The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Alpha- and beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture
Open accessAbstract
In order to examine the control of expression of the gene coding for the brown fat specific uncoupling protein thermogenin (UCP), brown fat cells isolated as undifferentiated precursors from the interscapular brown adipose tissue of young mice were grown in culture. In these cells, it was possible by norepinephrine (NE) addition to induce specifically the expression of the UCP gene. The effect of NE was due to activation of transcription. The ability to express the UCP gene was maximal in cells around confluence; cell cultures younger or older than this showed a lower response. The response to NE showed a sharp optimum around 0.1 microM and was linear with time over the 4-h period studied. The presence of insulin or thyroid hormones facilitated the NE response. Pharmacological analysis of the adrenergic response indicated that UCP gene expression could be induced both via beta-receptors (probably beta 3) and via alpha 1-receptors; these effects were synergistic. It was concluded that it is possible to promote these precursor cells to advance to such a state of differentiation that they can demonstrate the selective feature of the brown fat cell, i.e. the ability to express UCP. The expression of the UCP gene is regulated via interacting adrenergic mechanisms.
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“These molecules are also known to upregulate UCP-1 expression in many models, including mouse [40,41], rat [42,43], and human [44] brown adipose tissues.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [40]
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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
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Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases
Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476
“These molecules are also known to upregulate UCP-1 expression in many models, including mouse [40,41], rat [42,43], and human [44] brown adipose tissues.”
Background
Metadata
- Authors
- Rehnmark, S., Néchad, M., Herron, D., Cannon, B., & Nedergaard, J.
- Affiliations
- Stockholm University (SE)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-09
- Volume
- 265
- Issue
- 27
- Pages
- 16464-16471
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1501975414
- Cited by
- 201
- References
- 49
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- thermogenin, uncoupling proteins, brown adipocytes, brown adipose tissue, adipogenesis, norepinephrine, alpha1-adrenoceptors, beta3-adrenergic receptor, gene expression regulation, transcriptional activation, insulin, thyroid hormones
- MeSH terms
- Uncoupling Protein 1, Adrenergic beta-Antagonists, Animals, Adipose Tissue, Brown, Carrier Proteins, Cells, Cultured, Colforsin, Insulin, Ion Channels, Male, Membrane Proteins, Norepinephrine, Nucleic Acid Hybridization, Oxymetazoline, Phenylephrine, Prazosin, Propanolamines, Propranolol, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta, RNA, RNA, Messenger, Thyroxine, Triiodothyronine, 8-Bromo Cyclic Adenosine Monophosphate, Blotting, Northern, Gene Expression, Mitochondrial Proteins, Mice
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