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Cited by 446Adipokines, Inflammation, and Metabolic DiseasesLipoproteins and Cardiovascular HealthObesity, Physical Activity, Diet

The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.

C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors

Cook, Derek G, Mendall, Mike A, Whincup, Peter H, Carey, Iain M, Ballam, Lydia, Morris, Julia E, Miller, George J, Strachan, David P·2000·Atherosclerosis
DOI 10.1016/s0021-9150(99)00312-3
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Abstract

Whether or not C-reactive protein (CRP) predicts heart disease in adults because it is a marker of damage or atherosclerosis is difficult to assess. In children, there is no confounding with coronary disease or active smoking. We measured CRP in 699 children aged 10-11 years. CRP levels were 47% higher in girls than boys, and rose with age by 15%/year. CRP levels were 270% (95% CI, 155-439%) higher in the top fifth than the bottom fifth of Ponderal index (weight/height(3)). After adjustment, CRP levels remained 104% (95% CI, 23-236%) higher in the 56 children of South Asian origin. CRP was unrelated to: birth weight, height, social class, Helicobacter pylori infection or passive smoke exposure. CRP was correlated with several cardiovascular risk factors, but only fibrinogen (r = 0.33, P = 0.0001), HDL-cholesterol (r = -0.13, P = 0.0006), heart rate (r = 0.12, P = 0.002) and systolic blood pressure (r = 0.08, P = 0.02) remained statistically significant after adjustment. We conclude that adiposity is the major determinant of CRP levels in children while physical fitness has a small independent effect. The strong relationships with fibrinogen and HDL-cholesterol suggest a role for inflammation throughout life in the development of atherosclerosis and cardiovascular disease. Longitudinal studies are needed to determine whether these associations reflect long term elevations of these risk factors in some individuals, or short term fluctuations in different individuals.

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Crossref · 10.1016/s0021-9150(99)00312-3

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Citations

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Research works printed but not linked: 1

  1. Whincup, 1997, European–South Asian differences in cardiovascular risk profile in childhood, Canad J Cardiol, 13, 38B

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Metadata

Authors
Cook, D. G., Mendall, M. A., Whincup, P. H., Carey, I. M., Ballam, L., Morris, J. E., Miller, G. J., & Strachan, D. P.
Affiliations
  • St George's, University of London (GB)
  • The Royal Free Hospital (GB)
Corresponding author
Cook, Derek G
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2000-03
Volume
149
Issue
1
Pages
139-150
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/s0021-9150(99)00312-3
OpenAlex
W2075826908
Cited by
446
References
24
Citations by year
2026: 5 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 14 · 2021: 7 · 2020: 5 · 2019: 15 · 2018: 14 · 2017: 14 · 2016: 19 · 2015: 21 · 2014: 19 · 2013: 29 · 2012: 17
FWCI
13.36
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
C-reactive protein, childhood adiposity, cardiovascular risk factors, inflammation, fibrinogen, HDL cholesterol, physical fitness, South Asian children, sex differences, ponderal index, systolic blood pressure, heart rate, Helicobacter pylori infection, passive smoking
MeSH terms
C-Reactive Protein, Cardiovascular Diseases, Child, Enzyme-Linked Immunosorbent Assay, Female, United Kingdom, Humans, Male, Obesity, Population Surveillance, Risk Factors, Sampling Studies, Sensitivity and Specificity, Biomarkers, Comorbidity, Linear Models, Age Distribution, Sex Distribution

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