Targeted Mass Spectrometry and Flow Sorting Analysis Methods Detected the Decreased Serum Apolipoprotein E Level in Alzheimer's Disease Patients

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Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study

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Apolipoprotein gene E4 allele promoter polymorphisms as risk factors for Alzheimer's disease

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A megalin polymorphism associated with promoter activity and Alzheimer's disease risk

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Apolipoprotein E gene ε4ε4 is associated with elevated risk of primary open angle glaucoma in Asians: a meta-analysis

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Effect of Apolipoprotein E Genotype and Saturated Fat Intake on Plasma Lipids and Myocardial Infarction in the Central Valley of Costa Rica

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Correlation between APOE -491AA Promoter in ɛ 4 Carriers and Clinical Deterioration in Early Stage of Traumatic Brain Injury

Jiang, Y., Sun, X., Gui, L., Xia, Y., Tang, W., Cao, Y., & Gu, Y. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.0299 · Cited by 28

Apolipoprotein E Is a Prime Suspect, Not Just an Accomplice, in Alzheimer's Disease

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Comprehensive Evaluation of the Association of APOE Genetic Variation with Plasma Lipoprotein Traits in U.S. Whites and African Blacks

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DGGE method for the mutational analysis of the coding and proximal promoter regions of the Alzheimer's disease presenilin-1 gene: Two novel mutations

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The Apolipoprotein E Gene Promoter (−219G/T) Polymorphism Determines Insulin Sensitivity in Response to Dietary Fat in Healthy Young Adults

Moreno, J. A., Pérez‐Jiménez, F., Marín, C., Pérez‐Martínez, P., Moreno‐Luna, R., Gómez, P., Jiménez, Y., Paniagua, J. A., Lairon, D., & López‐Miranda, J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2535 · Cited by 27

Apolipoprotein E gene promoter −219G→T polymorphism increases LDL-cholesterol concentrations and susceptibility to oxidation in response to a diet rich in saturated fat

Moreno, J. A., Pérez‐Jiménez, F., Marı́n, C., Gómez, P., Pérez‐Martínez, P., Moreno‐Luna, R., Bellido, C., Fuentes, F. J., & López‐Miranda, J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1404 · Cited by 27

Allelic polymorphism −491A/T in apo E gene modulates the lipid‐lowering response in combined hyperlipidemia treatment

García-Otín, A. L., Civeira, F., Arístegui, R., Díaz, C., Recalde, D., Sol, J. M., Masramon, X., Hernández, G., Pocovı́, M., & the ATOMIX Study Group (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.00996.x · Cited by 27

Effects of APOE promoter polymorphism on the topological organization of brain structural connectome in nondemented elderly

Shu, N., Li, X., Ma, C., Zhang, J., Chen, K., Liang, Y., Chen, Y., & Zhang, Z. (2015) · Human Brain Mapping · doi:10.1002/hbm.22954 · Cited by 25

Analysis of the Expression and Polymorphism of APOE, HSP, BDNF, and GRIN2B Genes Associated with the Neurodegeneration Process in the Pathogenesis of Primary Open Angle Glaucoma

Nowak, A., Majsterek, I., Przybyłowska-Sygut, K., Pytel, D., Szymanek, K., Szaflik, J., & Szaflik, J. P. (2015) · BioMed Research International · doi:10.1155/2015/258281 · Cited by 25

The Effects of anAPOEPromoter Polymorphism on Human Cortical Morphology during Nondemented Aging

Chen, Y., Li, P., Gu, B., Liu, Z., Li, X., Evans, A. C., Gong, G., & Zhang, Z. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1946-14.2015 · Cited by 27

Molecular Genetics of Alzheimer's Disease

Verdile, G., & Martin, R. (2008) · Nucleic acids and molecular biology · doi:10.1007/978-3-540-85383-1_8 · Cited by 25

The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms

Limon-Sztencel, A., Lipska-Ziętkiewicz, B. S., Chmara, M., Wasąg, B., Bidzan, L., Godlewska, B. R., & Limon, J. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0187-9 · Cited by 24

