The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Binding specificities and affinities of egf domains for ErbB receptors
Abstract
ErbB receptor activation is a complex process and is dependent upon the type and number of receptors expressed on a given cell. Previous studies with defined combinations of ErbB receptors expressed in mammalian cells have helped elucidate specific biological responses for many of the recognized gene products that serve as ligands for these receptors. However, no study has examined the binding of these ligands in a defined experimental system. To address this issue, the relative binding affinities of the egf domains of eleven ErbB ligands were measured on six ErbB receptor combinations using a soluble receptor‐ligand binding format. The ErbB2/4 heterodimer was shown to bind all ligands tested with moderate to very high affinity. In contrast, ErbB3 showed much more restrictive ligand binding specificity and measurable binding was observed only with heregulin, neuregulin2β, epiregulin and the synthetic heregulin/egf chimera, biregulin. These studies also revealed that ErbB2 preferentially enhances ligand binding to ErbB3 or ErbB4 and to a lesser degree to ErbB1.
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Cites
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Identification of Heregulin, a Specific Activator of p185 erbB2
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Self-citationErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.
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Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.
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Self-citationNeuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases
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Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4
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Ligands for ErbB-family receptors encoded by a neuregulin-like gene
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Cited by
Untangling the ErbB signalling network
Yarden, Y., & Sliwkowski, M. X. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052073 · Cited by 6,974
Self-citationStructure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
Cho, H.-S., Mason, K., Ramyar, K. X., Stanley, A. M., Gabelli, S. B., Denney, D. W., & Leahy, D. J. (2003) · Nature · doi:10.1038/nature01392 · Cited by 1,612
Epidermal growth factor receptor: Mechanisms of activation and signalling
Jorissen, R. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00098-8 · Cited by 1,565
A comprehensive pathway map of epidermal growth factor receptor signaling
Oda, K., Matsuoka, Y., Funahashi, A., & Kitano, H. (2005) · Molecular Systems Biology · doi:10.1038/msb4100014 · Cited by 1,158
Neuregulins: functions, forms, and signaling strategies
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Metadata
- Authors
- Jones, J. T., Akita, R. W., & Sliwkowski, M. X.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-03-26
- Volume
- 447
- Issue
- 2-3
- Pages
- 227-231
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2083831897
- Cited by
- 381
- References
- 37
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- closed
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