Hydroxymethylglutaryl-coenzyme A reductase inhibition stimulates caspase-1 activity and Th1-cytokine release in peripheral blood mononuclear cells.

Montero, Marı́a Teresa; Hernández, Osvaldo; Suárez, Yajaira; Matilla, Joaquı́n; Ferruelo, Antonio J; Martı́nez-Botas, Javier; Gómez-Coronado, Diego; Lasunción, Miguel A

doi:10.1016/s0021-9150(00)00417-2

Cited by 97Atherosclerosis and Cardiovascular DiseasesInflammasome and immune disordersLipoproteins and Cardiovascular Health

Hydroxymethylglutaryl-coenzyme A reductase inhibition stimulates caspase-1 activity and Th1-cytokine release in peripheral blood mononuclear cells.

Montero, Marı́a Teresa, Hernández, Osvaldo, Suárez, Yajaira, Matilla, Joaquı́n, Ferruelo, Antonio J, Martı́nez-Botas, Javier, Gómez-Coronado, Diego, Lasunción, Miguel A·2000·Atherosclerosis

DOI 10.1016/s0021-9150(00)00417-2

Open this paper in CoChat — free account

Abstract

T cells are prominent components of both early and late atherosclerotic lesions and the role of Th1/Th2 cells subsets in the evolution and rupture of the plaque is currently under investigation. Statins, which are inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase, exert actions beyond that of simply lowering cholesterol levels, and some effects on immune function have been reported. We studied in vitro the effects of fluvastatin on Th1/Th2 cytokine release in relation to caspase-1 activation, in human peripheral-blood mononuclear cells (PBMC) stimulated or not with Mycobacterium tuberculosis. Fluvastatin treatment resulted in the activation of caspase-1 and in a small secretion of interleukin (IL)-1beta, IL-18, and IFNgamma (Th1). In the presence of bacteria, the release of these cytokines was highly increased by the statin in a synergistic way. By contrast, production of IL-12, IL-10 and IL-4 were unaffected by the statin. Not only did mevalonate abolish the effects of the statin but it also prevented the caspase-1 activation induced by the bacteria, suggesting the involvement of isoprenoids in the response to M. tuberculosis. It is proposed that inhibition of HMG-CoA reductase may be immunoprotective by enhancing the Th1 response, which has therapeutical potential not only in atherosclerosis but also in infectious diseases.

Integrity signals

Registry

Crossref · 10.1016/s0021-9150(00)00417-2

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Fluvastatin enhances the Th1 protective response to Mycobacterium tuberculosis infection in human peripheral blood mononuclear cells via increased Caspase I activity.
“in a study investigating the in vitro role of fluvastatin in Mycobacterium tuberculosis infection in human peripheral blood mononuclear cells, fluvastatin was found to enhance the Th1 protective response to the infection (Montero et al., 2000). The proposed mechanism for this effect was an increased activity of Caspase I.”
From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as Montero et al., 2000

