Cited by 355Fungal and yeast genetics researchSignaling Pathways in DiseaseBacterial Genetics and Biotechnology

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The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

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Mendoza, I., Rubio, F., Rodriguez-Navarro, A., Pardo, J.M.·1994·Journal of Biological Chemistry

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Abstract

NaCl-sensitive yeast mutants were isolated to identify genes essential for NaCl tolerance. Complementation of a mutant highly sensitive to Na+ and Li+ led to the isolation of the CNB1 gene. This gene encodes the regulatory subunit (CNB) of the Ca2+/calmodulin-dependent protein phosphatase calcineurin. Cells deficient in CNB accumulated Li+ due to reduced expression of ENA1, a gene encoding a P-type ATPase involved in Na+ and Li+ efflux. In addition, the K+ transport system of cnb1 delta cells was not converted to the high affinity state that facilitates better discrimination of K+ over Na+. Thus the cnb1 delta strain resembled a trk1 mutant. These results indicate that adaptation to NaCl stress in Saccharomyces cerevisiae requires a signal transduction pathway involving Ca2+ and protein phosphorylation-dephosphorylation. In this pathway, calcineurin would coordinate gene expression and activity of ion transporters to facilitate ion homeostasis.

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Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222
Getting started with yeast
Sherman, F. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94004-v · Cited by 4,078
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
Clipstone, N. A., & Crabtree, G. R. (1992) · Nature · doi:10.1038/357695a0 · Cited by 1,635
Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase
Carlson, M., & Botstein, D. (1982) · Cell · doi:10.1016/0092-8674(82)90384-1 · Cited by 1,541
An Osmosensing Signal Transduction Pathway in Yeast
Brewster, J. L., de Valoir, T., Dwyer, N. D., Winter, E., & Gustin, M. C. (1993) · Science · doi:10.1126/science.7681220 · Cited by 1,248
Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast.
Guarente, L. P. (1983) · Methods in Enzymology · doi:10.1016/0076-6879(83)01013-7 · Cited by 1,022
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
O’Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J., & O’Neill, E. A. (1992) · Nature · doi:10.1038/357692a0 · Cited by 841
[12] High-efficiency transformation of yeast by electroporation
Becker, D. M., & Guarente, L. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94015-5 · Cited by 805

Show all 32 references

Research works printed but not linked: 3

Gaber, 1988, Mol. Cell. Biol., 8, 2848
Klee, 1988, Adv. Enzymol. Relat. Areas Mol. Biol., 61, 149
Cyert, 1992, Mol. Cell. Biol., 12, 3460

