The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Cyclic ADP-Ribose in Insulin Secretion from Pancreatic βCells
Abstract
Inositol 1,4,5-trisphosphate (IP 3 ) is thought to be a second messenger for intracellular calcium mobilization. However, in a cell-free system of islet microsomes, cyclic adenosine diphosphate-ribose (cADP-ribose), a nicotinamide adenine dinucleotide (NAD + ) metabolite, but not IP 3 , induced calcium release. In digitonin-permeabilized islets, cADP-ribose and calcium, but not IP 3 , induced insulin secretion. Islet microsomes released calcium when combined with the extract from intact islets that had been incubated with high concentrations of glucose. Sequential additions of cADP-ribose inhibited the calcium release response to extracts from islets treated with high concentrations of glucose. Conversely, repeated additions of the islet extract inhibited the calcium release response to a subsequent addition of cADP-ribose. These results suggest that cADP-ribose is a mediator of calcium release from islet microsomes and may be generated in islets by glucose stimulation, serving as a second messenger for calcium mobilization in the endoplasmic reticulum.
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Cites
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Cited by
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Malavasi, F., Deaglio, S., Funaro, A., Ferrero, E., Horenstein, A. L., Ortolan, E., Vaisitti, T., & Aydin, S. (2008) · Physiological Reviews · doi:10.1152/physrev.00035.2007 · Cited by 862
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Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers
Lee, H. C. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.317 · Cited by 433
Monoclonal antibodies targeting CD 38 in hematological malignancies and beyond
van de Donk, N. W. C. J., Janmaat, M. L., Mutis, T., Lammerts van Bueren, J. J., Ahmadi, T., Sasser, A. K., Lokhorst, H. M., & Parren, P. W. H. I. (2016) · Immunological Reviews · doi:10.1111/imr.12389 · Cited by 353
New functions of a long‐known molecule: Emerging roles of NAD in cellular signaling
Ziegler, M. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01187.x · Cited by 289
Metadata
- Authors
- Takasawa, S., Nata, K., Yonekura, H., & Okamoto, H.
- Venue
- Science
- Published
- 1993-01-15
- Volume
- 259
- Issue
- 5093
- Pages
- 370-373
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040593177
- Cited by
- 441
- References
- 25
- FWCI
- 18.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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