Cited by 277Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthAlzheimer's disease research and treatments

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.

Open access

Innerarity, T L, Friedlander, E J, Rall, S C, Weisgraber, K H, Mahley, R W·1983·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(17)44180-9

Open this paper in CoChat — free account

Abstract

To identify the domain of apolipoprotein E (apo-E) involved in binding to low density lipoprotein (LDL) receptors on cultured human fibroblasts, apo-E was cleaved and the fragments were tested for receptor binding activity. Two large thrombolytic peptides (residues 1-191 and 216-299) of normal apo-E3 were combined with the phospholipid dimyristoylphosphatidylcholine (DMPC) and tested for their ability to compete with 125I-LDL for binding to the LDL (apo-B,E) receptors on human fibroblasts. The NH2-terminal two-thirds (residues 1-191) of apo-E3 was as active as intact apo-E3 . DMPC, while the smaller peptide (residues 216-299) was devoid of receptor-binding activity. When apo-E3 was digested with cyanogen bromide (CNBr) and the four largest CNBr fragments were combined with DMPC and tested, only one fragment competed with 125I-LDL for binding to cultured human fibroblasts (CNBr II, residues 126-218). This fragment possessed binding activity similar to that of human LDL. The 125I-labeled CNBr II . DMPC complex also demonstrated high affinity, calcium-dependent saturable binding to solubilized bovine adrenal membranes. The binding of CNBr II . DMPC was inhibited by 1,2-cyclohexanedione modification of arginyl residues or diketene modification of lysyl residues. In addition, the CNBr II had to be combined with DMPC before it demonstrated any receptor-binding activity. Pronase treatment of the membranes abolished the ability of this fragment to bind to the apo-B,E receptors. This…

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(17)44180-9

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations
Bilheimer, D. W., Eisenberg, S., & Levy, R. I. (1972) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(72)90034-3 · Cited by 1,815
Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts
Goldstein, J. L., & Brown, M. S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42341-7 · Cited by 1,123
Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.
Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52510-8 · Cited by 777
Self-citation
Lipoprotein receptors and cholesterol homeostasis
Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 756
Self-citation
Human apolipoprotein E. The complete amino acid sequence
Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34702-1 · Cited by 741
Self-citation
Abnormal lipoprotein receptor‐binding activity of the human E apoprotein due to cysteine‐arginine interchange at a single site
Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34954-8 · Cited by 673
Self-citation
Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.
Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34284-9 · Cited by 616
Self-citation
Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification
Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563

