The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication
Abstract
In patients with intermittent claudication, exercise is associated with a marked increase in oxidative stress, likely responsible for systemic endothelial perturbation. In 31 claudicant patients, we assessed the effect of vitamin C administration on the acute changes induced by maximal and submaximal exercise in endothelium-dependent, flow-mediated dilation (FMD), and in plasma levels of thiobarbituric acid-reactive substances (TBARS) and soluble intercellular adhesion molecule-1 (sICAM-1). In 16 claudicants, maximal exercise reduced FMD (from 8.5+/-0.9 to 3.7+/-0.8%, P<0.01), and increased plasma levels of TBARS (from 1.93+/-0.06 to 2.22+/-0.1 nmol/ml, P<0.02) and of sICAM-1 (from 282+/-17 to 323+/-19 ng/ml, P<0.01). In eight of these patients, randomized to vitamin C, exercise-induced changes in FMD and biochemistry were abolished. This beneficial effect was not observed in the eight patients randomized to saline. In 15 patients, who walked until the onset of claudication pain (submaximal exercise), and in ten control subjects, who performed maximal exercise, no changes were observed with exercise. Thus, in claudicants, vitamin C prevents the acute, systemic impairment in endothelial function induced by maximal exercise. This finding provides a rationale for trials investigating antioxidant therapy and cardiovascular risk in patients with intermittent claudication.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“superoxide radicals produced as a consequence of intense exercise may directly remove NO (Li and Forstermann 2000; Silvestro et al. 2002).”
From Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure (2016) · cites this paper as Silvestro et al. 2002
Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
[42] Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal
Esterbauer, H., & Cheeseman, K. H. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86134-h · Cited by 3,360
Mortality over a Period of 10 Years in Patients with Peripheral Arterial Disease
Criqui, M. H., Langer, R. D., Fronek, A., Feigelson, H. S., Klauber, M. R., McCann, T. J., & Browner, D. (1992) · New England Journal of Medicine · doi:10.1056/nejm199202063260605 · Cited by 2,579
Stephens, N. G., Parsons, A., Brown, M. J., Schofield, P. M., Kelly, F., Cheeseman, K., & Mitchinson, M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90866-1 · Cited by 2,148
Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00327-4 · Cited by 2,033 · cited 1×
“Brachial artery endotheliumdependent vasodilation is mediated by nitric oxide [17], correlates well with the coronary artery response to acetylcholine [18], is impaired in the presence of classical risk factors also in the absence of overt atherosclerotic disease [19], and the degree of impairment is related to degree…”
BackgroundVitamin E Supplementation and Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420302 · Cited by 1,957
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870
Joannidès, R., Haefeli, W. E., Linder, L., Richard, V. J., Bakkali, E. H., Thuillez, C., & Lüscher, T. F. (1995) · Circulation · doi:10.1161/01.cir.91.5.1314 · Cited by 1,622
Antioxidants and Atherosclerotic Heart Disease
Diaz, M. N., Frei, B. B., Vita, J. A., & Keaney, J. F. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708073370607 · Cited by 1,353
Cited by
Sorted by citations
Exercise for intermittent claudication
Lane, R., Harwood, A. E., Watson, L. C., & Leng, G. C. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000990.pub4 · Cited by 864
Acute exercise and oxidative stress: a 30 year history
Fisher‐Wellman, K. H., & Bloomer, R. J. (2009) · Dynamic Medicine · doi:10.1186/1476-5918-8-1 · Cited by 684
“These investigations have typically noted an exacerbation in oxidative stress in diseased subjects compared to healthy controls [60,61,65,74,78,110,319,321].”
BackgroundResultEndothelial Dysfunction and Cardiovascular Risk Prediction in Peripheral Arterial Disease
Brevetti, G., Silvestro, A., Schiano, V., & Chiariello, M. (2003) · Circulation · doi:10.1161/01.cir.0000095273.92468.d9 · Cited by 481
Self-citationRakobowchuk, M., Tanguay, S., Burgomaster, K. A., Howarth, K. R., Gibala, M. J., & MacDonald, M. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00069.2008 · Cited by 335
“This delay before measurement was designed to limit the effects of oxidative stress induced by the final training session on FMD, which has been noted by other researchers following ischemia inducing exercise (30, 41).”
