Neuroenhancement of love and marriage: the chemicals between us.
Open accessAbstract
This paper reviews the evolutionary history and biology of love and marriage. It examines the current and imminent possibilities of biological manipulation of lust, attraction and attachment, so called neuroenhancement of love. We examine the arguments for and against these biological interventions to influence love. We argue that biological interventions offer an important adjunct to psychosocial interventions, especially given the biological limitations inherent in human love.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Natural selection did not shape basic mating strategies nor underlying brain chemistry to foster life-long, monogamous matrimony in the modern world, but rather to promote reproductive success of progenitors in the Pleistocene.
“Natural selection did not shape our basic mating strategies—nor our underlying brain chemistry—to foster life-long, monogamous matrimony in the modern world, but rather to promote the reproductive success of our progenitors in the environment of the Pleistocene [2, 3].”
From Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations (2013) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1976) · Cited by 10,423 · see citing works
Philosophical transactions of the Royal Society of London. B
Press, H. (1886) · Cited by 10,087 · see citing works
Well-being : the foundations of hedonic psychology
Kahneman, D. J., Diener, E. F., & Schwarz, N. (1999) · Cited by 7,472 · see citing works
Social Relationships and Health
House, J. S., Landis, K. R., & Umberson, D. (1988) · Science · doi:10.1126/science.3399889 · Cited by 7,073 · see citing works
Parfit, D. (1986) · Princeton University Press eBooks · doi:10.1093/019824908x.001.0001 · Cited by 5,803 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Kant: The Metaphysics of Morals
Kant, I., & Sullivan, R. J. (1996) · Cambridge University Press eBooks · doi:10.1017/cbo9780511809644 · Cited by 1,942 · see citing works
Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774 · see citing works
An Economic Analysis of Marital Instability
Becker, G. S., Landes, E. M., & Michael, R. T. (1977) · Journal of Political Economy · doi:10.1086/260631 · Cited by 1,760 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,448 · cited 2× · see citing works
“In humans, brain regions activated by seeing beloved people (either partners or children) appear to correspond to regions with oxytocin, vasopressin and dopamine receptors [5, 6].”
BackgroundOxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
The Role of Social Relations in Health Promotion
Berkman, L. F. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199505000-00006 · Cited by 1,233 · cited 1× · see citing works
“Conversely, social isolation increases the risk of depression [75] and mortality [ 8 , 32].”
BackgroundStandard cross-cultural sample
Murdock, G. P., & White, D. R. (1969) · Ethnology · doi:10.2307/3772907 · Cited by 1,149 · see citing works
The neural basis of romantic love
Bartels, A., & Zeki, S. (2000) · NeuroReport · doi:10.1097/00001756-200011270-00046 · Cited by 1,020 · see citing works
MHC-dependent mate preferences in humans
Wedekind, C., Seebeck, T., Bettens, F., & Paepke, A. J. (1995) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1995.0087 · Cited by 957 · see citing works
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 1× · see citing works
“Infusion of oxytocin into the brains of female prairie voles and vasopressin in males facilitated pair bonding even in the absence of mating (while the non-monogamous montane voles were unaffected) [12, 33, 82, 83].”
BackgroundAche Life History: The Ecology and Demography of a Foraging People.
Howell, N. E., Hill, K. R., & Hurtado, A. M. (1996) · Population and Development Review · doi:10.2307/2137817 · Cited by 843 · see citing works
Beyond therapy: biotechnology and the pursuit of happiness
President's Council on Bioethics (United States) (2004) · Choice Reviews Online · doi:10.5860/choice.42-1550 · Cited by 704 · see citing works
Nelson, E. E., & Panksepp, J. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00052-3 · Cited by 688 · cited 1× · see citing works
“They are important for the formation of mother–infant and other affiliative bonds [55].”
BackgroundA Cross-Cultural Perspective on Romantic Love
Jankowiak, W. R., & Fischer, E. F. (1992) · Ethnology · doi:10.2307/3773618 · Cited by 646 · see citing works
Lim, M. M., Wang, Z., Olazábal, D. E., Ren, X., Terwilliger, E. F., & Young, L. J. (2004) · Nature · doi:10.1038/nature02539 · Cited by 628 · see citing works
Liu, Y., & Wang, Z. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00555-4 · Cited by 580 · cited 1× · see citing works
“The strong dopamine and oxytocin signals elicited during the early romantic phase of a relationship and during sexual interaction are likely to act as learning signals: they help imprint details of the partner, positive emotional associations and relationship-related habits [2, 48].”
