Apoprotein (E–A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E–A-II) complex
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In vitro studies have shown that the apoA-II and apoE heterodimeric complex on HDL cholesterol modulates receptor affinity for the LDL receptor, and that LDL receptor affinity is dependent on available apoE, probably dependent on apoE isoform.
“Previously, in vitro studies have shown that the apoA-II and apoE heterodimeric complex on HDL cholesterol modulates the receptor affinity for the LDL receptor, and that the LDL receptor affinity is dependent on available apoE, an affinity probably dependent on apoE isoform [124,125].”
From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [125]
The apoE-apoAII complex in plasma was discovered in the late 1970s.
“The apoE-apoAII complex in plasma was discovered in the late 1970s [34]”
From Discovery of a Missense Mutation (Q222K) of the <i>APOE</i> Gene from the Australian Imaging, Biomarker and Lifestyle Study (2023) · cites this paper as [34]
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Self-citationRasmussen, K. L. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.10.037 · Cited by 125 · see citing works
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Blanchard, V., Ramin-Mangata, S., Billon-Crossouard, S., Aguesse, A., Durand, M., Chemello, K., Nativel, B., Flet, L., Chétiveaux, M., Jacobi, D., et al. (2018) · Journal of Lipid Research · doi:10.1194/jlr.p083576 · Cited by 43 · see citing works
Orth, M., Weng, W., Funke, H., Steinmetz, A., Assmann, G., Nauck, M., Dierkes, J., Ambrosch, A., Weisgraber, K. H., Mahley, R. W., et al. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.5.1306 · Cited by 42 · see citing works
Self-citationGiannisis, A., Al-Grety, A., Carlsson, H., Howell, J. C., Hu, W. T., Kultima, K., & Nielsen, H. M. (2023) · Alzheimer's Research & Therapy · doi:10.1186/s13195-023-01262-1 · Cited by 11 · see citing works
Roberts, B. R., Laffoon, S. B., Roberts, A. M., Porter, T., Fowler, C., Masters, C. L., Dratz, E. A., Laws, S. M., & for the AIBL research group (2023) · Journal of Alzheimer's Disease Reports · doi:10.3233/adr-220075 · Cited by 2 · see citing works
- Authors
- Innerarity, T. L., Mahley, R. W., Weisgraber, K. H., & Bersot, T. P.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Mahley, R.W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1978-09
- Volume
- 253
- Issue
- 17
- Pages
- 6289-6295
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W182198897
- Cited by
- 121
- References
- 0
- Citations by year
- 2024: 1 · 2023: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2012: 2
- FWCI
- 24.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- apolipoprotein E, apolipoprotein A-II, HDL subfractions, receptor binding activity, human plasma lipoproteins
- MeSH terms
- Acetylation, Amino Acids, Apolipoproteins, Cells, Cultured, Cholesterol Esters, Fibroblasts, Humans, Infant, Newborn, Kinetics, Lipoproteins, HDL, Lipoproteins, LDL, Male, Oleic Acids, Oxidation-Reduction, Receptors, Drug, Skin
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