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Thornberry, N., Bull, H., Calaycay, J., Chapman, K., Howard, A., Kostura, M., Miller, D. K., Molineaux, S., Weidner, J., Auniņš, J., et al. (1992) · Nature · doi:10.1038/356768a0 · Cited by 2,725 · see citing works
Atherosclerosis: Basic Mechanisms
Berliner, J. A., Navab, M., Fogelman, A. M., Frank, J. S., Demer, L. L., Edwards, P. A., Watson, A. D., & Lusis, A. J. (1995) · Circulation · doi:10.1161/01.cir.91.9.2488 · Cited by 1,726 · see citing works
Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production
Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A. B., Quintal, L. J., Sekut, L., Talanian, R. V., Paskind, M. P., et al. (1997) · Nature · doi:10.1038/386619a0 · Cited by 1,204 · see citing works
Monocyte deactivation in septic patients: Restoration by IFN-γ treatment
Döcke, W.-D., Randow, F., Syrbe, U., Krausch, D., Asadullah, K., Reinke, P., Volk, H.-D., & Kox, W. (1997) · Nature Medicine · doi:10.1038/nm0697-678 · Cited by 1,190 · see citing works
Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras
Luckman, S. P., Hughes, D. E., Coxon, F. P., Russell, R. G. G., & Rogers, M. J. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.4.581 · Cited by 1,175 · see citing works
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., et al. (1997) · Science · doi:10.1126/science.275.5297.206 · Cited by 1,159 · see citing works
Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines
Frostegård, J., Ulfgren, A., Nyberg, P., Hedin, U., Swedenborg, J., Andersson, U., & Hansson, G. K. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00011-8 · Cited by 1,002 · see citing works
New Concepts about the Mast Cell
Flier, J. S., Underhill, L. H., & Galli, S. J. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301283280408 · Cited by 991 · see citing works
Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme
Ray, C. A., Black, R. A., Kronheim, S. R., Greenstreet, T. A., Sleath, P. R., Salvesen, G. S., & Pickup, D. J. (1992) · Cell · doi:10.1016/0092-8674(92)90223-y · Cited by 977 · see citing works
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
Enari, M., Talanian, R. V., Wrong, W. W., & Nagata, S. (1996) · Nature · doi:10.1038/380723a0 · Cited by 958 · see citing works
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.
Gupta, S. K. S., Pablo, A. M., Jiang, X., Wang, N., Tall, A. R., & Schindler, C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119465 · Cited by 863 · see citing works
Infiltrates of Activated Mast Cells at the Site of Coronary Atheromatous Erosion or Rupture in Myocardial Infarction
Kovanen, P. T., Kaartinen, M., & Paavonen, T. (1995) · Circulation · doi:10.1161/01.cir.92.5.1084 · Cited by 615 · see citing works
Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells.
Amento, E. P., Ehsani, N., Palmer, H., & Libby, P. (1991) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.11.5.1223 · Cited by 609 · see citing works
Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages.
Pahan, K., Sheikh, F. G., Namboodiri, A. M., & Singh, I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119812 · Cited by 571 · see citing works
Regulation of interferon-γ production by IL-12 and IL-18
Okamura, H., Kashiwamura, S., Tsutsui, H., Yoshimoto, T., & Nakanishi, K. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80163-5 · Cited by 523 · see citing works
IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
Kohno, K., Kataoka, J., Ohtsuki, T., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.4.1541 · Cited by 521 · see citing works
Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.
Uyemura, K., Demer, L. L., Castle, S. C., Jullien, D., Berliner, J. A., Gately, M. K., Warrier, R. R., Pham, N., Fogelman, A. M., & Modlin, R. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118650 · Cited by 427 · see citing works
Interferon-γ: Biology and Role in Pathogenesis
Billiau, A. (1996) · Advances in immunology · doi:10.1016/s0065-2776(08)60428-9 · Cited by 417 · see citing works
Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice.
Zhou, X., Paulsson, G. B., Stemme, S., & Hansson, G. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1216 · Cited by 414 · see citing works
HMG-CoA Reductase Inhibitors Decrease CD11b Expression and CD11b-Dependent Adhesion of Monocytes to Endothelium and Reduce Increased Adhesiveness of Monocytes Isolated From Patients With Hypercholesterolemia
Weber, C., Erl, W., Weber, K. S. C., & Weber, P. C. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00324-0 · Cited by 411 · see citing works
Is atherosclerosis an immunologically mediated disease?
Wick, G., Schett, G. A., Amberger, A., Kleindienst, R., & Xu, Q. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80067-0 · Cited by 398 · see citing works
Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells
Puren, A. J., Fantuzzi, G., & Dinarello, C. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2256 · Cited by 379 · see citing works
Vastatins Inhibit Tissue Factor in Cultured Human Macrophages
Colli, S., Eligini, S., Lalli, M., Camera, M., Paoletti, R., & Tremoli, E. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.2.265 · Cited by 348 · see citing works
Association Between Myocardial Infarction and the Mast Cells in the Adventitia of the Infarct-Related Coronary Artery
