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Cited by 353Endometriosis Research and TreatmentGynecological conditions and treatmentsEctopic Pregnancy Diagnosis and Management

The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.

Genetic influences on endometriosis in an Australian twin sample

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Treloar, Susan A, O’Connor, Daniel T, O’Connor, Vivienne M, Martin, Nicholas G·1999·Fertility and Sterility
DOI 10.1016/s0015-0282(98)00540-8
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Abstract

Objective To investigate the prevalence of and twin pair concordance for endometriosis.Design A questionnaire survey incorporating validation.Setting An Australia-wide volunteer sample of female monozygotic (MZ) and dizygotic (DZ) twin pairs from the Australian National Health and Medical Research Council Twin Register.Patient(s) Twins were selected only on the basis of previous participation in twin research.Intervention(s) Questionnaires were sent to 3,298 individuals. Information was requested from physicians named by consenting twins.Main outcome measure(s) Reported endometriosis, validated where possible by pathology or surgical report.Result(s) Three thousand ninety-six (94%) of the twins and 145 (82%) of the physicians responded to the survey. Two hundred fifteen twins reported endometriosis, for a prevalence rate of .07 among question respondents. Tetrachoric twin pair correlations for self-reported endometriosis (MZ: n = 854 and DZ: n = 493) were rMz = .46+/-.09 and rDz = .28 +/-.13. When available medical and pathology reports were included, they changed to rMz =.52 +/-.08 and rDZ = .19+/-.16, suggesting that 51% of the variance of the latent liability to endometriosis may be attributable to additive genetic influences.Conclusion(s) These findings support the hypothesis that genes influence liability to endometriosis.

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Research works printed but not linked: 4

  1. Dmowski, 1990, Endometriosis, Prog Clin Biol Res, 323, 99
  2. Treloar, 1990, Age at menarche as a fitness trait, Am J Hum Genet, 47, 137
  3. Duffy D. Asthma and allergic diseases in Australian twins and their families [thesis]. Brisbane, Australia: University of Queensland, 1994.
  4. Eaves L. Aspects of human psychogenetics [dissertation]. University of Birmingham, 1970.

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Metadata

Authors
Treloar, S. A., O’Connor, D. T., O’Connor, V. M., & Martin, N. G.
Affiliations
QIMR Berghofer Medical Research Institute (AU)
Corresponding author
Treloar, Susan A
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
1999-04
Volume
71
Issue
4
Pages
701-710
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/s0015-0282(98)00540-8
OpenAlex
W2097313599
Cited by
353
References
60
Citations by year
2026: 13 · 2025: 20 · 2024: 11 · 2023: 23 · 2022: 18 · 2021: 18 · 2020: 19 · 2019: 28 · 2018: 19 · 2017: 19 · 2016: 15 · 2015: 13 · 2014: 11 · 2013: 14 · 2012: 11
FWCI
7.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Queensland
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, genetic susceptibility, twin concordance, monozygotic twins, dizygotic twins, heritability, prevalence, twin registry, additive genetic effects
MeSH terms
Adolescent, Adult, Australia, Diseases in Twins, Endometriosis, Female, Humans, Male, Middle Aged, Models, Genetic, Phenotype, Surveys and Questionnaires, Risk Factors, Twins, Dizygotic, Twins, Monozygotic

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