The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Influence of dietary nitrate on nitrite content of human saliva: Possible relevance to in vivo formation of N-nitroso compounds
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In the citing paper
“Through early cancer research, it was known that up to 25% of circulating nitrate is actively taken up by the salivary glands and concentrated 10-to 20-fold in saliva, but the reason and mechanism for this were unknown, other than its proposed pathologic role in formation of carcinogenic nitrosamines.10”
From Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care (2010) · cites this paper as [10]
In the citing paper
“An enterosalivary circulation of ingested nitrate exists in which, after absorption in the gastrointestinal tract, circulating nitrate is actively secreted in saliva and oral commensal bacteria reduced nitrate to nitrite. 10”
From Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care (2010) · cites this paper as [10]
In the citing paper
“Most estimates suggest that 20-28% of a nitrate load is secreted in saliva [107,113,115,116].”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [116]
In the citing paper
“Ingested inorganic nitrate circulates in the plasma, and a portion (~25 %) is taken up by the salivary glands and concentrated in the saliva [8].”
From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [8]
In the citing paper
“Following ingestion, nitrate is converted in the body to nitrite and stored and circulated in the blood.”
From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [8]
In the citing paper
“Most of the nitrate is then excreted in the urine, while up to 25% of plasma nitrate is taken up by the salivary glands and placed in the enterosalivary circulation (Spiegelhalder et al., 1976).”
From Do Changes in Oral Microbiota Correlate With Plasma Nitrite Response? A Systematic Review (2019) · cites this paper as Spiegelhalder et al., 1976
In the citing paper
“In proportion to the dietary load of nitrate, approximately 25% of total circulating nitrate is actively sequestered into salivary glands and concentrated in saliva up to 20 times that in plasma[73,75,82–88].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [82]
In the citing paper
“Approximately 25% of the absorbed nitrate is delivered to the salivary gland and secreted into saliva in the oral cavity [21]”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [21]
In the citing paper
“reductions of nitrate to nitrite depend entirely on oral commensal bacteria, and individual differences in microflora may affect nitrate reduction (61, 86, 174).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [174]
In the citing paper
“As such, nitrate dependent nitrite production is predominantly generated from the enterosalivary circulatory system delivery of nitrate to the oral cavity where it is reduced by commensal bacteria nitrate reductase activity present in the digestive system (Figure 2) [49–53].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [51]
In the citing paper
“Dietary NO3− supplementation has been observed to elevate nitric oxide (NO) bioavailability via the reduction of exogenous NO3− to nitrite (NO2−) by commensal anaerobic bacteria in the oral cavity [79], followed by the one-electron reduction of NO2− to NO (and other nitrogen intermediates) catalyzed by various NO2− reductases [80,81,82,83,84] in the tissue and blood.”
From Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review (2020) · cites this paper as [79]
Citations
Cites
Formation of N-nitroso compounds: Chemistry, kinetics, and in vivo occurrence
Mirvish, S. S. (1975) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(75)90255-0 · Cited by 779
The effect of nitrate intake on nitrite formation in human saliva
Tannenbaum, S. R., Weisman, M., & Fett, D. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80006-5 · Cited by 381
Relative significance of dietary sources of nitrate and nitrite
White, J. W. (1975) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60201a034 · Cited by 267
Nitrite in Human Saliva. Its Possible Relationship to Nitrosamine Formation23
Tannenbaum, S. R., Sinskey, A. J., Weisman, M., & Bishop, W. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.1.79 · Cited by 237
N -Nitrosation by Nitrite Ion in Neutral and Basic Medium
Keeper, L. K., & Roller, P. P. (1973) · Science · doi:10.1126/science.181.4106.1245 · Cited by 191
Vesell, E. S., Passananti, G. T., Glenwright, P. A., et al. (1975) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1975183259 · Cited by 116
Effect of thiocyanate on nitrosation of amines
Boyland, E. J., & WALKER, S. A. (1974) · Nature · doi:10.1038/248601a0 · Cited by 87
Nitrate Reduction in Whole Saliva
Goaz, P. W., & Biswell, H. A. (1961) · Journal of Dental Research · doi:10.1177/00220345610400022201 · Cited by 53
Studies on In Vivo Formation of Nitroso Compounds (II)
ISHIWATA, H., Boriboon, P., Nakamura, Y., Harada, M., TANIMURA, A., & Ishidate, M. (1975) · Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) · doi:10.3358/shokueishi.16.19 · Cited by 32
Studies on In Vivo Formation of Nitroso Compounds (III)
ISHIWATA, H., TANIMURA, A., & Ishidate, M. (1975) · Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) · doi:10.3358/shokueishi.16.89 · Cited by 31
Studies on In Vivo Formation of Nitroso Compounds (I)
Harada, M., ISHIWATA, H., Nakamura, Y., et al. (1975) · Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) · doi:10.3358/shokueishi.16.11 · Cited by 30
Untersuchungen Über den Nitritgehalt des Speichels, des Magensaftes und des Harnes
Várady, J., & Szántó, G. (1940) · Journal of Molecular Medicine · doi:10.1007/bf02071933 · Cited by 17
Studies on In Vivo Formation of Nitroso Compounds (IV)
ISHIWATA, H., Boriboon, P., Harada, M., TANIMURA, A., & Ishidate, M. (1975) · Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) · doi:10.3358/shokueishi.16.93 · Cited by 14
Nitrosamine formation in the presence of carbonyl compounds.
