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The von Hippel-Lindau Tumor Suppressor Gene Product Interacts with Sp1 To Repress Vascular Endothelial Growth Factor Promoter Activity

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The Tumor Suppressor p53 and Histone Deacetylase 1 Are Antagonistic Regulators of the Cyclin-Dependent Kinase Inhibitor p21/WAF1/CIP1 Gene

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Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression

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Transcriptional Activation of the Human Epidermal Growth Factor Receptor Promoter by Human p53

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p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents

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DNA Damage-Induced Downregulation of Cdc25C Is Mediated by p53 via Two Independent Mechanisms

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Sp1 Plays a Critical Role in the Transcriptional Activation of the Human Cyclin-dependent Kinase Inhibitor p21 Gene by the p53 Tumor Suppressor Protein

Koutsodontis, G., Tentes, I. K., Papakosta, P., Moustakas, A., & Kardassis, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104130200 · Cited by 159

p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1

Ohlsson, C., Kley, N., Werner, H., & LeRoith, D. (1998) · Endocrinology · doi:10.1210/endo.139.3.5832 · Cited by 157

Steroidogenic Factor 1 (SF-1) and SP1 Are Required for Regulation of Bovine CYP11A Gene Expression in Bovine Luteal Cells and Adrenal Y1 Cells

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Inhibition of DNA Topoisomerase IIα Gene Expression by the p53 Tumor Suppressor

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Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.

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Tumor-Derived p53 Mutants Induce NF-κB2 Gene Expression

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p53 Down-regulates Human Matrix Metalloproteinase-1 (Collagenase-1) Gene Expression

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Nuclear Receptor-Mediated Transactivation Through Interaction with Sp Proteins

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Transcriptional activation of hTERT through the NF-κB pathway in HTLV-I–transformed cells

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Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter

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p53: A Cell Cycle Regulator Activated by DNA Damage

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Modulation of Gene Expression by Tumor-Derived p53 Mutants

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The Cyclin A1-CDK2 Complex Regulates DNA Double-Strand Break Repair

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Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

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p53 Regulates Caveolin Gene Transcription, Cell Cholesterol, and Growth by a Novel Mechanism

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Functional and Physical Interaction between p53 and BZLF1: Implications for Epstein-Barr Virus Latency

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Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.

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p53 and Sp1 Interact and Cooperate in the Tumor Necrosis Factor-induced Transcriptional Activation of the HIV-1 Long Terminal Repeat

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The (patho)physiological functions of the MRP family

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Sp1 Is a Critical Regulator of the Wilms' tumor-1 Gene

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ATF3 Represses 72-kDa Type IV Collagenase (MMP-2) Expression by Antagonizing p53-dependent trans-Activation of the Collagenase Promoter

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Wild Type and Mutant p53 Differentially Regulate the Gene Expression of Human Collagenase-3 (hMMP-13)

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p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor.

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Sp1-Mediated Transcription of the Werner Helicase Gene Is Modulated by Rb and p53

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The tumor suppressor protein p53 strongly alters human immunodeficiency virus type 1 replication

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Tumor Suppressor p53 Mutations and Breast Cancer: A Critical Analysis

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A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage

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The Tumor Suppressor Protein p53 Requires a Cofactor to Activate Transcriptionally the Human BAX Promoter

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Regulation of Sp1 by cell cycle related proteins

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A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening

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Role of Sp1 in cAMP-dependent Transcriptional Regulation of the Bovine CYP11A Gene

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p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter

Pietrzak, M., & Puzianowska‐Kuźnicka, M. (2008) · Biological Chemistry · doi:10.1515/bc.2008.039 · Cited by 77

The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene

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Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression

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Regulation of parathyroid hormone-related protein (PTHrP) gene expression. Sp1 binds through an inverted CACCC motif and regulates promoter activity in cooperation with Ets1.

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The Gene Encoding p202, an Interferon-inducible Negative Regulator of the p53 Tumor Suppressor, Is a Target of p53-mediated Transcriptional Repression

D’Souza, S., Xin, H., Walter, S., & Choubey, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007155200 · Cited by 72

DNA Damage-induced Down-regulation of Human Cdc25C and Cdc2 Is Mediated by Cooperation between p53 and Maintenance DNA (Cytosine-5) Methyltransferase 1

Gac, G. L., Estève, P., Férec, C., & Pradhan, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603724200 · Cited by 70

P14ARF inhibits human glioblastoma–induced angiogenesis by upregulating the expression of TIMP3

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Mutant p53 Forms a Complex with Sp1 on HIV-LTR DNA

Chicas, A., Molina, P. E., & Bargonetti, J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3965 · Cited by 69

Regulation of multidrug resistance through the cAMP and EGF signalling pathways

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Wild Type p53 Stimulates Expression from the Human Multidrug Resistance Promoter in a p53-negative Cell Line

Goldsmith, M. E., Gudas, J. M., Schneider, E., & Cowan, K. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.4.1894 · Cited by 67

Transcriptional Regulation of the Human DNA Polymerase δ Catalytic Subunit Gene POLD1 by p53 Tumor Suppressor and Sp1

Li, B., & Lee, M. Y. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101167200 · Cited by 65

p53 Homologue p63 Represses Epidermal Growth Factor Receptor Expression

Nishi, H., Senoo, M., Nishi, K., Murphy, B., Rikiyama, T., Matsumura, Y., Habu, S., & Johnson, A. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101241200 · Cited by 65

Infrequent mutations of the p53 gene in pulmonary carcinoid tumors.

