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Cited by 142Gastrointestinal motility and disordersPelvic floor disorders treatmentsGastroesophageal reflux and treatments

Lower functional gastrointestinal disorders: evidence of abnormal colonic transit in a 287 patient cohort

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manabe, n., wong, b. s., camilleri, m., burton, d., mckinzie, s., zinsmeister, a. r.·2010·Neurogastroenterology & Motility
DOI 10.1111/j.1365-2982.2009.01442.xPMC PMC2852497
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Abstract

BACKGROUND Abnormalities of colonic motility were reported in relatively small studies of patients with lower functional gastrointestinal disorders (FGID) including irritable bowel syndrome (IBS). The influence of gender and body mass on the observed motor pathophysiology is unclear. We sought to compare colonic transit in patients within different lower FGID subgroups and healthy controls, controlling for gender and BMI, and to determine whether BMI independently influences colonic motility. METHODS We evaluated a scintigraphic gastrointestinal and colonic transit database of 287 lower FGID patients associated with constipation (IBS-C, or functional constipation, n = 118), diarrhoea (IBS-D or functional diarrhoea, n = 139) or mixed bowel function (IBS-M, n = 30) and 170 healthy controls. We measured colon filling at 6 h (CF 6 h), and overall colonic transit at 8, 24 and 48 h. KEY RESULTS Colon filling at 6 h did not differentiate health from FGID. Colonic transit was abnormal at 24 h (GC24 of <1.50 or >3.86) in 29.7% of all lower FGID patients. There was a significant overall association between colonic transit and subject group (healthy controls and FGID subgroups) at 8 (P = 0.01), 24 (P < 0.001) and 48 h (P < 0.001) in particular for those with diarrhoea or constipation at 24 and 48 h (P < 0.05), even after adjusting for age, gender and BMI. In addition, BMI was associated with colonic transit after adjusting for age, gender and subject group. CONCLUSIONS & INFERENCES Abnormal transit is documented non-invasively with scintigraphy in 30% of lower FGID patients; transit measurement may help document pathophysiology and inform selection of therapy in lower FGID.

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  • Distinguishing slow-transit constipation from evacuation disorders (e.g., pelvic floor dyssynergia) is a useful first step because confirmatory tests and treatment strategies differ.

    “A useful first step is to distinguish slow-transit constipation from evacuation disorders (e.g., pelvic floor dyssynergia), because confirmatory tests and treatment strategies differ (Manabe et al., 2010; Metcalf et al., 1987).”

    From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Manabe et al., 2010

    The Discussion (page unavailable) says colonic-transit measurements may guide further diagnostic tests and the choice of therapy, including prokinetics for patients with delayed transit. It does not discuss distinguishing slow-transit constipation from evacuation disorders or specify different confirmatory tests and treatments for those disorders. (LLM, conf=0.82)