Laine, P., Kaartinen, M., Penttilä, A., Panula, P., Paavonen, T., & Kovanen, P. T. (1999) · Circulation · doi:10.1161/01.cir.99.3.361 · Cited by 343 · see citing works
IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha
Howard, A. D., Kostura, M. J., Thornberry, N. A., DING, G. J.-F., Limjuco, G. A., Weidner, J. R., Salley, J. P., Hogquist, K. A., Chaplin, D., & Mumford, R. A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.9.2964 · Cited by 323 · see citing works
The Role of Interleukin 12 in the Development of Atherosclerosis in ApoE-Deficient Mice
Lee, T., Yen, H.-C., Pan, C., & Chau, L. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.734 · Cited by 311 · see citing works
Expression of Interleukin-10 in Advanced Human Atherosclerotic Plaques
Mallat, Z., Heymes, C., Ohan, J., Faggin, E., Lesèche, G., & Tedgui, A. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.611 · Cited by 265 · see citing works
Interferon-gamma inhibits scavenger receptor expression and foam cell formation in human monocyte-derived macrophages.
Geng, Y., & Hansson, G. K. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115718 · Cited by 265 · see citing works
IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice.
Bohn, E., Sing, A., Zumbihl, R., Bielfeldt, C., Okamura, H., Kurimoto, M., Heesemann, J., & Autenrieth, I. B. (1998) · PubMed · Cited by 230 · see citing works
Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP.
Marcelli, M., Cunningham, G. R., Haidacher, S. J., Padayatty, S. J., Sturgis, L., Kagan, C., & Denner, L. A. (1998) · PubMed · Cited by 210 · see citing works
[43] Interleukin-1β converting enzyme
Thornberry, N. A. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)44045-x · Cited by 204 · see citing works
IL-18 (IFN-γ-Inducing Factor) Regulates Early Cytokine Production in, and Promotes Resolution of, Bacterial Infection in Mice
Bohn, E., Sing, A., Zumbihl, R., Bielfeldt, C., Okamura, H., Kurimoto, M., Heesemann, J., & Autenrieth, I. B. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.1.299 · Cited by 204 · see citing works
THE PATHOGENESIS OF TUBERCULOSIS
Rook, G. A. W., & Hernández‐Pando, R. (1996) · Annual Review of Microbiology · doi:10.1146/annurev.micro.50.1.259 · Cited by 175 · see citing works
Cell-mediated immunity in atherosclerosis
Hansson, G. K. (1997) · Current Opinion in Lipidology · doi:10.1097/00041433-199710000-00009 · Cited by 171 · see citing works
Lipopolysaccharide Activates Caspase-1 (Interleukin-1–Converting Enzyme) in Cultured Monocytic and Endothelial Cells
Schumann, R. R., Belka, C., Reuter, D., Lamping, N., Kirschning, C. J., Weber, J. R., & Pfeil, D. (1998) · Blood · doi:10.1182/blood.v91.2.577 · Cited by 165 · see citing works
The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages
Hilbi, H., Chen, Y., Thirumalai, K., et al. (1997) · Infection and Immunity · doi:10.1128/iai.65.12.5165-5170.1997 · Cited by 164 · see citing works
Inhibition of the mevalonate pathway: benefits beyond cholesterol reduction?
Massy, Z. A., Keane, W. F., & Kasiske, B. L. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90217-2 · Cited by 161 · see citing works
Localization of T lymphocytes and macrophages expressing IL-1, IL-2 receptor, IL-6 and TNF in human aortic intima. Role of cell-mediated immunity in human atherogenesis
Kishikawa, H., Shimokama, T., & Watanabe, T. (1993) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01606532 · Cited by 159 · see citing works
T lymphocytes inhibit the vascular response to injury.
Hansson, G. K., Holm, J., Holm, S., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10530 · Cited by 152 · see citing works
Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation
Chakrabarti, R., & Engleman, E. G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98884-8 · Cited by 145 · see citing works
IL-18 Promotes Type 1 Cytokine Production from NK Cells and T Cells in Human Intracellular Infection
García, V., Uyemura, K., Sieling, P. A., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.10.6114 · Cited by 140 · see citing works
Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursors
Shalhoub, V., Faust, J., Boyle, W. J., Dunstan, C. R., Kelley, M., Kaufman, S., Scully, S. A., Van, G. Y., & Lacey, D. L. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990201)72:2 · Cited by 123 · see citing works
Atypical Atrioventricular Node Reciprocating Tachycardia Masquerading as Tachycardia Using a Left-Sided Accessory Pathway
Hwang, C., Martin, D. J., Goodman, J. S., et al. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00114-9 · Cited by 121 · see citing works
Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite
Makkonen, N., Salminen, A., Rogers, M. J., et al. (1999) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(98)00065-7 · Cited by 113 · see citing works
Interleukin-12 secretion by Mycobacterium tuberculosis-infected macrophages
Ladel, C. H., Szalay, G., Riedel, D., et al. (1997) · Infection and Immunity · doi:10.1128/iai.65.5.1936-1938.1997 · Cited by 96 · see citing works
Human Th1 cells preferentially induce interleukin (IL)‐1β while Th2 cells induce IL‐1 receptor antagonist production upon cell/cell contact with monocytes
Chizzolini, C., Chicheportiche, R., Burger, D., & Dayer, J. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270125 · Cited by 89 · see citing works
