The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium
Open accessAbstract
Objective The role of natural killer (NK) cells in the decreased cellular immunity of women with endometriosis was investigated.Design, setting, patients Thirty-four women were investigated prospectively before a CO2-laser laparoscopy for infertility and/or pain at the University Hospital Gasthuisberg. Endometriosis was scored blindly.Main outcome measure The cytotoxicity, directed against the endometrium, was mediated by NK cells because this cytotoxicity could be removed by treating the effector cells with the NK-specific anti-Leu-11b monoclonal antibody. Consequently, we evaluated prospectively in those women the lymphocyte-mediated cytotoxicity toward NK sensitive (K562-assay) and autologous endometrial target cells.Results The NK activity (K562-assay) and the cytotoxicity against autologous endometrial cells were similarly decreased in women with endometriosis and correlated with the severity of the disease. Using heterologous effector cells, the decreased chromium release in women with endometriosis was less pronounced but still present.Conclusion The decreased cytotoxicity to endometrial cells in women with endometriosis is mainly because of a defect in NK activity but is also partially because of a resistance of the endometrium to NK cytotoxicity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The natural killer activity is decreased in PF and in plasma of women with endometriosis (103-105) and after excision of deep endometriosis their activity remains low, whereas elevated CA-125 concentrations return to normal (106).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [103]
Citations
Cites
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334
Revised American Fertility Society Classification of Endometriosis: 1985
(1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48430-x · Cited by 1,803
Deeply infiltrating pelvic endometriosis: histology and clinical significance
Cornillie, F. J., Oosterlynck, D., Lauweryns, J. M., & Koninckx, P. R. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53570-5 · Cited by 594
Strathy, J. H., Molgaard, C. A., Coulam, C. B., & Melton, L. J. (1982) · Fertility and Sterility · doi:10.1016/s0015-0282(16)46691-4 · Cited by 425
Deficient cellular immunity in endometriosis
Dmowski, W. P., Steele, R. W., & Baker, G. F. (1981) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(81)90598-6 · Cited by 302
Endometriosis: its association with retrograde menstruation, dysmenorrhoea and tubal pathology
LIU, D. T. Y., & HITCHCOCK, A. (1986) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1986.tb07995.x · Cited by 230
Immunologic Aspects of Human Endometriosis
Steele, R. W., Dmowski, W. P., & Marmer, D. J. (1984) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1984.tb00106.x · Cited by 223
Characterization of Functional Surface Structures on Human Natural Killer Cells
Ritz, J., Schmidt, R. E., Michon, J. M., Hercend, T., & Schlossman, S. F. (1988) · Advances in immunology · doi:10.1016/s0065-2776(08)60845-7 · Cited by 177
Subtle appearance of pelvic endometriosis
Stripling, M. C., Martin, D. C., Chatman, D. L., Zwaag, R. V., & Poston, W. M. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59767-2 · Cited by 167
New aspects of the pathophysiology of endometriosis and associated infertility.
Koninckx, P. R., Ide, P. S., Vandenbroucke, W. V. A., & Brosens, I. A. (1980) · PubMed · Cited by 145
Research works printed but not linked: 1
- Trinchieri, 1984, Biology of disease, Human natural killer cells: biologic and pathologic aspects. Lab Invest, 50, 489
Cited by
Sorted by citations
Items 401–441 of 441
Banu, L. A., & Tasnim, S. (2014) · Journal of Bangladesh College of Physicians and Surgeons · doi:10.3329/jbcps.v31i3.20981
Visible and Invisible (Occult) Endometriosis
Khan, K. N. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_3
The biological basis of medical treatment of endometriosis
Venturini, P. L., Semino, A., & Cecco, L. D. (1995) · Gynecological Endocrinology · doi:10.3109/09513599509160455
CO2-laser excision of endometriosis does not improve the decreased natural killer activity
Oosterlynck, D. J., Meuleman, C., Waer, M., & Koninckx, P. R. (1992) · Neuro-Ophthalmology · doi:10.3109/01658109209058106
Immunological aspects of endometriosis
de Flandre, H. J. (1996)
Olivares, C. N. (2012) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Uchida, M. (2014) · Journal of Womens Health Issues and Care · doi:10.4172/2325-9795.1000155
“In peritoneal fluid of women with endometriosis, the decreased NK cell activity [12,13], dysfunction of T lymphocytes [17,18], infiltration of macrophage [19] as well as aberrant concentrations of immune-related cytokines [20] has been reported in the past two decades.”
