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Genetic influences on endometriosis in an Australian twin sample
Open accessAbstract
Objective To investigate the prevalence of and twin pair concordance for endometriosis.Design A questionnaire survey incorporating validation.Setting An Australia-wide volunteer sample of female monozygotic (MZ) and dizygotic (DZ) twin pairs from the Australian National Health and Medical Research Council Twin Register.Patient(s) Twins were selected only on the basis of previous participation in twin research.Intervention(s) Questionnaires were sent to 3,298 individuals. Information was requested from physicians named by consenting twins.Main outcome measure(s) Reported endometriosis, validated where possible by pathology or surgical report.Result(s) Three thousand ninety-six (94%) of the twins and 145 (82%) of the physicians responded to the survey. Two hundred fifteen twins reported endometriosis, for a prevalence rate of .07 among question respondents. Tetrachoric twin pair correlations for self-reported endometriosis (MZ: n = 854 and DZ: n = 493) were rMz = .46+/-.09 and rDz = .28 +/-.13. When available medical and pathology reports were included, they changed to rMz =.52 +/-.08 and rDZ = .19+/-.16, suggesting that 51% of the variance of the latent liability to endometriosis may be attributable to additive genetic influences.Conclusion(s) These findings support the hypothesis that genes influence liability to endometriosis.
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“However, studies in Australian twins, 45 in the Icelandic population, 43 and in rhesus macaques 49 provide strong evidence for a genetic contribution to the disease with the heritability of endometriosis estimated to be around 50%. 45”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [45]
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“In twin sisters a prevalence of endometriosis (158-161) and age of onset (162) are similar.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [161]
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Cites
Akaike, H. (1987) · Psychometrika · doi:10.1007/bf02294359 · Cited by 5,264
Akaike, H. (1987) · Springer Series in Statistics · doi:10.1007/978-1-4612-1694-0_29 · Cited by 4,027
Methodology for Genetic Studies of Twins and Families
Neale, M. C., & Cardon, L. R. (1992) · doi:10.1007/978-94-015-8018-2 · Cited by 4,005
Revised American Society for Reproductive Medicine classification of endometriosis: 1996
American Society for Reproductive Medicine (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81391-x · Cited by 3,018
Case-Control Studies: Design, Conduct, Analysis.
Youkeles, L., & Schlesselman, J. J. (1983) · Journal of the American Statistical Association · doi:10.2307/2288156 · Cited by 2,358
Revised American Fertility Society Classification of Endometriosis: 1985
(1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48430-x · Cited by 1,803
Eskenazi, B., & Warner, M. L. (1997) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70302-8 · Cited by 1,617
Linkage strategies for genetically complex traits. II. The power of affected relative pairs.
RISCH, N. J. (1990) · PubMed · Cited by 868
Heath, A. C., Bucholz, K. K., Madden, P. A. F., Dinwiddie, S. H., Slutske, W. S., Bierut, L. J., Statham, D. J., Dunne, M. P., Whitfield, J. B., & Martin, N. G. (1997) · Psychological Medicine · doi:10.1017/s0033291797005643 · Cited by 846
Self-citationGenes, culture, and personality : an empirical approach
Eaves, L. J., Eysenck, H. J., & Martin, N. G. (1989) · Cited by 637
Self-citationRier, S. (1993) · Fundamental and Applied Toxicology · doi:10.1006/faat.1993.1119 · Cited by 502
The power of the classical twin study
Martin, N. G., Eaves, L. J., Kearsey, M. J., & Davies, P. H. O. (1978) · Heredity · doi:10.1038/hdy.1978.10 · Cited by 501
Self-citationHeritable aspects of endometriosis
Simpson, J. L., Elias, S., Malinak, L. R., & Buttram, V. C. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90917-5 · Cited by 468
Heath, A. C., Cloninger, C. R., & Martin, N. G. (1994) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.66.4.762 · Cited by 427
Self-citationEath, A. C. H., Ucholz, K. K. B., Adden, P. A. F. M., Inwiddie, S. H. D., Lutske, W. S. S., Ierut, L. J. B., Tatham, D. J. S., Hitfield, J. B. W., & Artin, N. G. M. (1997) · Cited by 423
Introduction to Biometrical Genetics
Mather, K., & Jinks, J. L. (1977) · Springer eBooks · doi:10.1007/978-94-009-5787-9 · Cited by 410
Genetic covariation between neuroticism and the symptoms of anxiety and depression
Jardine, R., Martin, N. G., Henderson, A. S., & Rao, D. C. (1984) · Genetic Epidemiology · doi:10.1002/gepi.1370010202 · Cited by 351
Self-citationNonpigmented endometriosis: Clinical, laparoscopic, and pathologic definition
Jansen, R. P. S., & Russell, P. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90136-5 · Cited by 345
Heath, A. C., Cloninger, C. R., & Martin, N. G. (1994) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.66.4.762 · Cited by 314
Self-citationTesting structural equation models for twin data using LISREL
Heath, A. C., Neale, M. C., Hewitt, J. K., Eaves, L. J., & Fulker, D. W. (1989) · Behavior Genetics · doi:10.1007/bf01065881 · Cited by 311
The familial risk of endometriosis
Moen, M. H., & Magnus, P. (1993) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349309058164 · Cited by 248
(1991) · PubMed · Cited by 202
Martin, N. G., & Martin, P. G. (1975) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1975.tb00124.x · Cited by 174
Self-citationAge at menarche as a fitness trait: nonadditive genetic variance detected in a large twin sample.