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  1. Bharucha AE Camilleri M Haydock S Effects of a serotonin 5-HT(4) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans Gut 2000 47 667 74 11034583 PMC1728108
  2. Viramontes BE Camilleri M McKinzie S Gender-related differences in slowing colonic transit by a 5-HT3 antagonist in subjects with diarrhea-predominant irritable bowel syndrome Am J Gastroenterol 2001 96 2671 6 11569693
  3. Viramontes BE Malcolm A Camilleri M Effects of an alpha(2)-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans Am J Physiol Gastrointest Liver Physiol 2001 281 G1468 76 11705752
  4. Delgado-Aros S Chial HJ Camilleri M Effects of a kappa-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans Am J Physiol Gastrointest Liver Physiol 2003 284 G558 66 12631557
  5. Kim HJ Camilleri M McKinzie S A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome Aliment Pharmacol Ther 2003 17 895 904 12656692
  6. Gonenne J Camilleri M Ferber I Effect of alvimopan and codeine on gastrointestinal transit: a randomized controlled study Clin Gastroenterol Hepatol 2005 3 784 91 16234007
  7. Gonenne J Esfandyari T Camilleri M Effect of female sex hormone supplementation and withdrawal on gastrointestinal and colonic transit in postmenopausal women Nuerogastroenterol Motil 2006 18 911 8 16961694
  8. Park MI Ferber I Camilleri M Effect of atilmotin on gastrointestinal transit in healthy subjects: a randomized, placebo-controlled study Neurogastroenterol Motil 2006 18 28 36 16371080
  9. Esfandyari T Camilleti M Ferber I Effect of a cannabinoid agonist on gastrointestinal transit and postprandial satiation in healthy human subjects: a randomized, placebo-controlled study Neurogastroenterol Motil 2006 18 831 8 16918762
  10. Camilleri M Vazquez-Roque MI Burton D Pharmacodynamic effects of a novel prokinetic 5-HT receptor agonist, ATI-7505, in humans Neurogastroenterol Motil 2007 19 30 8 17187586
  11. Andresen V Camilleri M Busciglio IA Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome Gastroenterology 2007 133 761 8 17854590
  12. Grudell AB Camilleri M Jensen KL Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health Am J Physiol Gastrointest Liver Physiol 2008 294 G1114 9 18372395
  13. Sweetser S Camilleri M Linker Nord SJ Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome? Am J Physiol Gastrointest Liver Physiol 2009 296 G1299 306 19342506 PMC2697942
  14. [2]Everhart JE Renault PF Irritable bowel syndrome in office based practice in the United States Gastroenterology 1991 100 988 1005 2001837
  15. [4]Camilleri M Motor function in irritable bowel syndrome Can J Gastroenterol 1999 13 Suppl A 8A 11A 10202201
  16. [5]Harraf F Schmulson M Saba L Subtypes of constipation predominant irritable bowel syndrome based on rectal perception Gut 1998 43 388 394 9863485 PMC1727233
  17. [6]Rao SS Ozturk R De Ocampo S Clinical utility of diagnostic tests for constipation in adults: a systemic review Am J Gastroenterol 2005 100 1605 1615 15984989
  18. [7]Mertz H Naliboff B Mayer EA Symptoms and physiology in severe chronic constipation Am J Gastroenterol 1999 94 131 138 9934743
  19. [8]Camilleri M Zinsmeister AR Towards a relatively inexpensive, noninvasive, accurate test for colonic motility disorders Gastroenterology 1992 103 36 42 1612355
  20. [9]Vassallo M Camilleri M Phillips SF Transit through the proximal colon influences stool weight in the irritable bowel syndrome Gastroenterology 1992 102 102 108 1727743
  21. [10]Flegal KM Carroll MD Odgen CL Prevalence and trends in obesity among US adults, 1999–2000 JAMA 2002 288 1723 1727 12365955
  22. [11]Delgado-Aros S Locke GR Camilleri M Obesity is associated with increased risk of gastrointestinal symptoms: a population-based study Am J Gastroenterol 2004 99 1801 1806 15330922
  23. [12]Talley NJ Howel S Poulton R Obesity and chronic gastrointestinal tract symptoms in young adults: a birth cohort study Am J Gastroenterol 2004 99 1807 1814 15330923
  24. [13]Talley NJ Quan C Jones MP Association of upper and lower gastrointestinal symptoms with body mass index in an Australian cohort Neurogastroenterol Motil 2004 16 413 419 15305996
  25. [14]Proano M Camilleri M Phillips SF Transit of solids through the human colon: regional quantification in the unprepared bowel Am J Physiol 1990 258 G856 G862 2360632
  26. [15]Burton DD Camilleri M Mullan BP Colonic transit scintigraphy labeled activated charcoal compared with ion exchange pellets J Nucl Med 1997 38 1807 1810 9374360
  27. [16]Cremonini F Mullan BP Camilleri M Performance characteristics of scintigraphic transit measurements for studies of experimental therapies Aliment Pharmacol Ther 2002 16 1781 1790 12269971
  28. [17]Bennett EJ Evans P Scott AM Psychological and sex features of delayed gut transit in functional gastrointestinal disorders Gut 2000 46 83 87 10601060 PMC1727796
  29. [18]Bouchoucha M Devroede G Dorval E Different segmental transit times in patients with irritable bowel syndrome and “normal” colonic transit time: is there a correlation with symptoms? Tech Coloproctol 2006 10 287 296 17115321