Protein Synthesis Is Required for Caspase Activation and Induction of Apoptosis by Bisphosphonate Drugs
Coxon, F. P., Benford, H. L., Russell, R. G. G., et al. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13063-5 · Cited by 89 · see citing works
Dissociation of IL-1 beta synthesis and secretion in human blood monocytes stimulated with bacterial cell wall products.
Chin, J. E., & Kostura, M. J. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.10.5574 · Cited by 83 · see citing works
Cytokine Modulation of LDL Oxidation by Activated Human Monocytes
Folcik, V. A., Aamir, R., & Cathcart, M. K. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.1954 · Cited by 79 · see citing works
Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro
Mönkkönen, J., Similä, J., & Rogers, M. J. (1998) · Life Sciences · doi:10.1016/s0024-3205(97)01178-8 · Cited by 79 · see citing works
Tissue inhibitors of metalloproteinases and metalloproteinases in atherosclerosis
George, S. J. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199810000-00005 · Cited by 76 · see citing works
The mechanism of cell death in Listeria monocytogenes-infected murine macrophages is distinct from apoptosis
Barsig, J., & Kaufmann, S. H. E. (1997) · Infection and Immunity · doi:10.1128/iai.65.10.4075-4081.1997 · Cited by 73 · see citing works
Regression of arteriosclerotic lesions induced by immunization with heat shock protein 65-containing material in normocholesterolemic, but not hypercholesterolemic, rabbits
Xu, Q., Kleindienst, R., Schett, G. A., et al. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05800-5 · Cited by 69 · see citing works
Fas-Mediated Stimulation Induces IL-8 Secretion by Rheumatoid Arthritis Synoviocytes Independently of CPP32-Mediated Apoptosis
Sekine, C., Yagita∥, H., Kobata, T., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1610 · Cited by 63 · see citing works
Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells
Terkeltaub, R. A., Solan, J. L., Barry, M. E., Santoro, D. A., & Bokoch, G. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.6.749 · Cited by 55 · see citing works
Prenyltransferase Inhibitors Induce Apoptosis in Proliferating Thyroid Cells through a p53-Independent, CrmA-Sensitive, and Caspase-3-Like Protease- Dependent Mechanism1
Vitale, M., Matola, T. D., Rossi, G., et al. (1999) · Endocrinology · doi:10.1210/endo.140.2.6494 · Cited by 45 · see citing works
Interleukin‐1β converting enzyme
Reiter, L. A., & Martin, J. J. (1993) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1993.tb00467.x · Cited by 43 · see citing works
Transformation-specific secreted phosphoproteins
Senger, D. R., Wirth, D. F., & Hynes, R. O. (1980) · Nature · doi:10.1038/286619a0 · Cited by 40 · see citing works
The Role of Mast Cells in Atherosclerosis
Metzler, B., & Xu, Q. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000237636 · Cited by 39 · see citing works
Use of monoclonal antibodies to study interleukin ‐1β‐converting enzyme expression: only precursor forms are detected in interleukin‐1β‐secreting cells
Miossec, C., Decoen, M., Durand, L., et al. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260512 · Cited by 33 · see citing works
Human Cellular Immune Responses to Mycobacterium tuberculosis
Barnes, P. F., & Modlin, R. L. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80166-2_9 · Cited by 28 · see citing works
Flavonoid-Induced Ability of Minimally Modified Low-Density Lipoproteins to Support Lymphocyte Proliferation
Carrero, P., Ortega, H., Martı́nez-Botas, J., et al. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00635-7 · Cited by 24 · see citing works
Self-citation
Effects of activation on lipid and lipoprotein metabolism in murine macrophages.
Kraemer, F. B., Tavangar, K., Gandjei, R. K., Kirlew, K., & Behr, S. R. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.1.8 · Cited by 23 · see citing works
Editorial
Rossen, R. D. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00325-2 · Cited by 22 · see citing works
New developments in the use of cytokines for cancer therapy.
Maini, A., Morse, P., Cy, W., et al. (1998) · PubMed · Cited by 11 · see citing works
Prenyltransferase Inhibitors Induce Apoptosis in Proliferating Thyroid Cells through a p53-Independent, CrmA-Sensitive, and Caspase-3-Like Protease- Dependent Mechanism
Vitale, M. (1999) · Endocrinology · doi:10.1210/en.140.2.698 · Cited by 10 · see citing works
Effect of HMG CoA reductase inhibition on TGF-beta 1 mRNA expression in diabetic rat glomeruli.
Dc, H., Jh, K., Mk, C., et al. (1995) · PubMed · Cited by 9 · see citing works
Down-modulation of mycobacterial-induced IL-1β production in human mononuclear cells by IL-4
Méndez‐Samperio, P., Hernández-Garay, M., Badillo-Flores, A., et al. (1996) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1996.06695.x · Cited by 7 · see citing works
Atherosclerosis and the Immune System
Niculescu, F. I., & Rus, H. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.3.315 · Cited by 5 · see citing works
[Kinetics of vascular wall cells and atherogenesis].
Nagornev, V. A. (1998) · PubMed · Cited by 1 · see citing works
Correspondence
Seely, S. (1998) · International Journal of Cardiology · doi:10.1016/s0167-5273(98)00246-0 · Cited by 1 · see citing works