Treloar, S. A., & Martin, N. G. (1990) · Europe PMC (PubMed Central) · Cited by 173
Self-citationEndometriosis in monozygotic twins
Hadfield, R. M., Mardon, H. J., Barlow, D. H., & Kennedy, S. H. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00359-2 · Cited by 166
Kennedy, S., Mardon, H., & Barlow, D. (1995) · Journal of Assisted Reproduction and Genetics · doi:10.1007/bf02214126 · Cited by 157
Genetics of educational attainment in Australian twins: Sex differences and secular changes
Baker, L. A., Treloar, S. A., Reynolds, C. A., Heath, A. C., & Martin, N. G. (1996) · Behavior Genetics · doi:10.1007/bf02359887 · Cited by 147
Self-citationZygosity Diagnosis of Twins by Questionnaire
Ooki, S., Yamada, K., Asaka, A., & Hayakawa, K. (1990) · Acta geneticae medicae et gemellologiae · doi:10.1017/s0001566000005626 · Cited by 138
Fitting genetic models with LISREL: Hypothesis testing
Neale, M. C., Heath, A. C., Hewitt, J. K., Eaves, L. J., & Fulker, D. W. (1989) · Behavior Genetics · doi:10.1007/bf01065882 · Cited by 134
Dioxin pollution and endometriosis in Belgium
Koninckx, P. R., Braet, P., Kennedy, S., & Barlow, D. H. (1994) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138623 · Cited by 132
Etiology and epidemiology of endometriosis
Barbieri, R. L. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90430-f · Cited by 126
Endometriosis in monozygotic twins
Moen, M. H. (1994) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349409013396 · Cited by 114
Kendler, K. S., Silberg, J. L., Neale, M. C., Kessler, R. C., Heath, A. C., & Eaves, L. J. (1992) · Psychological Medicine · doi:10.1017/s0033291700032761 · Cited by 111
Introduction to Biometrical Genetics
Mather, K., & Jinks, J. L. (1978) · Springer eBooks · doi:10.1007/978-1-4613-3387-6 · Cited by 111
Kennedy, S. (1999) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(98)00213-9 · Cited by 110
Status of current research on endometriosis.
Giudice, L. C., Tazuke, S. I., & Swiersz, L. M. (1998) · PubMed · Cited by 107
Family trait analysis: A case-control study of 43 women with endometriosis and their best friends
Lamb, K., Hoffmann, R. G., & Nichols, T. R. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90608-3 · Cited by 98
Familial inheritance of endometriosis in a British population. A case control study
Coxhead, D., & Thomas, E. J. (1993) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443619309151773 · Cited by 97
Pathways to hysterectomy: Insights from longitudinal twin research
Treloar, S. A., Martin, N. G., Dennerstein, L., Raphael, B., & Heath, A. C. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)91632-9 · Cited by 90
Self-citationRisk factors for endometriosis in the rhesus monkey (Macaca mulatta): a case-control study
Hadfield, R. (1997) · Human Reproduction Update · doi:10.1093/humupd/3.2.109 · Cited by 86
Genes, Culture, and Personality
(1989) · Elsevier eBooks · doi:10.1016/c2009-0-02796-2 · Cited by 81
The Epidemiology of Pelvic Endometriosis
Houston, D. E., Noller, K. L., Melton, L. J., & Selwyn, B. J. (1988) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-198812000-00005 · Cited by 80
Treloar, S. A., Martin, N. G., & Heath, A. C. (1998) · Behavior Genetics · doi:10.1023/a:1021419907305 · Cited by 65
Self-citationTwins reared together: Minimizing shared environmental effects
Grayson, D. A. (1989) · Behavior Genetics · doi:10.1007/bf01066256 · Cited by 64
Age of onset of pain symptoms in non-twin sisters concordant for endometriosis
Kennedy, S., Hadfield, R., Mardon, H., & Barlow, D. (1996) · Human Reproduction · doi:10.1093/humrep/11.2.403 · Cited by 63
Semino, C., Semino, A., Pietra, G., Mingari, M. C., Barocci, S., Venturini, P. L., Ragni, N., & Melioli, G. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57901-1 · Cited by 62
Shin, J.-C., Ross, H. L., Elias, S., Nguyen, D. D., Mitchell‐Leef, D., Simpson, J. L., & Bischoff, F. Z. (1997) · Human Genetics · doi:10.1007/s004390050524 · Cited by 59
The genetics of endometriosis.
Kennedy, S. (1998) · PubMed · Cited by 49
Wardle, P. G., & Hull, M. G. R. (1993) · Baillière s Clinical Obstetrics and Gynaecology · doi:10.1016/s0950-3552(05)80457-2 · Cited by 44
Endometriosis. IV. Hereditary tendency.
RANNEY, B. (1971) · PubMed · Cited by 43
Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin.
Bois, F. Y., & Eskenazi, B. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102476 · Cited by 41
Sexual Activity, Contraception, and Reproductive Factors in Predicting Endometriosis
Darrow, S. L., Selman, S., Batt, R. E., Zielezny, M. A., & Vena, J. E. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117276 · Cited by 37
Silberg, J. L., Martin, N. G., & Heath, A. C. (1987) · Behavior Genetics · doi:10.1007/bf01068137 · Cited by 37
Self-citationOf biases and more in the study of twins reared together: A reply to grayson
Hewitt, J. K. (1989) · Behavior Genetics · doi:10.1007/bf01066257 · Cited by 36
The Current Status of Endometriosis: Research and Management
Donnez, J., & Brosens, I. A. (1993) · DIAL (Catholic University of Leuven) · Cited by 34
EVIDENCE FOR POLYGENIC EPISTATIC INTERACTIONS IN MAN?
Heath, A. C., Martin, N. G., Eaves, L. J., & Loesch, D. Z. (1984) · Genetics · doi:10.1093/genetics/106.4.719 · Cited by 32
Self-citationEndometriosis: genetic and immunologic aspects.
Dmowski, W. P., Braun, D., & Gebel, H. M. (1990) · PubMed · Cited by 29
Immune dysfunction – a potential target for treatment in endometriosis
Gleicher, N. (1995) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1995.tb09158.x · Cited by 21
Minimal and mild endometriosis. Is there anything new under the sun?
Vercellini, P., & Crosignani, P. G. (1993) · PubMed · Cited by 14
Research works printed but not linked: 4
- Dmowski, 1990, Endometriosis, Prog Clin Biol Res, 323, 99
- Treloar, 1990, Age at menarche as a fitness trait, Am J Hum Genet, 47, 137
- Duffy D. Asthma and allergic diseases in Australian twins and their families [thesis]. Brisbane, Australia: University of Queensland, 1994.
- Eaves L. Aspects of human psychogenetics [dissertation]. University of Birmingham, 1970.
Cited by
Sorted by citations
Giudice, L. C., & Kao, L. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17403-5 · Cited by 3,166
Endometriosis is a chronic systemic disease: Clinical challenges and novel innovations
Taylor, H. S., Kotlyar, A. M., & Flores, V. A. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00389-5 · Cited by 1,425
Rethinking mechanisms, diagnosis and management of endometriosis
Chapron, C., Marcellin, L., Borghese, B., & Santulli, P. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0245-z · Cited by 1,084
Simoens, S., Dunselman, G., Dirksen, C., Hummelshoj, L., Bokor, A., Brandes, I., Brodszky, V., Canis, M., Colombo, G. L., DeLeire, T., et al. (2012) · Human Reproduction · doi:10.1093/humrep/des073 · Cited by 1,070
Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00242 · Cited by 844
Metadata
- Authors
- Treloar, S. A., O’Connor, D. T., O’Connor, V. M., & Martin, N. G.
- Affiliations
- QIMR Berghofer Medical Research Institute (AU)
- Corresponding author
- Treloar, Susan A
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 71
- Issue
- 4
- Pages
- 701-710
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2097313599
- Cited by
- 353
- References
- 60
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 11 · 2023: 23 · 2022: 18 · 2021: 18 · 2020: 19 · 2019: 28 · 2018: 19 · 2017: 19 · 2016: 15 · 2015: 13 · 2014: 11 · 2013: 14 · 2012: 11
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Queensland
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, genetic susceptibility, twin concordance, monozygotic twins, dizygotic twins, heritability, prevalence, twin registry, additive genetic effects
- MeSH terms
- Adolescent, Adult, Australia, Diseases in Twins, Endometriosis, Female, Humans, Male, Middle Aged, Models, Genetic, Phenotype, Surveys and Questionnaires, Risk Factors, Twins, Dizygotic, Twins, Monozygotic
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