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Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.
Open accessAbstract
Inositol 1,4,5-trisphosphate is an intracellular second messenger, produced upon stimulation of the phosphoinositide system, capable of mobilizing calcium from intracellular stores. We have recently identified high levels of specific binding sites for inositol 1,4,5-trisphosphate in brain membranes (Worley, P. F., Baraban, J. M., Colvin, J. S., and Snyder, S. H. (1987) Nature 325, 159-161) and have now further characterized these sites. In cerebellar membranes, inositol 1,4,5-trisphosphate binding sites are abundant (20 pmol/mg protein) and display high affinity and selectivity for inositol 1,4,5-trisphosphate (KD approximately equal to 40 nM), whereas other inositol phosphates such as inositol 1,3,4,5-tetrakisphosphate (Ki approximately equal to 10 microM) and inositol 1,4-bisphosphate (Ki approximately equal to 10 microM) exhibit much lower affinity for this site. Submicromolar concentrations of calcium strongly inhibit inositol 1,4,5-trisphosphate binding (IC50 approximately equal to 300 nM). A sharp increase in binding occurs at slightly alkaline pH. These results suggest that actions of inositol 1,4,5-trisphosphate are regulated by physiological alterations in intracellular pH and calcium concentrations.
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Citations
Cited by
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Solubilization, purification, and characterization of an inositol trisphosphate receptor.
Supattapone, S., Worley, P. F., Baraban, J. M., & Snyder, S. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57336-7 · Cited by 649
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Mechanisms and function of intercellular calcium signaling
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Metadata
- Authors
- Worley, P. F., Baraban, J. M., Supattapone, S., Wilson, V. S., & Snyder, S. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1987-09
- Volume
- 262
- Issue
- 25
- Pages
- 12132-12136
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1523078822
- Cited by
- 546
- References
- 0
- FWCI
- 26.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Worley, P. F., Baraban, J. M., Supattapone, S., Wilson, V. S., & Snyder, S. H. (1987). Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)45326-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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