Mc, A., Tannenbaum, S. R., & Js, W. (1976) · PubMed · Cited by 8
Miller, M. C., Biswell, H. A., & Goaz, P. W. (1962) · Journal of Dental Research · doi:10.1177/00220345620410030701 · Cited by 5
Micellar catalysis of nitrosamine formation.
Okun, J. D., & Mc, A. (1976) · PubMed · Cited by 4
Goaz, P. W., Biswell, H. A., & Miller, M. C. (1964) · Journal of Dental Research · doi:10.1177/00220345640430031001 · Cited by 2
Research works printed but not linked: 4
- Sander, 1971, Untersuchungen über die Entstehung cancerogener Nitrosoverbindungen im Magen von Versuchstieren und ihre Bedeutung für den Menschen. 1., 2. & 3. Mitteil, Arzneimittel-Forsch, 21, 1572
- Sander, 1971, Untersuchungen über die Entstehung cancerogener Nitrosoverbindungen im Magen von Versuchstieren und ihre Bedeutung für den Menschen. 1., 2. & 3. Mitteilung, Arzneimittel-Forsch, 21, 1707
- Sander, 1971, Untersuchungen über die Entstehung cancerogener Nitrosoverbindungen im Magen von Versuchstieren und ihre Bedeutung für den Menschen. 1., 2. & 3. Mitteilung, Arzneimittel-Forsch, 21, 2034
- Stephany, 1975, De Aanwezigheid van Nitriet in Menselijk Speeksel en het N-Nitrosamine Probleem. Berichten uit het Rijksinstituut voor de Volksgezondheid, 33/34 Utrecht; waar, Liber Amicorum, 184
Cited by
Sorted by citations
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739
Drinking Water Nitrate and Human Health: An Updated Review
Ward, M., Jones, R., Brender, J., De Kok, T., Weyer, P., Nolan, B., Villanueva, C., & Van Breda, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15071557 · Cited by 1,576
Webb, A. J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103523 · Cited by 1,078
Food sources of nitrates and nitrites: The physiologic context for potential health benefits
Hord, N. G., Tang, Y., & Bryan, N. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27131 · Cited by 1,069
Nitrate in vegetables: toxicity, content, intake and EC regulation
Santamaria, P. (2006) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2351 · Cited by 1,064
Metadata
- Authors
- Spiegelhalder, B., Eisenbrand, G., & Preussmann, R.
- Affiliations
- German Cancer Research Center (DE)
- ORCID
- Eisenbrand, G.
- Venue
- Food and Cosmetics Toxicology
- Publisher
- Elsevier BV
- Published
- 1976-01
- Volume
- 14
- Issue
- 6
- Pages
- 545-548
- ISSN
- 0015-6264 (ISSN-L)
- OpenAlex
- W2043562592
- Cited by
- 596
- References
- 17
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 12 · 2023: 13 · 2022: 32 · 2021: 17 · 2020: 8 · 2019: 21 · 2018: 18 · 2017: 31 · 2016: 25 · 2015: 25 · 2014: 24 · 2013: 21 · 2012: 23
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Cosmetics Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- dietary nitrate, salivary nitrite, salivary nitrate, N-nitroso compounds, nitrite production, vegetables, vegetable juice, nitrate ingestion, endogenous nitrosation, gastrointestinal tract
- MeSH terms
- Adult, Diet, Humans, Nitrates, Nitrites, Nitroso Compounds, Saliva, Time Factors, Vegetables
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