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Cited by 1,778

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

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Grundke-Iqbal, I, Iqbal, K, Quinlan, M, Tung, Y C, Zaidi, M S, Wisniewski, H M·1986·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(17)38495-8
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Abstract

Microtubule-associated protein tau was purified from bovine brain microtubules by either (1) phosphocellulose chromatography, (2) heat treatment at pH 6.4, (3) heat treatment at pH 2.7, (4) heat treatment at pH 2.7 followed by extraction with perchloric acid and precipitation with glycerol, or (5) by precipitation with ammonium sulfate followed by extraction with perchloric acid. All of these tau preparations reacted specifically with antibodies to Alzheimer paired helical filaments. Affinity purified antibodies to tau labeled both Alzheimer neurofibrillary tangles and plaque neurites but not amyloid in Alzheimer brain tissue sections and labeled paired helical filament polypeptides on Western blots. Human brain tau and paired helical filament polypeptides co-migrated on sodium dodecyl sulfate-polyacrylamide gels. These results suggest that tau is a major component of Alzheimer paired helical filaments.

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Citations

Cites

Show all 4 references

Research works printed but not linked: 30

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Cited by

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Metadata

Authors
Grundke-Iqbal, I., Iqbal, K., Quinlan, M., Tung, Y. C., Zaidi, M. S., & Wisniewski, H. M.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1986-05
Volume
261
Issue
13
Pages
6084-6089
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(17)38495-8
OpenAlex
W1611407165
Cited by
1,778
References
4
FWCI
47.45
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. https://app.cochat.ai/papers/10.1016/s0021-9258(17)38495-8
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Grundke-Iqbal, I., Iqbal, K., Quinlan, M., Tung, Y. C., Zaidi, M. S., & Wisniewski, H. M. (1986). Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)38495-8

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.