Influence of multiple APOE genetic variants on cognitive function in a cohort of older men – results from the Normative Aging Study

Prada, D., Colicino, E., Power, M. C., Cox, D. G., Weisskopf, M. G., Hou, L., Spiro, A., Vokonas, P., Zhong, J., Sánchez-Guerra, M., et al. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0223-x · Cited by 24

Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease

Nicodemus, K. K., Stenger, J. E., Schmechel, D. E., Welsh-Bohmer, K. A., Saunders, A. M., Roses, A. D., Gilbert, J. R., Vance, J. M., Haines, J. L., Pericak‐Vance, M. A., et al. (2004) · Neurogenetics · doi:10.1007/s10048-004-0189-9 · Cited by 24

The −491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEϵ4 allele and Alzheimer's Disease

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Is there a significant interaction effect between apolipoprotein E rs405509 T/T and ε4 genotypes on cognitive impairment and gray matter volume?

Ma, C., Zhang, Y., Li, X., Zhang, J., Chen, K., Liang, Y., Chen, Y., Liu, Z., & Zhang, Z. (2016) · European Journal of Neurology · doi:10.1111/ene.13052 · Cited by 23

Polymorphism of apolipoprotein E (APOE) and lipoprotein lipase (LPL) genes and ischaemic stroke in individuals of Yakut ethnicity

Parfenov, M. G., Nikolaeva, T. Y., Sudomoina, M. A., Федорова, С. А., Guekht, A. B., Gusev, E. I., & Favorova, O. O. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.068 · Cited by 23

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer’s disease

Bratosiewicz‐Wąsik, J., Liberski, P. P., Pepłońska, B., Styczyńska, M., Smoleń‐Dzirba, J., Cycoń, M., & Wąsik, T. J. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.07.010 · Cited by 22

Privacy-Preserving Similar Patient Queries for Combined Biomedical Data

Salem, A., Berrang, P., Humbert, M., & Michael Backes, A. (2018) · Proceedings on Privacy Enhancing Technologies · doi:10.2478/popets-2019-0004 · Cited by 22

Relations of APOE promoter polymorphisms to LDL cholesterol and markers of subclinical atherosclerosis in young adults

Viiri, L. E., Raitakari, O. T., Huhtala, H., Kaähoänen, M., Rontu, R., Juonala, M., Hutri-Kaähoänen, N., Marniemi, J., Viikari, J. S. A., Karhunen, P. J., et al. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600033-jlr200 · Cited by 22

Polymorphisms in the Apolipoprotein E Gene Regulatory Region in Relation to Coronary Heart Disease and Their Effect on Plasma Apolipoprotein E

Corbo, R. M., Scacchi, R., Vilardo, T., & Ruggeri, M. (2001) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2001.002 · Cited by 22

Association of promoter polymorphism of apolipoprotein E gene with cerebral vasospasm after spontaneous SAH

Wu, H., Ruan, J., Zhang, X.-D., Xia, H., Jiang, Y. Q., & Sun, X. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.013 · Cited by 21

Variation in GYS1 Interacts with Exercise and Gender to Predict Cardiovascular Mortality

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Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism

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Dietary, Physiological, and Genetic Impacts on Postprandial Lipid Metabolism

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Neuronal specific regulatory elements in apolipoprotein E gene proximal promoter

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Allele Frequencies of Apolipoprotein E Gene Polymorphisms in the Protein Coding Region and Promoter Region (-491a/T) in a Healthy Norwegian Population

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Lack of allelic imbalance in APOE ϵ 3/4 brain mRNA expression in Alzheimer's disease

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An association between polymorphisms within the APOE gene and concussion aetiology in rugby union players

Abrahams, S., Fie, S. M., Patricios, J., Suter, J., Posthumus, M., & September, A. V. (2017) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2017.06.004 · Cited by 20

The molecular basis for genetic polymorphism of human deoxyribonuclease II (DNase II): a single nucleotide substitution in the promoter region of human DNase II changes the promoter activity

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Neuropathological epidemiology of cerebral aging: a study of two genetic polymorphisms

