Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter

WAF1, a potential mediator of p53 tumor suppression

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p53 Mutations in Human Cancers

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Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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The p53 tumour suppressor gene

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Participation of p53 protein in the cellular response to DNA damage.

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Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

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Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

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Definition of a consensus binding site for p53

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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p53 function and dysfunction

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Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Kuerbitz, S. J., Plunkett, B., Walsh, W., & Kastan, M. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7491 · Cited by 1,837 · see citing works

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

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mdm2 expression is induced by wild type p53 activity.

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Identification of p53 as a Sequence-Specific DNA-Binding Protein

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Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

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Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

Kern, S. E., Pietenpol, J., Thiagalingam, S., Seymour, A., Kinzler, K. W., & Vogelstein, B. (1992) · Science · doi:10.1126/science.1589764 · Cited by 940 · see citing works

Gain of function mutations in p53

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The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

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Proliferating cell nuclear antigen is required for DNA excision repair

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Presence of a Potent Transcription Activating Sequence in the p53 Protein

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p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

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Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

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A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

Funk, W. D., Pak, D. T. S., Karas, R. H., Wright, W. E., & Shay, J. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2866 · Cited by 732 · see citing works

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

Chin, K., Ueda, K., Pastan, I. H., & Gottesman, M. M. (1992) · Science · doi:10.1126/science.1346476 · Cited by 726 · see citing works

Mapping of the p53 and mdm-2 Interaction Domains

Chen, J., Maréchal, V., & Levine, A. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4107 · Cited by 689 · see citing works

High levels of p53 protein in UV-irradiated normal human skin.

Hall, P. A., Ph, M., Hd, M., Dover, R., & Lane, D. P. (1993) · PubMed · Cited by 673 · see citing works

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

Li, R., Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature · doi:10.1038/371534a0 · Cited by 645 · see citing works

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

Raycroft, L., Wu, H., & Lozano, G. (1990) · Science · doi:10.1126/science.2144364 · Cited by 620 · see citing works

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

Milner, J., & Medcalf, E. (1991) · Cell · doi:10.1016/0092-8674(91)90384-b · Cited by 612 · see citing works

Wild-type p53 activates transcription in vitro

Farmer, G., Bargonetti, J., Zhu, H., Friedman, P., Prywes, R., & Prives, C. (1992) · Nature · doi:10.1038/358083a0 · Cited by 579 · see citing works

Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

Waga, S., & Stillman, B. (1994) · Nature · doi:10.1038/369207a0 · Cited by 557 · see citing works

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.Preprint

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THE TUMOR SUPPRESSOR GENES

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Wild-type p53 binds to the TATA-binding protein and represses transcription.

Seto, E., Usheva, A., Zambetti, G. P., Momand, J. A., Horikoshi, N., Weinmann, R. S., Levine, A. J., & Shenk, T. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12028 · Cited by 504 · see citing works

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

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p53 Transcriptional Activation Mediated by Coactivators TAF II 40 and TAF II 60

Thut, C. J., Chen, J.-L., Klemm, R. D., & Tjian, R. (1995) · Science · doi:10.1126/science.7809597 · Cited by 439 · see citing works

Wild-type p53 can down-modulate the activity of various promoters.

Ginsberg, D., Mechta‐Grigoriou, F., Yaniv, M., & Oren, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.9979 · Cited by 434 · see citing works

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

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Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

Santhanam, U., Ray, A., & Sehgal, P. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7605 · Cited by 390 · see citing works

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

Bargonetti, J., Friedman, P. N., Kern, S. E., Vogelstein, B., & Prives, C. L. (1991) · Cell · doi:10.1016/0092-8674(91)90560-l · Cited by 367 · see citing works

The transcriptional transactivation function of wild‐type p53 is inhibited by SV40 large T‐antigen and by HPV‐16 E6 oncoprotein.

Mietz, J. A., Unger, T., Huibregtse, J. M., & Howley, P. M. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05608.x · Cited by 366 · see citing works

Binding of Basal Transcription Factor TFIIH to the Acidic Activation Domains of VP16 and p53

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Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

Kern, S. E., Pietenpol, J. A., Thiagalingam, S., et al. (1992) · Science · doi:10.1126/science.256.5058.827 · Cited by 342 · see citing works

The tumore suppressor p53

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Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

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Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.Preprint

Zambetti, G. P., Bargonetti, J., Walker, K. K., Prives, C. L., & Levine, A. J. (1992) · Genes & Development · doi:10.1101/gad.6.7.1143 · Cited by 311 · see citing works

Regulation of the Human hsp70 Promoter by p53

Agoff, S. N., Hou, J., Linzer, D. I., & Wu, B. (1993) · Science · doi:10.1126/science.8418500 · Cited by 292 · see citing works

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53‐mediated repression of transcription.