BackgroundCortical remodelling induced by activity of ventral tegmental dopamine neurons
Bao, S., Chan, V. T., & Merzenich, M. M. (2001) · Nature · doi:10.1038/35083586 · Cited by 569 · see citing works
Sherwin, B. B., Gelfand, M. M., & Brender, W. (1985) · Psychosomatic Medicine · doi:10.1097/00006842-198507000-00004 · Cited by 549 · see citing works
Cho, M. M., DeVries, A. C., Williams, J. R., & Carter, C. S. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.1071 · Cited by 529 · see citing works
Insel, T. R., & Hulihan, T. J. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.782 · Cited by 528 · see citing works
Evolutionary Social Psychology
Neuberg, S. L., Kenrick, D., & Schaller, M. (2010) · doi:10.1002/9780470939376.ch28 · Cited by 514 · see citing works
Sexual Infidelity Among Married and Cohabiting Americans
Treas, J., & Giesen, D. (2000) · Journal of Marriage and Family · doi:10.1111/j.1741-3737.2000.00048.x · Cited by 503 · see citing works
Wedekind, C., & Füri, S. (1997) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.1997.0204 · Cited by 494 · cited 1× · see citing works
“People describe body odors as pleasant when they come from people with dissimilar immune systems [76, 77].”
BackgroundAche life history: The ecology and demography of a foraging people
Low, B. S. (1997) · Evolution and Human Behavior · doi:10.1016/s1090-5138(97)00035-4 · Cited by 484 · see citing works
Williams, J. R., Insel, T. R., Harbaugh, C. R., & Carter, C. S. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00579.x · Cited by 483 · see citing works
Aragona, B. J., Liu, Y., Yu, Y. J., Curtis, J. T., Detwiler, J. M., Insel, T. R., & Wang, Z. (2006) · Nature Neuroscience · doi:10.1038/nn1613 · Cited by 473 · cited 1× · see citing works
“The strong dopamine and oxytocin signals elicited during the early romantic phase of a relationship and during sexual interaction are likely to act as learning signals: they help imprint details of the partner, positive emotional associations and relationship-related habits [2, 48].”
BackgroundLight, K. C., Grewen, K. M., & Amico, J. A. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2004.11.002 · Cited by 470 · see citing works
Understanding infidelity: Correlates in a national random sample.
Atkins, D. C., Baucom, D. H., & Jacobson, N. S. (2001) · Journal of Family Psychology · doi:10.1037/0893-3200.15.4.735 · Cited by 458 · see citing works
Braunstein, G. D., Sundwall, D. A., Katz, M., Shifren, J. L., Buster, J. E., Simon, J. A., Bachman, G., Aguirre, O. A., Lucas, J. D., Rodenberg, C., et al. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.14.1582 · Cited by 458 · see citing works
Vollenweider, F. X., Gamma, A., Liechti, M., & Huber, T. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00013-x · Cited by 448 · see citing works
Lust, attraction, and attachment in mammalian reproduction
Fisher, H. E. (1998) · Human Nature · doi:10.1007/s12110-998-1010-5 · Cited by 429 · see citing works
Enhancing human traits: ethical and social implications
(1999) · Choice Reviews Online · doi:10.5860/choice.36-4517 · Cited by 426 · see citing works
Subjective Reports of the Effects of MDMA in a Clinical Setting
Greer, G., & Tolbert, R. (1986) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1986.10472364 · Cited by 413 · see citing works
Romantic love: a mammalian brain system for mate choice
Fisher, H. E., Aron, A., & Brown, L. L. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1938 · Cited by 411 · see citing works
The role of androgen in the maintenance of sexual functioning in oophorectomized women.
Sherwin, B. B., & Gelfand, M. M. (1987) · Psychosomatic Medicine · doi:10.1097/00006842-198707000-00009 · Cited by 394 · see citing works
Buss, D. M. (2000) · PubMed · Cited by 388 · see citing works
Extramarital sex: Prevalence and correlates in a national survey
Wiederman, M. W. (1997) · The Journal of Sex Research · doi:10.1080/00224499709551881 · Cited by 340 · see citing works
Sexual Motivation and the Duration of Partnership
Klusmann, D. (2002) · Archives of Sexual Behavior · doi:10.1023/a:1015205020769 · Cited by 340 · see citing works
Buss, D. M. (2000) · American Psychologist · doi:10.1037/0003-066x.55.1.15 · Cited by 320 · see citing works
Murdock, G. P. (1981) · University of Pittsburgh Press eBooks · doi:10.2307/jj.13110803 · Cited by 317 · see citing works
Defining the Brain Systems of Lust, Romantic Attraction, and Attachment
Fisher, H. E., Aron, A., Mashek, D., Li, H., & Brown, L. L. (2002) · Archives of Sexual Behavior · doi:10.1023/a:1019888024255 · Cited by 317 · see citing works
Marital Conflict in Older Adults: Endocrinological and Immunological Correlates
Kiecolt-Glaser, J. K., Glaser, R., Cacioppo, J. T., MacCallum, R. C., Snydersmith, M., Kim, C., & Malarkey, W. B. (1997) · Psychosomatic Medicine · doi:10.1097/00006842-199707000-00001 · Cited by 281 · see citing works
Enhancing human traits : ethical and social implications
Parens, E. (1998) · Cited by 260 · see citing works
Close relationships and quality of life.
