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Cited by 57Menopause: Health Impacts and TreatmentsSexual function and dysfunction studiesHormonal and reproductive studies

Randomized clinical trials of combined estrogen-androgen preparations: effects on sexual functioning

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Sherwin, Barbara B·2002·Fertility and Sterility
DOI 10.1016/s0015-0282(02)03002-9
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Abstract

Objective To review the randomized controlled trials of the efficacy of combined estrogen-androgen (E-A) preparations on sexual functioning in postmenopausal women.Patient(s) Naturally and surgically menopausal women.Main outcome measure(s) Changes in aspects of sexual functioning.Result(s) In general, a high degree of agreement exists among the findings of these well-controlled trials that combined E-A preparations enhance psychological well-being as well as sexual desire and interest and, sometimes, increases the frequency of sexual intercourse and orgasm compared with estrogen-alone treatment in both naturally and surgically postmenopausal women.Conclusion(s) In selected cases, combined E-A therapy can enhance the quality of life for both naturally and surgically postmenopausal women.

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  • By heightening sexual desire in the less aroused partner or reducing it in the more aroused partner, the discrepancy could be minimized, possibly softening a major source of relationship strain.

    “By heightening sexual desire in the less aroused partner (by using testosterone, for instance, see Braunstein et al. 2005; Sherwin 2002; Sherwin and Gelfand 1987; Sherwin et al. 1985) or reducing it in the more aroused partner, the discrepancy could be minimized, possibly softening a major source of relationship strain.”

    From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Sherwin 2002

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Research works printed but not linked: 3

  1. Burger HG, Dudley EC, Cui J, Dennerstein L, Hopper JL. A prospec- tive longitudinal study of serum testosterone dehydroepiandrosterone sulphate, and sex hormone-binding globulin levels through the meno- pause transition, J Clin Endocrinol Metab 2000;85:2832-8.
  2. Longcope C. Metabolism clearance and blood production rates of estrogen in postmenopausal women. Am J Obstet Gynecol 1981;111: 779 -85.
  3. Sarrel P, Dobay B, Wiita B. Estrogen and estrogen-androgen replace- ment in postmenopausal women dissatisfied with estrogen-alone ther- apy. J Reprod Med 1998;43:847-56.

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Authors
Sherwin, B. B.
Affiliations
McGill University (CA)
Corresponding author
Sherwin, Barbara B
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2002-04
Volume
77
Pages
49-54
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/s0015-0282(02)03002-9
OpenAlex
W2069172850
Cited by
57
References
33
Citations by year
2026: 1 · 2025: 1 · 2022: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 7
FWCI
0.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
postmenopausal women, sexual function, sexual desire, sexual frequency, orgasm, surgical menopause, quality of life, psychological well-being, estrogen therapy
MeSH terms
Androgens, Animals, Estrogens, Female, Humans, Libido, Sexual Behavior, Estrogen Replacement Therapy, Randomized Controlled Trials as Topic, Postmenopause

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