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Response of heat shock element within the human HSP70 promoter to mutated p53 genes.

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Induction of p53-Dependent, Insulin-Like Growth Factor-Binding Protein-3-Mediated Apoptosis in Glioblastoma Multiforme Cells by a Protein Kinase Cα Antisense Oligonucleotide

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Lead Exposure in Pheochromocytoma (PC12) Cells Alters Neural Differentiation and Sp1 DNA-Binding

Crumpton, T. L., Atkins, D. S., Zawia, N. H., & Barone, S. (2001) · NeuroToxicology · doi:10.1016/s0161-813x(00)00008-5 · Cited by 62

Specificity Protein 1 (Sp1) Maintains Basal Epithelial Expression of the miR-200 Family

Kolesnikoff, N., Attema, J. L., Roslan, S., Bert, A. G., Schwarz, Q., Gregory, P. A., & Goodall, G. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.529172 · Cited by 60

Transcription factor Sp1 is expressed by three different developmentally regulated messenger ribonucleic acids in mouse spermatogenic cells

Persengiev, S. P., Raval, P., Rabinovitch, S., Millette, C. F., & Kilpatrick, D. L. (1996) · Endocrinology · doi:10.1210/en.137.2.638 · Cited by 60

Regulation of constitutive expression of mouse PTEN by the 5′-untranslated region

Han, B., Dong, Z., Liu, Y., Chen, Q., Hashimoto, K., & Zhang, J. (2003) · Oncogene · doi:10.1038/sj.onc.1206783 · Cited by 58

p53-Dependent Transcriptional Control of Cellular Prion by Presenilins

Vincent, B., Sunyach, C., Orzechowski, H., George‐Hyslop, P. S., & Checler, F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0789-09.2009 · Cited by 62

Epigenetic regulation of miR-200 as the potential strategy for the therapy against triple-negative breast cancer

Ramaiah, M. J., Naushad, S. M., Ponnusamy, L., Arivazhagan, G., Sakthiprasad, V., & Pal‐Bhadra, M. (2017) · Gene · doi:10.1016/j.gene.2017.10.018 · Cited by 59

p53 down‐regulates matrix metalloproteinase‐1 by targeting the communications between AP‐1 and the basal transcription complex

Sun, Y., Zeng, X., Wenger, L., Firestein, G. S., & Cheung, H. S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20044 · Cited by 57

A comprehensive study of p53 protein

Patil, M. R., & Bihari, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30331 · Cited by 57

Sp1-p53 Heterocomplex Mediates Activation of HTLV-I Long Terminal Repeat by 12-O-Tetradecanoylphorbol-13-acetate That Is Antagonized by Protein Kinase C

Torgeman, A., Mor‐Vaknin, N., Zelin, E., Ben-Aroya, Z., Löchelt, M., Flügel, R. M., & Aboud, M. (2001) · Virology · doi:10.1006/viro.2000.0779 · Cited by 54

RelA-Associated Inhibitor Blocks Transcription of Human Immunodeficiency Virus Type 1 by Inhibiting NF-κB and Sp1 Actions

Takada, N., Sanda, T., Okamoto, H., Yang, J., Asamitsu, K., Sarol, L. D. C., Kimura, G., Uranishi, H., Tetsuka, T., & Okamoto, T. (2002) · Journal of Virology · doi:10.1128/jvi.76.16.8019-8030.2002 · Cited by 53

Transcriptional Repression of Protein Kinase Cα via Sp1 by Wild Type p53 Is Involved in Inhibition of Multidrug Resistance 1 P-Glycoprotein Phosphorylation

Zhan, M., Yu, D., Liu, J., Hannay, J. A. F., & Pollock, R. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407450200 · Cited by 52

Additive effect between NF-κB subunits and p53 protein for transcriptional activation of human p53 promoter

Benoît, V., Hellin, A., Huygen, S., GIELEN, J. E., Bours, V., & Merville, M.-P. (2000) · Oncogene · doi:10.1038/sj.onc.1203831 · Cited by 52

Epidermal Growth Factor Sensitizes Cells to Ionizing Radiation by Down-regulating Protein Mutated in Ataxia-Telangiectasia

Gueven, N., Keating, K. E., Chen, P., Fukao, T., Khanna, K. K., Watters, D. J., Rodemann, H. P., & Lavin, M. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006190200 · Cited by 51

Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: Evidence that 15-lipoxygenase is a mutator gene

Kelavkar, U. P., & Badr, K. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4378 · Cited by 49

A Comparison of Apoptosis and Necrosis Induced by Hepatotoxins in HepG2 Cells

O’Brien, T. J., Babcock, G. F., Cornelius, J. R., Dingeldein, M., Talaska, G., Warshawsky, D., & Mitchell, K. R. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.8917 · Cited by 49

Regulation of Constitutive Gene Expression through Interactions of Sp1 Protein with the Nuclear Aryl Hydrocarbon Receptor Complex

Wang, F., Wang, W., & Safe, S. H. (1999) · Biochemistry · doi:10.1021/bi982578f · Cited by 49

The Polycystic Kidney Disease-1 Gene Is a Target for p53-mediated Transcriptional Repression

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p53, proto-oncogene and rheumatoid arthritis

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