The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter
Open accessAbstract
The myeloid integrin CD11b is expressed selectively on the surface of mature monocytes, macrophages, granulocytes, and natural killer cells. Tissue-specific and developmentally regulated expression of CD11b is controlled at the level of mRNA transcription, and recent characterization of the human CD11b promoter indicates that the first 92 bp of 5'-flanking DNA are sufficient to direct tissue-specific expression of a reporter gene. Here we show that the sequence AAAAGGAGAAG at base pair -20 of the CD11b promoter binds the proto-oncogene PU.1 in vitro and that mutation of this site significantly reduces the ability of the CD11b promoter to direct expression of a reporter gene in myeloid cells but not in nonmyeloid cells. PU.1 may thus represent a major determinant of the myeloid expression of CD11b.
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“PU.1 imparts its key functions by regulating vast number of myeloid gene promoters that include GM-CSF receptor a, M-CSF receptor (M-CSFR), scavenger receptor CD163, and CD11b, etc (6,7).”
From FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1 (2021) · cites this paper as [7]
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Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
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Metadata
- Authors
- Pahl, H. L., Scheibe, R. J., Zhang, D. E., Chen, H. M., Galson, D. L., Maki, R. A., & Tenen, D. G.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1993-03
- Volume
- 268
- Issue
- 7
- Pages
- 5014-5020
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1599437019
- Cited by
- 301
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 2
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- National Institutes of Health (5r01ai030656-08)
- National Cancer Institute (CA 41456, R01CA041456)
- National Institute of Allergy and Infectious Diseases (AI30656)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- PU.1, CD11b, promoter regulation, transcription factor binding sites, monocytes, macrophages, granulocytes, natural killer cells, tissue-specific gene expression, transcriptional regulation
- MeSH terms
- Proto-Oncogene Mas, Base Sequence, Binding Sites, Cell Line, DNA, DNA-Binding Proteins, Gene Expression Regulation, HeLa Cells, Humans, Molecular Sequence Data, Monocytes, Oligonucleotides, Promoter Regions, Genetic, Proto-Oncogenes, RNA, Messenger, Retroviridae Proteins, Oncogenic, Antigens, CD, CD11 Antigens
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