MethodInflammation in Peripheral Artery Disease
Brevetti, G., Giugliano, G., Brevetti, L., & Hiatt, W. R. (2010) · Circulation · doi:10.1161/circulationaha.109.918417 · Cited by 323
Self-citationJuraschek, S. P., Güallar, E., Appel, L. J., & Miller, E. R. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.027995 · Cited by 302
“Moreover, in short-term human trials, vitamin C supplementation has been shown to improve endothelial function of both brachial (74, 75) and coronary (76) arteries.”
BackgroundCirculating markers of endothelial function in cardiovascular disease
Constans, J., & Conri, C. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.030 · Cited by 282
Exercise for intermittent claudication
Watson, L. C., Ellis, B., & Leng, G. C. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000990.pub2 · Cited by 251
Soluble intercellular adhesion molecule-1 (sICAM-1): an overview.
Witkowska, A. M., & Borawska, M. H. (2004) · PubMed · Cited by 231
Mitochondrial defects and oxidative damage in patients with peripheral arterial disease
Pipinos, I. I., Judge, A. R., Zhu, Z. H., Selsby, J. T., Swanson, S. A., Johanning, J. M., Baxter, B. T., Lynch, T. G., & DODD, S. L. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.003 · Cited by 233
Environmental factors and unhealthy lifestyle influence oxidative stress in humans—an overview
Aseervatham, G. S. B., Thilagar, S., Jeyadevi, R., & Ananth, D. A. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1748-0 · Cited by 239
“…consumption Diabetes mellitus Hassan et al. (2002) Unbalanced exercise Intermittent claudication, diabetes, obesity, hypercholesterolemia Silvestro et al. (2002); Davison et al. (2002); Radak et al. (2001); Chen et al. (1994); Vincent et al. (2005) beta-nitrate esters, beta-carbonyl,…”
Effects of acute exercise on flow-mediated dilatation in healthy humans
Dawson, E. A., GREEN, D. J., Cable, N. T., & Thijssen, D. H. J. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00450.2013 · Cited by 207
Ashor, A. W., Lara, J., Mathers, J. C., & Siervo, M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.04.004 · Cited by 197
A Review of the Pathophysiology and Potential Biomarkers for Peripheral Artery Disease
Krishna, S. M., Moxon, J. V., & Golledge, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160511294 · Cited by 179
“Furthermore, plasma levels of ROS components have been reported to be increased in IC patients [52,77].”
BackgroundPipinos, I. I., Judge, A. R., Selsby, J. T., Zhu, Z. H., Swanson, S. A., Nella, A. A., & DODD, S. L. (2008) · Vascular and Endovascular Surgery · doi:10.1177/1538574408315995 · Cited by 177
“In a study comparing maximal exercise (exercise to maximal walking distance) to submaximal exercise (exercise to initial claudication distance), plasma MDA was significantly increased following maximal exercise only.(38) Although most studies measure the stable end products of the reaction between oxidants and either…”
Exercise for intermittent claudication
Lane, R., Ellis, B., Watson, L., & Leng, G. C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000990.pub3 · Cited by 170
Brevetti, G., Silvestro, A., Giacomo, S. D., Bucur, R., Donato, A. D., Schiano, V., & Scopacasa, F. (2003) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(03)00124-1 · Cited by 165
Self-citationBrevetti, G., Schiano, V., & Chiariello, M. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.002 · Cited by 167
“Interestingly, the cute endothelial dysfunction induced in PAD patients by xercise is prevented by the antioxidant vitamin C [6] and c e n H”
BackgroundInfluentialSelf-citationIntermittent claudication: An overview
Meru, A. V., Mittra, S., Thyagarajan, B., & Chugh, A. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.11.027 · Cited by 136
Fisher‐Wellman, K. H., Bell, H. K., & Bloomer, R. J. (2008) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.1.7732 · Cited by 131
Exercise Training and Peripheral Arterial Disease
Haas, T. L., Lloyd, P. G., Yang, H., & Terjung, R. L. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110065 · Cited by 151
The exercise dose affects oxidative stress and brachial artery flow-mediated dilation in trained men
Johnson, B. D., Padilla, J., & Wallace, J. P. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1946-8 · Cited by 124
“Indeed, Vitamin C supplementation attenuates both the increase in oxidative stress and reduction in flowmediated dilation (FMD) following maximal exercise (Silvestro et al. 2002), thus establishing a link between post-exercise ROS and endothelial function.”