Myers, D. G. (1999) · Cited by 254 · see citing works
Thompson, M. R., Callaghan, P. D., Hunt, G. E., Cornish, J. L., & McGregor, I. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.032 · Cited by 237 · see citing works
Evolution of human serial pairbonding
Fisher, H. E. (1989) · American Journal of Physical Anthropology · doi:10.1002/ajpa.1330780303 · Cited by 234 · see citing works
Hormonal changes when falling in love
Marazziti, D., & Canale, D. (2003) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.08.006 · Cited by 219 · see citing works
Daly, M., & WILSON, M. I. (1996) · Current Directions in Psychological Science · doi:10.1111/1467-8721.ep10772793 · Cited by 196 · see citing works
Rethinking Polygyny: Co-Wives, Codes, and Cultural Systems [and Comments and Reply]
White, D. R., Betzig, L. L., Mulder, M. B., Chick, G., Hartung, J., Irons, W., Low, B. S., Otterbein, K. F., Rosenblatt, P. C., & Spencer, P. (1988) · Current Anthropology · doi:10.1086/203674 · Cited by 193 · see citing works
(1996) · doi:10.1093/oso/9780198548614.001.0001 · Cited by 190 · see citing works
Is better always good? The Enhancement Project.
Parens, E. (1998) · PubMed · Cited by 186 · see citing works
Sex differences in response to physical and social factors involved in human mate selection
Herz, R. S., & Inzlicht, M. (2002) · Evolution and Human Behavior · doi:10.1016/s1090-5138(02)00095-8 · Cited by 177 · see citing works
Smelling a Single Component of Male Sweat Alters Levels of Cortisol in Women
Wyart, C., Webster, W. W., Chen, J. H., Wilson, S. R., McClary, A. C., Khan, R. M., & Sobel, N. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4430-06.2007 · Cited by 175 · see citing works
Holt‐Lunstad, J., Uchino, B. N., Smith, T. W., Olson-Cerny, C., & Nealey-Moore, J. B. (2003) · Health Psychology · doi:10.1037/0278-6133.22.4.388 · Cited by 150 · see citing works
The Availability of Social Support Reduces Cardiovascular Reactivity to Acute Psychological Stress
Uchino, B., & Garvey, T. S. (1997) · Journal of behavioral medicine · doi:10.1023/a:1025583012283 · Cited by 145 · see citing works
Human pheromones and sexual attraction.
Grammer, K., Fink, B., & Neave, N. (2005) · European Journal of Obstetrics, Gynecology, and Reproductive Biology · doi:10.1016/j.ejogrb.2004.08.010 · Cited by 134 · see citing works
Perceived Causes of Divorce: An Analysis of Interrelationships
Cleek, M. G., & Pearson, T. (1985) · Journal of Marriage and the Family · doi:10.2307/352080 · Cited by 133 · see citing works
(2009) · doi:10.1093/acprof:osobl/9780199234509.001.0001 · Cited by 129 · see citing works
Uchino, B. N., Holt‐Lunstad, J., Smith, T. W., & Bloor, L. E. (2004) · Journal of Social and Clinical Psychology · doi:10.1521/jscp.23.2.123.31014 · Cited by 127 · see citing works
The Welfarist Account of Disability
Kahane, G., & Savulescu, J. (2009) · doi:10.1093/acprof:osobl/9780199234509.003.0002 · Cited by 126 · see citing works
Self-citationWhat evidence is there for the existence of individual genes with antagonistic pleiotropic effects?
Leroi, A. M., Bartke, A., Benedictis, G. D., Franceschi, C., Gartner, A., Gonos, E. S., Feder, M. E., Kivisild, T., Lee, S. Y., Özer, N. K., et al. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.07.012 · Cited by 121 · see citing works
Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA
(1990) · Topics in the neurosciences · doi:10.1007/978-1-4613-1485-1 · Cited by 111 · see citing works
Hunt, A. E., & Evan, G. I. (2001) · Science · doi:10.1126/science.11546862 · Cited by 97 · see citing works
Corticotropin-releasing factor induces social preferences in male prairie voles
DeVries, A. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00073-7 · Cited by 97 · see citing works
The Death of “Till Death Us Do Part”: The Transformation of Pair‐Bonding in the 20th Century*
Pinsof, W. M. (2002) · Family Process · doi:10.1111/j.1545-5300.2002.41202.x · Cited by 78 · see citing works
Human pheromones: have they been demonstrated?
Hays, W. S. T. (2003) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-003-0613-4 · Cited by 71 · see citing works
Vasopressin and pair-bond formation: genes to brain to behavior.
