Nedergaard, Jan

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews

Adipose Tissue and MetabolismLipid metabolism and biosynthesis

Cited by 6,433

Unexpected evidence for active brown adipose tissue in adult humans

Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,824

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism

Adipose Tissue and MetabolismRegulation of Appetite and Obesity

Cited by 1,318

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 1,263

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages

Timmons, J. A., Wennmalm, K., Larsson, O., Walden, T. B., Lassmann, T., Petrovic, N., Hamilton, D. L., Gimeno, R. E., Wahlestedt, C., Baar, K., et al. (2007) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 732

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S. (2009) · The FASEB Journal

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 725

Nonshivering thermogenesis and its adequate measurement in metabolic studies

Cannon, B., & Nedergaard, J. (2011) · Journal of Experimental Biology

Adipose Tissue and MetabolismPhysiological and biochemical adaptations

Cited by 677

UCP1: The only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency

Nedergaard, J., Golozoubova, V., Matthias, A., Asadi, A., Jacobsson, A., & Cannon, B. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 615

Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold

Golozoubova, V., Hohtola, E., Matthias, A., Jacobsson, A., Cannon, B., & Nedergaard, J. (2001) · The FASEB Journal

Adipose Tissue and MetabolismThermoregulation and physiological responses

Cited by 503

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation

Hansen, J. B., Jørgensen, C., Petersen, R. K., Hallenborg, P., De Matteis, R., Bøye, H. A., Petrovic, N., Enerbäck, S., Nedergaard, J., Cinti, S., et al. (2004) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 287

Alpha- and beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture

Rehnmark, S., Néchad, M., Herron, D., Cannon, B., & Nedergaard, J. (1990) · Journal of Biological Chemistry

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 201

Uncoupling proteins: A role in protection against reactive oxygen species—or not?

Cannon, B., Shabalina, I. G., Kramarova, T. V., Petrovic, N., & Nedergaard, J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 182

Depressed Thermogenesis but Competent Brown Adipose Tissue Recruitment in Mice Devoid of All Hormone-Binding Thyroid Hormone Receptors

Golozoubova, V., Gullberg, H., Matthias, A., Cannon, B., Vennström, B., & Nedergaard, J. (2004) · Molecular Endocrinology

Adipose Tissue and MetabolismThyroid Disorders and Treatments

Cited by 155

Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice

de Jong, J. M. A., Sun, W., Pires, N. D., Frontini, A., Balaz, M., Jespersen, N. Z., Feizi, A., Petrovic, K., Fischer, A. W., Bokhari, M. H., et al. (2019) · Nature Metabolism

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 137

Mitochondrial (‘mild’) uncoupling and ROS production: Physiologically relevant or not?

Shabalina, I. G., & Nedergaard, J. (2011) · Biochemical Society Transactions

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 110

Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture

Herron, D., Rehnmark, S., Néchad, M., Lončar, D., Cannon, B., & Nedergaard, J. (1990) · FEBS Letters

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 43

Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis

Abreu-Vieira, G., Hagberg, C. E., Spalding, K. L., Cannon, B., & Nedergaard, J. (2015) · American Journal of Physiology-Endocrinology and Metabolism

Adipose Tissue and MetabolismThermoregulation and physiological responses

Cited by 34