The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
The multidrug resistance gene PDR1 from Saccharomyces cerevisiae.
Open accessAbstract
The Saccharomyces cerevisiae gene PDR1, responsible for pleiotropic drug resistance, was isolated from a genomic DNA cosmid library by hybridization to the flanking LEU1 gene, followed by subcloning the drug-sensitive phenotype into the transformed pdr1-1, pdr1-2, and pdr1-3 drug-resistant mutants. A RNA molecule of 3.5 kilobases was identified as the PDR1 transcript. The nucleotide sequence of the complementing DNA fragment contained a 3192-nucleotide open reading frame. Disruption of the pdr1 and PDR1 genes restored or increased drug sensitivity. Analysis of the PDR1 deduced amino acid sequence revealed several homologies to four different regulatory proteins involved in the control of gene expression, including a cysteine-rich motif suggested to be a metal-binding domain for DNA recognition. A model is proposed of a general transcriptional control by PDR1 of several target genes encoding proteins from plasma, mitochondria, and possibly other permeability barriers.
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Cites
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[12] One-step gene disruption in yeast
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Expression of a multidrug-resistance gene in human tumors and tissues.
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Cited by
The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein
McGrath, J. P., & Varshavsky, A. (1989) · Nature · doi:10.1038/340400a0 · Cited by 601
Prasad, R., De Wergifosse, P., Goffeau, A., & Balzi, E. (1995) · Current Genetics · doi:10.1007/bf00352101 · Cited by 486
Self-citationBalzi, E., Wang, M., Leterme, S., Van Dyck, L., & Goffeau, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42155-7 · Cited by 447
Self-citationA nuclear receptor-like pathway regulating multidrug resistance in fungi
Thakur, J. K., Arthanari, H., Yang, F., Pan, S.-J., Fan, X., Breger, J., Frueh, D. P., Gulshan, K., Li, D. K., Mylonakis, E., et al. (2008) · Nature · doi:10.1038/nature06836 · Cited by 343
An update on antifungal targets and mechanisms of resistance in Candidaalbicans
Akins, R. A. (2005) · Medical Mycology · doi:10.1080/13693780500138971 · Cited by 291
Metadata
- Authors
- Balzi, E., Chen, W., Ulaszewski, S., Capieaux, E., & Goffeau, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1987-12
- Volume
- 262
- Issue
- 35
- Pages
- 16871-16879
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1639259334
- Cited by
- 276
- References
- 48
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Balzi, E., Chen, W., Ulaszewski, S., Capieaux, E., & Goffeau, A. (1987). The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)45464-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