Flagged first, then by citations

Sorted by citations

Targeting inflammation in the treatment of type 2 diabetes: time to start
Donath, M. Y. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4275 · Cited by 690 · see citing works
Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways
Koushki, K., Shahbaz, S. K., Mashayekhi, K., Sadeghi, M., Zayeri, Z. D., Taba, M. Y., Banach, M., Al-Rasadi, K., Johnston, T. P., & Sahebkar, A. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08791-9 · Cited by 382 · see citing works
The role of interleukin-18 in the metabolic syndrome
Trøseid, M., Seljeflot, I., & Arnesen, H. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-11 · Cited by 155 · see citing works
Antimicrobial and Immunomodulatory Attributes of Statins: Relevance in Solid‐Organ Transplant Recipients
Sun, H., & Singh, N. (2009) · Clinical Infectious Diseases · doi:10.1086/597039 · Cited by 65 · see citing works
Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice
Rahal, E. A., Constantin, W. N., Zeidan, N., & Abdelnoor, A. M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01474 · Cited by 14 · see citing works
Repurposing of statins for Buruli Ulcer treatment: antimicrobial activity against Mycobacterium ulcerans
Dominguez, J., Mendes, A. I., Pacheco, A. R., Peixoto, M. J., Pedrosa, J., & Fraga, A. G. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1266261 · Cited by 4 · see citing works

Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages
Bernini, F., Didoni, G., Bonfadini, G., Bellosta, S., & Fumagalli, R. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90172-q · Cited by 79 · see citing works
Regulation of cytochrome P450 expression by inhibitors of hydroxymethylglutaryl-coenzyme A reductase in primary cultured rat hepatocytes and in rat liver.
Kocarek, T. A., & Reddy, A. B. (1996) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)08451-x · Cited by 42 · see citing works
Regulation of rat liver cell 3-hydroxy-3-methylglutaryl coenzyme A reductase by methoxypolyoxyethylated cholesterol
Martin, G. G., & Shapiro, D. J. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90239-5 · Cited by 4 · see citing works
Biosynthesis and characterization of (S)-and (R)-3-hydroxy-3-methylglutaryl coenzyme A
Bischoff, K. M., & Rodwell, V. W. (1992) · Biochemical Medicine and Metabolic Biology · doi:10.1016/0885-4505(92)90060-c · Cited by 28 · see citing works
Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase
Kita, T., Brown, M. S., & Goldstein, J. L. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109938 · Cited by 306 · see citing works

Authors: Montero, M. T., Hernández, O., Suárez, Y., Matilla, J., Ferruelo, A. J., Martı́nez-Botas, J., Gómez-Coronado, D., & Lasunción, M. A.
Affiliations: Hospital Universitario Ramón y Cajal (ES)
Universidad de Alcalá (ES)
Corresponding author: Lasunción, Miguel A
ORCID: Suárez, Yajaira
Matilla, Joaquı́n
Ferruelo, Antonio J
Martı́nez-Botas, Javier
Lasunción, Miguel A
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2000-12
Volume: 153
Issue: 2
Pages: 303-313
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/s0021-9150(00)00417-2
OpenAlex: W2084961971
Cited by: 97
References: 73
Citations by year: 2026: 2 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 3 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 3
FWCI: 0.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords: HMG-CoA reductase inhibition, statins, fluvastatin, caspase-1 activation, Th1 cytokines, Th1/Th2 balance, peripheral blood mononuclear cells, Mycobacterium tuberculosis, IL-1β, IL-18, interferon-gamma, mevalonate, terpenoids, immunomodulation
MeSH terms: Fluvastatin, Fatty Acids, Monounsaturated, Humans, Hydroxymethylglutaryl CoA Reductases, Indoles, Leukocytes, Mononuclear, Cytokines, Th1 Cells, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Caspase 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hydroxymethylglutaryl-coenzyme A reductase inhibition stimulates caspase-1 activity and Th1-cytokine release in peripheral blood mononuclear cells.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks