Cited by 305Redox biology and oxidative stressNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

Protection against peroxynitrite

Arteel, Gavin E., Briviba, Karlis, Sies, Helmut·1999·FEBS Letters

Abstract

Peroxynitrite formed in vivo from superoxide and nitric oxide can mediate oxidation, nitration, or nitrosation reactions, leading to impaired function, toxicity, and alterations in signaling pathways. Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation. Biological protection against peroxynitrite is organized in three categories: prevention, interception, and repair. Prevention is the control of the formation of peroxynitrite precursors, nitric oxide and superoxide. Interception is by direct reaction with peroxynitrite, leading to non‐toxic products. In this regard, organoselenium compounds, metalloporphyrin derivatives, and peroxidases (e.g. glutathione peroxidase and myeloperoxidase) exhibit high second‐order rate constants with peroxynitrite. Ebselen, like glutathione peroxidase, protects in a catalytic fashion utilizing glutathione as reductant in the peroxynitrite reductase reaction. Protection by metalloporphyrins can be maintained through glutathione or ascorbate. Repair processes remove damaged products and restitute intact biomolecules.

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Crossref · 10.1016/s0014-5793(99)00073-3

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74 of 74 references verified0 citation errors · 0 not checkable

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Authors
Arteel, G. E., Briviba, K., & Sies, H.
Affiliations
Heinrich Heine University Düsseldorf (DE)
Corresponding author
Sies, Helmut
Venue
FEBS Letters
Publisher
Wiley
Published
1999-02-26
Volume
445
Issue
2-3
Pages
226-230
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2027107445
Cited by
305
References
74
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 11 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 13 · 2012: 10
FWCI
2.34
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
peroxynitrite, peroxynitrite scavenging, superoxide, nitric oxide, ebselen, glutathione peroxidase, myeloperoxidase, metalloporphyrins, organoselenium compounds, nitration, nitrosation, oxidative stress, inflammation
MeSH terms
Animals, Humans, Nitrates, Molecular Structure, Oxidants

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