The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Inositol 1,4,5-Trisphosphate Receptor Is Located to the Inner Nuclear Membrane Vindicating Regulation of Nuclear Calcium Signaling by Inositol 1,4,5-Trisphosphate
Open accessAbstract
Transient rise in nuclear calcium concentration is implicated in the regulation of events controlling gene expression. Mechanism by which calcium is transported to the nucleus is vehemently debated. Inositol 1,4,5-trisphosphate (InsP3) and inositol-1,3,4,5-tetrakisphosphate (InsP4) receptors have been located to the nucleus and their role in nuclear calcium signaling has been proposed. Outer nuclear membrane was separated from the inner membrane. The two membrane preparations were, as best as possible, devoid of cross contamination as attested by marker enzyme activity, Western blotting with antilamin antibody, and electron microscopy. InsP4 receptor and Ca(2+)-ATPase were located to the outer nuclear membrane. InsP3 receptor was located to the inner nuclear membrane. ATP or InsP4 induced nuclear calcium uptake. External free calcium concentration, in the medium bathing the nuclei, determined the choice for ATP or InsP4-mediated calcium transport. We present a mechanistic model for nuclear calcium transport. According to this model, calcium can reach the nucleus envelope either by the action of ATP or InsP4. However, the calcium release from the nucleus envelope to the nucleoplasm is mediated by InsP3 through the activation of InsP3 receptor, which is located to the inner nuclear membrane. The action of InsP3 in this process was instantaneous and transient and was sensitive to heparin.
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Cites
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Ca2+/CaM-Dependent Kinases: From Activation to Function
Hook, S. S., & Means, A. R. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.471 · Cited by 482
Endoplasmic reticulum of animal cells and its organization into structural and functional domains
Baumann, O., & Walz, B. (2001) · International Review of Cytology · doi:10.1016/s0074-7696(01)05004-5 · Cited by 458
Nuclear calcium signalling in the regulation of brain function
Bading, H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3531 · Cited by 373
The role of the nuclear pore complex in adenovirus DNA entry
Greber, U. F., Suomalainen, M., Stidwill, R. P., Boucke, K., Ebersold, M. W., & Helenius, A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.19.5998 · Cited by 299
Emanuelli, M., Carnevali, F., Saccucci, F., Pierella, F., Amici, A., Raffaelli, N., & Magni, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008700200 · Cited by 189
Metadata
- Authors
- Humbert, J.-P., Matter, N., Artault, J.-C., Köppler, P., & Malviya, A. N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 271
- Issue
- 1
- Pages
- 478-485
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1589002191
- Cited by
- 277
- References
- 27
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Inositol 1,4,5-Trisphosphate Receptor Is Located to the Inner Nuclear Membrane Vindicating Regulation of Nuclear Calcium Signaling by Inositol 1,4,5-Trisphosphate. https://app.cochat.ai/papers/10.1074/jbc.271.1.478
- The paper
- Humbert, J.-P., Matter, N., Artault, J.-C., Köppler, P., & Malviya, A. N. (1996). Inositol 1,4,5-Trisphosphate Receptor Is Located to the Inner Nuclear Membrane Vindicating Regulation of Nuclear Calcium Signaling by Inositol 1,4,5-Trisphosphate. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.1.478
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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