The distribution of tau in the mammalian central nervous system.
Open accessAbstract
We have determined the biochemical and immunocytochemical localization of the heterogeneous microtubule-associated protein tau using a monoclonal antibody that binds to all of the tau polypeptides in both bovine and rat brain. Using immunoblot assays and competitive enzyme-linked immunosorbent assays, we have shown tau to be more abundant in bovine white matter extracts and microtubules than in extracts and microtubules from an enriched gray matter region of the brain. On a per mole basis, twice-cycled microtubules from white matter contained three times more tau than did twice-cycled microtubules from gray matter. Immunohistochemical studies that compared the localization of tau with that of MAP2 and tubulin demonstrated that tau was restricted to axons, extending the results of the biochemical studies. Tau localization was not observed in glia, which indicated that, at least in brain, tau is neuron specific. These observations indicate that tau may help define a subpopulation of microtubules that is restricted to axons. Furthermore, the monoclonal antibody described in this report should prove very useful to investigators studying axonal sprouting and growth because it is an exclusive axonal marker.
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Tau is predominantly expressed in cortical and hippocampal neurons, with expression also in oligodendrocytes and astrocytes.
“Tau is predominantly expressed in cortical and hippocampal neurons [5–7], although there is also expression in other cell types such as oligodendrocytes and astrocytes [8, 9].”
From Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease (2026) · cites this paper as [7]
The Results (p. 1374) locate tau mainly in neuronal axons, supporting the neuronal part of the claim. The paper examines the medulla, substantia nigra, and cerebellum, but does not establish predominant expression in cortical or hippocampal neurons. The glial-cell clause has separate citations [8, 9] and is not attributed to this source. (LLM, conf=0.84)
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Beaudet, D., Berger, C. L., & Hendricks, A. G. (2026) · eLife · doi:10.7554/elife.110011
- Authors
- Binder, L. I., Frankfurter, A., & Rebhun, L. I.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1985-10-01
- Volume
- 101
- Issue
- 4
- Pages
- 1371-1378
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2113928
- OpenAlex
- W1994030229
- Cited by
- 1,588
- References
- 3
- Citations by year
- 2026: 27 · 2025: 36 · 2024: 46 · 2023: 46 · 2022: 59 · 2021: 59 · 2020: 55 · 2019: 48 · 2018: 41 · 2017: 30 · 2016: 31 · 2015: 31 · 2014: 40 · 2013: 27 · 2012: 37
- FWCI
- 30.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 17588)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- tau protein, microtubule-associated proteins, axons, white matter, gray matter, microtubules, neuron-specific proteins, MAP2, tubulin, monoclonal antibodies, axonal sprouting, central nervous system
- MeSH terms
- Animals, Antibodies, Monoclonal, Axons, Brain Chemistry, Cattle, Immunologic Techniques, Mice, Inbred BALB C, Microtubule-Associated Proteins, Microtubules, Nerve Tissue Proteins, Neuroglia, Tubulin, tau Proteins, Mice, Rats
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