InfluentialEffects of Exercise Intensity on Flow Mediated Dilation in Healthy Humans
Birk, G., Dawson, E. A., Batterham, A. M., Atkinson, G., Cable, N. T., Thijssen, D. H. J., & GREEN, D. J. (2012) · International Journal of Sports Medicine · doi:10.1055/s-0032-1323829 · Cited by 122
McGowan, C. L. M., Levy, A. S., Millar, P. J., Guzmán, J. C., Morillo, C. A., McCartney, N., & MacDonald, M. J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01113.2005 · Cited by 121
Weiss, D. J., Casale, G. P., Koutakis, P., Nella, A. A., Swanson, S. A., Zhu, Z. H., Miserlis, D., Johanning, J. M., & Pipinos, I. I. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-230 · Cited by 123
“This finding together with the observation of increased ROS biomarkers in the plasma of PAD patients after a single bout of exerciseinduced claudication [29,30] suggests that damaged electron transport chain complexes and increased ROS production may contribute to the pathophysiology of PAD.”
BackgroundObesity Exacerbates Oxidative Stress Levels after Acute Exercise
Vincent, H. K., MORGAN, J. W., & Vincent, K. R. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000126576.53038.e9 · Cited by 116
Muller, M. D., Drew, R. C., Blaha, C., Mast, J. L., Cui, J. G., Reed, A. B., & Sinoway, L. I. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.241281 · Cited by 112
Skin microcirculation in peripheral arterial obliterative disease
Rossi, M., & Carpi, A. (2004) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2004.08.004 · Cited by 105
Badrov, M. B., Horton, S., Millar, P., & McGowan, C. (2013) · Psychophysiology · doi:10.1111/psyp.12031 · Cited by 93
Vitamin C supplementation for the primary prevention of cardiovascular disease
Al-Khudairy, L., Flowers, N., Wheelhouse, R., Ghannam, O., Hartley, L., Stranges, S., & Rees, K. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011114.pub2 · Cited by 94
Sellami, M., Bragazzi, N. L., Prince, M. S., Denham, J., & Elrayess, M. A. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.652497 · Cited by 91
Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease
Ismaeel, A., Brumberg, R. S., Kirk, J. S., Papoutsi, E., Farmer, P. J., Bohannon, W. T., SMITH, R. S., Eidson, J. L., Sawicki, I., & Koutakis, P. (2018) · Antioxidants · doi:10.3390/antiox7100145 · Cited by 91
“However, when patients received an infusion of 50 mg/min of vitamin C for 20 min prior to exercise, there were no decreases in FMD or elevations in TBARS and sCAM-1, even following maximal exercise [98].”
BackgroundInfluentialFlow-Mediated Dilation Is Acutely Improved after High-Intensity Interval Exercise
Currie, K. D., McKelvie, R. S., & MacDonald, M. J. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318260ff92 · Cited by 82
Vascular Dysfunction and Chronic Obstructive Pulmonary Disease
Ives, S. J., Harris, R. A., Witman, M. A., Fjeldstad, A. S., Garten, R. S., McDaniel, J., Wray, D. W., & Richardson, R. S. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02255 · Cited by 82
“Although we did not see an effect of the acute AOC on TBARS in either group, this lack of an effect agrees with previous work.(35,56) Specifically, such acute treatments may reduce free radicals either through the inhibition of pro-oxidant enzymes (nicotinamide adenine dinucleotide phosphate oxidase or xanthine oxidas…”
ResultSoluble ICAM-1: a marker of vascular inflammation and lifestyle.