  30. [19]Sadik R Stotzer PO Simren M Gastrointestinal transit abnormalities are frequently detected in patients with unexplained GI symptoms at a tertiary center Neurogastroenterol Motil 2008 20 197 205 17999649
  31. [20]Cann PA Read NW Brown C Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom pattern Gut 1983 24 405 411 6840614 PMC1419989
  32. [21]Stivland T Camilleri M O’Brien MD Scintigraphic measurement of regional gut transit in idiopathic constipation Gastroenterology 1991 101 107 115 2044899
  33. [22]Debongnie JC Phillips SF Capacity of the human colon to absorb fluid Gastroenterology 1978 74 698 703 631507
  34. [25]Bulpitt CJ Palmer AJ Battersby C Association of symptoms of type II diabetic patients with severity of disease, obesity, and blood pressure Diabetes Care 1998 21 111 115 9538980
  35. [26]Delgado-Aros S Camilleri M Garcia MA High body mass alters colonic sensory-motor function and transit in humans Am J Physiol 2008 295 G382 G388 PMC2519862 18617555
  36. [27]Bertin E Schneider N Abdelli N Gastric emptying is accelerated in obese type 2 diabetic patients without autonomic neuropathy Diabetes Metab 2001 27 357 364 11431601
  37. [28]Verdich C Madsen JL Toubro S Effect of obesity and major weight reduction on gastric emptying Int J Obes Relat Metab Disord 2000 24 899 905 10918538
  38. [29]Miettinen TA Cholesterol production in obesity Circulation 1971 44 842 850 5115077
  39. [30]Reuben A Qureshi Y Murphy GM Effect of obesity and weight reduction on biliary cholesterol saturation and the response to chenodeoxycholic acid Eur J Clin Invest 1986 16 133 42 3089808
  40. [31]Sadik R Abrahamsson H Ung KA Accelerated regional bowel transit and overweight shown in idiopathic bile acid malabsorption Am J Gastroenterol 2004 99 711 718 15089906
  41. [33]Camilleri M McKinzie S Busciglio I Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome Clin Gastroenterol Hepatol 2008 6 772 781 18456567 PMC2495078
  42. [34]Choi MG Camilleri M O’Brien MD Kammer PP Hanson RB A pilot study of motility and tone of the left colon in patients with diarrhea due to functional disorders and dysautonomia Am J Gastroenterol 1997 92 297 302 9040210
  43. [35]Chey WY Jin HO Lee MH Sun SW Lee KY Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea Am J Gastroenterol 2001 96 1499 1506 11374689
  44. [36]Cook IJ Furukawa Y Panagopoulos V Collins PJ Dent J Relationships between spatial patterns of colonic pressure and individual movements of content Am J Physiol 2000 278 G329 G341 10666058
  45. [38]Mearin F Balboa A Badia X Irritable bowel syndrome subtypes according to bowel habit: Revisiting the alternating subtype Eur J Gastroenterol Hepatol 2003 15 165 172 12560761
  46. [40]Mearin F Baró E Roset M Clinical pattern over time in irritable bowel syndrome: Symptom instability and severity variability Am J Gastroenterol 2004 99 113 21 14687152
  47. [42]Heaton KW Radvan J Cripps H Defecation frequency and timing, and stool form in the general population: a prospective study Gut 1992 33 818 824 1624166 PMC1379343
  48. [43]Viramontes BE Camilleri M McKinzie S Gender-related differences in slowing colonic transit by a 5-HT3 antagonist in subjects with diarrhea-predominant irritable bowel syndrome Am J Gastroenterol 2001 96 2671 2676 11569693
  49. [44]Prather CM Camilleri M Zinsmeister AR Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome Gastroenterology 2000 118 463 468 10702196
  50. [45]Bouras EP Camilleri M Burton DD Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder Gastroenterology 2001 120 354 360 11159875
  51. [46]Camilleri M Kerstens R Rykx A A placebo-controlled trial of prucalopride for severe chronic constipation N Engl J Med 2008 29 2344 2354 18509121
  52. [47]Camilleri M Chang L Challenges to the therapeutic pipeline for irritable bowel syndrome: end points and regulatory hurdles Gastroenterology 2008 135 1877 1891 18848833 PMC2671226

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Authors
manabe, N., wong, B. S., camilleri, M., burton, D., mckinzie, S., & zinsmeister, A. R.
Affiliations
Mayo Clinic (US)
Corresponding author
camilleri, m.
ORCID
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2010-03
Volume
22
Issue
3
Pages
293-e82
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
DOI
10.1111/j.1365-2982.2009.01442.x
PMC
PMC2852497
OpenAlex
W2006541740
Cited by
142
References
6
Citations by year
2026: 5 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 14 · 2013: 8 · 2012: 12
FWCI
13.82
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2010 d)
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Mayo Clinic
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK-54681, R01DK054681)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
irritable bowel syndrome, colonic transit, colonic motility, body mass index, gender differences, constipation, functional diarrhea, scintigraphy, gastrointestinal transit
MeSH terms
Adult, Colon, Colonic Diseases, Functional, Constipation, Female, Gastric Emptying, Gastrointestinal Transit, Humans, Male, Sex Factors, Cohort Studies, Chi-Square Distribution, Patient Selection

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