Cited by 355Fungal and yeast genetics researchSignaling Pathways in DiseaseBacterial Genetics and Biotechnology

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The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

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Mendoza, I., Rubio, F., Rodriguez-Navarro, A., Pardo, J.M.·1994·Journal of Biological Chemistry

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Abstract

NaCl-sensitive yeast mutants were isolated to identify genes essential for NaCl tolerance. Complementation of a mutant highly sensitive to Na+ and Li+ led to the isolation of the CNB1 gene. This gene encodes the regulatory subunit (CNB) of the Ca2+/calmodulin-dependent protein phosphatase calcineurin. Cells deficient in CNB accumulated Li+ due to reduced expression of ENA1, a gene encoding a P-type ATPase involved in Na+ and Li+ efflux. In addition, the K+ transport system of cnb1 delta cells was not converted to the high affinity state that facilitates better discrimination of K+ over Na+. Thus the cnb1 delta strain resembled a trk1 mutant. These results indicate that adaptation to NaCl stress in Saccharomyces cerevisiae requires a signal transduction pathway involving Ca2+ and protein phosphorylation-dephosphorylation. In this pathway, calcineurin would coordinate gene expression and activity of ion transporters to facilitate ion homeostasis.

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Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222
Getting started with yeast
Sherman, F. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94004-v · Cited by 4,078
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
Clipstone, N. A., & Crabtree, G. R. (1992) · Nature · doi:10.1038/357695a0 · Cited by 1,635
Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase
Carlson, M., & Botstein, D. (1982) · Cell · doi:10.1016/0092-8674(82)90384-1 · Cited by 1,541
An Osmosensing Signal Transduction Pathway in Yeast
Brewster, J. L., de Valoir, T., Dwyer, N. D., Winter, E., & Gustin, M. C. (1993) · Science · doi:10.1126/science.7681220 · Cited by 1,248
Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast.
Guarente, L. P. (1983) · Methods in Enzymology · doi:10.1016/0076-6879(83)01013-7 · Cited by 1,022
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
O’Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J., & O’Neill, E. A. (1992) · Nature · doi:10.1038/357692a0 · Cited by 841
[12] High-efficiency transformation of yeast by electroporation
Becker, D. M., & Guarente, L. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94015-5 · Cited by 805

Show all 32 references

Research works printed but not linked: 3

Gaber, 1988, Mol. Cell. Biol., 8, 2848
Klee, 1988, Adv. Enzymol. Relat. Areas Mol. Biol., 61, 149
Cyert, 1992, Mol. Cell. Biol., 12, 3460

