Cited by 355Fungal and yeast genetics researchSignaling Pathways in DiseaseBacterial Genetics and Biotechnology

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The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

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Mendoza, I., Rubio, F., Rodriguez-Navarro, A., Pardo, J.M.·1994·Journal of Biological Chemistry

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Abstract

NaCl-sensitive yeast mutants were isolated to identify genes essential for NaCl tolerance. Complementation of a mutant highly sensitive to Na+ and Li+ led to the isolation of the CNB1 gene. This gene encodes the regulatory subunit (CNB) of the Ca2+/calmodulin-dependent protein phosphatase calcineurin. Cells deficient in CNB accumulated Li+ due to reduced expression of ENA1, a gene encoding a P-type ATPase involved in Na+ and Li+ efflux. In addition, the K+ transport system of cnb1 delta cells was not converted to the high affinity state that facilitates better discrimination of K+ over Na+. Thus the cnb1 delta strain resembled a trk1 mutant. These results indicate that adaptation to NaCl stress in Saccharomyces cerevisiae requires a signal transduction pathway involving Ca2+ and protein phosphorylation-dephosphorylation. In this pathway, calcineurin would coordinate gene expression and activity of ion transporters to facilitate ion homeostasis.

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Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222
Getting started with yeast
Sherman, F. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94004-v · Cited by 4,078
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
Clipstone, N. A., & Crabtree, G. R. (1992) · Nature · doi:10.1038/357695a0 · Cited by 1,635
Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase
Carlson, M., & Botstein, D. (1982) · Cell · doi:10.1016/0092-8674(82)90384-1 · Cited by 1,541
An Osmosensing Signal Transduction Pathway in Yeast
Brewster, J. L., de Valoir, T., Dwyer, N. D., Winter, E., & Gustin, M. C. (1993) · Science · doi:10.1126/science.7681220 · Cited by 1,248
Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast.
Guarente, L. P. (1983) · Methods in Enzymology · doi:10.1016/0076-6879(83)01013-7 · Cited by 1,022
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
O’Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J., & O’Neill, E. A. (1992) · Nature · doi:10.1038/357692a0 · Cited by 841
[12] High-efficiency transformation of yeast by electroporation
Becker, D. M., & Guarente, L. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94015-5 · Cited by 805

Show all 32 references

Research works printed but not linked: 3

Gaber, 1988, Mol. Cell. Biol., 8, 2848
Klee, 1988, Adv. Enzymol. Relat. Areas Mol. Biol., 61, 149
Cyert, 1992, Mol. Cell. Biol., 12, 3460

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Stress responses
Dawes, I. W. (2004) · CRC Press eBooks · doi:10.1201/9780203503867.ch9 · Cited by 22
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Matsumoto, T. K., Pardo, J. M., Takeda, S., Bressan, R. A., & Hasegawa, P. M. (2001) · Plant Molecular Biology · doi:10.1023/a:1010659207604 · Cited by 21
Self-citation
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Self-citation
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Marquina, M., González, A., Barreto, L., Gelis, S., Munoz, I. M., Ruiz, A., Álvarez, M. C., Ramos, J., & Ariño, J. (2012) · Genetics · doi:10.1534/genetics.112.138370 · Cited by 16
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Role Of Calcium In Alleviating Salinity Effects In Coastal Halophytes
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Tol1, a Fission Yeast Phosphomonoesterase, Is an In Vivo Target of Lithium, and Its Deletion Leads to Sulfite Auxotrophy
Miyamoto, R., Sugiura, R., Kamitani, S., Yada, T., Lü, Y., Sio, S. O., Asakura, M., Matsuhisa, A., Shuntoh, H., & Kuno, T. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.13.3619-3625.2000 · Cited by 16
Salt-Sensitive Mutants of Chlamydomonas reinhardtii Isolated after Insertional Tagging
Prieto, R., Pardo, J. M., Niu, X., Bressan, R. A., & Hasegawa, P. M. (1996) · PLANT PHYSIOLOGY · doi:10.1104/pp.112.1.99 · Cited by 16
Self-citation
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Patiño-Medina, J. A., Reyes-Mares, N. Y., Valle-Maldonado, M. I., Jácome-Galarza, I. E., Arques, C. P., Núñez‐Anita, R. E., Campos‐García, J., Anaya-Martı́nez, V., Ortíz‐Alvarado, R., Ramírez-Díaz, M. I., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226682 · Cited by 15
Transcriptional regulation of the S. cerevisiae ENA1 gene by casein kinase II
Tenney, K. A., & Glover, C. V. C. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006893824947 · Cited by 15
“cerevisiae, including the plasma membrane H-ATPase encoded by the PMA1 gene [5, 13, 23].”
BackgroundMethodResultInfluential
The Transcriptional Activator Imp2p Maintains Ion Homeostasis in Saccharomyces cerevisiae
Masson, J., & Ramotar, D. (1998) · Genetics · doi:10.1093/genetics/149.2.893 · Cited by 15
ARL1 participates with ATC1/LIC4 to regulate responses of yeast cells to ions
Munson, A. M., Love, S. L., Shu, J., Palanivel, V., & Rosenwald, A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.099 · Cited by 15
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Programmed Cell Death and Apoptosis in Fungi
Ramsdale, M. (2006) · Springer eBooks · doi:10.1007/3-540-30809-1_7 · Cited by 14
Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae
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Iyengar, E. R. R., & Reddy, M. (1999) · Books in soils, plants, and the environment · doi:10.1201/9780824746728.ch50 · Cited by 14
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Patel, A., Khare, P., & Patra, D. D. (2017) · Springer eBooks · doi:10.1007/978-981-10-6744-0_6 · Cited by 14
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Perrino, B. A., & Soderling, T. R. (1998) · Elsevier eBooks · doi:10.1016/b978-0-08-092636-0.50008-6 · Cited by 12
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Background
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Reinhold, L., & Guy, M. (2002) · Springer eBooks · doi:10.1007/0-306-48155-3_18 · Cited by 10
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Natural adaptations, tolerance mechanisms, and management concepts of crop plants against salt stress: A critical review
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Authors: Mendoza, I., Rubio, F., Rodriguez-Navarro, A., & Pardo, J. M.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
ORCID: Mendoza, I.
Rubio, F.
Pardo, J.M.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1994-03
Volume: 269
Issue: 12
Pages: 8792-8796
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(17)37038-2
OpenAlex: W1587918801
Semantic Scholar: 03506f73fdcb61ede7c6c76f8d244bbac6fb382e
Cited by: 350
References: 32
Citations by year: 2025: 2 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 2
FWCI: 7.68
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 9735 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: calcineurin, NaCl tolerance, salt stress, Saccharomyces cerevisiae, ENA1, P-type ATPase, lithium accumulation, ion homeostasis, potassium transport, Trk1, Ca2+/calmodulin signaling, protein phosphorylation, gene essentiality
MeSH terms: Adenosine Triphosphatases, Sodium-Potassium-Exchanging ATPase, Base Sequence, Biological Transport, Active, Calmodulin-Binding Proteins, Chromosome Mapping, Cloning, Molecular, Fungal Proteins, Genes, Fungal, Genetic Complementation Test, Homeostasis, Molecular Sequence Data, Phosphoprotein Phosphatases, Saccharomyces cerevisiae, Sodium, Sodium Chloride, Water-Electrolyte Balance, Restriction Mapping, Lithium Chloride, Calcineurin, Cation Transport Proteins, Saccharomyces cerevisiae Proteins

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The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

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