Show all 33 references

Research works printed but not linked: 1

Mahley, R. W., and Angelin, B. (1983) Adv. Intern. Med., in press

Sorted by citations

Items 201–277 of 277

Idenitification and characterization of a new variant of apolipoprotein E (apo E-Kochi).
SUEHIRO, T., YOSHIDA, K., YAMANO, T., & OHNO, F. (1990) · Japanese Journal of Medicine · doi:10.2169/internalmedicine1962.29.587 · Cited by 17
Characterization of a novel variant of apolipoprotein E, E2 Fukuoka (Arg-224 → Gln) in a hyperlipidemic patient with xanthomatosis
Moriyama, K., Sasaki, J., Takada, Y., Arakawa, F., Matsunaga, A., Ito, Y., & Arakawa, K. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00014-8 · Cited by 17
Anionic phospholipids inhibit apolipoprotein E—Low-density lipoprotein receptor interactions
Yamamoto, T., & Ryan, R. O. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.066 · Cited by 13
NMR studies of the low‐density lipoprotein receptor‐binding peptide of apolipoprotein E bound to dodecylphosphocholine micelles
Clayton, D., Brereton, I. M., Kroon, P. A., & Smith, R. (1999) · Protein Science · doi:10.1110/ps.8.9.1797 · Cited by 13
The conformation of apolipoprotein E isoforms in phospholipid complexes and their interaction with human Hep G2 cells
Cassel, D., Phillips, M. C., Rostron, P. L., Rothblat, G. H., & Utermann, G. (1984) · Atherosclerosis · doi:10.1016/0021-9150(84)90119-9 · Cited by 12
Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes
Zhu, M.-Y., Hasty, A. H., Harris, C. M., Linton, M. F., Fazio, S., & Swift, L. L. (2005) · Metabolism · doi:10.1016/j.metabol.2005.04.019 · Cited by 12
[44] Rat apolipoprotein A-IV: Application of computational methods for studying the structure, function, and evolution of a protein
Boguski, M. S., Elshourbagy, N. A., Taylor, J. M., & Gordon, J. I. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)28104-5 · Cited by 12
A Chinese Hamster Ovarian Cell Line Imports Cholesterol by High Density Lipoprotein Degradation
Pagler, T. A., Golsabahi, S., Doringer, M., Rhode, S., Schütz, G. J., Pavelka, M., Wadsack, C., Gauster, M., Lohninger, A., Laggner, H., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603334200 · Cited by 11
Introduction of sulfhydryl groups into proteins at carboxyl sites
Lin, C., Mihal, K. A., & Krueger, R. J. (1990) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(90)90252-b · Cited by 11
Human apolipoprotein E7: lysine mutations in the carboxy-terminal domain are directly responsible for preferential binding to very low density lipoproteins
Dong, J., Balestra, M. E., Newhouse, Y. M., & Weisgraber, K. H. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31971-4 · Cited by 11
Self-citation
Nucleotide sequence encoding the carboxyl-terminal half of apolipoprotein B from spontaneously hypercholesterolemic pigs
Purtell, C. S., Maeda, N., Ebert, D., Kaiser, M., Lund‐Katz, S., Sturley, S., Kodoyianni, V., Grunwald, K. A. A., Nevin, D. N., & Aiello, R. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36962-5 · Cited by 11
Effect of Apolipoprotein E genotypes on incidence and development of coronary stenosis in Iranian patients with coronary artery disease
Fallah, S., Seifi, M., Firoozrai, M., Ghohari, L. H., Samadikuchaksaraei, A., & Samadirad, B. (2011) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.20428 · Cited by 10
Crystal Structures of the Common Apolipoprotein E Variants: Insights into Functional Mechanisms
Wardell, M. R., Wilson, C., Agard, D. A., Mahley, R. W., & Weisgraber, K. H. (1993) · Springer eBooks · doi:10.1007/978-3-642-84634-2_8 · Cited by 10
Self-citation
Isolation, sequencing, and expression analysis of a bovine apolipoprotein E (APOE) cDNA and chromosomal localization of the APOE locus
