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Cited by 311Endometriosis Research and TreatmentMenstrual Health and DisordersEctopic Pregnancy Diagnosis and Management

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis

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Vercellini, Paolo, Trespidi, Laura, Colombo, Alberto, Vendola, Nicoletta, Marchini, Maurizio, Crosignani, Pier Giorgio·1993·Fertility and Sterility
DOI 10.1016/s0015-0282(16)56039-7
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Abstract

Objectives To evaluate the efficacy of goserelin versus a low-dose cyclic oral contraceptive (OC) in improving pelvic pain in women with endometriosis and to compare recurrence of symptoms during follow-up.Design Open-label, randomized trial.Setting University hospital endometriosis center.Patients Fifty-seven women with moderate or severe pelvic pain and laparoscopically diagnosed endometriosis.Interventions Six-month treatment with goserelin depot (n = 29) or a low-dose cyclic OC (n = 28) followed by 6-month follow-up.Main outcome measures Variation in severity of symptoms during treatment and at the end of follow-up as shown by a linear analog scale and a verbal rating scale.Results At 6 months of treatment, a significant reduction in deep dyspareunia was observed in both groups, with goserelin superior to the OC at linear analog scale assessment. Nonmenstrual pain was diminished on both scales without differences between treatments. Women taking the OC experienced a significant reduction in dysmenorrhea. At the end of follow-up, symptoms reappeared without differences in severity between the groups.Conclusions Low-dose cyclic OCs may be a valuable alternative for the treatment of dysmenorrhea and nonmenstrual pain associated with endometriosis. Symptoms recurred in most subjects 6 months after drug withdrawal.

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Research works printed but not linked: 1

  1. Vercellini P, Crosignani PG. Epidemiology of endometriosis. In: Brosens I, Donnez J, editors. Proceedings of the 3rd World Congress on Endometriosis; 1992 June 1–3; Brussels. Casterton Hall: Parthenon Publishing. In press.

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Metadata

Authors
Vercellini, P., Trespidi, L., Colombo, A., Vendola, N., Marchini, M., & Crosignani, P. G.
Affiliations
University of Milan (IT)
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
1993-07
Volume
60
Issue
1
Pages
75-79
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/s0015-0282(16)56039-7
OpenAlex
W252619442
Cited by
311
References
19
Citations by year
2026: 5 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 16 · 2017: 6 · 2016: 11 · 2015: 9 · 2014: 17 · 2013: 11 · 2012: 18
FWCI
3.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
  • Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, pelvic pain, goserelin, GnRH agonist, low-dose oral contraceptives, dysmenorrhea, deep dyspareunia, symptom recurrence, treatment efficacy
MeSH terms
Adolescent, Adult, Contraceptives, Oral, Dysmenorrhea, Dyspareunia, Endometriosis, Female, Follow-Up Studies, Humans, Pain, Recurrence, Goserelin

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