Lechner, M. S., Mack, D. H., Finicle, A. B., Crook, T., Vousden, K. H., & Laimins, L. A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05375.x · Cited by 272 · see citing works

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

Lin, D., Shields, M. T., Ullrich, S. J., Appella, E., & Mercer, W. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9210 · Cited by 267 · see citing works

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.

Unger, T., Nau, M. M., Segal, S., & Minna, J. D. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05183.x · Cited by 261 · see citing works

The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription

Liu, X. E., Miller, C. W., Koeffler, H. P., & Berk, A. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3291-3300.1993 · Cited by 260 · see citing works

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

Mercer, W. E., Shields, M. T., Lin, D. P., Appella, E., & Ullrich, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1958 · Cited by 248 · see citing works

Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis.

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p53 domains: identification and characterization of two autonomous DNA-binding regions.Preprint

Wang, Y., Reed, M. J., Wang, P., Stenger, J. E., Mayr, G. A., Anderson, M. E., Schwedes, J. F., & Tegtmeyer, P. (1993) · Genes & Development · doi:10.1101/gad.7.12b.2575 · Cited by 239 · see citing works

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

Truant, R., Xiao, H., Ingles, C. J., & Greenblatt, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53769-8 · Cited by 203 · see citing works

p53 and human cancers

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Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein

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Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression

Horikoshi, N., Usheva, A., Chen, J., Levine, A. J., Weinmann, R. S., & Shenk, T. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.227 · Cited by 182 · see citing works

Inhibition of viral and cellular promoters by human wild-type p53

Subler, M. A., Martin, D. W., & Deb, S. (1992) · Journal of Virology · doi:10.1128/jvi.66.8.4757-4762.1992 · Cited by 171 · see citing works

Increased nuclear cyclin/PCNA antigen staining of non S‐phase transformed human amnion cells engaged in nucleotide excision DNA repair

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Mutant p53 proteins bind DNA abnormally in vitro.

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Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells

Deb, S., Jackson, C. T., Subler, M. A., & Martin, D. W. (1992) · Journal of Virology · doi:10.1128/jvi.66.10.6164-6170.1992 · Cited by 160 · see citing works

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.

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Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein.

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Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.

Borellini, F., & Glazer, R. I. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53046-5 · Cited by 147 · see citing works

How loops, β sheets, and α helices help us to understand p53

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A potential transcriptional activation element in the p53 protein.

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Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.Preprint

Chen, X., Farmer, G., Zhu, H., Prywes, R., & Prives, C. L. (1993) · Genes & Development · doi:10.1101/gad.7.10.1837 · Cited by 123 · see citing works

The core promoter region of the P-glycoprotein gene is sufficient to confer differential responsiveness to wild-type and mutant p53.

Zastawny, R. L., Salvino, R., Chen, J., Benchimol, S., & Ling (1993) · PubMed · Cited by 118 · see citing works

p53 binds to the TATA-binding protein-TATA complex

Martin, D. W., Muñoz, R. M., Subler, M. A., & Deb, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38619-3 · Cited by 107 · see citing works

Wild-type human p53 activates the human epidermal growth factor receptor promoter.

Deb, S., Muñoz, R. M., Brown, D. R., Subler, M. A., & Deb, S. (1994) · PubMed · Cited by 98 · see citing works

Response of heat shock element within the human HSP70 promoter to mutated p53 genes.

Tsutsumi‐Ishii, Y., Tadokoro, K., Hanaoka, F., & Tsuchida, N. (1995) · PubMed · Cited by 64 · see citing works

The Tumor Suppressor p53 and the Oncoprotein Simian Virus 40 T Antigen Bind to Overlapping Domains on the MDM2 Protein

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Analysis of the proliferating cell nuclear antigen promoter and its response to adenovirus early region 1.

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N-terminal 130 amino acids of MDM2 are sufficient to inhibit p53-mediated transcriptional activation.

Leng, R. P., Brown, D. R., Shivakumar, C., Deb, S., & Deb, S. (1995) · PubMed · Cited by 48 · see citing works

Transcriptional Regulation of the PCNA Promoter by p53

Jackson, P., Ridgway, P., Rayner, J. R., Noble, J., & Braithwaite, A. W. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2159 · Cited by 46 · see citing works

Overlapping domains on the p53 protein regulate its transcriptional activation and repression functions.

