Cited by 301Genomics and Chromatin DynamicsCell Adhesion Molecules ResearchRetinoids in leukemia and cellular processes

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The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter

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Pahl, H.L., Scheibe, R.J., Zhang, D.E., Chen, H.M., Galson, D.L., Maki, R.A., Tenen, D.G.·1993·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(18)53496-7

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Abstract

The myeloid integrin CD11b is expressed selectively on the surface of mature monocytes, macrophages, granulocytes, and natural killer cells. Tissue-specific and developmentally regulated expression of CD11b is controlled at the level of mRNA transcription, and recent characterization of the human CD11b promoter indicates that the first 92 bp of 5'-flanking DNA are sufficient to direct tissue-specific expression of a reporter gene. Here we show that the sequence AAAAGGAGAAG at base pair -20 of the CD11b promoter binds the proto-oncogene PU.1 in vitro and that mutation of this site significantly reduces the ability of the CD11b promoter to direct expression of a reporter gene in myeloid cells but not in nonmyeloid cells. PU.1 may thus represent a major determinant of the myeloid expression of CD11b.

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Authors: Pahl, H. L., Scheibe, R. J., Zhang, D. E., Chen, H. M., Galson, D. L., Maki, R. A., & Tenen, D. G.
Affiliations: Beth Israel Deaconess Medical Center (US)
ORCID: Zhang, D.E.
Chen, H.M.
Galson, D.L.
Maki, R.A.
Tenen, D.G.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1993-03
Volume: 268
Issue: 7
Pages: 5014-5020
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)53496-7
OpenAlex: W1599437019
Cited by: 301
References: 29
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 2
FWCI: 9.82
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10089 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Funders: National Institutes of Health (5r01ai030656-08)
National Cancer Institute (CA 41456, R01CA041456)
National Institute of Allergy and Infectious Diseases (AI30656)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Keywords: PU.1, CD11b, promoter regulation, transcription factor binding sites, monocytes, macrophages, granulocytes, natural killer cells, tissue-specific gene expression, transcriptional regulation
MeSH terms: Proto-Oncogene Mas, Base Sequence, Binding Sites, Cell Line, DNA, DNA-Binding Proteins, Gene Expression Regulation, HeLa Cells, Humans, Molecular Sequence Data, Monocytes, Oligonucleotides, Promoter Regions, Genetic, Proto-Oncogenes, RNA, Messenger, Retroviridae Proteins, Oncogenic, Antigens, CD, CD11 Antigens

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The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter

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