Brzozowska, A., Fries, R., Womack, J. E., Grimholt, U., Myklebost, O., & Rogne, S. (1993) · Mammalian Genome · doi:10.1007/bf00364665 · Cited by 10
A patient with apolipoprotein E2 variant (Q187E) without lipoprotein glomerulopathy
Hayakawa, M., Okubo, M., Katori, H., Nagahama, K., Murase, T., Kobayashi, T., Tanaka, S., Nakanishi, K., Odawara, M., Matsushita, H., et al. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.31426 · Cited by 9
Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis
Zurnic, I., Djurić, T., KONCAR, I. B., Stanković, A., Dinčić, D., & Živković, M. (2014) · Vojnosanitetski pregled · doi:10.2298/vsp1404362z · Cited by 8
Replacement of helix 1′ enhances the lipid binding activity of apoE3 N‐terminal domain
Redmond, K. A., Murphy, C., Narayanaswami, V., Kiss, R. S., Hauser, P. S., Guigard, E., Kay, C. M., & Ryan, R. O. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05089.x · Cited by 9
Conformational Reorganization of Apolipoprotein E Triggered by Phospholipid Assembly
Prakashchand, D. D., & Mondal, J. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.1c03011 · Cited by 7
Chapter 12 Lipoprotein genetics and molecular biology
Breslow, J. L. (1987) · New comprehensive biochemistry · doi:10.1016/s0167-7306(08)60206-9 · Cited by 7
[31] Immunochemical methods for studying lipoprotein structure
Krul, E. S., & Schonfeld, G. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)28091-x · Cited by 7
Apolipoprotein E: Receptor Binding Properties
Weisgraber, K. H., Innerarity, T. L., Rall, S. C., & Mahley, R. W. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2459-1_13 · Cited by 7
Self-citation
Structural Change of ApoE–Lipid Nanoparticles Alters Receptor-Mediated Endocytosis and Induces Endosomal Disruption
Mo, Y., Liu, H., Keszei, A. F. A., Dai, D. L., Makky, A., Ding, L., Pan, A., Bu, J., Mazhab‐Jafari, M. T., Chen, J., et al. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c16025 · Cited by 6
Apolipoprotein E gene polymorphisms in Lebanese with hypercholesterolemia
Mahfouz, R. A., Charafeddine, K. M., Tanios, R. F., Karaky, N., Khalik, R. N. A., & Daher, R. T. (2013) · Gene · doi:10.1016/j.gene.2013.03.019 · Cited by 6
Role of leucine zipper motif in apoE3 N-terminal domain lipid binding activity
Yamamoto, T., & Ryan, R. O. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.07.006 · Cited by 7
The sequence of porcine apolipoprotein E (APOE) cDNA
Brzozowska, A., Grimholt, U., Kulseth, M. A., Wold, I., & Rogne, S. (1993) · DNA sequence · doi:10.3109/10425179309015633 · Cited by 7
Key Issues in the Delivery of Pharmacological Agents Using Lipoproteins: Design of a Synthetic Apoprotein-Lipid Carrier
Michael, J., & Shaw, K. V. (2017) · CRC Press eBooks · doi:10.1201/9780203748831-11 · Cited by 6
HDL Receptor and Reverse Cholesterol Transport in Adipose Cells
Barbaras, R., Puchois, P., Grimaldi, P. A., Barkia, A., Fruchart, J., & Ailhaud, G. P. (1988) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0733-4_34 · Cited by 6
Domains of Apolipoprotein E Involved in the Binding to the Protein Core of Biglycan of the Vascular Extracellular Matrix Potential Relationship between Retention and Anti-Atherogenic Properties of this Apolipoprotein
Klezovitch, O. (2001) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00121-9 · Cited by 6
Human apolipoprotein E N-terminal domain displacement of apolipophorin III from insect low density lipophorin creates a receptor-competent hybrid lipoprotein
Fisher, C. A., Kiss, R. S., Francis, G. A., Gao, P., & Ryan, R. O. (1999) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(99)00028-0 · Cited by 6
Apolipoprotein E Mimetic Peptides: Cholesterol-Dependent and Cholesterol-Independent Properties