BackgroundDEVELOPMENT OF A DOMESTIC ANIMAL MODEL OF ENDOMETRIOSIS
Varughese, E. E. (2016) · University Library - University of Saskatchewan (University of Saskatchewan)
ENDOMETRIOSIS: MEDICAL AND SURGICAL TREATMENTEduardo
Gonzalez-Fabbrizzi, A. (1996)
Peptide inhibitors of angiogenesis in endometriosis and the female reproductive system
Edwards, A. K. (2014) · QSpace (Queen's University Library)
Interactions of Immunomodulatory HLA-G with Immune Cells during Pregnancy and Endometriosis
Parasar, P. (2015) · Gynecology and Obstetrics Research - Open Journal · doi:10.17140/goroj-2-121
Papel do HLA-G na endometriose
Rached, M. R. (2017) · doi:10.11606/d.5.2017.tde-06092017-121750
Endometrial Immune Profiling: An Emerging Paradigm for Reproductive Disorders
Lédée, N. (2019) · Springer eBooks · doi:10.1007/978-3-030-28584-5_5
Burney, R. O., & Giudice, L. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00130-x
Autoimmune Endocrinopathies in Female Reproductive Dysfunction
Gargiulo, A., & Hill, J. A. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-704-8_16
Chua, H. K., & Snyder, M. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-66049-9_41
Malik, E. (2005) · Springer eBooks · doi:10.1007/3-540-26406-x_20
Endometriosis Research: From Bench to Bedside
Laganà, A. S., & La Rosa, V. L. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-2798-7
Malik, E., & Vogt, J. (2009) · Springer eBooks · doi:10.1007/978-3-540-89760-6_21
Rubal, L., & Israel, R. (2010) · doi:10.1002/9781444323030.ch69
Helvacioglu, A. (1996) · Springer eBooks · doi:10.1007/978-3-642-60961-9_13
Biochemische Aspekte der Endometriose
Runnebaum, B., Kohl, C., & Kiesel, L. (1993) · Archives of Gynecology and Obstetrics · doi:10.1007/bf02266107
“In Zytotoxizit~its-Expefimenten mit Effektorzellen gegen autologe Endometriumszellen oder K562-Zellen konnte eine signifikant eingeschr~inkte F~ihigkeit zur Zellyse bei Patientinnen gezeigt werden, die um so ansgeprggter war, je ausgedehnter die Endometriose war (32).”
BackgroundSnyder, M. J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1584-9_25
Nardi, P. D., & Ferrari, S. M. (2011) · Springer eBooks · doi:10.1007/978-88-470-1866-2_1
Snyder, M. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-25970-3_42
Marin, M. L. A. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2022.tde-22092022-151310
Cali, J. R., & Snyder, M. J. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1724-2.00033-7
NEZHAT, C. R., Nezhat, F. R., NEZHAT, C. R., Lakhi, N. A., & Nezhat, A. A. (2025) · Cambridge University Press eBooks · doi:10.1017/9781108561440.013
Koch, Y. (2014) · DuEPublico (University of Duisburg-Essen)
Etude phénotypique des cellules endométriosiques profondes
Leconte, M. (2012) · theses.fr (ABES) · doi:10.70675/6c60e34az6799z41eaz8bacz16682a3d37ea
Génétique et épigénétique de l'endométriose : analyse des micro-ARNs et séquençage de familles
Abo, C. (2020) · theses.fr (ABES) · doi:10.70675/1f196b86zdff4z4171zaff3zba99042c1a5d
Physiopathologie de l’endométriose : plus de pistes que d’arrivées
Dabi, Y., Zerbib, E., Favier, A., Varinot, J., Dahan, M., Ferrier, C., Touboul, C., & Ilic, J. (2026) · EMC - Gynécologie · doi:10.1016/s0246-1064(26)48145-1
A Theoretical Exploration of the Application of “Mu Yu Da Zhi” Theory in Endometriosis-Related Pain
毛, 佳. (2026) · Traditional Chinese Medicine · doi:10.12677/tcm.2026.1510555
Regulação da resposta imune e endometriose
Poppe, A. C. M. (2008) · UNESP Institutional Repository (São Paulo State University)
Role of NK Cells in Endometriosis
Maeda, N. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_5
Metadata
- Authors
- Oosterlynck, D. J., Cornillie, F. J., Waer, M., Vandeputte, M., & Koninckx, P. R.
- Affiliations
- Rega Institute for Medical Research (BE)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1991-07
- Volume
- 56
- Issue
- 1
- Pages
- 45-51
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W141728048
- Cited by
- 441
- References
- 13
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 11 · 2023: 6 · 2022: 13 · 2021: 12 · 2020: 18 · 2019: 12 · 2018: 11 · 2017: 7 · 2016: 12 · 2015: 14 · 2014: 21 · 2013: 16 · 2012: 13
- FWCI
- 16.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Keywords
- endometriosis, natural killer cells, NK cell cytotoxicity, cell-mediated immunity, infertility, disease severity
- MeSH terms
- Chromium Radioisotopes, Cytotoxicity, Immunologic, Endometriosis, Endometrium, Female, Flow Cytometry, Humans, Immunity, Cellular, Killer Cells, Natural, Leukocyte Count, Prospective Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
