Cited by 214Ovarian function and disordersEstrogen and related hormone effectsMenopause: Health Impacts and Treatments

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The climacteric ovary as a functional gonadotropin-driven androgen-producing gland.

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Adashi, Eli Y.·1994·Fertility and Sterility

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Abstract

Objective To assess the hypothesis that the climacteric ovary is a functional endocrine gland.Design Review of the English-speaking literature as it relates to the physiology and pathophysiology of the climacteric ovary.Results By several accounts, the climacteric ovary appears to be a gonadotropin-dependent androgen-producing gland. Although the estrogen-producing potential of the climacteric ovary remains a matter of controversy, most studies would suggest limited aromatase activity.Conclusions [1] The climacteric ovary is not a defunct endocrine organ. [2] The climacteric ovary is a site of gonadotropin reception and action. [3] The climacteric ovary contributes few if any estrogens to the circulating pool by way of direct production. [4] Circulating estrogens are derived virtually exclusively from the extraglandular conversion of androgens, a proportion of which are of ovarian origin. [5] The climacteric ovary contributes 40% and 20% of the total production rates of T and androstenedione, respectively. [6] Androgen biosynthesis by the climacteric ovary is partially gonadotropin-dependent.

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Authors: Adashi, E. Y.
Affiliations: University of Maryland, Baltimore (US)
Corresponding author: Adashi, Eli Y.
ORCID: Adashi, Eli Y.
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 1994-07
Volume: 62
Issue: 1
Pages: 20-27
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/s0015-0282(16)56810-1
OpenAlex: W2417679673
Cited by: 214
References: 69
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 2 · 2017: 8 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 9
FWCI: 5.26
Type: journal article
Language: en
Update notices: erratum (1995-03-01)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 10192 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: ovarian androgen production, aromatase activity, estrogen synthesis, androstenedione, testosterone, ovarian endocrine function, menopause
MeSH terms: Androgens, Climacteric, Estrogens, Female, Gonadotropins, Humans, Ovary, Receptors, Gonadotropin

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The climacteric ovary as a functional gonadotropin-driven androgen-producing gland.

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