Witkowska, A. (2005) · Cytokine · doi:10.1016/j.cyto.2005.04.007 · Cited by 101
Testosterone-Induced Effects on Lipids and Inflammation
Vodo, S., Bechi, N., Petroni, A., Muscoli, C., & Aloisi, A. M. (2013) · Mediators of Inflammation · doi:10.1155/2013/183041 · Cited by 75
“A large body of evidence indicates that, with exercise, limb ischemia evokes an acute systemic response characterized by increased oxidative stress, local and systemic inflammation and endothelial dysfunction [66, 67].”
BackgroundSilvestro, A., Scopacasa, F., Ruocco, A., Oliva, G., Schiano, V., Zincarelli, C., & Brevetti, G. (2003) · Vascular Medicine · doi:10.1191/1358863x03vm503oa · Cited by 75
Self-citationMitochondriopathy of Peripheral Arterial Disease
Makris, K. I., Nella, A. A., Zhu, Z. H., Swanson, S. A., Casale, G. P., Gutti, T. L., Judge, A. R., & Pipinos, I. I. (2007) · Vascular · doi:10.2310/6670.2007.00054 · Cited by 72
Impact of sympathetic nervous system activity on post‐exercise flow‐mediated dilatation in humans
Atkinson, C. L., Lewis, N. C. S., Carter, H. H., Thijssen, D. H. J., Ainslie, P. N., & GREEN, D. J. (2015) · The Journal of Physiology · doi:10.1113/jp270946 · Cited by 65
“Vascular function and FMD can be modulated by inflammation and oxidative stress and several studies have reported improvements in FMD following treatments that ameliorate oxidation and inflammation (Ellis et al. 2000; Silvestro et al. 2002; Donato et al. 2010; Johnson et al. 2012a,2013; Wray et al. 2012).”
BackgroundROS and NO Dynamics in Endothelial Cells Exposed to Exercise-Induced Wall Shear Stress
Wang, Y.-X., Liu, H.-B., Li, P.-S., Yuan, W.-X., Liu, B., Liu, S.-T., & Qin, K.-R. (2019) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-018-00557-w · Cited by 61
Oxidative stress and antioxidant treatment in patients with peripheral artery disease
Koutakis, P., Ismaeel, A., Farmer, P. J., Purcell, S. T., SMITH, R. S., Eidson, J. L., & Bohannon, W. T. (2018) · Physiological Reports · doi:10.14814/phy2.13650 · Cited by 57
“More recently, administration of 200 mg of vitamin E along with 500 mg of vitamin C for 4 weeks was shown to reduce exercise-associated oxidative stress (Wijnen et al. 2001), as did an intravenous infusion of vitamin C at a dosage of 50 mg/min for 20 min (Silvestro et al. 2002).”
BackgroundArterial dysfunction and functional performance in patients with peripheral artery disease: A review
Coutinho, T. A., Rooke, T. W., & Kullo, I. J. (2011) · Vascular Medicine · doi:10.1177/1358863x11400935 · Cited by 56
Oxidative Stress in Peripheral Arterial Disease (PAD) Mechanism and Biomarkers
Signorelli, S. S., Scuto, S., Marino, E., Xourafa, A., & Gaudio, A. (2019) · Antioxidants · doi:10.3390/antiox8090367 · Cited by 55
Pathophysiology of Peripheral Arterial Disease (PAD): A Review on Oxidative Disorders
Signorelli, S. S., Marino, E., Scuto, S., & Raimondo, D. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124393 · Cited by 56
Tauler, P., Aguiló, A., Gimeno, I., Noguera, A., Agustí, A. G. N., Tur, J. A., & Pons, A. (2003) · Free Radical Research · doi:10.1080/1071576031000150454 · Cited by 54
“These changes have been related to exercise-induced increase in oxidative stress, which were blunted by vitamin C intake.([45]) In a previous work, we evidenced that apnea divers showed lower neutrophil NO production in vitamin C supplemented subjects than in controls after a diving session.”
BackgroundGresele, P., & Momi, S. (2006) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2006.00148.x · Cited by 53
Migliacci, R., Procacci, A., Monte, P. D., Bonizzoni, E., & Gresele, P. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-10-0555 · Cited by 49
“Concerning the apparently small size of the effect observed in our study, the FMD drop induced by maximal exercise we observed was of a similar magnitude (approximately half) of that observed in the only previous study on the effect of a maximal treadmill exercise on brachial artery endothelial function (9) and Nitroa…”
BackgroundResultInfluentialJudge, A. R., & DODD, S. L. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00684.2003 · Cited by 49
Gonzales, J. U., Thompson, B. C., Thistlethwaite, J. R., & Scheuermann, B. W. (2011) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h10-097 · Cited by 47
“2008), cause no change (Silvestro et al. 2002), or decrease (McGowan et al.”
BackgroundHallmark, R. A., Patrie, J. T., Liu, Z., Gaesser, G. A., Barrett, E. J., & WELTMAN, A. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085450 · Cited by 44
“, marathon) [5] exercise may impair endothelial function immediately postexercise and within the first hour postexercise, although health status may play a role [9].”
BackgroundCellular adhesion molecules and peripheral arterial disease
Brevetti, G., Schiano, V., & Massimo Chiariello, A. (2006) · Vascular Medicine · doi:10.1191/1358863x06vm645ra · Cited by 44
Self-citationEffects of acute exercise on endothelial function in patients with abdominal aortic aneurysm
Bailey, T. G., Perissiou, M., Windsor, M., Schulze, K., Nam, M. C. Y., Magee, R., Leicht, A. S., GREEN, D. J., Greaves, K., Golledge, J., et al. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00344.2017 · Cited by 43
Life-style Modification in Peripheral Arterial Disease
Khan, S. A., Cleanthis, M., Smout, J. D., Flather, M. D., & Stansby, G. P. (2004) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2004.09.020 · Cited by 38
Padilla, J., Harris, R. A., & Wallace, J. P. (2007) · Cardiovascular Ultrasound · doi:10.1186/1476-7120-5-45 · Cited by 38
“Subjects have ranged from intercollegiate athletes [24] to apparently healthy adults [19] including pre- and post-menopausal women [18] and habitually sedentary men [20]; and to patients with claudication [17,21,22], renal disease [16], and who are overweight [23].”
InfluentialAlsop, P., & Hauton, D. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3418-7 · Cited by 37
“Indeed, superoxide radicals produced as a consequence of intense exercise may directly remove NO (Li and Forstermann 2000; Silvestro et al. 2002).”
BackgroundJohnson, B. D., Mather, K. J., Newcomer, S. C., Mickleborough, T. D., & Wallace, J. P. (2012) · Cardiovascular Ultrasound · doi:10.1186/1476-7120-10-34 · Cited by 37
“However, observations indicate that augmented oxidative stress is abolished when vitamin C is given prior to several different types of interventions [37-39].”
BackgroundAcute and Chronic Impact of Dynamic Exercise on Arterial Stiffness in Older Hypertensives
Aizawa, K., & Petrella, R. J. (2008) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192400802010003 · Cited by 37
Impact of acute exercise on brachial artery flow-mediated dilatation in young healthy people
Hwang, I., Kim, K., Choi, W. S., Kim, H.-J., Im, M.-S., Kim, Y.-J., Kim, S., Kim, M., Sohn, D., & Zo, J. (2012) · Cardiovascular Ultrasound · doi:10.1186/1476-7120-10-39 · Cited by 37
“Several researchers have reported reduction of FMD immediately after exercise [22-24], while others have reported improvement [25,26].”