Garber, D. W., Goldberg, D., & Anantharamaiah, G. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-17350-4_10 · Cited by 5
Apolipoprotein E3Basel: new insights into a highly conserved protein region
Miserez, A. R., Scharnagl, H., Muller, P. Y., Mirsaidi, R., Stähelin, H. B., Monsch, A. U., März, W., & Hoffmann, M. M. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01180.x · Cited by 5
Monoclonal antibodies to serum lipoproteins: Their present and future use in biology and medicine
Watt, R. M., Carhart, R. L., Gentile, T., & Watt, T. S. (1985) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(85)90081-6 · Cited by 5
Apolipoprotein structure: crystal and models
Atkinson, D. (1992) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(92)90075-i · Cited by 5
Application of Monoclonal Antibodies to Issues of Plasma Lipoprotein Structure and Function
Curtiss, L. K. (1985) · Springer eBooks · doi:10.1007/978-1-4684-4964-8_17 · Cited by 5
Whole Exome Sequencing Reveals a Novel APOE Mutation in a Patient With Sporadic Early-Onset Alzheimer's Disease
Bagaria, J., Moon, Y., Bagyinszky, E., Shim, K. H., An, S. S. A., Kim, S., & Han, S. H. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.899644 · Cited by 4
In vivo metabolism of apolipoprotein E in humans
Gregg, R. E., & Brewer, H. B. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)29087-4 · Cited by 4
Does Apolipoprotein E genotype affect cardiovascular risk in subjects with acromegaly?
Çetintaş, V. B., Zengi, A., Vardarli, A. T., Karadeniz, M., Ergonen, F., Küçükaslan, A. Ş., Tamsel, S., Kosova, B., Şahin, S. B., Saygılı, F., et al. (2011) · Endocrine · doi:10.1007/s12020-011-9585-8 · Cited by 4
Familial Dysbetalipoproteinemia: A Genetically Heterogeneous Disease Caused by Mutations of the Ligand Apolipoprotein E
Vermeer, B. J., Frants, R. R., & Havekes, L. M. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12462212 · Cited by 4
Tamoxifen‐induced modification of serum lipoprotein phospholipids in the cockerel
Breckenridge, W. C., & Lazier, C. B. (1987) · Lipids · doi:10.1007/bf02540366 · Cited by 4
Plasma Apolipoproteins: Gene Structure, Function, and Variants
Scanu, A. M. (1987) · Elsevier eBooks · doi:10.1016/b978-0-12-568405-7.50009-6 · Cited by 4
Familial disorders of plasma apolipoproteins
Sirtori, C. R., & Franceschini, G. (1985) · Journal of Molecular Medicine · doi:10.1007/bf01747977 · Cited by 3
Peptide model of a highly conserved, N-terminal domain of apolipoprotein E is able to modulate lipoprotein binding to a member of the class A scavenger receptor family
Dominguez, S. R., Miller-Auer, H., Reardon, C. A., & Meredith, S. C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32155-6 · Cited by 3
Phenotyping of Porcine Apolipoprotein E Using Isoelectric Focusing and Localization of the APOE Gene Within the Halothane-Susceptibility Linkage Group
Kurył, J. (1999) · Biochemical Genetics · doi:10.1023/a:1018703125687 · Cited by 2
Valeur sémiologique des apolipoprotéines
Fruchart, J. (1985) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(85)80076-x · Cited by 2
Thrombin cleavage of apolipoprotein Bh of rabbit LDL: structural comparisons with human apolipoprotein B-100.
Leroy, A., Castro, G., Agnani, G., Saı̈le, R., Barkia, A., & Fruchart, J. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41514-7 · Cited by 2
Binding of Apolipoproteins A to Adipose Cells : Role of Receptor Sites in Cholesterol Efflux and Purification of Binding Protein(S)
Barbaras, R., Puchois, P., Pradines, A., Steinmetz, A., Barthelemy-Clavey, V., Ghalim, N., Fruchart, J., & Ailhaud, G. P. (1990) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5904-3_11 · Cited by 2
Receptor-Mediated Regulation of Cholesterol Metabolism
