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Cited by 42Adipokines, Inflammation, and Metabolic DiseasesObesity, Physical Activity, DietPhysical Activity and Health

C-reactive protein in schoolchildren and its relation to adiposity, physical activity, aerobic fitness and habitual diet

Thomas, N-E, Baker, J S, Graham, M R, Cooper, S-M, Davies, B·2008·British Journal of Sports Medicine
DOI 10.1136/bjsm.2007.043604
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Abstract

Objective: To investigate the relation between C-reactive protein (CRP), adiposity, physical activity, aerobic fitness and habitual diet in a cohort of schoolchildren. Methods: A cross-sectional study of 164 schoolchildren aged 12–13 years was conducted in two schools. Adiposity was estimated using body mass index and waist circumference. Blood samples were taken after an overnight fast and measured for CRP. Aerobic fitness and habitual physical activity were assessed using the 20 metres multistage fitness test, and a seven-day recall, respectively. A seven-day food diary provided measures of dietary intake. Results: To improve the distribution of this variable, CRP levels were logarithmically transformed in all analyses. There was no significant difference in mean CRP concentration between boys (1.07 (1.33) mg/l) and girls (1.24 (1.87) mg/l) (p⩾0.05). Compared to girls, boys reported significantly higher (i) aerobic fitness 59.2 (20.3) shuttles vs 42.9 (15.3) shuttles, (ii) vigorous activity levels per week 92 (123) minutes vs 11.2 (34.6) minutes and (iii) waist circumference 69.8 (1.1) cm vs 65.2 (0.9) cm (p⩽0.05). Among boys and girls, adiposity was significantly associated with log transformed CRP (p⩽0.05). CRP was not significantly related to any other variable. Conclusion: Elevated CRP was evident in this cohort; however, whether high CRP levels during childhood and adolescence leads to an increased risk of CVD in later life has not been determined. Adiposity was related to CRP concentration, suggesting that reducing adiposity may be effective in lowering CRP and preventing future cardiovascular events.

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  • Postpartum iron supplementation of 80 mg per day for twelve weeks in non-anaemic iron-deficient women did not significantly alter CRP or leucocyte counts.

    “Furthermore, postpartum Fe supplementation (80 mg/d) for 12 weeks in non-anaemic Fe-deficient women did not significantly alter CRP concentration or leucocyte counts (726) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [726]

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Authors
Thomas, N.-E., Baker, J. S., Graham, M. R., Cooper, S.-M., & Davies, B.
Affiliations
  • Cardiff Metropolitan University (GB)
  • University of Glamorgan (GB)
ORCID
Baker, J S
Venue
British Journal of Sports Medicine
Publisher
BMJ
Published
2008-01-04
Volume
42
Issue
5
Pages
357-360
ISSN
  • 0306-3674 (ISSN-L)
  • 1473-0480
DOI
10.1136/bjsm.2007.043604
OpenAlex
W2156364547
Cited by
42
References
39
Citations by year
2025: 1 · 2022: 1 · 2021: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 8
FWCI
4.45
Type
journal article
Language
en
Open access
closed
Locations
  • British Journal of Sports Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
C-reactive protein, elementary school students, childhood adiposity, physical activity, cardiorespiratory fitness, habitual diet, waist circumference, cardiovascular risk, sex differences, cardiovascular disease prevention
MeSH terms
Adolescent, Body Composition, Body Weights and Measures, C-Reactive Protein, Cardiovascular Diseases, Child, Cross-Sectional Studies, Feeding Behavior, Female, Humans, Male, Physical Fitness, Risk Factors, Cohort Studies, Exercise, Body Mass Index, Adiposity

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