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Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene

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Artiga, Marı́a J, Bullido, Marı́a J, Sastre, Isabel, Recuero, Marı́a, Garcı́a, Miguel A, Aldudo, Jesús, Vázquez, Jesús, Valdivieso, Fernando·1998·FEBS Letters

DOI 10.1016/s0014-5793(97)01543-3

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Abstract

In this work, we explored the existence of genetic variants within the apolipoprotein E gene transcriptional regulatory region, using a denaturing gradient gel electrophoresis screening of a region comprising nucleotides −1017 to +406. Upon a population study, three new polymorphic sites (−491, −427 and −219) and two mutations were found. Functional effects of the polymorphisms, assayed by transient transfection and electrophoretic mobility shift assays in a human hepatoma cell line, showed that polymorphisms at sites −491 and −219 of the APOE promoter produce variations in the transcriptional activity of the gene, most probably through differential binding of nuclear proteins.

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
[31] Detection and localization of single base changes by denaturing gradient gel electrophoresis
Myers, R., Maniatis, T., & Lerman, L. S. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(87)55033-9 · Cited by 934
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.
Das, H. K., McPherson, J. D., Bruns, G. A. P., Karathanasis, S. K., & Breslow, J. L. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88963-3 · Cited by 354
Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements.
Smith, J. D., Melián, A., Leff, T., & Breslow, J. L. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68477-7 · Cited by 114
Polymorphism in the human apolipoprotein A-I gene promoter region. Association of the minor allele with decreased production rate in vivo and promoter activity in vitro.
Smith, J. D., Brinton, E. A., & Breslow, J. L. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115783 · Cited by 97

Show all 16 references

Research works printed but not linked: 1

Myers R.M. Sheffield V.C. and Cox D.R. (1989) in: Genome Analysis – A Practical Approach (Davies K.E. Ed.) pp. 94–139 IRL Press Oxford.

