The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication
Abstract
In patients with intermittent claudication, exercise is associated with a marked increase in oxidative stress, likely responsible for systemic endothelial perturbation. In 31 claudicant patients, we assessed the effect of vitamin C administration on the acute changes induced by maximal and submaximal exercise in endothelium-dependent, flow-mediated dilation (FMD), and in plasma levels of thiobarbituric acid-reactive substances (TBARS) and soluble intercellular adhesion molecule-1 (sICAM-1). In 16 claudicants, maximal exercise reduced FMD (from 8.5+/-0.9 to 3.7+/-0.8%, P<0.01), and increased plasma levels of TBARS (from 1.93+/-0.06 to 2.22+/-0.1 nmol/ml, P<0.02) and of sICAM-1 (from 282+/-17 to 323+/-19 ng/ml, P<0.01). In eight of these patients, randomized to vitamin C, exercise-induced changes in FMD and biochemistry were abolished. This beneficial effect was not observed in the eight patients randomized to saline. In 15 patients, who walked until the onset of claudication pain (submaximal exercise), and in ten control subjects, who performed maximal exercise, no changes were observed with exercise. Thus, in claudicants, vitamin C prevents the acute, systemic impairment in endothelial function induced by maximal exercise. This finding provides a rationale for trials investigating antioxidant therapy and cardiovascular risk in patients with intermittent claudication.
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“superoxide radicals produced as a consequence of intense exercise may directly remove NO (Li and Forstermann 2000; Silvestro et al. 2002).”
From Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure (2016) · cites this paper as Silvestro et al. 2002
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Metadata
- Authors
- Silvestro, A., Scopacasa, F., Oliva, G., de Cristofaro, T., Iuliano, L., & Brevetti, G.
- Affiliations
- Federico II University Hospital (IT)
- Sapienza University of Rome (IT)
- Corresponding author
- Silvestro, Antonio
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 165
- Issue
- 2
- Pages
- 277-283
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2069490874
- Cited by
- 159
- References
- 43
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 1 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 14 · 2013: 11 · 2012: 17
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- vitamin C, intermittent claudication, endothelial dysfunction, acute exercise, oxidative stress, flow-mediated dilation, TBARS, soluble intercellular adhesion molecule-1, antioxidant therapy, peripheral arterial disease, submaximal exercise
- MeSH terms
- Antioxidants, Ascorbic Acid, Brachial Artery, Endothelium, Vascular, Exercise Test, Female, Humans, Intermittent Claudication, Male, Middle Aged, Vasodilation, Exercise, Treatment Outcome, Oxidative Stress, Intercellular Adhesion Molecule-1
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