Nair, H. P., & Young, L. J. (2006) · Physiology · doi:10.1152/physiol.00049.2005 · Cited by 68 · see citing works
Greer, G. R., & Tolbert, R. (1990) · Topics in the Neurosciences · doi:10.1007/978-1-4613-1485-1_2 · Cited by 57 · see citing works
Randomized clinical trials of combined estrogen-androgen preparations: effects on sexual functioning
Sherwin, B. B. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03002-9 · Cited by 57 · see citing works
Addiction Is Not An Affliction: Addictive Desires Are Merely Pleasure-Oriented Desires
Foddy, B., & Savulescu, J. (2007) · The American Journal of Bioethics · doi:10.1080/15265160601064157 · Cited by 42 · see citing works
Self-citationSexual Conf lict and Remarriage in Preindustrial Human Populations Causes and Fitness Consequences
Käär, P. (1998) · Evolution and Human Behavior · doi:10.1016/s1090-5138(98)00007-5 · Cited by 38 · see citing works
Romantic Love: A Literary Universal?
Gottschall, J., & Nordlund, M. (2006) · Philosophy and Literature · doi:10.1353/phl.2006.0030 · Cited by 37 · see citing works
The Ethics of Relationality: The Moral Views of Therapists Engaged in Marital and Family Therapy
Wall, J., Needham, T., Browning, D. S., et al. (1999) · Family Relations · doi:10.2307/585077 · Cited by 25 · see citing works
Romantic Love: A Literary Universal?
Gottschall, J. (2008) · Palgrave Macmillan US eBooks · doi:10.1057/9780230615595_8 · Cited by 25 · see citing works
Watanabe, M., Irie, M., & Kobayashi, F. (2004) · Journal of Occupational Health · doi:10.1539/joh.46.78 · Cited by 21 · cited 1× · see citing works
“Conversely, social isolation increases the risk of depression [75] and mortality [8, 32].”
BackgroundPheromonal influences on sociosexual behavior in postmenopausal women
Friebely, J., & Rako, S. (2004) · Journal of Sex Research · doi:10.1080/00224490409552244 · Cited by 21 · see citing works
Sperm competition and female procurement of male resources
Klusmann, D. (2006) · Human Nature · doi:10.1007/s12110-006-1010-2 · Cited by 17 · see citing works
The relationship between serial monogamy and rape in the United States (1960–1995)
Starks, P. T. B., & Blackie, C. A. (2000) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2000.1136 · Cited by 16 · see citing works
Love and death in Wagner's Tristan und Isolde —an epic anticholinergic crisis
Weitz, G. (2003) · BMJ · doi:10.1136/bmj.327.7429.1469 · Cited by 14 · see citing works
leatherworkers and love potions
Lindholm, C. (1981) · American Ethnologist · doi:10.1525/ae.1981.8.3.02a00060 · Cited by 11 · see citing works
Leroi, A. M., Bartke, A., Benedictis, G. D., et al. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.001 · Cited by 1 · see citing works
(1988) · Current Anthropology · doi:10.1086/203675 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Griffin, J. 1986. Well-being. Oxford: Clarendon.
- Parfit, D. 1984. Reasons and persons. Oxford: Clarendon.
- Simpson J.A., D.T. Kenrick , pp. 237-264. Mahwah, New Jersey: Laurence Erlbaum.
Cited by
Sorted by citations
Does Oxytocin Increase Trust in Humans? A Critical Review of Research
Nave, G., Camerer, C., & McCullough, M. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615600138 · Cited by 309 · see citing works
EARP, B. D., SANDBERG, A., & SAVULESCU, J. (2015) · Cambridge Quarterly of Healthcare Ethics · doi:10.1017/s0963180114000206 · Cited by 57 · see citing works
Self-citationEarp, B. D., Sandberg, A., & Savulescu, J. (2012) · Philosophy & Technology · doi:10.1007/s13347-012-0081-8 · Cited by 54 · see citing works
Self-citationWudarczyk, O. A., Earp, B. D., Guastella, A., & Savulescu, J. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283642e10 · Cited by 52 · see citing works
Self-citation
- Authors
- Savulescu, J., & Sandberg, A.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Savulescu, Julian
- Venue
- Neuroethics
- Published
- 2008-02-07
- Volume
- 1
- Issue
- 1
- Pages
- 31-44
- ISSN
- 1874-5490 (ISSN-L)
- 1874-5504
- OpenAlex
- W2162553208
- Cited by
- 111
- References
- 89
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 1 · 2022: 10 · 2021: 16 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 6 · 2013: 10 · 2012: 4
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroethics (publishedVersion, cc-by-nc)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroethics, Human Enhancement, Biomedical Innovations
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Keywords
- cognitive enhancement, love, marriage, lust, romantic attraction, attachment, psychosocial interventions, emotions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review