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Identification of amino acid residues of transcription factor AP-2 involved in DNA binding 1 1Edited by M. Yaniv

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Basic research Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis

Al-Asmary, S. M., Kadasah, S., Arfin, M., Tariq, M., & Al-Asmari, A. (2015) · Archives of Medical Science · doi:10.5114/aoms.2015.53308 · Cited by 19

Cluster Analysis of Risk Factor Genetic Polymorphisms in Alzheimer’s Disease

Randall, C., Strasburger, D., Prozonic, J., Morris, S. N., Winkie, A. D., Parker, G. R., Cheng, D., Fennell, E. M., Lanham, I. S., Vakil, N. B., et al. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9626-8 · Cited by 18

Microparticle derived proteins as potential biomarkers for cerebral vasospasm post subarachnoid hemorrhage. A preliminary study

Przybycien–Szymanska, M. M., Yang, Y., & Ashley, W. W. (2015) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2015.12.012 · Cited by 17

Apolipoprotein E −491 promoter polymorphism is an independent risk factor for Alzheimer's disease in the Chinese population

Yang, J. D., Feng, G. Y., Zhang, J., Cheung, J., Clair, D. S., & He, L. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00815-2 · Cited by 17

Membership in genetic groups predicts Alzheimer disease.

Corder, E. H., Huang, R., Cathcart, H. M., Lanham, I. S., Parker, G. R., Cheng, D., Smith, S., & Poduslo, S. E. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.89 · Cited by 13

Contribution of regulatory and structural variations in APOE to predicting dyslipidemia

Stengård, J., Kardia, S. L. R., Hamon, S., Frikke‐Schmidt, R., Tybjærg‐Hansen, A., Salomaa, V. V., Boerwinkle, E., & Sing, C. F. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500491-jlr200 · Cited by 17

Association between polymorphisms in the promoter region of the apolipoprotein E (APOE) gene and Alzheimers disease

Xiao, H., Gao, Y., Liu, L., & Li, Y. (2017) · EXCLI journal · doi:10.17179/excli2017-289 · Cited by 17

Identification of a Functional Apolipoprotein E Promoter Polymorphism Regulating Plasma Apolipoprotein E Concentration

Mannila, M. N., Mahdessian, H., Franco‐Cereceda, A., Eggertsen, G., Fairé, U. D., Syvänen, A., Eriksson, P. O., Hamsten, A., & Hooft, F. M. V. ’. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300353 · Cited by 16

Apolipoprotein E DNA methylation and posttraumatic stress disorder are associated with plasma ApoE level: A preliminary study

Nielsen, D. A., Spellicy, C. J., Harding, M. J., & Graham, D. P. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.05.013 · Cited by 17

MRI changes and ApoE genotype, a prospective 1-year follow-up of traumatic brain injury: A pilot study

Hiekkanen, H., Kurki, T. J. I., Brandstack, N., Kairisto, V., & Tenovuo, O. S. (2007) · Brain Injury · doi:10.1080/02699050701739549 · Cited by 16

The APOE −219G/T and +113G/C polymorphisms affect insulin resistance among Turks

Kömürcü-Bayrak, E., Onat, A., Yüzbaşıoğulları, A. B., Mononen, N., Laaksonen, R., Kähönen, M. A. P., Hergenç, G., Lehtimäki, T. J., & Erginel‐Ünaltuna, N. (2010) · Metabolism · doi:10.1016/j.metabol.2010.06.016 · Cited by 16

Combined association and linkage analysis applied to the APOE locus

Beekman, M., Posthuma, D., Heijmans, B. T., Lakenberg, N., Suchiman, H. E. D., Snieder, H., de Knijff, P., Frants, R. R., van Ommen, G. J. B., Kluft, C., et al. (2004) · Genetic Epidemiology · doi:10.1002/gepi.10318 · Cited by 16

Evidence for Non‐additive Influence of Single Nucleotide Polymorphisms within the Apolipoprotein E Gene

Hamon, S., Stengård, J., Clark, A. G., Salomaa, V. V., Boerwinkle, E., & Sing, C. F. (2004) · Annals of Human Genetics · doi:10.1046/j.1529-8817.2003.00112.x · Cited by 16