Mahley, R. W. (1987) · Springer eBooks · doi:10.1007/978-1-4684-5296-9_9 · Cited by 1
Self-citation
Genetic Risk Factors: Their Function and Comorbidities in Alzheimer′s Disease
Hiltunen, M. O., Bertram, L., & Saunders, A. J. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/925362 · Cited by 1
Role of Apolipoprotein E Genotype in Coronary Artery Disease
Tziakas, D. N., & Chalikias, G. K. (2007) · Future Cardiology · doi:10.2217/14796678.3.5.537 · Cited by 1
Attenuation of Acute Rat Renal Allograft Rejection by Apolipoprotein E-Mimetic Peptide
Zakrzewicz, A., Kutlimuratov, K., Atanasova, S., Zakrzewicz, D., Reichert, M., Schmitz, J., Wilhelm, J., Lochnit, G., Padberg, W. M., & Grau, V. (2015) · Transplantation · doi:10.1097/tp.0000000000000569 · Cited by 1
Apolipoprotein AI-Milano: A Structural Modification in an Apolipoprotein Variant Leading to Unusual Lipid Binding Properties
Franceschini, G., Calabresi, L., Apebe, P., Sirtori, M., Vecchio, G., & Sirtori, C. R. (1986) · Springer eBooks · doi:10.1007/978-1-4615-9474-1_8 · Cited by 1
Apolipoprotein E and Reverse Cholesterol Transport: The Role of Recycling in Plasma and Intracellular Lipid Trafficking
Swift, L. L., Hasty, A. H., Linton, M. F., & Fazio, S. (2007) · Wiley eBooks · doi:10.1002/9783527625178.ch3 · Cited by 1
Potential Biological Mechanisms of ApoE in Alzheimer’s Disease
Rebeck, G. W. (1997) · Humana Press eBooks · doi:10.1007/978-1-59259-471-9_2 · Cited by 1
Treatment of E2E2 homozygous familial dysbetalipoproteinemic subjects with gemfibrozil does not enhance the binding of their d < 1.019 lipoprotein fraction to the low-density lipoprotein receptor
Mulder, M. T., Smelt, A. H. M., Zhao, S. P., Frants, R. R., & Havekes, L. M. (1993) · Metabolism · doi:10.1016/0026-0495(93)90082-y · Cited by 1
Diagnostics of Lipids and Lipoproteins
Wieland, H., März, W., & Nauck, M. (1994) · Springer eBooks · doi:10.1007/978-3-642-78959-5_3
Cellular and Molecular Biology of Apolipoproteins: Receptor-Mediated Regulation of Cholesterol Metabolism
Mahley, R. W. (1987) · Proceedings in life sciences · doi:10.1007/978-3-642-71702-4_11
Self-citation
Regulierung und Verfügbarkeit von Apolipoprotein E in Astrozyten
Hamker, U. (2005) · edoc Publication server (Humboldt University of Berlin) · doi:10.18452/15272
Lipoprotein Receptors and Their Ligands: Structure and Function of Apoproteins E and B
Mahley, R. W. (1987) · Springer eBooks · doi:10.1007/978-3-642-83118-8_2
Self-citation
Genetic Factors Contributing to Cardiovascular Disease that may affect Endothelial Structure and Function: The Role of Proteins involved in Lipoprotein Transport
Zannis, V. I., Laccotripe, M., Makrides, S. C., Kardassis, D., & Zanni, E. E. (1996) · Springer eBooks · doi:10.1007/978-1-4613-0355-8_7
Partial apolipoprotein E-β-galactosidase fusion protein expressed in Escherichia coli retains binding activity to the LDL(B/E) receptor
Ribeiro, A., Cardot, P., Bénarous, R., Pernas, P., Pépin, D., Rybkine, T., Chambaz, J., & Bereziat, G. (1990) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(90)90208-j
Apolipoproteine E humaine: polymorphisme et domaine de fixation aux récepteurs
Bekaert, E. D., Ayrault-Jarrier, M., & Polonovski, J. (1986) · Biochimie · doi:10.1016/s0300-9084(86)80157-2
Classification of primary dyslipoproteinemias
Dargel, R. (1985) · Experimental Pathology · doi:10.1016/s0232-1513(85)80043-8
Correlation of frequencies of apolipoprotein E mutations with heritage in midwest individuals
Dang, M. (2012) · Cardinal Scholar (Ball State University)
Association of Apolipoprotein E Genotype with Early and Advanced Atherosclerotic Lesions
Ilveskoski, E. (2001) · Tampere University Institutional Repository (Tampere University)
Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis Polimorfizmi u genu za apolipoprotein E kao faktori rizika od ateroskleroze karotidnih arterija
Zurni, I., Djuri, T., Kon, I. I., Stankovi, A., & Dragan (2014)
Apolipoprotein B (ApoB)
Myant, N. B. (1990) · Elsevier eBooks · doi:10.1016/b978-0-12-512300-6.50011-9
A New Variant of Apolipoprotein E (apo E-Kochi) in a Hyperlipidemic Subject with Broad-beta Band
Suehiro, T., Yoshida, K., TAKAMATSU, K., Kawada, M., Hisatake, K., Yasuoka, N., Kishino, W., Shigetoshi, U. G. A., Mizutani, Y., Yamano, T., et al. (1986) · The Journal of Japan Atherosclerosis Society · doi:10.5551/jat1973.14.3_743
Conformational Reorganisation of Apolipoprotein E Triggered by Phospholipid AssemblyPreprint
Prakashchand, D. D., & Mondal, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.18.255299
References
(1998) · Elsevier eBooks · doi:10.1016/b978-012186060-8/50015-2
Apoprotein E3-Leiden: A Variant of Human Apolipoprotein E3 Associated with Familial Type III Hyperlipoproteinemia
Havekes, L. M., Klasen, E. C., & Utermann, G. (1986) · Springer eBooks · doi:10.1007/978-1-4615-9474-1_26
Conformational Dynamics in Risk and Resilience Alleles of Apolipoprotein E (APOE) for Alzheimer's DiseasePreprint
Martin, W., & Cheng, F. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4705580
Apolipoprotein E in drug delivery systems—targeted pharmacotherapeutics
Pandey, J., & Jain, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40563-1.00009-0
Apolipoprotein E and liver health: Implications in lipid metabolism and diseases
Alam, Q., Ganeshpurkar, A., & El‐Zahaby, S. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40563-1.00016-8
Targeting of Acid Sphingomyelinase, a Lysosomal Membrane Protein, Using Apolipoprotein E3-containing Nanodiscs
Metkar, V., Benedicto, V., Zheng, J., Zivkovic, A. M., Plascencia, N. D., Gredig, T., & Narayanaswami, V. (2026) · The Journal of Membrane Biology · doi:10.1007/s00232-026-00393-4
Molecular Biology of Human Apolipoprotein B and Related Diseases
Zannis, V. I., Hussain, M. M., Hadzopoulou‐Cladaras, M., Kouvatsi, A., Kardassis, D., & Cladaras, C. (1988) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0733-4_14
Structural Domains in Human Serum Low Density Lipoprotein Apolipoprotein B100
Aggerbeck, L. P. (1993) · Springer eBooks · doi:10.1007/978-3-642-84634-2_7
ApoE4 impairs astrocyte lipid droplet formation via endolysosomal dysfunction
Ralhan, I., Bae, J.-Y., Lee, N. Y., Cai, W., Chang, J., Jarad, S., Gu, H., Zhang, D., & Ioannou, M. S. (2026) · doi:10.64898/2026.09.01.748585

Authors: Innerarity, T. L., Friedlander, E. J., Rall, S. C., Weisgraber, K. H., & Mahley, R. W.
Affiliations: University of California, San Francisco (US)
ORCID: Mahley, R W
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1983-10
Volume: 258
Issue: 20
Pages: 12341-12347
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(17)44180-9
OpenAlex: W134453782
Cited by: 276
References: 33
Citations by year: 2026: 4 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 1 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 3 · 2012: 1
FWCI: 28.66
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 13542 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: apolipoprotein E, receptor binding domain, LDL receptor, apolipoprotein E3, CNBr fragments, dimyristoylphosphatidylcholine, calcium-dependent binding, fibroblasts
MeSH terms: Adrenal Cortex, Amino Acids, Animals, Apolipoproteins, Apolipoproteins E, Cattle, Cell Membrane, Cells, Cultured, Fibroblasts, Humans, Infant, Newborn, Kinetics, Lipoproteins, LDL, Male, Peptide Fragments, Receptors, Cell Surface, Receptors, LDL, Skin, Thrombin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks