Cited by 159Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressExercise and Physiological Responses

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Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication

Silvestro, Antonio, Scopacasa, Francesco, Oliva, Gabriella, de Cristofaro, Tiziana, Iuliano, Luigi, Brevetti, Gregorio·2002·Atherosclerosis

DOI 10.1016/s0021-9150(02)00235-6

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Abstract

In patients with intermittent claudication, exercise is associated with a marked increase in oxidative stress, likely responsible for systemic endothelial perturbation. In 31 claudicant patients, we assessed the effect of vitamin C administration on the acute changes induced by maximal and submaximal exercise in endothelium-dependent, flow-mediated dilation (FMD), and in plasma levels of thiobarbituric acid-reactive substances (TBARS) and soluble intercellular adhesion molecule-1 (sICAM-1). In 16 claudicants, maximal exercise reduced FMD (from 8.5+/-0.9 to 3.7+/-0.8%, P<0.01), and increased plasma levels of TBARS (from 1.93+/-0.06 to 2.22+/-0.1 nmol/ml, P<0.02) and of sICAM-1 (from 282+/-17 to 323+/-19 ng/ml, P<0.01). In eight of these patients, randomized to vitamin C, exercise-induced changes in FMD and biochemistry were abolished. This beneficial effect was not observed in the eight patients randomized to saline. In 15 patients, who walked until the onset of claudication pain (submaximal exercise), and in ten control subjects, who performed maximal exercise, no changes were observed with exercise. Thus, in claudicants, vitamin C prevents the acute, systemic impairment in endothelial function induced by maximal exercise. This finding provides a rationale for trials investigating antioxidant therapy and cardiovascular risk in patients with intermittent claudication.

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Authors: Silvestro, A., Scopacasa, F., Oliva, G., de Cristofaro, T., Iuliano, L., & Brevetti, G.
Affiliations: Federico II University Hospital (IT)
Sapienza University of Rome (IT)
Corresponding author: Silvestro, Antonio
ORCID: Oliva, Gabriella
Iuliano, Luigi
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2002-12
Volume: 165
Issue: 2
Pages: 277-283
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/s0021-9150(02)00235-6
OpenAlex: W2069490874
Cited by: 159
References: 43
Citations by year: 2026: 4 · 2025: 3 · 2024: 1 · 2023: 1 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 14 · 2013: 11 · 2012: 17
FWCI: 3.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: vitamin C, intermittent claudication, endothelial dysfunction, acute exercise, oxidative stress, flow-mediated dilation, TBARS, soluble intercellular adhesion molecule-1, antioxidant therapy, peripheral arterial disease, submaximal exercise
MeSH terms: Antioxidants, Ascorbic Acid, Brachial Artery, Endothelium, Vascular, Exercise Test, Female, Humans, Intermittent Claudication, Male, Middle Aged, Vasodilation, Exercise, Treatment Outcome, Oxidative Stress, Intercellular Adhesion Molecule-1

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Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication

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