BackgroundHusmann, M. J. W., Dörffler-Melly, J., Kalka, C., Diehm, N., Baumgärtner, I., & Silvestro, A. (2008) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2008.06.039 · Cited by 36
Self-citationVascular Function and the Role of Oxidative Stress in Heart Failure, Heart Transplant, and Beyond
Witman, M. A., Fjeldstad, A. S., McDaniel, J., Ives, S. J., Zhao, J., Barrett‐O’Keefe, Z., Nativi, J. N., Stehlik, J., Wray, D. W., & Richardson, R. S. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.193318 · Cited by 36
Gardner, A. W., Parker, D. E., Montgomery, P. S., Blevins, S. M., Teague, A. M., & Casanegra, A. I. (2013) · Angiology · doi:10.1177/0003319713489769 · Cited by 35
The relationship between shear rate and flow‐mediated dilation is altered by acute exercise
Llewellyn, T. L., Chaffin, M. E., Berg, K. E., & Meendering, J. R. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02417.x · Cited by 34
“On the other hand, running a marathon did not affect FMD compared with pre-marathon (Dawson et al. 2008), but maximal aerobic exercise (Silvestro et al. 2002) and intense running in college athletes (Rundell et al. 2007) decreased FMD.”
BackgroundInfluentialVitamin C prevents the acute decline of flow-mediated dilation after altered shear rate patterns
Johnson, B. D., Mather, K. J., Newcomer, S. C., Mickleborough, T. D., & Wallace, J. P. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0169 · Cited by 34
Ozemek, C., Hildreth, K. L., Blatchford, P. J., Hurt, K. J., Bok, R., Seals, D. R., Kohrt, W. M., & Moreau, K. L. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00488.2019 · Cited by 36
A comparison between active- and reactive-hyperaemia-induced brachial artery vasodilation
Padilla, J., Harris, R. A., Fly, A. D., Rink, L. D., & Wallace, J. P. (2006) · Clinical Science · doi:10.1042/cs20050328 · Cited by 33
Hemilä, H. (2014) · Allergy Asthma and Clinical Immunology · doi:10.1186/1710-1492-10-58 · Cited by 33
“Electron spin resonance studies have shown that vitamin C administration decreased the levels of free radicals generated during exercise [14,15] and vitamin C administration attenuated the increases in oxidative stress markers caused by exercise [16-18].”
Relationship Between Noninvasively Measured Endothelial Function and Peripheral Arterial Disease
Medina-Maldonado, F. J., Haro, J. D., Aguilar, E. M., González, A. F., García, J. R. M., & García, F. A. (2008) · Angiology · doi:10.1177/0003319708327787 · Cited by 32
Lombardini, R., Marchesi, S., Collebrusco, L., Vaudo, G., Pasqualini, L., Ciuffetti, G., Brozzetti, M., Lupattelli, G., & Mannarino, E. (2008) · Manual Therapy · doi:10.1016/j.math.2008.08.002 · Cited by 31
Effects of Alpha-Lipoic Acid Supplementation in Peripheral Arterial Disease: A Pilot Study
Vincent, H. K., Bourguignon, C. M., Vincent, K. R., & Taylor, A. G. (2007) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2007.6177 · Cited by 31
“4,5 Free radicals impair vasodilation, 6,7 and may contribute to claudication pain.”
Giugliano, G., Serafino, L. D., Perrino, C., Schiano, V., Laurenzano, E., Cassese, S., Laurentis, M. D., Schiattarella, G. G., Brevetti, L., Sannino, A., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.06.055 · Cited by 29
“studies showing that, in LE-PAD patients, ischemic exercise promotes neutrophil activation and is associated with increased endothelial permeability at distant sites [27–31].”
BackgroundHaro, J. D., Acín, F., López-Quintana, A., Medina, F. J., Martínez-Aguilar, E., Florez, A., & March, J. R. (2008) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2007.10.016 · Cited by 29
Tymko, M. M., Tremblay, J. C., Hansen, A. B., Howe, C. A., Willie, C. K., Stembridge, M. R., GREEN, D. J., Hoiland, R. L., Subedi, P., Anholm, J. D., et al. (2016) · The Journal of Physiology · doi:10.1113/jp273183 · Cited by 28
Oxidative damage to skeletal muscle following an acute bout of contractile claudication
Judge, A. R., & DODD, S. L. (2003) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.08.022 · Cited by 28
“[5] showed an increase in lipid peroxidation following maximal but not submaximal exercise.”