Subler, M. A., Martin, D. W., & Deb, S. (1994) · PubMed · Cited by 44 · see citing works

Differential ability of proximal and remote element pairs to cooperate in activating RNA polymerase II transcription.

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Erratum: Cooperative DNA binding of p53 with TFIID (TBP): A possible mechanism for transcriptional activation (Genes and Development 7 (1837- 1849))

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TRANSCRIPTIONAL ANTAGONISM BETWEEN P53 AND SV40 T-ANTIGEN

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p53: puzzle and paradigm.Preprint

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p53 and Human Cancer: The First Ten Thousand Mutations

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Census and evaluation of p53 target genes

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Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems

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Proliferating cell nuclear antigen (PCNA): ringmaster of the genome

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DNA microarrays identification of primary and secondary target genes regulated by p53

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Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks

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Tight junctions and the regulation of gene expression

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Transcriptional Activation by p53 of the Human Type IV Collagenase (Gelatinase A or Matrix Metalloproteinase 2) Promoter

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Transcriptional Activation of the Human Glutathione Peroxidase Promoter by p53

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Toxicogenomics-Based Discrimination of Toxic Mechanism in HepG2 Human Hepatoma Cells

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Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation

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Regulation of PCNA and Cyclin D1 Expression and Epithelial Morphogenesis by the ZO-1-Regulated Transcription Factor ZONAB/DbpA

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Tyrosinase Gene Expression is Regulated by p53

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p53-Mediated Regulation of Proliferating Cell Nuclear Antigen Expression in Cells Exposed to Ionizing Radiation

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Transcriptional activation of tyrosinase and TRP-1 by p53 links UV irradiation to the protective tanning response

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The UVB-induced gene expression profile of human epidermis in vivo is different from that of cultured keratinocytes

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The Impact of 5-Azacytidine on Placental Weight, Glycoprotein Pattern and Proliferating Cell Nuclear Antigen Expression in Rat Placenta

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Transcriptome profiling the gills of amoebic gill disease (AGD)-affected Atlantic salmon (Salmo salarL.): a role for tumor suppressor p53 in AGD pathogenesis?

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Deletion of the COOH-terminal region of p73alpha enhances both its transactivation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells.

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p53 Stimulates Promoter Activity of the sgk Serum/Glucocorticoid-inducible Serine/Threonine Protein Kinase Gene in Rodent Mammary Epithelial Cells

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Stable binding of the eukaryotic acidic phosphoproteins to the ribosome is not an absolute requirement for in vivo protein synthesis.

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The effect of environmental cues on the differentiation of myofibroblasts in peritoneal granulation tissue

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p53 Homologue p63 Represses Epidermal Growth Factor Receptor Expression

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Novel Interaction between Proliferating Cell Nuclear Antigen and HLA I on the Surface of Tumor Cells Inhibits NK Cell Function through NKp44

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Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen

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Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both

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Acute response of human skin to solar radiation: regulation and function of the p53 protein

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Thymidine Dinucleotide Mimics the Effect of Solar Simulated Irradiation on p53 and p53-Regulated Proteins

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Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis

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Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan

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Suppression of DNA Repair by HTLV Type 1 Tax Correlates with Tax trans -Activation of Proliferating Cell Nuclear Antigen Gene Expression

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Natural Biology of Polyomavirus Middle T Antigen

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Inhaled Asbestos Fibers Induce p53 Expression in the Rat Lung

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Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1

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In human hepatocellular carcinoma in cirrhosis proliferating cell nuclear antigen (PCNA) is involved in cell proliferation and cooperates with P21 in DNA repair

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Complex functions of mutant p53 alleles from human prostate cancer

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Inhibition of Mouse Thymidylate Synthase Promoter Activity by the Wild-Type p53 Tumor Suppressor Protein

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Adaptive response of the skin to UVB damage: role of the p53 protein

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Enhanced expression of Ki-67, topoisomerase IIα, PCNA, p53 and p21WAF1/Cip1 reflecting proliferation and repair activity in UV-irradiated melanocytic nevi

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p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation

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Involvement of RFX1 Protein in the Regulation of the Human Proliferating Cell Nuclear Antigen Promoter

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Association of p53 with Neurodegeneration in Parkinson’s Disease

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Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation