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Navarro-García, F., Alonso‐Monge, R., Rico, H., Plá, J., Sentandreu, R., & Nombela, C. (1998) · Microbiology · doi:10.1099/00221287-144-2-411 · Cited by 138
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Mendizabal, I., Rios, G., Mulet, J. M., Serrano, R., & de Larrinoa, I. F. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00249-x · Cited by 136
The Arabidopsis root stele transporter NPF2.3 contributes to nitrate translocation to shoots under salt stress
Taochy, C., Gaillard, I., Ipotesi, E., Oomen, R. J. F. J., Leonhardt, N., Zimmermann, S., Peltier, J., Szponarski, W., Simonneau, T., Sentenac, H., et al. (2015) · The Plant Journal · doi:10.1111/tpj.12901 · Cited by 137
Good fungi gone bad: The corruption of calcineurin
Fox, D. S., & Heitman, J. (2002) · BioEssays · doi:10.1002/bies.10157 · Cited by 137
The dawn of plant salt tolerance genetics
Hasegawa, M. P., Bressan, R. A., & Pardo, J. M. (2000) · Trends in Plant Science · doi:10.1016/s1360-1385(00)01692-7 · Cited by 135
Self-citation
Multiple transduction pathways regulate the sodium‐extrusion gene PMR2/ENA1 during salt stress in yeast
Márquez, J. A., & Serrano, R. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00157-3 · Cited by 134
Different signalling pathways contribute to the control of GPD1 gene expression by osmotic stress in Saccharomyces cerevisiae
Rep, M., Albertyn, J., Thevelein, J. M., Prior, B. A., & Hohmann, S. (1999) · Microbiology · doi:10.1099/13500872-145-3-715 · Cited by 131
“In addition to these osmo-sensing pathways, there is a signalling route specifically required for the adaptation to high salt but not to general osmotic stress (Danielsson et al., 1996; Hirata et al., 1995; Mendoza et al., 1994).”
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Chakraborty, K., Sairam, R. K., & Bhattacharya, R. (2011) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2011.10.001 · Cited by 128
Impairment of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, morphology and maintenance of the apical Ca2+ gradient
Prokisch, H., Yarden, O., Dieminger, M., Tropschug, M., & Barthelmess, I. B. (1997) · Molecular and General Genetics MGG · doi:10.1007/s004380050551 · Cited by 125
Constitutive over‐expression of AtGSK1 induces NaCl stress responses in the absence of NaCl stress and results in enhanced NaCl tolerance in Arabidopsis
Piao, H. L., Lim, J. H., Kim, S. J., Cheong, G., & Hwang, I. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.01099.x · Cited by 124
Role of HSP90 in salt stress tolerance via stabilization and regulation of calcineurin.
Imai, J., & Yahara, I. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.24.9262-9270.2000 · Cited by 123
Calcineurin Is Essential for Virulence in Candida albicans
Bader, T., Bodendorfer, B., Schröppel, K., & Morschhäuser, J. (2003) · Infection and Immunity · doi:10.1128/iai.71.9.5344-5354.2003 · Cited by 121
pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast
Sugiura, R., Toda, T., Shuntoh, H., Yanagida, M., & Kuno, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.140 · Cited by 121
Yeast translational response to high salinity: Global analysis reveals regulation at multiple levels
Melamed, D., Pnueli, L., & Arava, Y. (2008) · RNA · doi:10.1261/rna.864908 · Cited by 121
The complete inventory of the yeast Saccharomyces cerevisiae P‐type transport ATPases
Catty, P., d’Exaerde, A. D. K., & Goffeau, A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00446-8 · Cited by 120
Activated calcineurin confers high tolerance to ion stress and alters the budding pattern and cell morphology of yeast cells
Mendoza, I., Quintero, F. J., Bressan, R. A., Hasegawa, P. M., & Pardo, J. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23061 · Cited by 115
Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis
Juvvadi, P. R., Lamoth, F., & Steinbach, W. J. (2014) · Fungal Biology Reviews · doi:10.1016/j.fbr.2014.02.004 · Cited by 116
Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site
Boustany, L. M., & Cyert, M. S. (2002) · Genes & Development · doi:10.1101/gad.967602 · Cited by 115

Authors: Mendoza, I., Rubio, F., Rodriguez-Navarro, A., & Pardo, J. M.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
ORCID: Mendoza, I.
Rubio, F.
Pardo, J.M.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1994-03
Volume: 269
Issue: 12
Pages: 8792-8796
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(17)37038-2
OpenAlex: W1587918801
Semantic Scholar: 03506f73fdcb61ede7c6c76f8d244bbac6fb382e
Cited by: 350
References: 32
Citations by year: 2025: 2 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 2
FWCI: 7.68
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 9735 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: calcineurin, NaCl tolerance, salt stress, Saccharomyces cerevisiae, ENA1, P-type ATPase, lithium accumulation, ion homeostasis, potassium transport, Trk1, Ca2+/calmodulin signaling, protein phosphorylation, gene essentiality
MeSH terms: Adenosine Triphosphatases, Sodium-Potassium-Exchanging ATPase, Base Sequence, Biological Transport, Active, Calmodulin-Binding Proteins, Chromosome Mapping, Cloning, Molecular, Fungal Proteins, Genes, Fungal, Genetic Complementation Test, Homeostasis, Molecular Sequence Data, Phosphoprotein Phosphatases, Saccharomyces cerevisiae, Sodium, Sodium Chloride, Water-Electrolyte Balance, Restriction Mapping, Lithium Chloride, Calcineurin, Cation Transport Proteins, Saccharomyces cerevisiae Proteins

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The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

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