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Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer’s disease pathology in a mouse model
Wang, Z.-H., Xia, Y., Wu, Z., Kang, S. S., Zhang, J.-C., Liu, P., Liu, X., Song, W., Huin, V., Dhaenens, C., et al. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102212 · Cited by 48
Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy
van der Walt, A., Stankovich, J. M., Bahlo, M., Taylor, B. V., van der Mei, I. A. F., Foote, S. J., Kilpatrick, T. J., Rubio, J. P., & Butzkueven, H. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b9c85e · Cited by 47
APOE and APOC1 Promoter Polymorphisms and the Risk of Alzheimer Disease in African American and Caribbean Hispanic Individuals
Tycko, B., Lee, J. H., Ciappa, A., Saxena, A. D., Li, C.-M., Lin, F., Arriaga, A., Stern, Y., Lantigua, R., Shachter, N. S., et al. (2004) · Archives of Neurology · doi:10.1001/archneur.61.9.1434 · Cited by 46
The influence of the apolipoprotein E gene promoter (−219G/ T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males
Moreno, J. A., López‐Miranda, J., Marı́n, C., Gómez, P., Pérez‐Martínez, P., Fuentes, F. J., de la Puebla, R. Á. F., Paniagua, J. A., Ordovás, J. M., & Pérez‐Jiménez, F. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300124-jlr200 · Cited by 46
Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia
Dean, B., Laws, S. M., Hone, E., Taddei, K., Scarr, E., Thomas, E. A., Harper, C. G., McClean, C., Masters, C. L., Lautenschlager, N. T., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00075-1 · Cited by 46
Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression
Theuns, J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg098 · Cited by 45
Cognitive impairment in patients with multiple sclerosis: association with the APOE gene and promoter polymorphisms
Parmenter, B. A., Denney, D. R., LYNCH, S. G., Middleton, L. S., & Harlan, L. M. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506070682 · Cited by 45
The complex interaction between APOE promoter and AD: an Italian case–control study
Bizzarro, A., Seripa, D., Acciarri, A., Matera, M. G., Pilotto, A., Tiziano, F. D., Brahe, C., & Masullo, C. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.263 · Cited by 44
Apolipoprotein E region molecular signatures of Alzheimer's disease
Kulminski, A. M., Huang, J. V., Wang, J., He, L., Loika, Y., & Culminskaya, I. V. (2018) · Aging Cell · doi:10.1111/acel.12779 · Cited by 45
Functional characterization of three single‐nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA–protein interactions
Maloney, B., Ge, Y., Petersen, R. C., Hardy, J., Rogers, J. T., Pérez‐Tur, J., & Lahiri, D. K. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30973 · Cited by 43
Conserved protein motifs and structural organization of a fish gene homologous to mammalian apolipoprotein E
Durliat, M., André, M., & Babin, P. J. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01033.x · Cited by 43
Independent effects of the −219 G>T and ε2/ε3/ε4 polymorphisms in the apolipoprotein E gene on coronary artery disease: The Southampton Atherosclerosis Study
Ye, S., Dunleavey, L., Bannister, W. P., Day, L., Tapper, W., Collins, A. R., Day, I. N. M., & Simpson, I. A. (2003) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200983 · Cited by 43
Genetic variants modify the effect of age on APOE methylation in the G enetics of L ipid L owering D rugs and D iet N etwork study
Ma, Y., Smith, C. E., Lai, C., Irvin, M. R., Parnell, L. D., Lee, Y., Pham, L. D., Aslibekyan, S. W., Claas, S. A., Tsai, M. Y., et al. (2014) · Aging Cell · doi:10.1111/acel.12293 · Cited by 42
Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene
Fritsche, L. G., Freitag‐Wolf, S., Bettecken, T., Meitinger, T., Keilhauer, C. N., Krawczak, M., & Weber, B. H. F. (2008) · Human Mutation · doi:10.1002/humu.20957 · Cited by 43
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Bray, N. J., Jehu, L., Moskvina, V., Buxbaum, J. D., Dracheva, S., Haroutunian, V., Williams, J., Buckland, P. R., Owen, M. J., & O'Donovan, M. C. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh299 · Cited by 45
Genetic factors in traumatic brain injury
McAllister, T. W. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63521-1.00045-5 · Cited by 44
Alzheimer's risk associated with human apolipoprotein E, alpha-2 macroglobulin and lipoprotein receptor related protein polymorphisms: absence of genetic interactions, and modulation by gender
Bullido, M. J., Guallar‐Castillón, P., Artiga, M. J., Ramos, M. C., Sastre, I., Aldudo, J., Frank, A., Coria, F., Rodríguez‐Artalejo, F., & Valdivieso, F. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01304-5 · Cited by 40
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APOE promoter, ACE1 and CYP46 polymorphisms and β-amyloid in Alzheimer’s disease
Chalmers, K. A., Culpan, D., Kehoe, P. G., Wilcock, G. K., Hughes, A., & Love, S. (2003) · Neuroreport · doi:10.1097/00001756-200401190-00019 · Cited by 39
Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease
Rebeck, G. W., Cheung, B. S., Growdon, W. B., Deng, A., Akuthota, P., Locascio, J. J., Greenberg, S. M., & Hyman, B. T. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00602-3 · Cited by 38
Polymorphisms of APOE and LRP Genes in Brazilian Individuals With Alzheimer Disease
Bahia, V. S., Kok, F., Marie, S. K. N., Oba‐Shinjo, S. M., Caramelli, P., & Nitríni, R. (2008) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815a9da7 · Cited by 37
Linkage and association analysis of chromosome 19q13 in multiple sclerosis
Haines, J. L., Oksenberg, J. R., Barcellos, L. F., Pericak‐Vance, M. A., Rimmler, J. B., Goodkin, D. E., Hauser, S. L., García, M., Lincoln, R., & Martin, E. R. (2001) · Neurogenetics · doi:10.1007/s100480100119 · Cited by 37
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Apolipoprotein E and diets: a case of gene-nutrient interaction?
Rubin, J., & Berglund, L. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00005 · Cited by 37
The Neurobiology of Apolipoproteins in Psychiatric Disorders
Thomas, E. A., & Sutcliffe, J. G. (2002) · Molecular Neurobiology · doi:10.1385/mn:26:2-3:369 · Cited by 35
Analysis and Exploration of the Use of Rule-Based Algorithms and Consensus Methods for the Inferral of Haplotypes
Orzack, S. H., Gusfield, D., Olson, J. J., Nesbitt, S., Subrahmanyan, L., & Stanton, V. P. (2003) · Genetics · doi:10.1093/genetics/165.2.915 · Cited by 35
Genetic risk factors of sporadic Alzheimer’s disease among Chinese in Taiwan
Hu, C., Sung, S., Liu, H., Hsu, W.-C., Lee, L.-S., Lee, C.-C., Tsai, C.-H., & Chang, J.-G. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00443-3 · Cited by 34
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Zurutuza, L., Verpillat, P., Raux, G., Hannequin, D., Puel, M., Belliard, S., Michon, A., Pothin, Y., Camuzat, A., Penet, C., et al. (2000) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200513 · Cited by 34
Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures
Cedazo-Mı́nguez, Á., Hamker, U., Meske, V., Veh, R. W., Hellweg, R., Jacobi, C., Albert, F., Cowburn, R. F., & Ohm, T. G. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00224-x · Cited by 34

Authors: Artiga, M. J., Bullido, M. J., Sastre, I., Recuero, M., Garcı́a, M. A., Aldudo, J., Vázquez, J., & Valdivieso, F.
Affiliations: Centro de Biología Molecular Severo Ochoa (ES)
Corresponding author: Valdivieso, Fernando
ORCID: Sastre, Isabel
Aldudo, Jesús
Vázquez, Jesús
Venue: FEBS Letters
Publisher: Wiley
Published: 1998-01-09
Volume: 421
Issue: 2
Pages: 105-108
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(97)01543-3
OpenAlex: W1965849733
Cited by: 229
References: 16
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 5 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 12 · 2014: 5 · 2013: 8 · 2012: 3
FWCI: 7.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 32 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Funders: Centro de Biología Molecular Severo Ochoa
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: apolipoprotein E, APOE gene, transcriptional regulatory sequences, promoter polymorphism, genetic variants, transcriptional activity, nuclear protein binding, hepatoma cells, population genetics
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Alleles, Apolipoproteins E, Child, Child, Preschool, Electrophoresis, Polyacrylamide Gel, Gene Frequency, Genotype, Humans, Infant, Middle Aged, Nuclear Proteins, Polymorphism, Genetic, Promoter Regions, Genetic, Polymorphism, Restriction Fragment Length, Transcription, Genetic, Tumor Cells, Cultured

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Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene

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