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Induction of p53-dependent Activation of the Human Proliferating Cell Nuclear Antigen Gene in Chromatin by Ionizing Radiation

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Role of topoisomerase inhibition and DNA repair mechanisms in the genotoxicity of alternariol and altertoxin-II

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Damage to dopaminergic neurons is mediated by proliferating cell nuclear antigen through the p53 pathway under conditions of oxidative stress in a cell model of Parkinson's disease

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p53 is dispensable for apoptosis but controls neurogenesis of mouse dentate gyrus cells following γ-irradiation

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Spatial repression ofPCNAby p53 during kidney development

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p53 may positively regulate hepatocyte proliferation in rats

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Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluation

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Sulfuretin Attenuates MPP+-Induced Neurotoxicity through Akt/GSK3β and ERK Signaling Pathways

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p53 suppresses cytokine induced, Stat5 mediated activation of transcription

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Transcriptional Regulation by Mutant p53 and Oncogenesis

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Quantification of Inducible SOS-Like Photoprotective Responses in Human Skin

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Effects of ginsenoside Rg2 on the ultraviolet B-induced DNA damage responses in HaCaT cells

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Two Functionally Divergent p53-responsive Elements in the Rat Bradykinin B2 Receptor Promoter

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Taurine chloramine inhibits proliferation of rheumatoid arthritis synoviocytes by triggering a p53-dependent pathway

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Activation of pRL-TK by 12S E1A Oncoprotein: Drawbacks of Using an Internal Reference Reporter in Transcription Assays

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The Role of Ginseng and Its Bioactive Compounds in Aging: Cells and Animal Studies

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α-lipoic acid exerts neuroprotective effects on neuronal cells by upregulating the expression of PCNA via the P53 pathway in neurodegenerative conditions

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UV inducibility of rat proliferating cell nuclear antigen gene promoter

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Characterization of a putative p53 binding site in the promoter of the mouse tissue inhibitor of metalloproteinases-3 (TEMP-3) gene: TIMP-3 is not a p53 target gene

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Podophyllum hexandrum Fraction (REC-2006) Shows Higher Radioprotective Efficacy in the p53-Carrying Hepatoma Cell Line: A Role of Cell Cycle Regulatory Proteins

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Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling

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Binding sequence-dependent regulation of the human proliferating cell nuclear antigen promoter by p53

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The G1-phase Growth-arresting Action of Interleukin-1 Is Independent of p53 and p21/WAF1 Function

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Ablation of p21waf1cip1 expression enhances the capacity of p53-deficient human tumor cells to repair UVB-induced DNA damage.

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The Promoter of the Human Proliferating Cell Nuclear Antigen Gene Is Not Sufficient for Cell Cycle-dependent Regulation in Organotypic Cultures of Keratinocytes

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Differential Regulation of p53-dependent and -independent Proliferating Cell Nuclear Antigen Gene Transcription by 12 S E1A Oncoprotein Requires CBP

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Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells.

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Increased expression of p53 and p21 (Waf1/Cip1) in the lesional skin of bleomycin-induced scleroderma

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Investigation of the In-Vivo Cytotoxicity and the In Silico-Prediction of MDM2-p53 Inhibitor Potential of Euphorbia peplus Methanolic Extract in Rats

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The p53 Tumour Suppressor Protein

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DNA binding specificity of proteins derived from alternatively spliced mouse p53 mRNAs

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Dual action of the adenovirus E1A 243R oncoprotein on the human proliferating cell nuclear antigen promoter: repression of transcriptional activation by p53

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Cloning and characterization of PHGPx and its synergistic role with p53 in mediating stress in Penaeus monodon

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Expression of Bax, Bcl-2, Waf-1, and PCNA gene products in an immortalized human endothelial cell line undergoing p53-mediated apoptosis

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Molecular Pathways of Drug Resistance

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Sequential Alteration of Apoptosis, p53 Expression, and Cell Proliferation in the Rat Pancreas Treated with 4-Hydroxyaminoquinoline 1-Oxide

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The Roles of p53, DNA Repair, and Oxidative Stress in Ultraviolet C Induction of Proliferating Cell Nuclear Antigen Expression

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Differential binding of nuclear proteins to the TP53 gene promoter in male breast tumour

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p22/PACAP Response Gene 1 (PRG1): A Putative Target Gene for the Tumor Suppressor p53

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Tumour suppressor protein p53 released by nuclease digestion increases at the onset of rat liver regeneration

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