BackgroundJoras, M., & Poredoš, P. (2008) · Vascular Medicine · doi:10.1177/1358863x08096347 · Cited by 27
Shahin, Y., Cockcroft, J. R., & Chetter, I. C. (2013) · British journal of surgery · doi:10.1002/bjs.9198 · Cited by 26
Thomas, K. N., Cotter, J. D., Williams, M. J. A., & van Rij, A. M. (2016) · Vascular and Endovascular Surgery · doi:10.1177/1538574416639150 · Cited by 25
Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease
Sumpio, B. J., Citoni, G., Chin, J. A., & Sumpio, B. E. (2016) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.03.463 · Cited by 25
Gardner, A. W., Montgomery, P. S., Zhao, Y. D., Silva-Palacios, F., Ungvari, Z. I., Csiszár, A., & Sonntag, W. E. (2017) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.12.108 · Cited by 25
Gresele, P., Migliacci, R., Arosio, E., Bonizzoni, E., Minuz, P., & Violi, F. (2012) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2012.05.064 · Cited by 25
Lehr, H., Germann, G., McGregor, G. P., Migeod, F., Roesen, P., Tanaka, H., Uhlig, C., & Biesalski, H. K. (2006) · PubMed · Cited by 25
da Silva, N. D., Roseguini, B. T., Chehuen, M. D. R., Fernandes, T. M., da Mota, G. D. F. A., Martin, P. K. M., Han, S. W., Forjaz, C. L. M., Wolosker, N., & de Oliveira, E. M. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00158.2015 · Cited by 23
“Among other consequences, repeated exposure to these injurious events is thought to promote functional and structural abnormalities in skeletal muscle (13, 24, 44) and endothelial dysfunction (57).”
Silvestro, A., Schiano, V., Bucur, R., Brevetti, G., Scopacasa, F., & Massimo Chiariello, A. (2006) · Angiology · doi:10.1177/000331970605700203 · Cited by 23
Self-citationCarter, S. E., Faulkner, A., & Rakobowchuk, M. (2013) · Journal of Hypertension · doi:10.1097/hjh.0000000000000033 · Cited by 22
“Acute intra-arterial infusion of vitamin C decreases endothelial dysfunction in healthy individuals and peripheral artery disease patients [11] and attenuates the reduction in FMD following ischemia–reperfusion injury induced by exercise in patients with intermittent claudication [10].”
BackgroundInfluentialKals, J., Kampus, P., Kals, M., Pulges, A., Teesalu, R., & Zilmer, M. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.06.014 · Cited by 22
Lyall, G. K., Davies, M. J., Ferguson, C., Porter, K. E., & Birch, K. M. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00156.2019 · Cited by 21
Roseguini, B. T., Hirai, D. M., Alencar, M. C. N., Ramos, R. P., Silva, B. M., Wolosker, N., Neder, J. A., & Nery, L. E. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00183.2014 · Cited by 21
“Exercise-induced muscle ischemia in patients with IC evokes a potent increase in local and systemic markers of inflammation and oxidative stress (33, 47, 56), as well as an acute impairment in vascular reactivity (48).”
BackgroundEndothelial dysfunction in patients with Buerger disease
Igari, K., Kudo, T., Toyofuku, T., & Inoue, Y. (2017) · Vascular Health and Risk Management · doi:10.2147/vhrm.s139892 · Cited by 21
“Some authors have reported the association between the endothelial dysfunction measured using the FMD test and the ABI.”
Komai, H., Higami, Y., Tanaka, H., Honda, K., Juri, M., & Okamura, Y. (2008) · Angiology · doi:10.1177/0003319707303442 · Cited by 21
Andrade-Lima, A., Miranda, A. S., Correia, M. D. A., Germano-Soares, A. H., Cucato, G. G., Filho, D. C. S., Gomes, S. L., & Ritti‐Dias, R. M. (2015) · Journal of Vascular Nursing · doi:10.1016/j.jvn.2015.09.001 · Cited by 19
Does nutrition have a role in peripheral vascular disease?
Carrero, J. J., & Grimble, R. F. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051616 · Cited by 19
“A small study showed that vitamin C prevented endothelial function induced by exercise in PVD patients with IC, together with a decrease in thiobarbituric acid reactive substance and soluble intracellular adhesion molecule-1 levels (Silvestro et al. 2002).”
