Histologic study of ovarian endometriosis after hormonal therapy
Open accessAbstract
To evaluate the persistence of endometriosis and the morphologic changes occurring in endometriotic foci after hormonal therapy, microsurgical resection of ovarian endometriosis was performed in 148 women. After hormonal therapy (n = 116), a high prevalence of active endometriosis without signs of degeneration was found. Mitotic index was similar in the group of untreated women (n = 32) and in the three groups of women treated either with lynestrenol (Organon, Oss, The Netherlands), gestrinone (Roussel UCLAF, Paris, France), or buserelin (Hoechst, Frankfurt, West Germany). In conclusion, hormonal treatment leads to an incomplete suppression of endometriotic foci.
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During hormonal treatment, lesions are observed in most women taking GnRH agonists and progestagens.
“During hormonal treatment, lesions, which may be quiescent (perhaps neurologically inactive), are observed in most women on GnRH agonists and progestagens (Nisolle-Pochet et al., 1988).”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Nisolle-Pochet et al., 1988
The impact of progestogens on morphology and vascularization of ectopic endometrial tissue and atrophy is questionable.
“the impact of progestogens on the morphology and vascularization of ectopic endometrial tissue and atrophy is much more questionable [77,78,79,80,81].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [79]
The reduction in lesion volume with estroprogestins or progestins is not predictable and not significant in the vast majority of cases.
“The reduction in lesion volume is not predictable and not significant in the vast majority of cases. Conflicting results have been observed [77,78,79,80,81,82,86,87,88].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [79]
Some studies have revealed absence of proliferation index changes under progestogen therapy.
“Some studies have revealed the absence of proliferation index changes under progestogen therapy [77,78,79,80,81].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [79]
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- Authors
- Nisolle-Pochet, M., Casanas-Roux, F., & Donnez, J.
- Affiliations
- UCLouvain (BE)
- ORCID
- Donnez, Jacques
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1988-03
- Volume
- 49
- Issue
- 3
- Pages
- 423-426
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1672226597
- Cited by
- 111
- References
- 17
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2019: 3 · 2018: 4 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Update notices
- erratum (1988-07-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- ORBi (University of Liège) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- endometrioma, hormone therapy, mitotic index, lynestrenol, gestrinone, buserelin, microsurgical resection
- MeSH terms
- Adult, Buserelin, Endometriosis, Female, Gestrinone, Humans, Lynestrenol
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