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Saxena, B., Shukla, K., & Giri, B. (2017) · Springer eBooks · doi:10.1007/978-981-10-4115-0_4 · Cited by 56
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Shitamukai, A., Hirata, D., Sonobe, S., & Miyakawa, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306098200 · Cited by 56
Calcineurin homologous protein: a multifunctional Ca2+-binding protein family
Sole, F. D., Vadnagara, K., Moe, O. W., & Babich, V. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00628.2011 · Cited by 57
“due to a decrease in expression of the yeast Na -ATPase (88).”
ESCRT components regulate the expression of the ER/Golgi calcium pump gene PMR1 through the Rim101/Nrg1 pathway in budding yeast
Zhao, Y., Du, J., Xiong, B., Xu, H., & Jiang, L. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt025 · Cited by 55
The yeast SR protein kinase Sky1p modulates salt tolerance, membrane potential and the Trk1,2 potassium transporter
Forment, J., Mulet, J. M., Vicente, Ó., & Serrano, R. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00503-5 · Cited by 55
Osmoregulation and protein expression in a pbs2Δ mutant of Saccharomyces cerevisiae during adaptation to hypersaline stress
Akhtar, N., Blomberg, A., & Adler, L. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00048-3 · Cited by 54
The capacity to transport potassium influences sodium tolerance inSaccharomyces cerevisiae
mez, M. J. G., Luyten, K., & Ramos, J. (1996) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1996.tb07982.x · Cited by 54
The pathway by which the yeast protein kinase Snf1p controls acquisition of sodium tolerance is different from that mediating glucose regulation
Tian, Y., Elbing, K., & Hohmann, S. (2008) · Microbiology · doi:10.1099/mic.0.2008/020149-0 · Cited by 53
Coregulated Expression of the Na + /Phosphate Pho89 Transporter and Ena1 Na + -ATPase Allows Their Functional Coupling under High-pH Stress
Serra‐Cardona, A., Petrezsélyová, S., Canadell, D., Ramos, J., & Ariño, J. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01089-14 · Cited by 52
“Alkaline-pH stress results in the transcriptional induction of the Ena1 Na -ATPase, which actively extrudes Na cations (15, 26, 35, 61), whereas Pho89 is a Na -driven phosphate transporter active at alkaline pH (5).”
Background
The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance
Miyahara, K., Mizunuma, M., Hirata, D., Tsuchiya, E., & Miyakawa, T. (1996) · FEBS Letters · doi:10.1016/s0014-5793(96)01353-1 · Cited by 52
Arabidopsis thaliana Atrab28: a nuclear targeted protein related to germination and toxic cation tolerance
Borrell, A., Cutanda, M. C., Lumbreras, V., Pujal, J., Goday, A., Culiáñez‐Macià, F. A., & Pagès, M. (2002) · Plant Molecular Biology · doi:10.1023/a:1016084615014 · Cited by 52
“Lithium is considered a more toxic monovalent cation analogue to sodium (Mendoza et al., 1994) that has been related with inhibition of key components in the signal transduction pathways of inositol phosphatases (Manji et al., 1995) and RNA processing enzymes (Dichtl et al., 1997).”
Background
Functional Characterization of a Wheat NHX Antiporter Gene TaNHX2 That Encodes a K+/H+ Exchanger
Xu, Y., Zhou, Y., Hong, S., Xia, Z., Cui, D., Guo, J., Xu, H., & Jiang, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078098 · Cited by 51
Proteome analysis of an ectomycorrhizal fungus Boletus edulis under salt shock
Liang, Y., Chen, H., Tang, M., & Shen, S. (2007) · Mycological Research · doi:10.1016/j.mycres.2007.06.005 · Cited by 51
Athb-12, a homeobox-leucine zipper domain protein from Arabidopsis thaliana, increases salt tolerance in yeast by regulating sodium exclusion
Shin, D., Koo, Y. D., Lee, J., Lee, H., Baek, D., Lee, S., Cheon, C., Kwak, S., Lee, S. Y., & Yun, D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.127 · Cited by 52
The STK2 Gene, Which Encodes a Putative Ser/Thr Protein Kinase, Is Required for High-Affinity Spermidine Transport in Saccharomyces cerevisiae
Kaouass, M., Audette, M., Ramotar, D., Verma, S., Montigny, D. D., Gamache, I., Torossian, K., & Poulin, R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.6.2994 · Cited by 51
Genetic evidence for the functional redundancy of the calcineurin-and Mpk1-mediated pathways in the regulation of cellular events important for growth inSaccharomyces cerevisiae
Nakamura, T., Ohmoto, T., Hirata, D., Tsuchiya, E., & Miyakawa, T. (1996) · Molecular and General Genetics MGG · doi:10.1007/bf02172920 · Cited by 51
Luv1p/Rki1p/Tcs3p/Vps54p, a Yeast Protein That Localizes to the Late Golgi and Early Endosome, Is Required for Normal Vacuolar Morphology.
Conboy, M. J., & Cyert, M. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.7.2429 · Cited by 51
Key Role for Intracellular K+ and Protein Kinases Sat4/Hal4 and Hal5 in the Plasma Membrane Stabilization of Yeast Nutrient Transporters
Pérez‐Valle, J., Jenkins, H., Merchan, S., Montiel, V., Ramos, J., Sharma, S. C., Serrano, R., & Yenush, L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01375-06 · Cited by 50
Toward Understanding Molecular Mechanisms of Abiotic Stress Responses in Rice
Gao, J., Chao, D., & Lin, H. (2008) · Rice · doi:10.1007/s12284-008-9006-7 · Cited by 49
Trk1 and Trk2 Define the Major K + Transport System in Fission Yeast
Calero, F., Gómez, N., Ariño, J., & Ramos, J. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.2.394-399.2000 · Cited by 49
Na+ and K+ Transporters in Plant Signaling
Pardo, J. M., & Rubio, F. (2010) · Signaling and communication in plants · doi:10.1007/978-3-642-14369-4_3 · Cited by 48
Self-citation
An Arabidopsis SNF1-Related Protein Kinase, AtSR1, Interacts with a Calcium-Binding Protein, AtCBL2, of Which Transcripts Respond to Light
Nozawa, A., Koizumi, N., & Sano, H. (2001) · Plant and Cell Physiology · doi:10.1093/pcp/pce126 · Cited by 48
The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p
Williams, K. E., & Cyert, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3473 · Cited by 48
An Integrative Model of Ion Regulation in Yeast
Ke, R., Ingram, P. J., & Haynes, K. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002879 · Cited by 46
“(A) Experimentally measured ENA1 transcription activities [50], (upper panel) and simulated mRNA levels (lower panel) in wild type cells (a,c,e) and cnb1 mutant (b,d,f) under different stress conditions: pH 7.”
The osmotic stress response of Saccharomyces cerevisiae
Tamás, M. J., & Hohmann, S. (2007) · Springer eBooks · doi:10.1007/3-540-45611-2_4 · Cited by 46
Calcium Release and Influx in Yeast: TRPC and VGCC Rule Another Kingdom
Bonilla, M., & Cunningham, K. W. (2002) · Science s STKE · doi:10.1126/stke.2002.127.pe17 · Cited by 45

Authors: Mendoza, I., Rubio, F., Rodriguez-Navarro, A., & Pardo, J. M.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
ORCID: Mendoza, I.
Rubio, F.
Pardo, J.M.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1994-03
Volume: 269
Issue: 12
Pages: 8792-8796
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(17)37038-2
OpenAlex: W1587918801
Semantic Scholar: 03506f73fdcb61ede7c6c76f8d244bbac6fb382e
Cited by: 350
References: 32
Citations by year: 2025: 2 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 2
FWCI: 7.68
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 9735 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: calcineurin, NaCl tolerance, salt stress, Saccharomyces cerevisiae, ENA1, P-type ATPase, lithium accumulation, ion homeostasis, potassium transport, Trk1, Ca2+/calmodulin signaling, protein phosphorylation, gene essentiality
MeSH terms: Adenosine Triphosphatases, Sodium-Potassium-Exchanging ATPase, Base Sequence, Biological Transport, Active, Calmodulin-Binding Proteins, Chromosome Mapping, Cloning, Molecular, Fungal Proteins, Genes, Fungal, Genetic Complementation Test, Homeostasis, Molecular Sequence Data, Phosphoprotein Phosphatases, Saccharomyces cerevisiae, Sodium, Sodium Chloride, Water-Electrolyte Balance, Restriction Mapping, Lithium Chloride, Calcineurin, Cation Transport Proteins, Saccharomyces cerevisiae Proteins

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The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

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