Kinetics of plasma apolipoprotein E isoforms by LC-MS/MS: a pilot study
Open accessAbstract
Human apoE exhibits three major isoforms (apoE2, apoE3, and apoE4) corresponding to polymorphism in the APOE gene. Total plasma apoE concentrations are closely related to these isoforms, but the underlying mechanisms are unknown. We aimed to describe the kinetics of apoE individual isoforms to explore the mechanisms for variable total apoE plasma concentrations. We used LC-MS/MS to discriminate between isoforms by identifying specific peptide sequences in subjects (three E2/E3, three E3/E3, and three E3/E4 phenotypes) who received a primed constant infusion of 2 H 3 -leucine for 14 h. apoE concentrations and leucine enrichments were measured hourly in plasma. Concentrations of apoE2 were higher than apoE3, and concentrations of apoE4 were lower than apoE3. There was no difference between apoE3 and apoE4 catabolic rates and between apoE2 and apoE3 production rates (PRs), but apoE2 catabolic rates and apoE4 PRs were lower. The mechanisms leading to the difference in total plasma apoE concentrations are therefore related to contrasted kinetics of the isoforms. Production or catabolic rates are differently affected according to the specific isoforms. On these grounds, studies on the regulation of the involved biochemical pathways and the impact of pathological environments are now warranted.
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Genomic sequence variation can lead to differing peptide sequences in the population.
“Genomic sequence variation can lead to differing peptide sequences in the population.(25–27)”
From Putting humpty dumpty back together again: what does protein quantification mean in bottom-up proteomics? (2022) · cites this paper as [27]
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- Authors
- Blanchard, V., Ramin-Mangata, S., Billon-Crossouard, S., Aguesse, A., Durand, M., Chemello, K., Nativel, B., Flet, L., Chétiveaux, M., Jacobi, D., Bard, J.-M., Ouguerram, K., Lambert, G., Krempf, M., & Croyal, M.
- Affiliations
- Inserm (FR)
- PhysioPathologie des Adaptations Nutritionnelles (FR)
- Centre National de la Recherche Scientifique (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Corresponding author
- Croyal, Mikaël
- ORCID
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2018
- Volume
- 59
- Issue
- 5
- Pages
- 892-900
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC5928431
- OpenAlex
- W2793139489
- Cited by
- 43
- References
- 38
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 2 · 2022: 8 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 1
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-16-RHUS-0007 CHOPIN)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- apolipoprotein E, APOE isoforms, APOE2, APOE3, APOE ε4, APOE polymorphism, production rate, leucine infusion, stable isotope tracers
- MeSH terms
- Chromatography, High Pressure Liquid, Humans, Kinetics, Male, Middle Aged, Pilot Projects, Protein Isoforms, Apolipoprotein E3, Apolipoprotein E4, Apolipoprotein E2, Tandem Mass Spectrometry
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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