The −491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease

Alvarez-Arcaya, A., Combarros, O., Llorca, J., Sánchez-Guerra, M., Berciano, J., & Fernández-Luna, J. L. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01790-6 · Cited by 16

Subsets of SNPs define rare genotype classes that predict ischemic heart disease

Frikke‐Schmidt, R., Sing, C. F., Nordestgaard, B. G., Steffensen, R., & Tybjærg‐Hansen, A. (2006) · Human Genetics · doi:10.1007/s00439-006-0233-y · Cited by 16

Role of the APOE ε2/ε3/ε4 Polymorphism in the Development of Primary Open-Angle Glaucoma: Evidence from a Comprehensive Meta-Analysis

Song, Q., Chen, P., & Liu, Q. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082347 · Cited by 16

Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting

Koch, W., Mehilli, J., Pfeufer, A., Schömig, A., & Kastrati, A. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400148-jlr200 · Cited by 15

Interactions of Functional Apolipoprotein E Gene Promoter Polymorphisms With Smoking on Aortic Atherosclerosis

Viiri, L. E., Viiri, K. M., Ilveskoski, E., Huhtala, H., Mäki, M., Tienari, P. J., Perola, M., Lehtimäki, T. J., & Karhunen, P. J. (2008) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.108.791764 · Cited by 15

Lack of association between apolipoprotein E promoters in 4ɛ carriers and worsening on computed tomography in early stage of traumatic brain injury

Jiang, Y. Q., Sun, X., Gui, L., Tang, W. Y., Zhen, L. P., Gu, Y., & Wu, H. T. (2009) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-211-09469-3_45 · Cited by 14

Age at Onset: An Essential Variable for the Definition of Genetic Risk Factors for Sporadic Alzheimer's Disease

Beyer, K., Lao, J. I., Latorre, P., & Ariza, A. (2005) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2005.tb06138.x · Cited by 14

Identification of a protective allele against Alzheimer disease in the APOE gene promoter

Beyer, K., Lao, J. I., mez, M. G., Riutort, N., Latorre, P., Mate, J. L., & Ariza, A. (2002) · Neuroreport · doi:10.1097/00001756-200208070-00011 · Cited by 14

Polymorphisms of the Apolipoprotein E Gene Regulatory Region and of the LDL Receptor Gene in Late-Onset Alzheimer’s Disease in Relation to the Plasma Lipidic Pattern

Scacchi, R., Gambina, G., Martini, M. C., Ruggeri, M., Ferrari, G., Silvestri, M., Schiavon, R., & Corbo, R. M. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051237 · Cited by 13

Genetic susceptibility to traumatic brain injury and apolipoprotein E gene

Sun, X., & Jiang, Y. Q. (2008) · Chinese Journal of Traumatology · doi:10.1016/s1008-1275(08)60051-6 · Cited by 13

Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging

Georgoulias, P., Wozniak, G., Σαμαρά, Μ., Chiotoglou, I., Kontos, A., Tzavara, C. K., Valotassiou, V. J., Georgitsi, M., Aleporou‐Marinou, V., Patrinos, G. P., et al. (2009) · Journal of Human Genetics · doi:10.1038/jhg.2009.83 · Cited by 13

Genetic and Environmental Factors

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The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset

Beyer, K., Lao, J. I., Gómez, M., Riutort, N., Latorre, P., Mate, J. L., & Ariza, A. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00355-5 · Cited by 13

Association of apolipoprotein E promoter polymorphisms with bone structural traits is modified by dietary saturated fat intake — The Cardiovascular Risk in Young Finns Study

Tolonen, S., Mikkilä, V., Laaksonen, M. M. L., Sievänen, H. T., Mononen, N., Hernesniemi, J. A., Vehkalahti, K., Viikari, J. S. A., Raitakari, O. T., Kähönen, M. A. P., et al. (2011) · Bone · doi:10.1016/j.bone.2011.01.013 · Cited by 12

Genetic association of apolipoprotein E polymorphisms with inflammatory bowel disease

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Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients

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