Andrade-Lima, A., Correia, M. D. A., Germano-Soares, A. H., Farah, B. Q., Forjaz, C. L. M., Silva, A. S., Brasileiro‐Santos, M. S., dos Santos, A. C., & Ritti‐Dias, R. M. (2016) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12384 · Cited by 21
“…peripheral sympathetic nerve activity (Halliwill et al., 1996; Bisquolo et al., 2005) and depresses the vasoconstrictive response to sympathetic stimuli (Halliwill et al., 1996), and walking at submaximal intensity did not produce endothelial injury in patients with PAD (Silvestro et al., 2002).”
BackgroundResultInfluentialYan, J., Tie, G., & Messina, L. M. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00103 · Cited by 19
Currie, K. D., McKelvie, R. S., & MacDonald, M. J. (2014) · BioMed Research International · doi:10.1155/2014/591918 · Cited by 18
“Endothelial-independent function was assessed using a 0.4mg dose of nitroglycerin (NTG).”
MethodVascular Nitric Oxide–Superoxide Balance and Thrombus Formation after Acute Exercise
Przyborowski, K., Proniewski, B., Czarny, J., Smęda, M., SITEK, B., Zakrzewska, A., Zoladz, J. A., & Chłopicki, S. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001589 · Cited by 18
Tymko, M. M., Tremblay, J. C., Steinback, C. D., Moore, J. P., Hansen, A. B., Patrician, A., Howe, C. A., Hoiland, R. L., GREEN, D. J., & Ainslie, P. N. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00583.2017 · Cited by 18
Antioxidants attenuate oxidative damage in rat skeletal muscle during mild ischaemia
Judge, A. R., Selsby, J. T., & DODD, S. L. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2007.040972 · Cited by 18
“Furthermore, supplementation with vitamin C attenuates markers of oxidative stress in the plasma of exercising claudicants (Silvestro et al. 2002), and attenuates neutrophil infiltration and oedema following prolonged ischaemia–reperfusion in skeletal muscle (Kearns et al.”
BackgroundFrançois, M. E., & Little, J. P. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3649-2 · Cited by 16
Ritti‐Dias, R. M., Correia, M. D. A., Andrade-Lima, A., & Cucato, G. G. (2018) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2019.1553676 · Cited by 16
Coolen, S. A. J., Daykin, C. A., van Duynhoven, J., van Dorsten, F. A., Wülfert, F., Mathot, J. N. J. J., Scheltinga, M. R., Stroosma, O. B., Vader, H. L., & Wijnen, M. H. W. A. (2008) · NMR in Biomedicine · doi:10.1002/nbm.1242 · Cited by 17
de Oliveira, G. V., Cordeiro, E. M., Volino‐Souza, M., Rezende, C., Conte‐Júnior, C. A., & Álvares, T. S. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17145194 · Cited by 16
“Despite the abundance of evidence regarding the positive effects of long-term resistance training on the FMD response [11,12] studies showed increased [13–15] or reduced FMD [16,17] after a single aerobic and resistance exercise session.”
Background
Metadata
- Authors
- Silvestro, A., Scopacasa, F., Oliva, G., de Cristofaro, T., Iuliano, L., & Brevetti, G.
- Affiliations
- Federico II University Hospital (IT)
- Sapienza University of Rome (IT)
- Corresponding author
- Silvestro, Antonio
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 165
- Issue
- 2
- Pages
- 277-283
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2069490874
- Cited by
- 159
- References
- 43
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 1 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 14 · 2013: 11 · 2012: 17
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- vitamin C, intermittent claudication, endothelial dysfunction, acute exercise, oxidative stress, flow-mediated dilation, TBARS, soluble intercellular adhesion molecule-1, antioxidant therapy, peripheral arterial disease, submaximal exercise
- MeSH terms
- Antioxidants, Ascorbic Acid, Brachial Artery, Endothelium, Vascular, Exercise Test, Female, Humans, Intermittent Claudication, Male, Middle Aged, Vasodilation, Exercise, Treatment Outcome, Oxidative Stress, Intercellular Adhesion Molecule-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
